{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:37:59Z","timestamp":1778661479716,"version":"3.51.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004931","name":"Funda\u00e7\u00e3o Ary Frauzino para Pesquisa e Controle do C\u00e2ncer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004931","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia para o Controle do C\u00e2ncer"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Invest New Drugs"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s10637-016-0359-2","type":"journal-article","created":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T02:07:12Z","timestamp":1463537232000},"page":"541-551","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["In vitro and in vivo antineoplastic and immunological effects of pterocarpanquinone LQB-118"],"prefix":"10.1007","volume":"34","author":[{"given":"Eduardo J.","family":"Salustiano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus L.","family":"Dumas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel G.","family":"Silva-Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaquip D.","family":"Netto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo R. R.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian M.","family":"Rumjanek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,5,18]]},"reference":[{"key":"359_CR1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1039\/np9951200321","volume":"12","author":"DMX Donnelly","year":"1995","unstructured":"Donnelly DMX, Boland GM (1995) Isoflavonoids and neoflavonoids: naturally occurring O-heterocycles. Nat Prod Rep 12:321. doi:10.1039\/np9951200321","journal-title":"Nat Prod Rep"},{"key":"359_CR2","doi-asserted-by":"publisher","first-page":"7632","DOI":"10.1021\/jf034427b","volume":"51","author":"D Kostelac","year":"2003","unstructured":"Kostelac D, Rechkemmer G, Briviba K (2003) Phytoestrogens modulate binding response of estrogen receptors alpha and beta to the estrogen response element. J Agric Food Chem 51:7632\u20137635. doi:10.1021\/jf034427b","journal-title":"J Agric Food Chem"},{"key":"359_CR3","doi-asserted-by":"publisher","first-page":"4580","DOI":"10.1021\/jf900340b","volume":"57","author":"H Zhou","year":"2009","unstructured":"Zhou H, Lutterodt H, Cheng Z, Yu LL (2009) Anti-inflammatory and antiproliferative activities of trifolirhizin, a flavonoid from Sophora flavescens roots. J Agric Food Chem 57:4580\u20134585. doi:10.1021\/jf900340b","journal-title":"J Agric Food Chem"},{"key":"359_CR4","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1590\/S0103-50532004000600029","volume":"15","author":"AJ da Silva","year":"2004","unstructured":"da Silva AJ, Netto CD, Costa PR (2004) The first synthesis of (\u00b1)-3, 4-dihydroxy-8,9-methylenedioxypterocarpan, an antitumoral agent and its coumestan derivative. J Braz Chem Soc 15:979\u2013981. doi:10.1590\/S0103-50532004000600029","journal-title":"J Braz Chem Soc"},{"key":"359_CR5","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.ejmech.2008.01.027","volume":"44","author":"CD Netto","year":"2009","unstructured":"Netto CD, Santos ES, Castro CP, da Silva AJ, Rumjanek VM, Costa PR (2009) (+\/\u2212)-3,4-dihydroxy-8,9-methylenedioxypterocarpan and derivatives: cytotoxic effect on human leukemia cell lines. Eur J Med Chem 44:920\u2013925. doi:10.1016\/j.ejmech.2008.01.027","journal-title":"Eur J Med Chem"},{"key":"359_CR6","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1007\/s10637-014-0137-y","volume":"32","author":"V Kuete","year":"2014","unstructured":"Kuete V, Sandjo LP, Djeussi DE, Zeino M, Kwamou GM, Ngadjui B, Efferth T (2014) Cytotoxic flavonoids and isoflavonoids from Erythrina Sigmoidea towards multi-factorial drug resistant cancer cells. Investig New Drugs 32:1053\u20131062. doi:10.1007\/s10637-014-0137-y","journal-title":"Investig New Drugs"},{"key":"359_CR7","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.ejmech.2014.03.039","volume":"78","author":"CD Buarque","year":"2014","unstructured":"Buarque CD, Salustiano EJ, Fraga KC, Alves BR, Costa PR (2014) 11a-N-Tosyl-5-deoxi-pterocarpan (LQB-223), a promising prototype for targeting MDR leukemia cell lines. Eur J Med Chem 78:190\u2013197. doi:10.1016\/j.ejmech.2014.03.039","journal-title":"Eur J Med Chem"},{"key":"359_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0009-2797(91)90029-7","volume":"80","author":"PJ O'Brien","year":"1991","unstructured":"O'Brien PJ (1991) Molecular mechanisms of quinone cytotoxicity. Chem Biol Interact 80:1\u201341. doi:10.1016\/0009-2797(91)90029-7","journal-title":"Chem Biol Interact"},{"key":"359_CR9","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1111\/bjh.12894","volume":"166","author":"E Derenzini","year":"2014","unstructured":"Derenzini E, Casadei B, Broccoli A, Gandolfi L, Pellegrini C, Zinzani PL (2014) Sequential therapy with alternating short courses of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) and R-FM (rituximab, fludarabine, mitoxantrone) followed by autologous stem cell transplantation results in long term remission in advanced follicular lymphoma. Br J Haematol 166:625\u2013628. doi:10.1111\/bjh.12894","journal-title":"Br J Haematol"},{"key":"359_CR10","doi-asserted-by":"publisher","first-page":"3754","DOI":"10.1161\/CIRCULATIONAHA.105.576850","volume":"112","author":"L Wojnowski","year":"2005","unstructured":"Wojnowski L, Kulle B, Schirmer M, Schluter G, Schmidt A, Rosenberger A, Vonhof S, Bickeboller H, Toliat MR, Suk EK, Tzvetkov M, Kruger A, Seifert S, Kloess M, Hahn H, Loeffler M, Nurnberg P, Pfreundschuh M, Trumper L, Brockmoller J, Hasenfuss G (2005) NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity. Circulation 112:3754\u20133762. doi:10.1161\/CIRCULATIONAHA.105.576850","journal-title":"Circulation"},{"key":"359_CR11","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1093\/jac\/dkr158","volume":"66","author":"EF da Cunha-Junior","year":"2011","unstructured":"da Cunha-Junior EF, Pacienza-Lima W, Ribeiro GA, Netto CD, do Canto-Cavalheiro MM, da Silva AJ, Costa PR, Rossi-Bergmann B, Torres-Santos EC (2011) Effectiveness of the local or oral delivery of the novel naphthopterocarpanquinone LQB-118 against cutaneous leishmaniasis. J Antimicrob Chemother 66:1555\u20131559. doi:10.1093\/jac\/dkr158","journal-title":"J Antimicrob Chemother"},{"key":"359_CR12","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s10637-009-9231-y","volume":"28","author":"EJ Salustiano","year":"2010","unstructured":"Salustiano EJ, Netto CD, Fernandes RF, da Silva AJ, Bacelar TS, Castro CP, Buarque CD, Maia RC, Rumjanek VM, Costa PR (2010) Comparison of the cytotoxic effect of lapachol, alpha-lapachone and pentacyclic 1,4-naphthoquinones on human leukemic cells. Investig New Drugs 28:139\u2013144. doi:10.1007\/s10637-009-9231-y","journal-title":"Investig New Drugs"},{"key":"359_CR13","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1016\/j.bmc.2009.12.073","volume":"18","author":"CD Netto","year":"2010","unstructured":"Netto CD, da Silva AJ, Salustiano EJ, Bacelar TS, Rica IG, Cavalcante MC, Rumjanek VM, Costa PR (2010) New pterocarpanquinones: synthesis, antineoplasic activity on cultured human malignant cell lines and TNF-alpha modulation in human PBMC cells. Bioorg Med Chem 18:1610\u20131616. doi:10.1016\/j.bmc.2009.12.073","journal-title":"Bioorg Med Chem"},{"key":"359_CR14","doi-asserted-by":"publisher","unstructured":"Da Silva AJM, Rumjanek VMBD, Bergmann BR, Salustiano EJ, Costa PRR, Netto CD, Lima WP, Dos Santos ECT, Cavalcante MCM, Seabra SH (2014) Compounds of the pterocarpanquinone family, method for preparing the same, pharmaceutical composition containing the new compounds of the pterocarpanquinone family, uses and therapeutic method. United States Patent US8835489-B2, 16\u201309-2014 doi:10.13140\/RG.2.1.1944.7769","DOI":"10.13140\/RG.2.1.1944.7769"},{"key":"359_CR15","doi-asserted-by":"publisher","first-page":"3115","DOI":"10.1016\/j.bmc.2014.04.025","volume":"22","author":"T Martino","year":"2014","unstructured":"Martino T, Magalhaes FC, Justo GA, Coelho MG, Netto CD, Costa PR, Sabino KC (2014) The pterocarpanquinone LQB-118 inhibits tumor cell proliferation by downregulation of c-Myc and cyclins D1 and B1 mRNA and upregulation of p21 cell cycle inhibitor expression. Bioorg Med Chem 22:3115\u20133122. doi:10.1016\/j.bmc.2014.04.025","journal-title":"Bioorg Med Chem"},{"key":"359_CR16","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1093\/jac\/dks498","volume":"68","author":"GA Ribeiro","year":"2013","unstructured":"Ribeiro GA, Cunha-Junior EF, Pinheiro RO, da-Silva SA, Canto-Cavalheiro MM, da Silva AJ, Costa PR, Netto CD, Melo RC, Almeida-Amaral EE, Torres-Santos EC (2013) LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis. J Antimicrob Chemother 68:789\u2013799. doi:10.1093\/jac\/dks498","journal-title":"J Antimicrob Chemother"},{"key":"359_CR17","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.3892\/ijo.2014.2615","volume":"45","author":"G Nestal de Moraes","year":"2014","unstructured":"Nestal de Moraes G, Castro CP, Salustiano EJ, Dumas ML, Costas F, Lam EW, Costa PR, Maia RC (2014) The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors. Int J Oncol 45:1949\u20131958. doi:10.3892\/ijo.2014.2615","journal-title":"Int J Oncol"},{"key":"359_CR18","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55\u201363. doi:10.1016\/0022-1759(83)90303-4","journal-title":"J Immunol Methods"},{"key":"359_CR19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.4049\/jimmunol.128.1.337","volume":"128","author":"R Palacios","year":"1982","unstructured":"Palacios R (1982) Concanavalin a triggers T lymphocytes by directly interacting with their receptors for activation. J Immunol 128:337\u2013342","journal-title":"J Immunol"},{"key":"359_CR20","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1007\/s10637-010-9453-z","volume":"29","author":"RC Maia","year":"2011","unstructured":"Maia RC, Vasconcelos FC, de Sa BT, Salustiano EJ, da Silva LF, Pereira DL, Moellman-Coelho A, Netto CD, da Silva AJ, Rumjanek VM, Costa PR (2011) LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells. Investig New Drugs 29:1143\u20131155. doi:10.1007\/s10637-010-9453-z","journal-title":"Investig New Drugs"},{"key":"359_CR21","doi-asserted-by":"publisher","first-page":"6885","DOI":"10.1016\/j.bmc.2011.09.025","volume":"19","author":"CD Buarque","year":"2011","unstructured":"Buarque CD, Militao GC, Lima DJ, Costa-Lotufo LV, Pessoa C, de Moraes MO, Cunha-Junior EF, Torres-Santos EC, Netto CD, Costa PR (2011) Pterocarpanquinones, aza-pterocarpanquinone and derivatives: synthesis, antineoplasic activity on human malignant cell lines and antileishmanial activity on Leishmania amazonensis. Bioorg Med Chem 19:6885\u20136891. doi:10.1016\/j.bmc.2011.09.025","journal-title":"Bioorg Med Chem"},{"key":"359_CR22","doi-asserted-by":"publisher","first-page":"341","DOI":"10.2174\/1871520611313020019","volume":"13","author":"FR de Souza Reis","year":"2013","unstructured":"de Souza Reis FR, de Faria FC, Castro CP, de Souza PS, da Cunha VF, Bello RD, da Silva AJ, Costa PR, Maia RC (2013) The therapeutical potential of a novel pterocarpanquinone LQB-118 to target inhibitor of apoptosis proteins in acute myeloid leukemia cells. Anti Cancer Agents Med Chem 13:341\u2013351. doi:10.2174\/1871520611313020019","journal-title":"Anti Cancer Agents Med Chem"},{"key":"359_CR23","doi-asserted-by":"publisher","first-page":"345","DOI":"10.2174\/18715206113139990108","volume":"15","author":"FC de Faria","year":"2015","unstructured":"de Faria FC, Leal ME, Bernardo PS, Costa PR, Maia RC (2015) NFkappaB pathway and microRNA-9 and \u221221 are involved in sensitivity to the pterocarpanquinone LQB-118 in different CML cell lines. Anti Cancer Agents Med Chem 15:345\u2013352. doi:10.2174\/18715206113139990108","journal-title":"Anti Cancer Agents Med Chem"},{"key":"359_CR24","doi-asserted-by":"publisher","first-page":"609","DOI":"10.5483\/BMBRep.2015.48.11.190","volume":"48","author":"ET Oh","year":"2015","unstructured":"Oh ET, Park HJ (2015) Implications of NQO1 in cancer therapy. BMB Rep 48:609\u2013617","journal-title":"BMB Rep"},{"key":"359_CR25","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1111\/bph.12935","volume":"172","author":"SM Cheng","year":"2015","unstructured":"Cheng SM, Chang YC, Liu CY, Lee JY, Chan HH, Kuo CW, Lin KY, Tsai SL, Chen SH, Li CF, Leung E, Kanwar JR, Huang CC, Chang JY, Cheung CH (2015) YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Br J Pharmacol 172:214\u2013234. doi:10.1111\/bph.12935","journal-title":"Br J Pharmacol"},{"key":"359_CR26","first-page":"880","volume":"62","author":"Q Ma","year":"2015","unstructured":"Ma Q, Chang Z, Wang W, Wang B (2015) Rapamycin-mediated mTOR inhibition reverses drug resistance to Adriamycin in Colon cancer cells. Hepato-Gastroenterology 62:880\u2013886","journal-title":"Hepato-Gastroenterology"},{"key":"359_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.coph.2016.02.004","volume":"28","author":"AS Chagin","year":"2016","unstructured":"Chagin AS (2016) Effectors of mTOR-autophagy pathway: targeting cancer, affecting the skeleton. Curr Opin Pharmacol 28:1\u20137. doi:10.1016\/j.coph.2016.02.004","journal-title":"Curr Opin Pharmacol"},{"key":"359_CR28","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1007\/s10637-009-9257-1","volume":"28","author":"JC Buckner","year":"2010","unstructured":"Buckner JC, Forouzesh B, Erlichman C, Hidalgo M, Boni JP, Dukart G, Berkenblit A, Rowinsky EK (2010) Phase I, pharmacokinetic study of temsirolimus administered orally to patients with advanced cancer. Investig New Drugs 28:334\u2013342. doi:10.1007\/s10637-009-9257-1","journal-title":"Investig New Drugs"},{"key":"359_CR29","doi-asserted-by":"publisher","first-page":"S169","DOI":"10.4161\/cbt.365","volume":"2","author":"MM Mita","year":"2003","unstructured":"Mita MM, Mita A, Rowinsky EK (2003) The molecular target of rapamycin (mTOR) as a therapeutic target against cancer. Cancer Biol Ther 2:S169\u2013S177","journal-title":"Cancer Biol Ther"},{"key":"359_CR30","doi-asserted-by":"publisher","first-page":"450390","DOI":"10.1155\/2014\/450390","volume":"2014","author":"F Capone","year":"2014","unstructured":"Capone F, Guerriero E, Sorice A, Colonna G, Storti G, Pagliuca J, Castello G, Costantini S (2014) Synergistic antitumor effect of doxorubicin and tacrolimus (FK506) on hepatocellular carcinoma cell lines. ScientificWorldJournal 2014:450390. doi:10.1155\/2014\/450390","journal-title":"ScientificWorldJournal"},{"key":"359_CR31","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.leukres.2005.05.024","volume":"30","author":"B Mazur","year":"2006","unstructured":"Mazur B, Szczepanski T, Karpe J, Sonta-Jakimczyk D, Bubala H, Torbus M (2006) Decreased numbers of CD4+ T lymphocytes in peripheral blood after treatment of childhood acute lymphoblastic leukemia. Leuk Res 30:33\u201336. doi:10.1016\/j.leukres.2005.05.024","journal-title":"Leuk Res"},{"key":"359_CR32","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nri798","volume":"2","author":"RN Germain","year":"2002","unstructured":"Germain RN (2002) T-cell development and the CD4-CD8 lineage decision. Nat Rev Immunol 2:309\u2013322. doi:10.1038\/nri798","journal-title":"Nat Rev Immunol"},{"key":"359_CR33","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.ijrobp.2015.07.2270","volume":"93","author":"RS Allodji","year":"2015","unstructured":"Allodji RS, Schwartz B, Veres C, Haddy N, Rubino C, Le Deley MC, Labbe M, Diop F, Jackson A, Dayet F, Benabdennebi A, Llanas D, Vu Bezin J, Chavaudra J, Lefkopoulos D, Deutsch E, Oberlin O, de Vathaire F, Diallo I (2015) Risk of subsequent leukemia after a solid tumor in childhood: impact of bone marrow radiation therapy and chemotherapy. Int J Radiat Oncol Biol Phys 93:658\u2013667. doi:10.1016\/j.ijrobp.2015.07.2270","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"359_CR34","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.bbadis.2010.11.010","volume":"1822","author":"D Ribatti","year":"2012","unstructured":"Ribatti D, Crivellato E (2012) Mast cells, angiogenesis, and tumour growth. Biochim Biophys Acta 1822:2\u20138. doi:10.1016\/j.bbadis.2010.11.010","journal-title":"Biochim Biophys Acta"},{"key":"359_CR35","doi-asserted-by":"publisher","first-page":"17","DOI":"10.4251\/wjgo.v7.i4.17","volume":"7","author":"T Aoyagi","year":"2015","unstructured":"Aoyagi T, Terracina KP, Raza A, Matsubara H, Takabe K (2015) Cancer cachexia, mechanism and treatment. World J Gastrointest Oncol 7:17\u201329. doi:10.4251\/wjgo.v7.i4.17","journal-title":"World J Gastrointest Oncol"},{"issue":"Suppl 1","key":"359_CR36","doi-asserted-by":"publisher","first-page":"S81","DOI":"10.1016\/j.ejphar.2011.07.007","volume":"668","author":"JM Argiles","year":"2011","unstructured":"Argiles JM, Busquets S, Lopez-Soriano FJ (2011) Anti-inflammatory therapies in cancer cachexia. Eur J Pharmacol 668(Suppl 1):S81\u2013S86. doi:10.1016\/j.ejphar.2011.07.007","journal-title":"Eur J Pharmacol"},{"key":"359_CR37","first-page":"129","volume":"32","author":"CA Camargo","year":"2012","unstructured":"Camargo CA, Gomes-Marcondes MC, Wutzki NC, Aoyama H (2012) Naringin inhibits tumor growth and reduces interleukin-6 and tumor necrosis factor alpha levels in rats with Walker 256 carcinosarcoma. Anticancer Res 32:129\u2013133","journal-title":"Anticancer Res"},{"key":"359_CR38","doi-asserted-by":"publisher","first-page":"12415","DOI":"10.1007\/s13277-014-2558-9","volume":"35","author":"B Li","year":"2014","unstructured":"Li B, Wan L, Li Y, Yu Q, Chen P, Gan R, Yang Q, Han Y, Guo C (2014) Baicalin, a component of Scutellaria Baicalensis, alleviates anorexia and inhibits skeletal muscle atrophy in experimental cancer cachexia. Tumour Biol 35:12415\u201312425. doi:10.1007\/s13277-014-2558-9","journal-title":"Tumour Biol"},{"key":"359_CR39","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/1471-2407-10-200","volume":"10","author":"SI de Oliveira","year":"2010","unstructured":"de Oliveira SI, Andrade LN, Onuchic AC, Nonogaki S, Fernandes PD, Pinheiro MC, Rohde CB, Chammas R, Jancar S (2010) Platelet-activating factor receptor (PAF-R)-dependent pathways control tumour growth and tumour response to chemotherapy. BMC Cancer 10:200. doi:10.1186\/1471-2407-10-200","journal-title":"BMC Cancer"}],"container-title":["Investigational New Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-016-0359-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10637-016-0359-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-016-0359-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-016-0359-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T04:57:01Z","timestamp":1678510621000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10637-016-0359-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,18]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["359"],"URL":"https:\/\/doi.org\/10.1007\/s10637-016-0359-2","relation":{},"ISSN":["0167-6997","1573-0646"],"issn-type":[{"value":"0167-6997","type":"print"},{"value":"1573-0646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,18]]},"assertion":[{"value":"1 December 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"LQB-118, compounds of the pterocarpanquinone family, methods for preparing the same, pharmaceutical compositions containing new compounds of the pterocarpanquinone family, uses and therapeutic methods are protected under patent number US8835489B2, assigned to the Federal University of Rio de Janeiro and granted by USPTO in 16\u201309-2014 []. Eduardo J. Salustiano, Chaquip D. Netto, Paulo R. Costa and Vivian M. Rumjanek are listed as inventors. Patent was not outlicenced and inventors did not receive money from private companies but grants from public agencies stated in Acknowledgments. Funding agencies had no role in study design, data collection or analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted. Procedures for animal experimentation were approved by the Centro de Ci\u00eancias da Sa\u00fade Ethics Committee for Animal Use (CEUA-CCS, UFRJ) under protocol number IBQM082.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}