{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T21:32:23Z","timestamp":1763155943063},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:00:00Z","timestamp":1501718400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:00:00Z","timestamp":1501718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Invest New Drugs"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1007\/s10637-017-0489-1","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T04:07:45Z","timestamp":1501733265000},"page":"691-705","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Synthesis, characterization, and evaluation of Cd[L-proline]2, a novel histone deacetylase inhibitor that induces epigenetic modification of histone deacetylase isoforms in A549 cells"],"prefix":"10.1007","volume":"35","author":[{"given":"Anusha","family":"Chidambaram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arunachalam","family":"Sekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavya","family":"S.H.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh Kumar","family":"Chidambaram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalaiarasi","family":"Arunachalam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senthilkumar","family":"G.P.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravikumar","family":"Vilwanathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,8,3]]},"reference":[{"key":"489_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0010-8545(98)00207-0","volume":"184","author":"DE Reichert","year":"1999","unstructured":"Reichert DE, Lewis JS, Anderson CJ (1999) Metal complexes as diagnostic tools. Coord Chem Rev 184:3\u201366","journal-title":"Coord Chem Rev"},{"key":"489_CR2","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/BF00133563","volume":"10","author":"G Sava","year":"1992","unstructured":"Sava G, Pacor S, Mestroni G, Alessio E (1992) Na [trans-RuCl4 (DMSO) Im], a metal complex of ruthenium with antimetastatic properties. Clin Exp Metastasis 10:273\u2013280","journal-title":"Clin Exp Metastasis"},{"key":"489_CR3","doi-asserted-by":"crossref","unstructured":"Thomson AJ, Williams RJP, Reslova S (1972) The chemistry of complexes related to cis-Pt(NH3)2Cl2. An anti-tumour drug. Structure and Bonding, Springer 11:1\u201346","DOI":"10.1007\/BFb0002459"},{"key":"489_CR4","doi-asserted-by":"publisher","first-page":"231","DOI":"10.4161\/epi.24042","volume":"8","author":"JM Phang","year":"2013","unstructured":"Phang JM, Liu W, Hancock C (2013) Bridging epigenetics and metabolism: role of nonessential amino acids. Epigenetics 8:231\u2013236","journal-title":"Epigenetics"},{"key":"489_CR5","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/S0010-8545(00)82029-9","volume":"12","author":"MJ Cleare","year":"1974","unstructured":"Cleare MJ (1974) Transition metal complexes in cancer chemotherapy. Coord Chem Rev 12:349\u2013405","journal-title":"Coord Chem Rev"},{"key":"489_CR6","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.cct.2003.11.002","volume":"248","author":"C Liu","year":"2004","unstructured":"Liu C, Wang M, Zhang T, Sun H (2004) DNA hydrolysis promoted by di-and multi-nuclear metal complexes. Coord Chem Rev 248:147\u2013168","journal-title":"Coord Chem Rev"},{"key":"489_CR7","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/1043-6618(89)90204-1","volume":"21","author":"G Sava","year":"1989","unstructured":"Sava G, Pacor S, Zorzet S, Alessio E, Mestroni G (1989) Antitumour properties of dimethylsulphoxide ruthenium (II) complexes in the Lewis lung carcinoma system. Pharmacol Res 21:617\u2013628","journal-title":"Pharmacol Res"},{"key":"489_CR8","doi-asserted-by":"crossref","unstructured":"Clarke MJ, Galang RD, Rodriguez VM, Kumar R, Pell S, Bryan DM (1988) Chemical considerations in the design of ruthenium anticancer agents. In Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy Springer, Boston, pp 582\u2013600","DOI":"10.1007\/978-1-4613-1717-3_65"},{"key":"489_CR9","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nrg962","volume":"3","author":"PA Jones","year":"2002","unstructured":"Jones PA, Baylin SB (2002) The fundamental role of epigenetic events in cancer. Nat Rev Genet 3:415\u2013428","journal-title":"Nat Rev Genet"},{"key":"489_CR10","doi-asserted-by":"publisher","first-page":"5420","DOI":"10.1038\/sj.onc.1210610","volume":"26","author":"MA Glozak","year":"2007","unstructured":"Glozak MA, Seto E (2007) Histone deacetylases and cancer. Oncogene 26:5420\u20135432","journal-title":"Oncogene"},{"key":"489_CR11","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S0092-8674(02)00644-X","volume":"108","author":"EJ Richards","year":"2002","unstructured":"Richards EJ, Elgin SCR (2002) Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects. Cell 108:489\u2013500","journal-title":"Cell"},{"key":"489_CR12","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/nrd772","volume":"1","author":"RW Johnstone","year":"2002","unstructured":"Johnstone RW (2002) Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat Rev Drug Discov 1:287\u2013299","journal-title":"Nat Rev Drug Discov"},{"key":"489_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canlet.2012.09.018","volume":"329","author":"HVK Diyabalanage","year":"2013","unstructured":"Diyabalanage HVK, Granda ML, Hooker JM (2013) Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer. Cancer Lett 329:1\u20138","journal-title":"Cancer Lett"},{"key":"489_CR14","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/nrm2395","volume":"9","author":"T Riley","year":"2008","unstructured":"Riley T, Sontag E, Chen P, Levine A (2008) Transcriptional control of human p53-regulated genes. Nat Rev Mol cell Biol. 9:402\u2013412","journal-title":"Nat Rev Mol cell Biol."},{"key":"489_CR15","doi-asserted-by":"publisher","first-page":"5097","DOI":"10.1021\/jm0303094","volume":"46","author":"TA Miller","year":"2003","unstructured":"Miller TA, Witter DJ, Belvedere S (2003) Histone deacetylase inhibitors. J Med Chem 46:5097\u20135116","journal-title":"J Med Chem"},{"key":"489_CR16","first-page":"929","volume":"52B","author":"B Thingom","year":"2013","unstructured":"Thingom B, Moirangthem SD, Laitonjam WS (2013) Cadmium- proline catalyzed direct asymmetric michael and aldol reactions in water. Indian J Chem 52B:929\u2013936","journal-title":"Indian J Chem"},{"key":"489_CR17","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.3748\/wjg.v10.i18.2731","volume":"10","author":"JP Yuan","year":"2004","unstructured":"Yuan JP, Wang GH, Ling H, Su Q, Yang YH, Song Y, Tang RJ, Liu Y, Huang C (2004) Diallyl disulfide-induced G2\/M arrest of human gastric cancer MGC803 cells involves activation of p38 MAP kinase pathways. World J Gastroenterol 10:2731\u20132734","journal-title":"World J Gastroenterol"},{"key":"489_CR18","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.biopha.2014.12.023","volume":"69","author":"S Karthik","year":"2015","unstructured":"Karthik S, Sankar R, Varunkumar K, Anusha C, Ravikumar V (2015) Blocking NF-\u03baB sensitizes non-small cell lung cancer cells to histone deacetylase inhibitor induced extrinsic apoptosis through generation of reactive oxygen species. Biomed Pharmacother 69:337\u2013344","journal-title":"Biomed Pharmacother"},{"key":"489_CR19","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3109\/13880209.2010.499517","volume":"49","author":"JG Wu","year":"2011","unstructured":"Wu JG, Ma L, Zhang SY (2011) Essential oil from rhizomes of Ligusticum chuanxiong induces apoptosis in hypertrophic scar fibroblasts. Pharm Biol 49:86\u201393","journal-title":"Pharm Biol"},{"issue":"6","key":"489_CR20","doi-asserted-by":"publisher","first-page":"4214","DOI":"10.18632\/oncotarget.2929","volume":"6","author":"X-S Liu","year":"2015","unstructured":"Liu X-S, John BL, Yuan Z-M (2015) Glycolytic metabolism influences global chromatin structure. Oncotarget 6(6):4214\u20134225","journal-title":"Oncotarget"},{"key":"489_CR21","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.biopha.2014.01.002","volume":"68","author":"S Karthik","year":"2014","unstructured":"Karthik S, Sankar R, Varunkumar K, Ravikumar V (2014) Romidepsin induces cell cycle arrest, apoptosis, histone hyperacetylation and reduces matrix metalloproteinases 2 and 9 expression in bortezomib sensitized non-small cell lung cancer cells. Biomed Pharmacother 68:327\u2013334","journal-title":"Biomed Pharmacother"},{"key":"489_CR22","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.poly.2013.02.068","volume":"54","author":"T Karmakar","year":"2013","unstructured":"Karmakar T, Kuang Y, Neamati N, Baruah JB (2013) Cadmium complexes and cocrystals of indium complexes of benzothiazole derivatives and anticancer activities of the cadmium complexes. Polyhedron 54:285\u2013293","journal-title":"Polyhedron"},{"key":"489_CR23","doi-asserted-by":"publisher","first-page":"4320","DOI":"10.1158\/0008-5472.CAN-06-2486","volume":"67","author":"YH Hsieh","year":"2007","unstructured":"Hsieh YH, Wu TT, Huang CY, Hsieh YS, Hwang JM, Liu JY (2007) p38 mitogen-activated protein kinase pathway is involved in protein kinase C\u03b1\u2013regulated invasion in human hepatocellular carcinoma cells. Cancer Res 67:4320\u20134327","journal-title":"Cancer Res"},{"key":"489_CR24","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1083\/jcb.201102147","volume":"196","author":"P Lu","year":"2012","unstructured":"Lu P, Weaver VM, Werb Z (2012) The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol 196:395\u2013406","journal-title":"J Cell Biol"},{"key":"489_CR25","first-page":"2","volume":"2","author":"S Moulik","year":"2014","unstructured":"Moulik S, Pal S, Biswas J, Chatterjee A (2014) Role of ERK in modulating MMP 2 and MMP 9 with respect to tumour invasiveness in human cancer cell line MCF-7 and MDA-MB-231. J Tumor 2:2","journal-title":"J Tumor"},{"key":"489_CR26","first-page":"599","volume":"23","author":"H Horiuchi","year":"2004","unstructured":"Horiuchi H, Kawamata H, Furihata T, Omotehara F, Hori H, Shinagawa Y, Ohkura Y, Tachibana M, Yamazaki T, Ajiki T, Kuroda Y (2004) A MEK inhibitor (U0126) markedly inhibits direct liver invasion of orthotopically inoculated human gallbladder cancer cells in nude mice. J Exp Clin cancer Res CR 23:599\u2013606","journal-title":"J Exp Clin cancer Res CR"},{"key":"489_CR27","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1101\/gad.13.12.1501","volume":"13","author":"CJ Sherr","year":"1999","unstructured":"Sherr CJ, Roberts JM (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13:1501\u20131512","journal-title":"Genes Dev"},{"key":"489_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1868-7083-4-5","volume":"4","author":"GP Delcuve","year":"2012","unstructured":"Delcuve GP, Khan DH, Davie JR (2012) Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors. Clin Epigenetics 4:1\u201313","journal-title":"Clin Epigenetics"},{"key":"489_CR29","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/nrm1075","volume":"4","author":"SK Kurdistani","year":"2003","unstructured":"Kurdistani SK, Grunstein M (2003) Histone acetylation and deacetylation in yeast. Nat Rev Mol cell Biol. 4:276\u2013284","journal-title":"Nat Rev Mol cell Biol."},{"key":"489_CR30","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s12094-008-0221-x","volume":"10","author":"O Mart\u00ednez-Iglesias","year":"2008","unstructured":"Mart\u00ednez-Iglesias O, Ruiz-Llorente L, S\u00e1nchez-Mart\u00ednez R, Garc\u00eda L, Zambrano A, Aranda A (2008) Histone deacetylase inhibitors: mechanism of action and therapeutic use in cancer. Clin Transl Oncol 10:395\u2013398","journal-title":"Clin Transl Oncol"},{"issue":"3","key":"489_CR31","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1042\/bj20021321","volume":"370","author":"AJ De Ruijter","year":"2003","unstructured":"De Ruijter AJ, Van Gennip AH, Caron HN, Stephan KEMP, Van Kuilenburg AB (2003) Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J 370(3):737\u2013749","journal-title":"Biochem J"},{"issue":"1","key":"489_CR32","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.canlet.2008.08.016","volume":"277","author":"O Witt","year":"2009","unstructured":"Witt O, Deubzer HE, Milde T, Oehme I (2009) HDAC family: what are the cancer relevant targets? Cancer Lett 277(1):8\u201321","journal-title":"Cancer Lett"},{"issue":"10","key":"489_CR33","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.bbagrm.2010.05.008","volume":"1799","author":"PA Marks","year":"2010","unstructured":"Marks PA (2010) Histone deacetylase inhibitors: a chemical genetics approach to understanding cellular functions. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1799(10):717\u2013725","journal-title":"Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms"},{"issue":"1","key":"489_CR34","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/nrc1779","volume":"6","author":"S Minucci","year":"2006","unstructured":"Minucci S, Pelicci PG (2006) Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 6(1):38\u201351","journal-title":"Nat Rev Cancer"},{"key":"489_CR35","doi-asserted-by":"crossref","unstructured":"Wang GG, Allis CD, Chi P (2007) Chromatin remodeling and cancer. Part I: Covalent histone modifications Trends Mol Med 13:363\u2013372","DOI":"10.1016\/j.molmed.2007.07.003"},{"key":"489_CR36","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1038\/sj.cdd.4401916","volume":"13","author":"O Laptenko","year":"2006","unstructured":"Laptenko O, Prives C (2006) Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ 13:951\u2013961","journal-title":"Cell Death Differ"},{"key":"489_CR37","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/35895","volume":"391","author":"RJ Lin","year":"1998","unstructured":"Lin RJ, Nagy L, Inoue S, Shao W, Miller WH, Evans RM (1998) Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature 391:811\u2013814","journal-title":"Nature"},{"key":"489_CR38","first-page":"G482","volume":"280","author":"JT Wu","year":"2001","unstructured":"Wu JT, Archer SY, Hinnebusch B, Meng S, Hodin RA (2001) Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis. Am J Physiol Liver Physiol 280:G482\u2013G490","journal-title":"Am J Physiol Liver Physiol"},{"key":"489_CR39","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/35077219","volume":"411","author":"J Taipale","year":"2001","unstructured":"Taipale J, Beachy PA (2001) The hedgehog and Wnt signalling pathways in cancer. Nature 411:349\u2013354","journal-title":"Nature"},{"key":"489_CR40","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S0092-8674(00)81871-1","volume":"88","author":"AJ Levine","year":"1997","unstructured":"Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88:323\u2013331","journal-title":"Cell"},{"key":"489_CR41","doi-asserted-by":"publisher","first-page":"12181","DOI":"10.1074\/jbc.272.18.12181","volume":"272","author":"R Rajah","year":"1997","unstructured":"Rajah R, Valentinis B, Cohen P (1997) Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-\u03b21 on programmed cell death through a p53-and IGF-independent mechanism. J Biol Chem 272:12181\u201312188","journal-title":"J Biol Chem"},{"key":"489_CR42","doi-asserted-by":"publisher","first-page":"25602","DOI":"10.1074\/jbc.272.41.25602","volume":"272","author":"ZP Gill","year":"1997","unstructured":"Gill ZP, Perks CM, Newcomb PV, Holly JMP (1997) Insulin-like growth factor-binding protein (IGFBP-3) predisposes breast cancer cells to programmed cell death in a non-IGF-dependent manner. J Biol Chem 272:25602\u201325607","journal-title":"J Biol Chem"},{"key":"489_CR43","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S1535-6108(02)00241-6","volume":"3","author":"JC Reed","year":"2003","unstructured":"Reed JC (2003) Apoptosis-targeted therapies for cancer. Cancer Cell 3:17\u201322","journal-title":"Cancer Cell"},{"key":"489_CR44","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/01926230701320337","volume":"35","author":"S Elmore","year":"2007","unstructured":"Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35:495\u2013516","journal-title":"Toxicol Pathol"},{"key":"489_CR45","doi-asserted-by":"crossref","unstructured":"Pajaniradje S, Mohankumar K, Pamidimukkala R, Subramanian S, Rajagopalan R (2014) Antiproliferative and apoptotic effects of Sesbania grandiflora leaves in human cancer cells Biomed Res Int:2014","DOI":"10.1155\/2014\/474953"},{"key":"489_CR46","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.pharmthera.2013.01.011","volume":"138","author":"S Diaz-Moralli","year":"2013","unstructured":"Diaz-Moralli S, Tarrado-Castellarnau M, Miranda A, Cascante M (2013) Targeting cell cycle regulation in cancer therapy. Pharmacol Ther 138:255\u2013271","journal-title":"Pharmacol Ther"},{"key":"489_CR47","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1021\/np400517g","volume":"77","author":"CJ Hsiao","year":"2014","unstructured":"Hsiao CJ, Hsiao G, Chen WL, Wang SW, Chiang CP, Liu LY, Guh JH, Lee TH, Chung CL (2014) Cephalochromin induces G0\/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption. J Nat Prod 77:758\u2013765","journal-title":"J Nat Prod"},{"issue":"4","key":"489_CR48","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1021\/np400517g","volume":"77","author":"J Guh","year":"2014","unstructured":"Guh J, Lee T, Chung C (2014) Cephalochromin induces G0\/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption. J Nat Prod 77(4):758\u2013765","journal-title":"J Nat Prod"},{"key":"489_CR49","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1111\/j.1349-7006.2004.tb03323.x","volume":"95","author":"D Li","year":"2004","unstructured":"Li D, Ueta E, Kimura T, Yamamoto T, Osaki T (2004) Reactive oxygen species (ROS) control the expression of Bcl-2 family proteins by regulating their phosphorylation and ubiquitination. Cancer Sci 95:644\u2013650","journal-title":"Cancer Sci"},{"key":"489_CR50","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/jcb.21979","volume":"106","author":"KC Chen","year":"2009","unstructured":"Chen KC, Kao PH, Lin SR, Chang LS (2009) Upregulation of Fas and FasL in Taiwan cobra phospholipase A2-treated human neuroblastoma SK-N-SH cells through ROS-and Ca2+\u2212mediated p38 MAPK activation. J Cell Biochem 106:93\u2013102","journal-title":"J Cell Biochem"},{"key":"489_CR51","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.mrfmmm.2003.07.015","volume":"533","author":"MD Pulido","year":"2003","unstructured":"Pulido MD, Parrish AR (2003) Metal-induced apoptosis: mechanisms. Mutat Res Mol Mech Mutagen. 533:227\u2013241","journal-title":"Mutat Res Mol Mech Mutagen."},{"key":"489_CR52","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S0278-6915(02)00238-7","volume":"41","author":"H Tuschl","year":"2003","unstructured":"Tuschl H, Schwab C (2003) Cytotoxic effects of the herbicide 2, 4-dichlorophenoxyacetic acid in HepG2 cells. Food Chem Toxicol 41:385\u2013393","journal-title":"Food Chem Toxicol"},{"key":"489_CR53","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0928-4680(00)00053-5","volume":"7","author":"K Kannan","year":"2000","unstructured":"Kannan K, Jain SK (2000) Oxidative stress and apoptosis. Pathophysiology 7:153\u2013163","journal-title":"Pathophysiology"},{"key":"489_CR54","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S0962-8924(00)01803-1","volume":"10","author":"S Desagher","year":"2000","unstructured":"Desagher S, Martinou JC (2000) Mitochondria as the central control point of apoptosis. Trends Cell Biol 10:369\u2013377","journal-title":"Trends Cell Biol"},{"key":"489_CR55","unstructured":"Hayat MA ed (2013) Autophagy: cancer, other pathologies, inflammation, immunity, infection, and aging. Volume 3-role in specific diseases (Vol. 3). Academic Press"},{"issue":"5","key":"489_CR56","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/74994","volume":"6","author":"G Kroemer","year":"2000","unstructured":"Kroemer G, Reed JC (2000) Mitochondrial control of cell death. Nat Med 6(5):513","journal-title":"Nat Med"},{"key":"489_CR57","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.ccr.2006.03.027","volume":"9","author":"M Certo","year":"2006","unstructured":"Certo M, Moore VDG, Nishino M, Wei G, Korsmeyer S, Armstrong SA, Letai A (2006) Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 9:351\u2013365","journal-title":"Cancer Cell"},{"key":"489_CR58","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1146\/annurev.immunol.16.1.395","volume":"16","author":"DT Chao","year":"1998","unstructured":"Chao DT, Korsmeyer SJ (1998) BCL-2 family: regulators of cell death. Annu Rev Immunol 16:395\u2013419","journal-title":"Annu Rev Immunol"},{"key":"489_CR59","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/nrm1496","volume":"5","author":"SJ Riedl","year":"2004","unstructured":"Riedl SJ, Shi Y (2004) Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol cell Biol 5:897\u2013907","journal-title":"Nat Rev Mol cell Biol"}],"container-title":["Investigational New Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10637-017-0489-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-017-0489-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-017-0489-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T05:10:40Z","timestamp":1678511440000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10637-017-0489-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,3]]},"references-count":59,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["489"],"URL":"https:\/\/doi.org\/10.1007\/s10637-017-0489-1","relation":{},"ISSN":["0167-6997","1573-0646"],"issn-type":[{"value":"0167-6997","type":"print"},{"value":"1573-0646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,3]]},"assertion":[{"value":"14 March 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was supported by the Department of Science and Technology, Science and Engineering Board (DST-SERB, SB\/FT\/CS-086\/2013), India.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"This article does not contain studies involving human participants or animals.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}