{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:57:37Z","timestamp":1790506657147,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,1,23]],"date-time":"2013-01-23T00:00:00Z","timestamp":1358899200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ecotoxicology"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1007\/s10646-013-1040-6","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T22:40:00Z","timestamp":1358808000000},"page":"469-475","source":"Crossref","is-referenced-by-count":27,"title":["Mercury exposure and neurochemical biomarkers in multiple brain regions of Wisconsin River Otters (Lontra canadensis)"],"prefix":"10.1007","volume":"22","author":[{"given":"Peter","family":"Dornbos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Strom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niladri","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,1,23]]},"reference":[{"key":"1040_CR1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ntt.2008.12.005","volume":"32","author":"N Basu","year":"2010","unstructured":"Basu N, Head J (2010) Mammalian wildlife as complementary models in environmental neurotoxicology. Neurotoxicol Teratol 32:114\u2013119","journal-title":"Neurotoxicol Teratol"},{"key":"1040_CR2","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1021\/es0483746","volume":"39","author":"N Basu","year":"2005","unstructured":"Basu N, Scheuhammer AM, Grochowina N, Klenavic K, Evans RD, O\u2019Brien M, Chan HM (2005) Effects of mercury on neurochemical receptors in wild river otters (Lontra canadensis). Environ Sci Technol 39:3585\u20133591","journal-title":"Environ Sci Technol"},{"key":"1040_CR5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/0960327107070570","volume":"26","author":"N Basu","year":"2007","unstructured":"Basu N, Scheuhammer AM, Evans RD, O\u2019Brien M, Chan HM (2007a) Cholinesterase and monoamine oxidase activity in relation to mercury levels in the\u00a0cerebral cortex\u00a0of wild river otters. Hum Exp Toxicol 26:213\u2013220","journal-title":"Hum Exp Toxicol"},{"key":"1040_CR6","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.neuro.2006.12.007","volume":"28","author":"N Basu","year":"2007","unstructured":"Basu N, Scheuhammer AM, Rouvinen-Watt K, Grochowina N, Evans RD, O\u2019Brien M, Chan HM (2007b) Decreased N-methyl-d-aspartic acid (NMDA) receptor levels are associated with mercury exposure in wild and captive mink. Neurotoxicology 28:587\u2013593","journal-title":"Neurotoxicology"},{"key":"1040_CR7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1897\/08-251.1","volume":"28","author":"N Basu","year":"2009","unstructured":"Basu N, Scheuhammer AM, Sonne C, Letcher RJ, Born EW, Dietz R (2009) Is dietary mercury of neurotoxicological concern to wild polar bears (Ursus maritimus)? Environ Toxicol Chem 28:133\u2013140","journal-title":"Environ Toxicol Chem"},{"key":"1040_CR8","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cbpc.2010.01.001","volume":"151","author":"N Basu","year":"2010","unstructured":"Basu N, Scheuhammer AM, Rouvinen-Watt K, Evans RD, Trudeau VL, Chan LH (2010) In vitro and whole animal evidence that methylmercury disrupts GABAergic systems in discrete brain regions in captive mink. Comp Biochem Physiol C Toxicol Pharmacol 151:379\u2013438","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"1040_CR9","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1021\/es903874x","volume":"44","author":"SP Bhavsar","year":"2010","unstructured":"Bhavsar SP, Gewurtz SB, McGoldrick DJ, Keir MJ, Backus SM (2010) Changes in mercury levels in Great Lakes fish between 1970s and 2007. Environ Sci Technol 44:3273\u20133279","journal-title":"Environ Sci Technol"},{"key":"1040_CR10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"1040_CR12","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1080\/10408440600845619","volume":"36","author":"TW Clarkson","year":"2006","unstructured":"Clarkson TW, Magos L (2006) The toxicology of mercury and its chemical compounds. Crit Rev Toxicol 36:609\u2013662","journal-title":"Crit Rev Toxicol"},{"key":"1040_CR13","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1021\/es9600892","volume":"31","author":"DR Engstrom","year":"1997","unstructured":"Engstrom DR, Swain EB (1997) Recent declines in atmospheric mercury deposition in the upper midwest. Environ Sci Technol 31:960\u2013967","journal-title":"Environ Sci Technol"},{"issue":"2","key":"1040_CR14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/enrs.2000.4077","volume":"84","author":"RD Evans","year":"2000","unstructured":"Evans RD, Addison EM, Villeneuve JY, McDonald KS, Joachim DG (2000) Distribution of inorganic and methylmercury among tissues in mink (Mustela vison) and otter (Lutra Canadensis). Environ Res 84(2):133\u2013139","journal-title":"Environ Res"},{"key":"1040_CR15","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1007\/s10646-011-0784-0","volume":"20","author":"DC Evers","year":"2011","unstructured":"Evers DC, Wiener JG, Basu N, Bodaly RA, Morrison HA, Williams KA (2011) Mercury in the Great Lakes region: bioaccumulation, spatial and temporal patterns, ecological risks, and policy. Ecotoxicology 20:1487\u20131499","journal-title":"Ecotoxicology"},{"issue":"3","key":"1040_CR18","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.scitotenv.2009.09.055","volume":"1408","author":"KJ Haines","year":"2010","unstructured":"Haines KJ, Evans RD, O\u2019Brien M, Evans HE (2010) Accumulation of mercury and selenium in the brain of river otters (Lontra Canadensis) and wild mink (Mustela vision) from Nova Scotia, Canada. Sci Total Environ 1408(3):537\u2013542","journal-title":"Sci Total Environ"},{"key":"1040_CR19","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1007\/s10646-011-0754-6","volume":"20","author":"M Hamilton","year":"2011","unstructured":"Hamilton M, Scheuhammer AM, Basu N (2011) Mercury, selenium and neurochemical biomarkers in different brain regions of migrating common loons from Lake Erie, Canada. Ecotoxicol 20:1677\u20131683","journal-title":"Ecotoxicol"},{"issue":"229","key":"1040_CR20","first-page":"237","volume":"297","author":"TR Hrabik","year":"2002","unstructured":"Hrabik TR, Watras CJ (2002) Recent declines in mercury concentration in a freshwater fishery: isolating the effects of deacidification and decreased atmospheric mercury deposition in Little Rock Lake. Sci Total Environ 297(229):237","journal-title":"Sci Total Environ"},{"key":"1040_CR21","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1006\/taap.1996.0247","volume":"140","author":"CS Huang","year":"1996","unstructured":"Huang CS, Narahashi T (1996) Mercury chloride modulation of the GABAA receptor channel complex in rat dorsal root ganglion neurons. Toxicol Appl Pharmacol 140:508\u2013520","journal-title":"Toxicol Appl Pharmacol"},{"issue":"2","key":"1040_CR22","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.envpol.2008.02.003","volume":"158","author":"K Klenavic","year":"2008","unstructured":"Klenavic K, Champoux L, O\u2019brien M, Daoust PY, Evans RD, Evans HE (2008) Mercury concentrations in wild mink (Mustela vison) and river otters\u00a0(Lontra canadensis) collected from eastern and Atlantic Canada: relationship to age and parasitism. Environ Pollut 158(2):359\u2013366","journal-title":"Environ Pollut"},{"key":"1040_CR23","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1139\/z83-297","volume":"61","author":"E Kucera","year":"1983","unstructured":"Kucera E (1983) Mink and otter as indicators of mercury in Manitoba waters. Can J Zool 61:2250\u20132256","journal-title":"Can J Zool"},{"key":"1040_CR25","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1021\/es0700294","volume":"41","author":"ER Madsen","year":"2007","unstructured":"Madsen ER, Stern HS (2007) Time trends of methylmercury in walleye in northern Wisconsin: a hierarchical Bayesian analysis. Environ Sci Technol 41:4568\u20134573","journal-title":"Environ Sci Technol"},{"key":"1040_CR26","doi-asserted-by":"crossref","first-page":"15A","DOI":"10.1021\/es053155l","volume":"39","author":"RP Mason","year":"2005","unstructured":"Mason RP, Abbott ML, Bodaly RA, Bullock OR, Driscoll CT, Evers DC, Lindberg SE, Murrary M, Swain EB (2005) Monitoring the response to changing mercury deposition. Environ Sci Technol 39:15A\u201322A","journal-title":"Environ Sci Technol"},{"key":"1040_CR27","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1007\/s10646-011-0759-1","volume":"20","author":"MW Meyer","year":"2011","unstructured":"Meyer MW, Rasmussen PW, Watras CJ, Fevold BM, Kenow KP, Evers DC (2011) Bi-phasic trends in Wisconsin common loon blood mercury concentrations. Ecotoxicology 20:1659\u20131668","journal-title":"Ecotoxicology"},{"key":"1040_CR28","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1021\/es8027378","volume":"43","author":"BA Monson","year":"2009","unstructured":"Monson BA (2009) Trend reversal of mercury concentrations in piscivorous fish from Minnesota Lakes: 1982\u20132006. Environ Sci Technol 43:1750\u20131755","journal-title":"Environ Sci Technol"},{"key":"1040_CR30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1752-153X-5-3","volume":"5","author":"DH Nam","year":"2011","unstructured":"Nam DH, Basu N (2011) Rapid methods to detect organic mercury and total selenium in biological samples. Chem Central J 5:3","journal-title":"Chem Central J"},{"key":"1040_CR31","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10661-010-1603-4","volume":"176","author":"DH Nam","year":"2010","unstructured":"Nam DH, Adams DH, Reyier EA, Basu B (2010) Mercury and selenium levels in lemon sharks (Negaprion brevirostris) in relation to a harmful red tide event. Environ Monit Assess 176:549\u2013559","journal-title":"Environ Monit Assess"},{"key":"1040_CR32","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S1352-2310(97)00353-1","volume":"32","author":"N Pirrone","year":"1998","unstructured":"Pirrone N, Allegrini I, Keeler GJ, Nriagu JO, Rossman R, Robbins JA (1998) Historical atmospheric mercury emissions and depositions in North America compared to mercury accumulations in sedimentary records. Atmos Environ 32:929\u2013940","journal-title":"Atmos Environ"},{"key":"1040_CR33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/01480549709011076","volume":"20","author":"B Rajanna","year":"1997","unstructured":"Rajanna B, Rajanna S, Hall E, Yallapragada PR (1997) In vitro metal inhibition of N methyl-d aspartate specific glutamate receptor binding in neonatal and adult rat brain. Drug Chem Toxicol 20:21\u201329","journal-title":"Drug Chem Toxicol"},{"key":"1040_CR34","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10646-007-0160-2","volume":"16","author":"PW Rasmussen","year":"2007","unstructured":"Rasmussen PW, Schrank CS, Campfield PA (2007) Temporal trends of mercury concentrations in Wisconsin walleye (Sander vitreus), 1982\u20132005. Ecotoxicology 16:541\u2013550","journal-title":"Ecotoxicology"},{"key":"1040_CR35","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ecoenv.2012.07.002","volume":"84","author":"J Rutkiewicz","year":"2012","unstructured":"Rutkiewicz J, Basu N (2012) Postmortem stability of brain GABAergic and glutamatergic receptors and enzymes under ecological conditions. Ecotoxol Environ Saf 84:133\u2013138","journal-title":"Ecotoxol Environ Saf"},{"key":"1040_CR36","doi-asserted-by":"crossref","unstructured":"Rutkiewicz J, Nam DH, Cooley T, Neumann K, Bueno Padilla IB, Route W, Strom S, Basu N (2011) Mercury exposure and neurochemical impacts in bald eagles across several Great Lakes states. Ecotoxicology 20(7):1669\u20131676","DOI":"10.1007\/s10646-011-0730-1"},{"key":"1040_CR37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1579\/0044-7447(2007)36[12:EOEMOT]2.0.CO;2","volume":"36","author":"AM Scheuhammer","year":"2007","unstructured":"Scheuhammer AM, Meyer MW, Sandheinrich MB, Murray MW (2007) Effects of environmental methylmercury on the health of wild birds, mammals, and fish. Ambio 36:12\u201318","journal-title":"Ambio"},{"key":"1040_CR39","first-page":"1117","volume":"49","author":"TB Sheffy","year":"1978","unstructured":"Sheffy TB (1978) An inventory of mercury burdens in Wisconsin furbearers. Wis Dep Nat Resour Bureau Water Qual 49:1117\u20131120","journal-title":"Wis Dep Nat Resour Bureau Water Qual"},{"issue":"3","key":"1040_CR40","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.7589\/0090-3558-46.3.1035","volume":"46","author":"JM Sleeman","year":"2010","unstructured":"Sleeman JM, Cristol DA, White AE, Evers DC, Gerhold RW, Keel MK (2010) Mercury poisoning in a free-living river otter (Lontra Candesis). J Wildl J 46(3):1035\u20131043","journal-title":"J Wildl J"},{"key":"1040_CR41","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/s00244-007-9053-x","volume":"54","author":"SM Strom","year":"2008","unstructured":"Strom SM (2008) Total mercury and methylmercury residues in River Otters (Lutra canadensis) from Wisconsin. Arch Environ Contam Toxicol 54:546\u2013555","journal-title":"Arch Environ Contam Toxicol"},{"key":"1040_CR42","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.envpol.2011.08.051","volume":"161","author":"JG Weiner","year":"2012","unstructured":"Weiner JG, Evers DC, Gay DA, Morrison HA, Williams KA (2012) Mercury contamination in the Lauernetian Great Lakes region: introduction and overview. Environ Pollut 161:243\u2013251","journal-title":"Environ Pollut"},{"issue":"2854","key":"1040_CR44","first-page":"2859","volume":"64","author":"CD Wren","year":"1986","unstructured":"Wren CD, Stokes PM, Fischer KL (1986) Mercury levels in Ontario Canada mink and otter relative to food levels and environmental acidification. Can J Zool 64(2854):2859","journal-title":"Can J Zool"},{"issue":"263\u2013274","key":"1040_CR45","first-page":"7","volume":"14","author":"DE Yates","year":"2005","unstructured":"Yates DE, Mayack DT, Munney K, Evers DC, Major A, Kaur T, Taylor RJ (2005) Mercury levels in mink (Mustela vison) and river otter (Lontra canadensis) from Northeastern North America. Ecotoxicology 14(263\u2013274):7","journal-title":"Ecotoxicology"}],"container-title":["Ecotoxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10646-013-1040-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10646-013-1040-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10646-013-1040-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T16:25:11Z","timestamp":1559233511000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10646-013-1040-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,23]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["1040"],"URL":"https:\/\/doi.org\/10.1007\/s10646-013-1040-6","relation":{},"ISSN":["0963-9292","1573-3017"],"issn-type":[{"value":"0963-9292","type":"print"},{"value":"1573-3017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,23]]}}}