{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:59:04Z","timestamp":1790834344993,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Invest New Drugs"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s10637-025-01567-y","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T01:59:42Z","timestamp":1753235982000},"page":"800-819","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Design and optimization of PLGA-based gemcitabine nanocapsule for enhanced pancreatic cancer efficacy"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2200-737X","authenticated-orcid":false,"given":"Gaurav","family":"Tiwari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6184-6152","authenticated-orcid":false,"given":"Satyajit","family":"Panda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0783-0686","authenticated-orcid":false,"given":"A. Salomy Monica","family":"Diyya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3750-0653","authenticated-orcid":false,"given":"Noel Vinay","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2898-8810","authenticated-orcid":false,"given":"Trinayan","family":"Deka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2162-9276","authenticated-orcid":false,"given":"Shashi Ravi Suman","family":"Rudrangi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7594-6717","authenticated-orcid":false,"given":"Gaurav","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0211-9606","authenticated-orcid":false,"given":"Pankaj","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"issue":"32","key":"1567_CR1","doi-asserted-by":"publisher","first-page":"4698","DOI":"10.3748\/wjg.v28.i32.4698","volume":"28","author":"I Ilic","year":"2022","unstructured":"Ilic I, Ilic M (2022) International patterns in incidence and mortality trends of pancreatic cancer in the last three decades: a joinpoint regression analysis. World J Gastroenterol 28(32):4698","journal-title":"World J Gastroenterol"},{"issue":"3","key":"1567_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. A Cancer J Clin 71(3):209\u201349","journal-title":"A Cancer J Clin"},{"issue":"213","key":"1567_CR3","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.trsl.2019.08.002","volume":"1","author":"L Qian","year":"2019","unstructured":"Qian L, Li Q, Baryeh K, Qiu W, Li K, Zhang J, Yu Q, Xu D, Liu W, Brand RE, Zhang X (2019) Biosensors for early diagnosis of pancreatic cancer: a review. Transl Res 1(213):67\u201389","journal-title":"Transl Res"},{"issue":"17","key":"1567_CR4","doi-asserted-by":"publisher","first-page":"4257","DOI":"10.3390\/cancers14174257","volume":"14","author":"AY Bazeed","year":"2022","unstructured":"Bazeed AY, Day CM, Garg S (2022) Pancreatic cancer: challenges and opportunities in locoregional therapies. Cancers 14(17):4257","journal-title":"Cancers"},{"key":"1567_CR5","first-page":"650","volume":"16","author":"P Zakeri-Milani","year":"2017","unstructured":"Zakeri-Milani P, Farkhani SM, Shirani A, Mohammadi S, Mojarrad JS, Akbari J, Valizadeh H (2017) Cellular uptake and anti-tumor activity of gemcitabine conjugated with new amphiphilic cell penetrating peptides. EXCLI J 16:650","journal-title":"EXCLI J"},{"issue":"7","key":"1567_CR6","doi-asserted-by":"publisher","first-page":"193","DOI":"10.3389\/fmolb.2020.00193","volume":"20","author":"Y Yao","year":"2020","unstructured":"Yao Y, Zhou Y, Liu L, Xu Y, Chen Q, Wang Y, Wu S, Deng Y, Zhang J, Shao A (2020) Nanoparticle-based drug delivery in cancer therapy and its role in overcoming drug resistance. Front Mol Biosci 20(7):193","journal-title":"Front Mol Biosci"},{"key":"1567_CR7","doi-asserted-by":"crossref","unstructured":"Sharma P, Akram W, Jain V, Tailang M (eds) (2024) Smart nanocarrier for effective drug delivery. CRC Press","DOI":"10.1201\/9781003438953"},{"issue":"1","key":"1567_CR8","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41392-023-01536-y","volume":"8","author":"D Fan","year":"2023","unstructured":"Fan D, Cao Y, Cao M, Wang Y, Cao Y, Gong T (2023) Nanomedicine in cancer therapy. Signal Transduct Target Ther 8(1):293","journal-title":"Signal Transduct Target Ther"},{"key":"1567_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12951-018-0392-8","volume":"16","author":"JK Patra","year":"2018","unstructured":"Patra JK, Das G, Fraceto LF, Campos EV, Rodriguez-Torres MD, Acosta-Torres LS, Diaz-Torres LA, Grillo R, Swamy MK, Sharma S, Habtemariam S (2018) Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnology 16:1\u201333","journal-title":"J Nanobiotechnology"},{"key":"1567_CR10","doi-asserted-by":"crossref","unstructured":"Sharma P, Dasputre N, Jain V. Nanomedicine: concepts, characteristics, and regulatory challenges. InSmart Nanocarrier for Effective Drug Delivery. CRC Press,\u00a0pp 1\u201316","DOI":"10.1201\/9781003438953-1"},{"issue":"32","key":"1567_CR11","doi-asserted-by":"publisher","first-page":"5875","DOI":"10.3748\/wjg.v23.i32.5875","volume":"23","author":"G Giordano","year":"2017","unstructured":"Giordano G, Pancione M, Olivieri N, Parcesepe P, Velocci M, Di Raimo T, Coppola L, Toffoli G, D\u2019Andrea MR (2017) Nano albumin bound-paclitaxel in pancreatic cancer: current evidences and future directions. World J Gastroenterol 23(32):5875","journal-title":"World J Gastroenterol"},{"key":"1567_CR12","doi-asserted-by":"crossref","unstructured":"Sharma P (2023) Nanostructured biomaterials in drug delivery: current trends and upcoming possibilities. In: Engineered biomaterials: synthesis and applications. Springer Nature Singapore,\u00a0Singapore, pp 261\u2013280","DOI":"10.1007\/978-981-99-6698-1_9"},{"issue":"3","key":"1567_CR13","doi-asserted-by":"publisher","first-page":"323","DOI":"10.3390\/receptors3030016","volume":"3","author":"A Prajapati","year":"2024","unstructured":"Prajapati A, Rangra S, Patil R, Desai N, Jyothi VG, Salave S, Amate P, Benival D, Kommineni N (2024) Receptor-targeted nanomedicine for cancer therapy. Receptors 3(3):323\u2013361","journal-title":"Receptors"},{"issue":"235","key":"1567_CR14","doi-asserted-by":"publisher","first-page":"119804","DOI":"10.1016\/j.biomaterials.2020.119804","volume":"1","author":"H Takemoto","year":"2020","unstructured":"Takemoto H, Inaba T, Nomoto T, Matsui M, Liu X, Toyoda M, Honda Y, Taniwaki K, Yamada N, Kim J, Tomoda K (2020) Polymeric modification of gemcitabine via cyclic acetal linkage for enhanced anticancer potency with negligible side effects. Biomaterials 1(235):119804","journal-title":"Biomaterials"},{"key":"1567_CR15","doi-asserted-by":"crossref","unstructured":"Parida RC, Thamizhanban D, Jena GK (2025) Quality by design approach for the development of polymeric nanoparticles: a focus on capecitabine. Curr Nanomater","DOI":"10.2174\/0124054615368563250319002905"},{"issue":"4","key":"1567_CR16","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1007\/s12668-023-01220-z","volume":"13","author":"A Patnaik","year":"2023","unstructured":"Patnaik A, Jena GK, Patra CN (2023) Recent advancements and patent search on polymeric nanoparticles. BioNanoScience 13(4):1463\u20131469","journal-title":"BioNanoScience"},{"issue":"8","key":"1567_CR17","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.3390\/pharmaceutics13081196","volume":"13","author":"R Scherlie\u00df","year":"2021","unstructured":"Scherlie\u00df R, Janke J (2021) Preparation of poly-lactic-co-glycolic acid nanoparticles in a dry powder formulation for pulmonary antigen delivery. Pharmaceutics 13(8):1196","journal-title":"Pharmaceutics"},{"issue":"2","key":"1567_CR18","doi-asserted-by":"publisher","first-page":"100078","DOI":"10.1016\/j.fhfh.2022.100078","volume":"1","author":"N Walia","year":"2022","unstructured":"Walia N, Zhang S, Wismer W, Chen L (2022) A low energy approach to develop nanoemulsion by combining pea protein and Tween 80 and its application for vitamin D delivery. Food Hydrocolloids for Health 1(2):100078","journal-title":"Food Hydrocolloids for Health"},{"issue":"1","key":"1567_CR19","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s12943-023-01849-0","volume":"22","author":"KR Gajbhiye","year":"2023","unstructured":"Gajbhiye KR, Salve R, Narwade M, Sheikh A, Kesharwani P, Gajbhiye V (2023) Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics. Mol Cancer 22(1):160","journal-title":"Mol Cancer"},{"issue":"8","key":"1567_CR20","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.3748\/wjg.v16.i8.1008","volume":"16","author":"L Jia","year":"2010","unstructured":"Jia L, Zheng JJ, Jiang SM, Huang KH (2010) Preparation, physicochemical characterization and cytotoxicity in vitro of gemcitabine-loaded PEG-PDLLA nanovesicles. World J Gastroenterol: WJG 16(8):1008","journal-title":"World J Gastroenterol: WJG"},{"issue":"15","key":"1567_CR21","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1016\/j.addr.2006.09.017","volume":"58","author":"W Abdelwahed","year":"2006","unstructured":"Abdelwahed W, Degobert G, Stainmesse S, Fessi H (2006) Freeze-drying of nanoparticles: formulation, process and storage considerations. Adv Drug Deliv Rev 58(15):1688\u20131713","journal-title":"Adv Drug Deliv Rev"},{"issue":"6","key":"1567_CR22","doi-asserted-by":"publisher","first-page":"571","DOI":"10.3390\/jpm11060571","volume":"11","author":"MA Subhan","year":"2021","unstructured":"Subhan MA, Yalamarty SS, Filipczak N, Parveen F, Torchilin VP (2021) Recent advances in tumor targeting via EPR effect for cancer treatment. J Personalized Med 11(6):571","journal-title":"J Personalized Med"},{"issue":"6","key":"1567_CR23","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1021\/mp200257y","volume":"8","author":"YJ Wang","year":"2011","unstructured":"Wang YJ, Chien YC, Wu CH, Liu DM (2011) Magnolol-loaded core\u2013shell hydrogel nanoparticles: drug release, intracellular uptake, and controlled cytotoxicity for the inhibition of migration of vascular smooth muscle cells. Mol Pharm 8(6):2339\u201349","journal-title":"Mol Pharm"},{"issue":"1","key":"1567_CR24","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s43094-022-00433-5","volume":"8","author":"P Sharma","year":"2022","unstructured":"Sharma P, Tailang M (2022) Primaquine-loaded transdermal patch for treating malaria: design, development, and characterization. Futur J Pharm Sci 8(1):43","journal-title":"Futur J Pharm Sci"},{"key":"1567_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s43094-020-00035-z","volume":"6","author":"P Sharma","year":"2020","unstructured":"Sharma P, Tailang M (2020) Design, optimization, and evaluation of hydrogel of primaquine loaded nanoemulsion for malaria therapy. Futur J Pharm Sci 6:1\u20131","journal-title":"Futur J Pharm Sci"},{"key":"1567_CR26","doi-asserted-by":"crossref","unstructured":"Ojha C, Sharma P, Jain V (2024) Design, optimization, and evaluation of topical gel of Cardiospermum halicacabum and Ricinus communis L. leaves extract for the treatment of rheumatoid arthritis. J Biomater Sci, Polym Edn 1\u201322","DOI":"10.1080\/09205063.2024.2340872"},{"issue":"11","key":"1567_CR27","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.3390\/pharmaceutics14112324","volume":"14","author":"O Gonz\u00e1lez-Gonz\u00e1lez","year":"2022","unstructured":"Gonz\u00e1lez-Gonz\u00e1lez O, Ramirez IO, Ramirez BI, O\u2019Connell P, Ballesteros MP, Torrado JJ, Serrano DR (2022) Drug stability: ICH versus accelerated predictive stability studies. Pharmaceutics 14(11):2324","journal-title":"Pharmaceutics"},{"issue":"1","key":"1567_CR28","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1021\/acsomega.2c04078","volume":"8","author":"A Sharma","year":"2022","unstructured":"Sharma A, Shambhwani D, Pandey S, Singh J, Lalhlenmawia H, Kumarasamy M, Singh SK, Chellappan DK, Gupta G, Prasher P, Dua K (2022) Advances in lung cancer treatment using nanomedicines. ACS Omega 8(1):10\u201341","journal-title":"ACS Omega"},{"issue":"14","key":"1567_CR29","doi-asserted-by":"publisher","first-page":"1116073","DOI":"10.3389\/fphar.2023.1116073","volume":"31","author":"H Zhang","year":"2023","unstructured":"Zhang H, Yan S, Zhan Y, Ma S, Bian Y, Li S, Tian J, Li G, Zhong D, Diao X, Miao L (2023) A mass balance study of [14C] SHR6390 (dalpiciclib), a selective and potent CDK4\/6 inhibitor in humans. Front Pharmacol 31(14):1116073","journal-title":"Front Pharmacol"},{"issue":"1","key":"1567_CR30","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s13045-022-01320-5","volume":"15","author":"H Tian","year":"2022","unstructured":"Tian H, Zhang T, Qin S, Huang Z, Zhou L, Shi J, Nice EC, Xie N, Huang C, Shen Z (2022) Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies. J Hematol Oncol 15(1):132","journal-title":"J Hematol Oncol"},{"issue":"9","key":"1567_CR31","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.3390\/pharmaceutics14091907","volume":"14","author":"GA Soares","year":"2022","unstructured":"Soares GA, Pereira GM, Romualdo GR, Biasotti GG, Stoppa EG, Bakuzis AF, Baffa O, Barbisan LF, Miranda JR (2022) Biodistribution profile of magnetic nanoparticles in cirrhosis-associated hepatocarcinogenesis in rats by AC biosusceptometry. Pharmaceutics 14(9):1907","journal-title":"Pharmaceutics"},{"issue":"7","key":"1567_CR32","doi-asserted-by":"publisher","first-page":"892","DOI":"10.3390\/polym16070892","volume":"16","author":"S Liu","year":"2024","unstructured":"Liu S, Jing Y, Liu G (2024) A systematic investigation of the kinetic models applied to the transport behaviors of aromatic solvents in unfilled hydrogenated nitrile rubber\/ethylene propylene diene monomer composites. Polymers 16(7):892","journal-title":"Polymers"},{"issue":"10","key":"1567_CR33","first-page":"3","volume":"13","author":"F Zothanpuii","year":"2020","unstructured":"Zothanpuii F, Rajesh R, Selvakumar KJ (2020) A review on stability testing guidelines of pharmaceutical products. Asian J Pharm Clin Res 13(10):3\u20139","journal-title":"Asian J Pharm Clin Res"},{"issue":"20","key":"1567_CR34","doi-asserted-by":"publisher","first-page":"19810","DOI":"10.1021\/acsnano.3c04037","volume":"17","author":"Q Chen","year":"2023","unstructured":"Chen Q, Yuan L, Chou WC, Cheng YH, He C, Monteiro-Riviere NA, Riviere JE, Lin Z (2023) Meta-analysis of nanoparticle distribution in tumors and major organs in tumor-bearing mice. ACS Nano 17(20):19810\u201319831","journal-title":"ACS Nano"},{"key":"1567_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12885-016-2798-8","volume":"16","author":"A Vogel","year":"2016","unstructured":"Vogel A, R\u00f6mmler-Zehrer J, Li JS, McGovern D, Romano A, Stahl M (2016) Efficacy and safety profile of nab-paclitaxel plus gemcitabine in patients with metastatic pancreatic cancer treated to disease progression: a subanalysis from a phase 3 trial (MPACT). BMC Cancer 16:1","journal-title":"BMC Cancer"},{"issue":"16","key":"1567_CR36","doi-asserted-by":"publisher","first-page":"2792","DOI":"10.3390\/cancers16162792","volume":"16","author":"J Yu","year":"2024","unstructured":"Yu J, Xu X, Griffin JI, Mu Q, Ho RJ (2024) Drug Combination nanoparticles containing gemcitabine and paclitaxel enable orthotopic 4T1 breast tumor regression. Cancers 16(16):2792","journal-title":"Cancers"},{"issue":"6","key":"1567_CR37","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1007\/s13346-021-01042-0","volume":"12","author":"GK Jena","year":"2022","unstructured":"Jena GK, Patra CN, Panigrahi KC, Sruti J, Patra P, Parhi R (2022) QbD enabled optimization of solvent shifting method for fabrication of PLGA-based nanoparticles for promising delivery of Capecitabine for antitumor activity. Drug Deliv Transl Res 12(6):1521\u20131539","journal-title":"Drug Deliv Transl Res"}],"container-title":["Investigational New Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-025-01567-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10637-025-01567-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10637-025-01567-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:03:10Z","timestamp":1760194990000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10637-025-01567-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["1567"],"URL":"https:\/\/doi.org\/10.1007\/s10637-025-01567-y","relation":{},"ISSN":["0167-6997","1573-0646"],"issn-type":[{"value":"0167-6997","type":"print"},{"value":"1573-0646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,23]]},"assertion":[{"value":"14 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}