{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:33:13Z","timestamp":1789979593361,"version":"4.0.1"},"reference-count":95,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T00:00:00Z","timestamp":1518480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ecotoxicology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s10646-018-1901-0","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T05:18:27Z","timestamp":1518499107000},"page":"369-384","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Early ecotoxic effects of ZnO nanoparticle chronic exposure in Mytilus galloprovincialis revealed by transcription of apoptosis and antioxidant-related genes"],"prefix":"10.1007","volume":"27","author":[{"given":"Jiji","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Schiavo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Xiangli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Rametta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lucia","family":"Miglietta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Oliviero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Changwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Manzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,13]]},"reference":[{"key":"1901_CR1","doi-asserted-by":"publisher","first-page":"3527","DOI":"10.1016\/j.watres.2006.08.004","volume":"40","author":"LK Adams","year":"2006","unstructured":"Adams LK, Lyon DY, Alvarez PJ (2006) Comparative eco-toxicity of nanoscale TiO2, SiO2, and ZnO water suspensions. Water Res 40:3527\u20133532","journal-title":"Water Res"},{"key":"1901_CR2","doi-asserted-by":"crossref","unstructured":"Altshuler I, Demiri B, Xu S, Constantin A, Yan ND, Cristescu ME (2011) An integrated multi-disciplinary approach for studying multiple stressors in freshwater ecosystems: Daphnia as a model organism. Integr Comp Biol 51: icr103.","DOI":"10.1093\/icb\/icr103"},{"key":"1901_CR3","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.scitotenv.2014.05.146","volume":"493","author":"T Balbi","year":"2014","unstructured":"Balbi T, Smerilli A, Fabbri R, Ciacci C, Montagna M, Grasselli E, Brunelli A, Pojana G, Marcomini A, Gallo G (2014) Co-exposure to n-TiO2 and Cd2+ results in interactive effects on biomarker responses but not in increased toxicity in the marine bivalve M. galloprovincialis. Sci Total Environ 493:355\u2013364","journal-title":"Sci Total Environ"},{"key":"1901_CR4","first-page":"414","volume":"149","author":"M Banni","year":"2009","unstructured":"Banni M, Negri A, Rebelo M, Rapallo F, Boussetta H, Viarengo A, Dondero F (2009) Expression analysis of the molluscan p53 protein family mRNA in mussels (Mytilus spp.) exposed to organic contaminants. Comp Biochem Phys C 149:414\u2013418","journal-title":"Comp Biochem Phys C"},{"key":"1901_CR5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.aquatox.2013.01.014","volume":"132","author":"C Barmo","year":"2013","unstructured":"Barmo C, Ciacci C, Canonico B, Fabbri R, Cortese K, Balbi T, Marcomini A, Pojana G, Gallo G, Canesi L (2013) In vivo effects of n-TiO2 on digestive gland and immune function of the marine bivalve Mytilus galloprovincialis. Aquat Toxicol 132:9\u201318","journal-title":"Aquat Toxicol"},{"key":"1901_CR6","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s10646-008-0208-y","volume":"17","author":"A Baun","year":"2008","unstructured":"Baun A, Hartmann NB, Grieger K, Kusk KO (2008) Ecotoxicity of engineered nanoparticles to aquatic invertebrates: a brief review and recommendations for future toxicity testing. Ecotoxicology 17:387\u2013395","journal-title":"Ecotoxicology"},{"key":"1901_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11356-015-5186-z","volume":"22","author":"MJ Bebianno","year":"2015","unstructured":"Bebianno MJ, Gonzalez-Rey M, Gomes T, Mattos JJ, Flores-Nunes F, Bainy AC (2015) Is gene transcription inmussel gills altered after exposure to Ag nanoparticles? Environ Sci Pollut Res 22:1\u20139","journal-title":"Environ Sci Pollut Res"},{"issue":"1","key":"1901_CR8","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0048-9697(98)00059-X","volume":"214","author":"MJ Bebianno","year":"1998","unstructured":"Bebianno MJ, Serafim MA (1998) Comparison of metallothionein induction in response to cadmium in the gills of the bivalve molluscs Mytilus galloprovincialis and Ruditapes decussatus. Sci Total Environ 214(1):123\u2013131","journal-title":"Sci Total Environ"},{"key":"1901_CR9","doi-asserted-by":"publisher","first-page":"2420","DOI":"10.1089\/ars.2012.4994","volume":"18","author":"DJ Brierley","year":"2013","unstructured":"Brierley DJ, Martin SA (2013) Oxidative stress and the DNA mismatch repair pathway. Antioxid Redox Signal 18:2420\u20132428","journal-title":"Antioxid Redox Signal"},{"key":"1901_CR10","first-page":"1620","volume":"47","author":"PE Buffet","year":"2013","unstructured":"Buffet PE, Richard M, Caupos F, Vergnoux A, Perrein-Ettajani H, Luna-Acosta A, Akcha F, Amiard JC, Amiard-Triquet C, Guibbolini M (2013) A mesocosm study of fate and effects of CuO nanoparticles on endobenthic species (Scrobicularia plana, Hediste diversicolor). Environ Sci Technol 47:1620\u20131628","journal-title":"Environ Sci Technol"},{"key":"1901_CR11","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.scitotenv.2013.10.114","volume":"470","author":"PE Buffet","year":"2014","unstructured":"Buffet PE, Zalouk-Vergnoux A, Ch\u00e2tel A, Berthet B, M\u00e9tais I, Perrein-Ettajani H, Poirier L, Luna-Acosta A, Thomas-Guyon H, Risso-de Faverney C (2014) A marine mesocosm study on the environmental fate of silver nanoparticles and toxicity effects on two endobenthic species: The ragworm Hediste diversicolor and the bivalve mollusc Scrobicularia plana. Sci Total Environ 470:1151\u20131159","journal-title":"Sci Total Environ"},{"key":"1901_CR12","first-page":"257","volume":"2","author":"KG Burnett","year":"2007","unstructured":"Burnett KG, Bain LJ, Baldwin WS, Callard GV, Cohen S, Di Giulio RT, Evans DH, G\u00f3mez-Chiarri M, Hahn ME, Hoover CA (2007) Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics. Comp Biochem Phys D 2:257\u2013286","journal-title":"Comp Biochem Phys D"},{"key":"1901_CR13","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.aquatox.2010.04.009","volume":"100","author":"L Canesi","year":"2010","unstructured":"Canesi L, Fabbri R, Gallo G, Vallotto D, Marcomini A, Pojana G (2010) Biomarkers in Mytilus galloprovincialis exposed to suspensions of selected nanoparticles (Nano carbon black, C60 fullerene, Nano-TiO2, Nano-SiO2). Aquat Toxicol 100:168\u2013177","journal-title":"Aquat Toxicol"},{"key":"1901_CR14","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.aquatox.2009.07.019","volume":"94","author":"YJ Chae","year":"2009","unstructured":"Chae YJ, Pham CH, Lee J, Bae E, Yi J, Gu MB (2009) Evaluation of the toxic impact of silver nanoparticles on Japanese medaka (Oryzias latipes). Aquat Toxicol 94:320\u2013327","journal-title":"Aquat Toxicol"},{"issue":"6","key":"1901_CR15","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.fsi.2011.09.002","volume":"31","author":"C Ciacci","year":"2012","unstructured":"Ciacci C, Barmo C, Fabbri R, Canonico B, Gallo G, Canesi L (2012) Immunomodulation in Mytilus galloprovincialis by non-toxic doses of hexavalent chromium. Fish Shellfish Immunol 31(6):1026\u20131033","journal-title":"Fish Shellfish Immunol"},{"key":"1901_CR16","doi-asserted-by":"publisher","first-page":"4950","DOI":"10.1128\/IAI.00204-06","volume":"74","author":"A Clauditz","year":"2006","unstructured":"Clauditz A, Resch A, Wieland KP, Peschel A, G\u00f6tz F (2006) Staphyloxanthin plays a role in the fitness of Staphylococcus aureus and its ability to cope with oxidative stress. Infect Immunol 74:4950\u20134953","journal-title":"Infect Immunol"},{"key":"1901_CR17","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3109\/17435390.2015.1073812","volume":"10","author":"C Coll","year":"2016","unstructured":"Coll C, Notter D, Gottschalk F, Sun T, Som C, Nowack B (2016) Probabilistic environmental risk assessment of five nanomaterials (nano-TiO2, nano-Ag, nano-ZnO, CNT, and fullerenes). Nanotoxicology 10:4","journal-title":"Nanotoxicology"},{"key":"1901_CR18","doi-asserted-by":"publisher","first-page":"248","DOI":"10.3856\/vol43-issue1-fulltext-21","volume":"43","author":"F Cremonte","year":"2015","unstructured":"Cremonte F, Puebla C, Tiller\u00eda J, Videla V (2015) Histopathological survey of the mussel Mytilus chilensis (Mytilidae) and the clam Gari solida (Psammobiidae) from southern Chile. Lat Am J Aquat Res 43:248\u2013254","journal-title":"Lat Am J Aquat Res"},{"key":"1901_CR19","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S0141-1136(00)00038-6","volume":"50","author":"L Ros Da","year":"2000","unstructured":"Da Ros L, Nasci C, Marigomez I, Soto M (2000) Biomarkers and trace metals in the digestive gland of indigenous and transplanted mussels, Mytilus galloprovincialis, in Venice Lagoon, Italy. Mar Environ Res 50:417\u2013423","journal-title":"Mar Environ Res"},{"key":"1901_CR20","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1021\/sc4000434","volume":"1","author":"L Dai","year":"2013","unstructured":"Dai L, Syberg K, Banta GT, Selck H, Forbes VE (2013) Effects, uptake, and depuration kinetics of silver oxide and copper oxide nanoparticles in a marine deposit feeder, Macoma balthica. ACS Sustain Chem Eng 1:760\u2013767","journal-title":"ACS Sustain Chem Eng"},{"key":"1901_CR21","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1080\/15216540051081010","volume":"5","author":"KJ Davies","year":"2000","unstructured":"Davies KJ (2000) Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems. IUBMB Life 5:279\u2013289","journal-title":"IUBMB Life"},{"key":"1901_CR22","doi-asserted-by":"publisher","first-page":"2866","DOI":"10.1021\/es011197d","volume":"36","author":"SA Diamond","year":"2002","unstructured":"Diamond SA, Peterson GS, Tietge JE, Ankley GT (2002) Assessment of the risk of solar ultraviolet radiation to amphibians. III. Prediction of impacts in selected northern midwestern wetlands. Environ Sci Technol 36:2866\u20132874","journal-title":"Environ Sci Technol"},{"issue":"1","key":"1901_CR23","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.gene.2006.02.015","volume":"376","author":"F Dondero","year":"2006","unstructured":"Dondero F, Piacentini L, Marsano F, Rebelo M, Vergani L, Venier P, Viarengo A (2006) Gene transcription profiling in pollutant exposed mussels (Mytilus spp.) using a new low-density oligonucleotide microarray. Gene 376(1):24\u201336","journal-title":"Gene"},{"key":"1901_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061502","volume":"8","author":"N Estevez-Calvar","year":"2013","unstructured":"Estevez-Calvar N, Romero A, Figueras A, Novoa B (2013) Genes of the mitochondrial apoptotic pathway in Mytilus galloprovincialis. PLoS ONE 8:e61502","journal-title":"PLoS ONE"},{"key":"1901_CR25","volume":"5","author":"E Fabbri","year":"2008","unstructured":"Fabbri E, Valbonesi P, Franzellitti S (2008) HSP expression in bivalves. ISJ 5:e161","journal-title":"ISJ"},{"key":"1901_CR26","unstructured":"FAO (2016) Cultured Aquatic Species Information Programme. Mytilus galloprovincialis. Text by Figueras, A. In: FAO Fisheries and Aquaculture Department [online]. Rome. Updated 1 January 2004 (Lamark, 1819)."},{"key":"1901_CR27","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.aquatox.2015.03.006","volume":"162","author":"H Falfushynska","year":"2015","unstructured":"Falfushynska H, Gnatyshyna L, Yurchak I, Sokolova I, Stoliar O (2015) The effects of zinc nanooxide on cellular stress responses of the freshwater mussels Unio tumidus are modulated by elevated temperature and organic pollutants. Aquat Toxicol 162:82\u201393","journal-title":"Aquat Toxicol"},{"key":"1901_CR28","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.aquatox.2007.11.013","volume":"86","author":"F Gagn\u00e9","year":"2008","unstructured":"Gagn\u00e9 F, Auclair J, Turcotte P, Fournier M, Gagnon C, Sauve S, Blaise C (2008) Ecotoxicity of CdTe quantum dots to freshwater mussels: impacts on immune system, oxidative stress and genotoxicity. Aquat Toxicol 86:333\u2013340","journal-title":"Aquat Toxicol"},{"key":"1901_CR29","first-page":"36","volume":"172\u2013173","author":"F Gagn\u00e9","year":"2015","unstructured":"Gagn\u00e9 F, Auclair J, Peyrot C, Wilkinson K (2015) The influence of zinc chloride and nanoparticles on air-time survival in freshwater mussels. Comp Biochem Phys C 172\u2013173:36\u201344","journal-title":"Comp Biochem Phys C"},{"key":"1901_CR30","first-page":"39","volume":"33","author":"H Gao","year":"2007","unstructured":"Gao H, Shi L, Cheng R, Chen Y, Pan J, Han J (2007) Photocatalytic degradation of aniline with nanometer ZnO\/conjugared polymer composite photocatalyst. Technol Water Treat 33:39\u201342","journal-title":"Technol Water Treat"},{"key":"1901_CR31","first-page":"1","volume":"15","author":"Y Gao","year":"2013","unstructured":"Gao Y, Luo Z, He N, Wang MK (2013) Metallic nanoparticle production and consumption in China between 2000 and 2010 and associative aquatic environmental risk assessment. J Nanopart Res 15:1\u20139","journal-title":"J Nanopart Res"},{"key":"1901_CR32","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.envpol.2012.11.014","volume":"174","author":"C Garc\u00eda-Negrete","year":"2013","unstructured":"Garc\u00eda-Negrete C, Blasco J, Volland M, Rojas TC, Hampel M, Lapresta-Fern\u00e1ndez A, De Haro MJ, Soto M, Fern\u00e1ndez A (2013) Behaviour of Au-citrate nanoparticles in seawater and accumulation in bivalves at environmentally relevant concentrations. Environ Pollut 174:134\u2013141","journal-title":"Environ Pollut"},{"key":"1901_CR33","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1080\/10934529.2012.672065","volume":"47","author":"J Gasparik","year":"2012","unstructured":"Gasparik J, Dobias M, Capcarova M, Smehyl P, Slamecka J, Bujko J, Gasparik Jr J (2012) Concentration of cadmium, mercury, zinc, copper and cobalt in the tissues of wild boar (Sus scrofa) hunted inu the western Slovakia. J Environ Sci Health, Part A 47:1212\u20131216","journal-title":"J Environ Sci Health, Part A"},{"key":"1901_CR34","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.marenvres.2012.11.009","volume":"84","author":"T Gomes","year":"2013","unstructured":"Gomes T, Ara\u00fajo O, Pereira R, Almeida AC, Cravo A, Bebianno MJ (2013) Genotoxicity of copper oxide and silver nanoparticles in the mussel Mytilus galloprovincialis. Mar Environ Res 84:51\u201359","journal-title":"Mar Environ Res"},{"key":"1901_CR35","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.aquatox.2014.07.015","volume":"155","author":"T Gomes","year":"2014","unstructured":"Gomes T, Chora S, Pereira CG, Cardoso C, Bebianno MJ (2014b) Proteomic response of mussels Mytilus galloprovincialis exposed to CuO NPs and Cu2+: an exploratory biomarker discovery. Aquat Toxicol 155:327\u2013336","journal-title":"Aquat Toxicol"},{"key":"1901_CR36","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.aquatox.2012.03.017","volume":"118","author":"T Gomes","year":"2012","unstructured":"Gomes T, Pereira CG, Cardoso C, Pinheiro JP, Cancio I, Bebianno MJ (2012) Accumulation and toxicity of copper oxide nanoparticles in the digestive gland of Mytilus galloprovincialis. Aquat Toxicol 118:72\u201379","journal-title":"Aquat Toxicol"},{"key":"1901_CR37","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.marenvres.2014.07.004","volume":"101","author":"T Gomes","year":"2014","unstructured":"Gomes T, Pereira CG, Cardoso C, Sousa VS, Teixeira MR, Pinheiro JP, Bebianno MJ (2014a) Effects of silver nanoparticles exposure in the mussel Mytilus galloprovincialis. Mar Environ Res 101:208\u2013214","journal-title":"Mar Environ Res"},{"key":"1901_CR38","doi-asserted-by":"publisher","first-page":"9356","DOI":"10.1021\/es200955s","volume":"45","author":"T Gomes","year":"2011","unstructured":"Gomes T, Pinheiro JP, Cancio I, Pereira CG, Cardoso C, Bebianno MJ (2011) Effects of copper nanoparticles exposure in the mussel Mytilus galloprovincialis. Environ Sci Technol 45:9356\u20139362","journal-title":"Environ Sci Technol"},{"key":"1901_CR39","first-page":"250","volume":"36","author":"H Gu","year":"2007","unstructured":"Gu H, Wang H, Wang H, Wang J (2007) The preparation of nanometer ZrO2-based catalytic absorbents loading different oxidations and their desulphurization performance. Rare Metal Mater Eng 36:250\u2013253","journal-title":"Rare Metal Mater Eng"},{"key":"1901_CR40","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.lfs.2009.12.015","volume":"86","author":"SC Gupta","year":"2010","unstructured":"Gupta SC, Sharma A, Mishra M, Mishra RK, Chowdhuri DK (2010) Heat shock proteins in toxicology: how close and how far? Life Sci 86:377\u2013384","journal-title":"Life Sci"},{"key":"1901_CR41","unstructured":"Han J (2011) Study on applications of ZnO\/Ag nano-composite antibacterial in medical plastic and ship antifouling paints. Dissertation, Qingdao University of Science & Technology, China"},{"key":"1901_CR42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061800","volume":"8","author":"SK Hanna","year":"2013","unstructured":"Hanna SK, Miller RJ, Muller EB, Nisbet RM, Lenihan HS (2013) Impact of engineered zinc oxide nanoparticles on the individual performance of Mytilus galloprovincialis. PLoS ONE 8:e61800","journal-title":"PLoS ONE"},{"key":"1901_CR43","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2007-8-2-r19","volume":"8","author":"J Hellemans","year":"2007","unstructured":"Hellemans J, Mortier G, De Paepe A, Speleman F, Vandesompele J (2007) qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data. Genome Biol 8:R19","journal-title":"Genome Biol"},{"key":"1901_CR44","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.chemosphere.2014.01.054","volume":"108","author":"W Hu","year":"2014","unstructured":"Hu W, Culloty S, Darmody G, Lynch S, Davenport J, Ramirez-Garcia S, Dawson KA, Lynch I, Blasco J, Sheehan D (2014) Toxicity of copper oxide nanoparticles in the blue mussel, Mytilus edulis: A redox proteomic investigation. Chemosphere 108:289\u2013299","journal-title":"Chemosphere"},{"key":"1901_CR45","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/sj.gene.6364190","volume":"6","author":"J Huggett","year":"2005","unstructured":"Huggett J, Dheda K, Bustin S, Zumla A (2005) Real-time RT-PCR normalisation; strategies and considerations. Genes Immunol 6:279\u2013284","journal-title":"Genes Immunol"},{"key":"1901_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11051-013-1692-4","volume":"15","author":"AA Keller","year":"2013","unstructured":"Keller AA, McFerran S, Lazareva A, Suh S (2013) Global life cycle releases of engineered nanomaterials. J Nanopart Res 15:1\u201317","journal-title":"J Nanopart Res"},{"key":"1901_CR47","first-page":"1","volume":"16","author":"AA Keller","year":"2014","unstructured":"Keller AA, Vosti W, Wang H, Lazareva A (2014) Release of engineered nanomaterials from personal care products throughout their life cycle. J Nanopart Res 16:1\u201310","journal-title":"J Nanopart Res"},{"key":"1901_CR48","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1016\/j.chemosphere.2011.04.043","volume":"84","author":"BM Kim","year":"2011","unstructured":"Kim BM, Rhee JS, Park GS, Lee J, Lee YM, Lee JS (2011) Cu\/Zn-and Mn-superoxide dismutase (SOD) from the copepod Tigriopusjaponicus: molecular cloning and expression in response to environmental pollutants. Chemosphere 84:1467\u20131475","journal-title":"Chemosphere"},{"key":"1901_CR49","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/BF00397254","volume":"66","author":"K K\u00f6hler","year":"1982","unstructured":"K\u00f6hler K, Riisg\u00e5rd H (1982) Formation of metallothioneins in relation to accumulation of cadmium in the common mussel Mytilus edulis. Mar Biol 66:53\u201358","journal-title":"Mar Biol"},{"key":"1901_CR50","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1081\/ESE-200046605","volume":"40","author":"M Kram\u00e1rov\u00e1","year":"2005","unstructured":"Kram\u00e1rov\u00e1 M, Mass\u00e1nyi P, Slamecka J, Tataruch F, Jancov\u00e1 A, Gasparik J, Fabis M, Kovacik J, Toman R, Galov\u00e1 J (2005) Distribution of cadmium and lead in liver and kidney of some wild animals in Slovakia. J Environ Sci Health 40:593\u2013600","journal-title":"J Environ Sci Health"},{"key":"1901_CR51","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1111\/j.1365-2109.2011.02916.x","volume":"43","author":"CS Lazo","year":"2012","unstructured":"Lazo CS, Pita IM (2012) Effect of temperature on survival, growth and development of Mytilus galloprovincialis larvae. Aquacult Res 43:1127\u20131133","journal-title":"Aquacult Res"},{"key":"1901_CR52","doi-asserted-by":"publisher","first-page":"105101","DOI":"10.1088\/0957-4484\/22\/10\/105101","volume":"22","author":"A Lipovsky","year":"2011","unstructured":"Lipovsky A, Nitzan Y, Gedanken A, Lubart R (2011) Antifungal activity of ZnO nanoparticles-the role of ROS mediated cell injury. Nanotechnology 22:105101","journal-title":"Nanotechnology"},{"key":"1901_CR53","unstructured":"Liu Q (2014) Study on the Processing and Preservation Technology of Preparaed Caixin. Dissertation, University of Jiangnan, China"},{"key":"1901_CR54","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"1901_CR55","unstructured":"Luo, D (2013) Preparation and Application of Hierarchical SnO2 and ZnO Nanomaterial. Dissertation, Central China Normal University"},{"key":"1901_CR56","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1016\/j.envpol.2011.03.013","volume":"159","author":"H Ma","year":"2011","unstructured":"Ma H, Kabengi N, Bertsch P, Unrine J, Glenn T, Williams P (2011) Comparative phototoxicity of nanoparticulate and bulk ZnO to a free-living nematode Caenorhabditis elegans: the importance of illumination mode and primary particle size. Environ Pollut 159:1473\u20131480","journal-title":"Environ Pollut"},{"key":"1901_CR57","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.envpol.2012.08.011","volume":"172","author":"H Ma","year":"2013","unstructured":"Ma H, Williams PL, Diamond SA (2013) Ecotoxicity of manufactured ZnO nanoparticles-a review. Environ Pollut 172:76\u201385","journal-title":"Environ Pollut"},{"key":"1901_CR58","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.scitotenv.2012.12.051","volume":"445-446","author":"S Manzo","year":"2013","unstructured":"Manzo S, Miglietta ML, Rametta G, Buono S, Di Francia G (2013a) Toxic effects of ZnO nanoparticles towards marine algae Dunaliella tertiolecta. Sci Total Environ 445-446:371\u2013376","journal-title":"Sci Total Environ"},{"key":"1901_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jhazmat.2013.03.027","volume":"254","author":"S Manzo","year":"2013","unstructured":"Manzo S, Miglietta ML, Rametta G, Buono S, Di Francia G (2013b) Embryotoxicity and spermiotoxicity of nanosized ZnO for Mediterranean sea urchin Paracentrotus lividus. J Hazard Mater 254:1\u20139","journal-title":"J Hazard Mater"},{"key":"1901_CR60","doi-asserted-by":"publisher","first-page":"15275","DOI":"10.1007\/s11356-016-6690-5","volume":"23","author":"I Marisa","year":"2016","unstructured":"Marisa I, Matozzo V, Munari M, Binelli A, Parolini M, Martucci A, Franceschinis E, Brianese N, Marin MG (2016) In vivo exposure of the marine clam Ruditapes philippinarum to zinc oxide nanoparticles: responses in gills, digestive gland and haemolymph. Environ Sci Poll Res 23:15275\u201315293","journal-title":"Environ Sci Poll Res"},{"key":"1901_CR61","doi-asserted-by":"publisher","first-page":"45","DOI":"10.5414\/TEP21045","volume":"21","author":"P Mass\u00e1nyi","year":"2004","unstructured":"Mass\u00e1nyi P, Toman R, Trandzik J, Nad P, Skalicka M, Korenekova B (2004) Concentration of copper, zinc, iron, cadmium, lead and nickel in bull, ram, boar, stallion and fox semen. Trace Elem Electrolytes 21:45\u201349","journal-title":"Trace Elem Electrolytes"},{"issue":"19","key":"1901_CR62","doi-asserted-by":"publisher","first-page":"7329","DOI":"10.1021\/es100247x","volume":"44","author":"RJ Miller","year":"2010","unstructured":"Miller RJ, Lenihan HS, Muller EB, Tseng N, Hanna SK, Keller AA (2010) Impacts of metal oxide nanoparticles on marine phytoplankton. Environ Sci Technol 44(19):7329\u20137334","journal-title":"Environ Sci Technol"},{"key":"1901_CR63","doi-asserted-by":"publisher","first-page":"8959","DOI":"10.1021\/es801785m","volume":"42","author":"E Navarro","year":"2008","unstructured":"Navarro E, Piccapietra F, Wagner B, Marconi F, Kaegi R, Odzak N, Sigg L, Behra R (2008) Toxicity of silver nanoparticles to Chlamydomonas reinhardtii. Environ Sci Technol 42:8959\u20138964","journal-title":"Environ Sci Technol"},{"key":"1901_CR64","first-page":"3","volume":"39","author":"TJ Norberg-King","year":"1993","unstructured":"Norberg-King TJ (1993) A linear interpolation method for sublethal toxicity: the inhibition concentration (ICp) approach. Natl Effl Toxic Assess Cent Tech Report 39:3\u201393","journal-title":"Natl Effl Toxic Assess Cent Tech Report"},{"key":"1901_CR65","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.envpol.2012.03.051","volume":"168","author":"JF Pan","year":"2012","unstructured":"Pan JF, Buffet PE, Poirier L, Amiard-Triquet C, Gilliland D, Joubert Y, Pilet P, Guibbolini M, de Faverney CR, Rom\u00e9o M (2012) Size dependent bioaccumulation and ecotoxicity of gold nanoparticles in an endobenthic invertebrate: the Tellinid clam Scrobicularia plana. Environ Pollut 168:37\u201343","journal-title":"Environ Pollut"},{"key":"1901_CR66","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.aquatox.2011.01.014","volume":"102","author":"X Peng","year":"2011","unstructured":"Peng X, Palma S, Fisher NS, Wong SS (2011) Effect of morphology of ZnO nanostructures on their toxicity to marine algae. Aquat Toxicol 102:186\u2013196","journal-title":"Aquat Toxicol"},{"issue":"1","key":"1901_CR67","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s002449900285","volume":"34","author":"F Regoli","year":"1998","unstructured":"Regoli F (1998) Trace metals and antioxidant enzymes in gills and digestive gland of the Mediterranean mussel Mytilus galloprovincialis. Arch Environ Contam Toxicol 34(1):48\u201363","journal-title":"Arch Environ Contam Toxicol"},{"key":"1901_CR68","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1007\/BF03216589","volume":"41","author":"S Renault","year":"2008","unstructured":"Renault S, Baudrimont M, Mesmer-Dudons N, Gonzalez P, Mornet S, Brisson A (2008) Impacts of gold nanoparticle exposure on two freshwater species: a phytoplanktonic alga (Scenedesmus subspicatus) and a benthic bivalve (Corbicula fluminea). Gold Bull 41:116\u2013126","journal-title":"Gold Bull"},{"key":"1901_CR69","doi-asserted-by":"publisher","first-page":"S49","DOI":"10.1016\/j.marenvres.2009.10.011","volume":"69","author":"AH Ringwood","year":"2010","unstructured":"Ringwood AH, McCarthy M, Bates TC, Carroll DL (2010) The effects of silver nanoparticles on oyster embryos. Mar Environ Res 69:S49\u2013S51","journal-title":"Mar Environ Res"},{"key":"1901_CR70","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.1021\/es062572a","volume":"41","author":"AP Roberts","year":"2007","unstructured":"Roberts AP, Mount AS, Seda B, Souther J, Qiao R, Lin S, Ke PC, Rao AM, Klaine SJ (2007) In vivo biomodification of lipid-coated carbon nanotubes by Daphnia magna. Environ Sci Technol 41:3025\u20133029","journal-title":"Environ Sci Technol"},{"key":"1901_CR71","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.marenvres.2015.06.013","volume":"111","author":"TL Rocha","year":"2015","unstructured":"Rocha TL, Gomes T, Sousa VS, Mestre NC, Bebianno MJ (2015) Ecotoxicological impact of engineered nanomaterials in bivalve molluscs: An overview. Mar Environ Res 111:74\u201388","journal-title":"Mar Environ Res"},{"issue":"7","key":"1901_CR72","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1016\/j.sjbs.2015.10.021","volume":"24","author":"K Saddick","year":"2015","unstructured":"Saddick K, Afifi M, Zinada OAA (2015) Effect of Zinc nanoparticleson oxidative stress-related genes and antioxidant enzymes activityin the brain of Oreochromis niloticus and Tilapia zillii. Saudi J Biol Sci 24(7):1672\u20131678","journal-title":"Saudi J Biol Sci"},{"key":"1901_CR73","first-page":"261","volume":"1","author":"OA Scarlato","year":"1981","unstructured":"Scarlato OA (1981) Bivalve mollusks of temperate latitudes of the western portion of the Pacific Ocean. Guidebooks on the fauna of the USSR. Zoological Institute. USSR Acad Sci 1:261\u2013479","journal-title":"USSR Acad Sci"},{"key":"1901_CR74","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.scitotenv.2016.01.135","volume":"550","author":"S Schiavo","year":"2016","unstructured":"Schiavo S, Oliviero M, Miglietta M, Rametta G, Manzo S (2016) Genotoxic and cytotoxic effects of ZnO nanoparticles for Dunaliella tertiolecta and comparison with SiO2 and TiO2 effects at population growth inhibition levels. Sci Total Environ 550:619\u2013627","journal-title":"Sci Total Environ"},{"key":"1901_CR75","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","volume":"3","author":"TD Schmittgen","year":"2008","unstructured":"Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative CT method. Nat Protoc 3:1101\u20131108","journal-title":"Nat Protoc"},{"key":"1901_CR76","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/j.envint.2011.03.009","volume":"37","author":"BJ Shaw","year":"2011","unstructured":"Shaw BJ, Handy RD (2011) Physiological effects of nanoparticles on fish: a comparison of nanometals versus metal ions. Environ Int 37:1083\u20131097","journal-title":"Environ Int"},{"key":"1901_CR77","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1007\/s00244-012-9868-y","volume":"64","author":"SK Sheir","year":"2013","unstructured":"Sheir SK, Handy RD, Henry TB (2013) Effect of pollution history on immunological responses and organ histology in the marine mussel Mytilus edulis exposed to cadmium. Arch Environ Contam Toxicol 64:701\u2013716","journal-title":"Arch Environ Contam Toxicol"},{"key":"1901_CR78","first-page":"008","volume":"1","author":"AL Shen","year":"2009","unstructured":"Shen AL, Ma JZ, Ping XY, Shen XQ (2009) A study on the bioaccumulation and attenuation of heavy metals in Mytilus crassitesta. J Oceanogr Taiwan Strait 1:008","journal-title":"J Oceanogr Taiwan Strait"},{"key":"1901_CR79","unstructured":"Shi W (2015) Studies on rapid detection techniques and control measurements of jujube shrink disease and grape crown gall in Xinjian. Dissertation, Zhejiang University, China"},{"key":"1901_CR80","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.taap.2013.06.004","volume":"272","author":"S Tang","year":"2013","unstructured":"Tang S, Cai Q, Chibli H, Allagadda V, Nadeau JL, Mayer GD (2013) Cadmium sulfate and CdTe-quantum dots alter DNA repair in zebrafish (Danio rerio) liver cells. Toxicol Appl Pharmacol 272:443\u2013452","journal-title":"Toxicol Appl Pharmacol"},{"key":"1901_CR81","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.aquatox.2010.03.001","volume":"100","author":"S Tedesco","year":"2010","unstructured":"Tedesco S, Doyle H, Blasco J, Redmond G, Sheehan D (2010a) Oxidative stress and toxicity of gold nanoparticles in Mytilus edulis. Aquat Toxicol 100:178\u2013186","journal-title":"Aquat Toxicol"},{"key":"1901_CR82","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.cbpc.2009.10.002","volume":"151","author":"S Tedesco","year":"2010","unstructured":"Tedesco S, Doyle H, Blasco J, Redmond G, Sheehan D (2010b) Exposure of the blue mussel, Mytilus edulis, to gold nanoparticles and the pro-oxidant menadione. Comp Biochem Physiol C Toxicol Pharmacol 151:167\u2013174","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"1901_CR83","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.aquatox.2014.03.018","volume":"153","author":"R Trevisan","year":"2014","unstructured":"Trevisan R, Delapedra G, Mello DF, Arl M, Schmidt \u00c9C, Meder F, Monopoli M, Cargnin-Ferreira E, Bouzon ZL, Fisher AS (2014) Gills are an initial target of zinc oxide nanoparticles in oysters Crassostrea gigas, leading to mitochondrial disruption and oxidative stress. Aquat Toxicol 153:27\u201338","journal-title":"Aquat Toxicol"},{"key":"1901_CR84","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ecoenv.2014.07.035","volume":"109","author":"G Vale","year":"2014","unstructured":"Vale G, Franco C, Diniz MS, dos Santos MM, Domingos RF (2014) Bioavailability of cadmium and biochemical responses on the freshwater bivalve Corbicula fluminea\u2013the role of TiO2 nanoparticles. Ecotoxicol Environ Saf 109:161\u2013168","journal-title":"Ecotoxicol Environ Saf"},{"key":"1901_CR85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11051-014-2369-3","volume":"16","author":"R Varela-Valencia","year":"2014","unstructured":"Varela-Valencia R, G\u00f3mez-Ortiz N, Oskam G, de Coss R, Rubio-Pi\u00f1a J, del R\u00edo-Garc\u00eda M, Albores-Medina A, Zapata-Perez O (2014) The effect of titanium dioxide nanoparticles on antioxidant gene expression in tilapia (Oreochromis niloticus). J Nanopart Res 16:1\u201312","journal-title":"J Nanopart Res"},{"key":"1901_CR86","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.mrfmmm.2006.08.007","volume":"602","author":"P Venier","year":"2006","unstructured":"Venier P, De Pitt\u00e0 C, Pallavicini A, Marsano F, Varotto L, Romualdi C, Dondero F, Viarengo A, Lanfranchi G (2006) Development of mussel mRNA profiling: can gene expression trends reveal coastal water pollution? Mutat Res 602:121\u2013134","journal-title":"Mutat Res"},{"key":"1901_CR87","first-page":"558","volume":"150","author":"Q Wan","year":"2009","unstructured":"Wan Q, Whang I, Lee JS, Lee J (2009) Novel omega glutathione S-transferases in disk abalone: characterization and protective roles against environmental stress. Comp Biochem Physiol C: Toxicol Pharmacol 150:558\u2013568","journal-title":"Comp Biochem Physiol C: Toxicol Pharmacol"},{"key":"1901_CR88","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/j.fsi.2013.01.011","volume":"34","author":"Q Wang","year":"2013","unstructured":"Wang Q, Yuan Z, Wu H, Liu F, Zhao J (2013) Molecular characterization of a manganese superoxide dismutase and copper\/zinc superoxide dismutase from the mussel Mytilus galloprovincialis. Fish Shellfish Immunol 34:1345\u20131351","journal-title":"Fish Shellfish Immunol"},{"key":"1901_CR89","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.scitotenv.2013.09.060","volume":"470","author":"Y Wang","year":"2014","unstructured":"Wang Y, Hu M, Li Q, Li J, Lin D, Lu W (2014) Immune toxicity of TiO2 under hypoxia in the green-lipped mussel Perna viridis based on flow cytometric analysis of hemocyte parameters. Sci Total Environ 470:791\u2013799","journal-title":"Sci Total Environ"},{"key":"1901_CR90","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.marenvres.2009.05.002","volume":"68","author":"JE Ward","year":"2009","unstructured":"Ward JE, Kach DJ (2009) Marine aggregates facilitate ingestion of nanoparticles by suspension-feeding bivalves. Mar Environ Res 68:137\u2013142","journal-title":"Mar Environ Res"},{"key":"1901_CR91","first-page":"344","volume":"155","author":"EJ Won","year":"2012","unstructured":"Won EJ, Rhee JS, Kim RO, Ra K, Kim KT, Shin KH, Lee JS (2012) Susceptibility to oxidative stress and modulated expression of antioxidant genes in the copper-exposed polychaete Perinereis nuntia. Comp Biochem Physiol C: Toxicol Pharmacol 155:344\u2013351","journal-title":"Comp Biochem Physiol C: Toxicol Pharmacol"},{"key":"1901_CR92","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s00216-009-3249-z","volume":"396","author":"SWY Wong","year":"2010","unstructured":"Wong SWY, Leung PTY, Djuri\u0161i\u0107 AB, Leung KMY (2010) Toxicities of nano zinc oxide to five marine organisms: influences of aggregate size and ion solubility. Anal Bioanal Chem 396:609\u2013618","journal-title":"Anal Bioanal Chem"},{"key":"1901_CR93","first-page":"292","volume":"30","author":"YY Ye","year":"2011","unstructured":"Ye YY, Xu MY, Wu CW (2011) Influences of some environmental factors on growth and survival of Mytilus coruscus Gould Larvae. J Zhejiang Ocean Univ (Nat Sci) 30:292\u2013296","journal-title":"J Zhejiang Ocean Univ (Nat Sci)"},{"key":"1901_CR94","unstructured":"Yue X (2014) Preparation and properties research of novel marine anticorrosion and antifouling nano-composite coatings. Dissertation, Tianjin University, China"},{"key":"1901_CR95","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/S0891-5849(02)00905-X","volume":"33","author":"IN Zelko","year":"2002","unstructured":"Zelko IN, Mariani TJ, Folz RJ (2002) Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic Biol Med 33:337\u2013349","journal-title":"Free Radic Biol Med"}],"container-title":["Ecotoxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10646-018-1901-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10646-018-1901-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10646-018-1901-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T02:27:41Z","timestamp":1550024861000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10646-018-1901-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,13]]},"references-count":95,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["1901"],"URL":"https:\/\/doi.org\/10.1007\/s10646-018-1901-0","relation":{},"ISSN":["0963-9292","1573-3017"],"issn-type":[{"value":"0963-9292","type":"print"},{"value":"1573-3017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,13]]},"assertion":[{"value":"13 January 2018","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2018","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}