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The LC\n                    <jats:sub>50<\/jats:sub>\n                    value of Profenofos (PRO) was resolved in Grass carp (\n                    <jats:italic>Ctenopharyngodon idella<\/jats:italic>\n                    ) with average body weight (55.82\u2009\u00b1\u20095.42\u2009g) and determined the 96\u2009h LC\n                    <jats:sub>50<\/jats:sub>\n                    value as 7.2\u2009\u00b5g\/L for the assay. Twenty-one-day exposures to 1.8\u2009\u00b5g\/ L and 3.6\u2009\u00b5g\/ L doses were conducted to evaluate the sub-lethal effects, and various toxicological endpoints were assessed on the 1\n                    <jats:sup>st<\/jats:sup>\n                    , 7\n                    <jats:sup>th<\/jats:sup>\n                    , 15\n                    <jats:sup>th<\/jats:sup>\n                    and 21\n                    <jats:sup>st<\/jats:sup>\n                    days of exposure. Acute toxic stress was observed with fish displaying behavioral toxicity. The most hematological change was extreme microcytic hypochromic anemia. Leucocyte count increased in experimented fish. Moderate neutrophilia, monocytosis and lymphocytosis were observed. Serum total protein, albumin, and globulin concentrations were significantly diminished. Overall, increments over control were recognized in serum urea, creatinine and acid phosphatase. However, serum glucose, total lipid, cholesterol, serum ALT and AST activity showed a significant decrease in fish exposed to both concentrations of PRO. Serum IgM concentrations insignificantly changed in treated fish except for on the 21\n                    <jats:sup>st<\/jats:sup>\n                    day of exposure to 3.6\u2009\u00b5g\/ L of PRO, while serum lysozyme significantly decreased. Furthermore, total protein, lipid and glycogen concentrations in muscles and the liver exhibited a decreasing trend at all concentrations. Moreover, histopathological alterations in the liver, kidney, and muscles occurred exclusively after treatment. From the obtained results, it is assumed that profenofos induced general toxic impacts under field conditions and might disturb ecologically relevant processes.\n                  <\/jats:p>","DOI":"10.1007\/s10646-023-02628-9","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T09:23:44Z","timestamp":1674897824000},"page":"196-210","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Toxicity bioassay and sub-lethal effects of profenofos-based insecticide on behavior, biochemical, hematological, and histopathological responses in Grass carp (Ctenopharyngodon idella)"],"prefix":"10.1007","volume":"32","author":[{"given":"Zeinab. M.","family":"El-bouhy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma. A. 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