{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:13:27Z","timestamp":1791195207242,"version":"4.1.0"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100005299","name":"Vicerrector\u00eda de Investigaci\u00f3n, Universidad de Costa Rica","doi-asserted-by":"publisher","award":["802-B8-510; 802-C1-034"],"award-info":[{"award-number":["802-B8-510; 802-C1-034"]}],"id":[{"id":"10.13039\/501100005299","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UCREA, Universidad de Costa Rica","award":["802-B7-A09"],"award-info":[{"award-number":["802-B7-A09"]}]},{"DOI":"10.13039\/501100006473","name":"Ministerio de Ciencia, Innovaci\u00f3n, Tecnolog\u00eda y Telecomunicaciones","doi-asserted-by":"publisher","award":["FI-197B-17"],"award-info":[{"award-number":["FI-197B-17"]}],"id":[{"id":"10.13039\/501100006473","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ecotoxicology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s10646-025-02885-w","type":"journal-article","created":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T06:52:59Z","timestamp":1745736779000},"page":"935-947","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Individual and mixture effect of selected high-hazard pharmaceuticals on aquatic primary producers"],"prefix":"10.1007","volume":"34","author":[{"given":"Jos\u00e9 R.","family":"Montiel-Mora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Lizano-Fallas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"M\u00e9ndez-Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Mar\u00edn-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Cambronero-Heinrichs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.","family":"Rodr\u00edguez-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,27]]},"reference":[{"key":"2885_CR2","unstructured":"A language and environment for statistical computing. In R Foundation for Statistical Computing. (2023). [Software]. R Core Team."},{"issue":"Pt B","key":"2885_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.114993","volume":"265","author":"GD Alkimin","year":"2020","unstructured":"Alkimin GD, Soares AMVM, Barata C, Nunes B (2020) Evaluation of ketoprofen toxicity in two freshwater species: effects on biochemical, physiological and population endpoints. Environ Pollut 265(Pt B):114993. https:\/\/doi.org\/10.1016\/j.envpol.2020.114993.","journal-title":"Environ Pollut"},{"key":"2885_CR4","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.aquatox.2017.01.008","volume":"185","author":"C Amy-Sagers","year":"2017","unstructured":"Amy-Sagers C, Reinhardt K, Larson DM (2017) Ecotoxicological assessments show sucralose and fluoxetine affect the aquatic plant, Lemna minor. Aquat Toxicol 185:76\u201385. https:\/\/doi.org\/10.1016\/j.aquatox.2017.01.008.","journal-title":"Aquat Toxicol"},{"issue":"4","key":"2885_CR5","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1208\/s12248-016-9907-0","volume":"18","author":"T Backhaus","year":"2016","unstructured":"Backhaus T (2016) Environmental risk assessment of pharmaceutical mixtures: demands, gaps, and possible bridges. AAPS J 18(4):804\u2013813. https:\/\/doi.org\/10.1208\/s12248-016-9907-0.","journal-title":"AAPS J"},{"key":"2885_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2023.104258","volume":"103","author":"A Barreto","year":"2023","unstructured":"Barreto A, Silva ARR, Capit\u00e3o A, Sousa \u00c9ML, Calisto V, Maria VL (2023) Nanoplastics increase the toxicity of a pharmaceutical, at environmentally relevant concentrations \u2013 A mixture design with Daphnia magna. Environ Toxicol Pharm 103: 104258. https:\/\/doi.org\/10.1016\/j.etap.2023.104258.","journal-title":"Environ Toxicol Pharm"},{"key":"2885_CR7","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1016\/j.chemosphere.2015.10.137","volume":"144","author":"H B\u00e1rt\u00edkov\u00e1","year":"2016","unstructured":"B\u00e1rt\u00edkov\u00e1 H, Podlipn\u00e1 R, Sk\u00e1lov\u00e1 L (2016) Veterinary drugs in the environment and their toxicity to plants. Chemosphere 144:2290\u20132301. https:\/\/doi.org\/10.1016\/j.chemosphere.2015.10.137.","journal-title":"Chemosphere"},{"issue":"3","key":"2885_CR8","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1002\/ieam.5630030307","volume":"3","author":"JB Belden","year":"2007","unstructured":"Belden JB, Gilliom RJ, Lydy MJ (2007) How well can we predict the toxicity of pesticide mixtures to aquatic life?. Integr Environ Assess Manag 3(3):364\u2013372.","journal-title":"Integr Environ Assess Manag"},{"issue":"9","key":"2885_CR9","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1002\/etc.590","volume":"30","author":"JP Berninger","year":"2011","unstructured":"Berninger JP, Du B, Connors KA, Eytcheson SA, Kolkmeier MA, Prosser KN, Valenti TW, Chambliss CK, Brooks BW (2011) Effects of the antihistamine diphenhydramine on selected aquatic organisms. Environ Toxicol Chem 30(9):2065\u20132072. https:\/\/doi.org\/10.1002\/etc.590.","journal-title":"Environ Toxicol Chem"},{"issue":"1","key":"2885_CR10","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.cbpc.2009.02.005","volume":"150","author":"A Binelli","year":"2009","unstructured":"Binelli A, Cogni D, Parolini M, Riva C, Provini A (2009) Cytotoxic and genotoxic effects of in vitro exposure to triclosan and trimethoprim on zebra mussel (Dreissena polymorpha) hemocytes. Comp Biochem Physiol Part C: Toxicol Pharm 150(1):50\u201356. https:\/\/doi.org\/10.1016\/j.cbpc.2009.02.005.","journal-title":"Comp Biochem Physiol Part C: Toxicol Pharm"},{"key":"2885_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.138312","volume":"725","author":"A Bownik","year":"2020","unstructured":"Bownik A, Jasieczek M, Kosztowny E (2020) Ketoprofen affects swimming behavior and impairs physiological endpoints of Daphnia magna. Sci Total Environ 725: 138312. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.138312.","journal-title":"Sci Total Environ"},{"issue":"6","key":"2885_CR12","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1021\/jf053041t","volume":"54","author":"ABA Boxall","year":"2006","unstructured":"Boxall ABA, Johnson P, Smith EJ, Sinclair CJ, Stutt E, Levy LS (2006) Uptake of veterinary medicines from soils into plants. J Agric Food Chem 54(6):2288\u20132297. https:\/\/doi.org\/10.1021\/jf053041t.","journal-title":"J Agric Food Chem"},{"issue":"9","key":"2885_CR13","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1289\/ehp.1104477","volume":"120","author":"ABA Boxall","year":"2012","unstructured":"Boxall ABA, Rudd MA, Brooks BW, Caldwell DJ, Choi K, Hickmann S, Innes E, Ostapyk K, Staveley JP, Verslycke T, Ankley GT, Beazley KF, Belanger SE, Berninger JP, Carriquiriborde P, Coors A, Deleo PC, Dyer SD, Ericson JF, Van Der Kraak G (2012) Pharmaceuticals and personal care products in the environment: What are the big questions?. Environ Health Perspect 120(9):1221\u20131229. https:\/\/doi.org\/10.1289\/ehp.1104477.","journal-title":"Environ Health Perspect"},{"key":"2885_CR14","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/978-0-387-71724-1_3","volume":"192","author":"RA Brain","year":"2008","unstructured":"Brain RA, Hanson ML, Solomon KR, Brooks BW (2008) Aquatic plants exposed to pharmaceuticals: Effects and risks. Rev Environ Contam Toxicol 192:67\u2013115. https:\/\/doi.org\/10.1007\/978-0-387-71724-1_3.","journal-title":"Rev Environ Contam Toxicol"},{"issue":"1","key":"2885_CR15","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0045-6535(03)00103-6","volume":"52","author":"BW Brooks","year":"2003","unstructured":"Brooks BW, Turner PK, Stanley JK, Weston JJ, Glidewell EA, Foran CM, Slattery M, La Point TW, Huggett DB (2003b) Waterborne and sediment toxicity of fluoxetine to select organisms. Chemosphere 52(1):135\u2013142. https:\/\/doi.org\/10.1016\/S0045-6535(03)00103-6.","journal-title":"Chemosphere"},{"issue":"3","key":"2885_CR16","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/s0378-4274(03)00066-3","volume":"142","author":"BW Brooks","year":"2003","unstructured":"Brooks BW, Foran CM, Richards SM, Weston J, Turner PK, Stanley JK, Solomon KR, Slattery M, La Point TW (2003a) Aquatic ecotoxicology of fluoxetine. Toxicol Lett 142(3):169\u2013183. https:\/\/doi.org\/10.1016\/s0378-4274(03)00066-3.","journal-title":"Toxicol Lett"},{"issue":"5","key":"2885_CR17","doi-asserted-by":"publisher","first-page":"e96580","DOI":"10.1371\/journal.pone.0096580","volume":"9","author":"N Cedergreen","year":"2014","unstructured":"Cedergreen N (2014) Quantifying synergy: a systematic review of mixture toxicity studies within environmental toxicology. PLoS ONE 9(5):e96580. https:\/\/doi.org\/10.1371\/journal.pone.0096580.","journal-title":"PLoS ONE"},{"issue":"5","key":"2885_CR18","doi-asserted-by":"publisher","first-page":"4975","DOI":"10.1007\/s11356-020-11496-3","volume":"28","author":"S Ceschin","year":"2021","unstructured":"Ceschin S, Bellini A, Scalici M (2021) Aquatic plants and ecotoxicological assessment in freshwater ecosystems: a review. Environ Sci Pollut Res 28(5):4975\u20134988. https:\/\/doi.org\/10.1007\/s11356-020-11496-3.","journal-title":"Environ Sci Pollut Res"},{"issue":"8","key":"2885_CR19","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1897\/05-415R.1","volume":"25","author":"AM Christensen","year":"2006","unstructured":"Christensen AM, Ingerslev F, Baun A (2006) Ecotoxicity of mixtures of antibiotics used in aquacultures. Environ Toxicol Chem 25(8):2208\u20132215. https:\/\/doi.org\/10.1897\/05-415R.1.","journal-title":"Environ Toxicol Chem"},{"issue":"1","key":"2885_CR20","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1897\/06-219r.1","volume":"26","author":"AM Christensen","year":"2007","unstructured":"Christensen AM, Faaborg-Andersen S, Ingerslev F, Baun A (2007) Mixture and single-substance toxicity of selective serotonin reuptake inhibitors toward algae and crustaceans. Environ Toxicol Chem 26(1):85\u201391. https:\/\/doi.org\/10.1897\/06-219r.1.","journal-title":"Environ Toxicol Chem"},{"key":"2885_CR1","volume-title":"Technical Guidance Document on Risk Assessment","author":"Commission of the European Communities.","year":"1996","unstructured":"Commission of the European Communities., 1996. Technical Guidance Document on Risk Assessment. European Chemicals Bureau."},{"key":"2885_CR46","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.ecoenv.2012.05.016","volume":"82","author":"M De Liguoro","year":"2012","unstructured":"De Liguoro M, Di Leva V, Dalla Bona M, Merlanti R, Caporale G, Radaelli G (2012) Sublethal effects of trimethoprim on four freshwater organisms. Ecotoxicol Environ Saf 82:114\u2013121. https:\/\/doi.org\/10.1016\/j.ecoenv.2012.05.016.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"11","key":"2885_CR45","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1016\/j.chemosphere.2009.02.002","volume":"75","author":"M De Liguoro","year":"2009","unstructured":"De Liguoro M, Fioretto B, Poltronieri C, Gallina G (2009) The toxicity of sulfamethazine to Daphnia magna and its additivity to other veterinary sulfonamides and trimethoprim. Chemosphere 75(11):1519\u20131524. https:\/\/doi.org\/10.1016\/j.chemosphere.2009.02.002.","journal-title":"Chemosphere"},{"issue":"2","key":"2885_CR21","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s40572-014-0015-y","volume":"1","author":"RP Deo","year":"2014","unstructured":"Deo RP (2014) Pharmaceuticals in the surface water of the USA: a review. Curr Environ Health Rep. 1(2):113\u2013122. https:\/\/doi.org\/10.1007\/s40572-014-0015-y.","journal-title":"Curr Environ Health Rep."},{"key":"2885_CR22","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.chemosphere.2016.01.017","volume":"148","author":"J Ding","year":"2016","unstructured":"Ding J, Lu G, Li Y (2016) Interactive effects of selected pharmaceutical mixtures on bioaccumulation and biochemical status in crucian carp (Carassius auratus). Chemosphere 148:21\u201331. https:\/\/doi.org\/10.1016\/j.chemosphere.2016.01.017.","journal-title":"Chemosphere"},{"key":"2885_CR23","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.toxrep.2021.02.020","volume":"8","author":"V Diniz","year":"2021","unstructured":"Diniz V, Rath G, Rath S, Rodrigues-Silva C, Guimar\u00e3es JR, Cunha DGF (2021) Long-term ecotoxicological effects of ciprofloxacin in combination with caffeine on the microalga Raphidocelis subcapitata. Toxicol Rep. 8:429\u2013435. https:\/\/doi.org\/10.1016\/j.toxrep.2021.02.020.","journal-title":"Toxicol Rep."},{"issue":"39","key":"2885_CR24","doi-asserted-by":"publisher","first-page":"52233","DOI":"10.1007\/s11356-024-34659-y","volume":"31","author":"BS Diogo","year":"2024","unstructured":"Diogo BS, Rodrigues S, Golovko O, Antunes SC (2024) From bacteria to fish: ecotoxicological insights into sulfamethoxazole and trimethoprim. Environ Sci Pollut Res 31(39):52233\u201352252. https:\/\/doi.org\/10.1007\/s11356-024-34659-y.","journal-title":"Environ Sci Pollut Res"},{"key":"2885_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.105267","volume":"134","author":"E Drakvik","year":"2020","unstructured":"Drakvik E, Altenburger R, Aoki Y, Backhaus T et al. (2020) Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment. Environ Int 134: 105267. https:\/\/doi.org\/10.1016\/j.envint.2019.105267.","journal-title":"Environ Int"},{"key":"2885_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12302-018-0135-3","volume":"30","author":"V Dulio","year":"2018","unstructured":"Dulio V, van Bavel B, Brorstr\u00f6m-Lund\u00e9n E, Harmsen J, Hollender J, Schlabach M, Slobodnik J, Thomas K, Koschorreck J (2018) Emerging pollutants in the EU: 10 years of NORMAN in support of environmental policies and regulations. Environ Sci Eur 30:1\u201313. https:\/\/doi.org\/10.1186\/s12302-018-0135-3.","journal-title":"Environ Sci Eur"},{"issue":"11","key":"2885_CR27","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1016\/j.chemosphere.2004.07.017","volume":"57","author":"K Eguchi","year":"2004","unstructured":"Eguchi K, Nagase H, Ozawa M, Endoh YS, Goto K, Hirata K, Miyamoto K, Yoshimura H (2004) Evaluation of antimicrobial agents for veterinary use in the ecotoxicity test using microalgae. Chemosphere 57(11):1733\u20131738. https:\/\/doi.org\/10.1016\/j.chemosphere.2004.07.017.","journal-title":"Chemosphere"},{"issue":"1","key":"2885_CR28","doi-asserted-by":"publisher","DOI":"10.1007\/s10661-019-7984-0","volume":"192","author":"VGO Falc\u00e3o","year":"2019","unstructured":"Falc\u00e3o VGO, de Carneiro DC, Pereira SA, da Silva MRD, Cand\u00e9 AA, da Cunha Lima ST (2019) Analyzing the toxicity of bisphenol-A to microalgae for ecotoxicological applications. Environ Monit Assess 192(1):8. https:\/\/doi.org\/10.1007\/s10661-019-7984-0.","journal-title":"Environ Monit Assess"},{"issue":"2","key":"2885_CR29","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.aquatox.2005.09.009","volume":"76","author":"K Fent","year":"2006","unstructured":"Fent K, Weston AA, Caminada D (2006) Ecotoxicology of human pharmaceuticals. Aquat Toxicol 76(2):122\u2013159. https:\/\/doi.org\/10.1016\/j.aquatox.2005.09.009.","journal-title":"Aquat Toxicol"},{"issue":"2","key":"2885_CR30","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.chemosphere.2005.02.016","volume":"61","author":"CM Flaherty","year":"2005","unstructured":"Flaherty CM, Dodson SI (2005) Effects of pharmaceuticals on Daphnia survival, growth, and reproduction. Chemosphere 61(2):200\u2013207. https:\/\/doi.org\/10.1016\/j.chemosphere.2005.02.016.","journal-title":"Chemosphere"},{"issue":"4","key":"2885_CR31","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s00244-003-3042-5","volume":"46","author":"CM Foran","year":"2004","unstructured":"Foran CM, Weston J, Slattery M, Brooks BW, Huggett DB (2004) Reproductive assessment of Japanese medaka (Oryzias latipes) following a four-week fluoxetine (SSRI) exposure. Arch Environ Contam Toxicol 46(4):511\u2013517. https:\/\/doi.org\/10.1007\/s00244-003-3042-5.","journal-title":"Arch Environ Contam Toxicol"},{"key":"2885_CR32","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.chemosphere.2014.01.016","volume":"115","author":"O Fr\u00e9d\u00e9ric","year":"2014","unstructured":"Fr\u00e9d\u00e9ric O, Yves P (2014) Pharmaceuticals in hospital wastewater: Their ecotoxicity and contribution to the environmental hazard of the effluent. Chemosphere 115:31\u201339. https:\/\/doi.org\/10.1016\/j.chemosphere.2014.01.016.","journal-title":"Chemosphere"},{"issue":"6","key":"2885_CR33","doi-asserted-by":"publisher","DOI":"10.1007\/s10661-016-5375-3","volume":"188","author":"S Gheorghe","year":"2016","unstructured":"Gheorghe S, Petre J, Lucaciu I, Stoica C, Nita-Lazar M (2016) Risk screening of pharmaceutical compounds in Romanian aquatic environment. Environ Monit Assess 188(6):379. https:\/\/doi.org\/10.1007\/s10661-016-5375-3.","journal-title":"Environ Monit Assess"},{"key":"2885_CR34","doi-asserted-by":"publisher","unstructured":"Gomez Cortes, L, Marinov, D, Sanseverino, I, Cuenca, AN, Niegowska, M, Rodriguez, EP, & Lettieri, T (2020). Selection of substances for the 3rd Watch List under the Water Framework Directive, EUR 30297 EN, Luxembourg: Publications Office of the European Union. https:\/\/doi.org\/10.2760\/194067","DOI":"10.2760\/194067"},{"issue":"2","key":"2885_CR35","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s00244-007-9018-0","volume":"54","author":"TB Henry","year":"2008","unstructured":"Henry TB, Black MC (2008) Acute and chronic toxicity of fluoxetine (selective serotonin reuptake inhibitor) in western mosquitofish. Arch Environ Contam Toxicol 54(2):325\u2013330. https:\/\/doi.org\/10.1007\/s00244-007-9018-0.","journal-title":"Arch Environ Contam Toxicol"},{"key":"2885_CR36","doi-asserted-by":"publisher","first-page":"47844","DOI":"10.1039\/C6RA05406D","volume":"6","author":"KA Heys","year":"2016","unstructured":"Heys KA, Shore RF, Pereira MG, Jones KC, Martin FL (2016) Risk assessment of environmental mixture effects. RSCAdv 6:47844\u201347857. https:\/\/doi.org\/10.1039\/C6RA05406D.","journal-title":"RSCAdv"},{"key":"2885_CR37","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.chemosphere.2016.11.106","volume":"169","author":"A Huete-Soto","year":"2017","unstructured":"Huete-Soto A, Mas\u00eds-Mora M, Lizano-Fallas V, Chin-Pampillo JS, Carazo-Rojas E, Rodr\u00edguez-Rodr\u00edguez CE (2017) Simultaneous removal of structurally different pesticides in a biomixture: Detoxification and effect of oxytetracycline. Chemosphere 169:558\u2013567. https:\/\/doi.org\/10.1016\/j.chemosphere.2016.11.106.","journal-title":"Chemosphere"},{"key":"2885_CR38","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.jhazmat.2013.09.017","volume":"262","author":"V Iori","year":"2013","unstructured":"Iori V, Zacchini M, Pietrini F (2013) Growth, physiological response and phytoremoval capability of two willow clones exposed to ibuprofen under hydroponic culture. J Hazard Mater 262:796\u2013804. https:\/\/doi.org\/10.1016\/j.jhazmat.2013.09.017.","journal-title":"J Hazard Mater"},{"key":"2885_CR39","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.scitotenv.2012.06.059","volume":"433","author":"A Jelic","year":"2012","unstructured":"Jelic A, Fatone F, Di Fabio S, Petrovic M, Cecchi F, Barcelo D (2012) Tracing pharmaceuticals in a municipal plant for integrated wastewater and organic solid waste treatment. Sci Total Environ 433:352\u2013361. https:\/\/doi.org\/10.1016\/j.scitotenv.2012.06.059.","journal-title":"Sci Total Environ"},{"issue":"1","key":"2885_CR40","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.ecoenv.2006.03.016","volume":"67","author":"DJ Johnson","year":"2007","unstructured":"Johnson DJ, Sanderson H, Brain RA, Wilson CJ, Solomon KR (2007) Toxicity and hazard of selective serotonin reuptake inhibitor antidepressants fluoxetine, fluvoxamine, and sertraline to algae. Ecotoxicol Environ Saf 67(1):128\u2013139. https:\/\/doi.org\/10.1016\/j.ecoenv.2006.03.016.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"15","key":"2885_CR41","doi-asserted-by":"publisher","first-page":"E3463","DOI":"10.1073\/pnas.1717295115","volume":"115","author":"EY Klein","year":"2018","unstructured":"Klein EY, Van Boeckel TP, Martinez EM, Pant S, Gandra S, Levin SA, Goossens H, Laxminarayan R (2018) Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proc Natl Acad Sci USA 115(15):E3463\u2013E3470. https:\/\/doi.org\/10.1073\/pnas.1717295115.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"2885_CR42","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1016\/j.jenvman.2009.01.023","volume":"90","author":"K K\u00fcmmerer","year":"2009","unstructured":"K\u00fcmmerer K (2009b) The presence of pharmaceuticals in the environment due to human use\u2014Present knowledge and future challenges. J Environ Manag 90(8):2354\u20132366. https:\/\/doi.org\/10.1016\/j.jenvman.2009.01.023.","journal-title":"J Environ Manag"},{"issue":"4","key":"2885_CR43","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.chemosphere.2008.11.086","volume":"75","author":"K K\u00fcmmerer","year":"2009","unstructured":"K\u00fcmmerer K (2009a) Antibiotics in the aquatic environment \u2013 A review \u2013 Part I. Chemosphere 75(4):417\u2013434. https:\/\/doi.org\/10.1016\/j.chemosphere.2008.11.086.","journal-title":"Chemosphere"},{"issue":"4","key":"2885_CR44","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1080\/10807039.2015.1133242","volume":"22","author":"KA Lewis","year":"2016","unstructured":"Lewis KA, Tzilivakis J, Warner DJ, Green A (2016) An international database for pesticide risk assessments and management. Hum Ecol Risk Assess: Int J 22(4):1050\u20131064. https:\/\/doi.org\/10.1080\/10807039.2015.1133242.","journal-title":"Hum Ecol Risk Assess: Int J"},{"issue":"9","key":"2885_CR47","doi-asserted-by":"publisher","first-page":"9891","DOI":"10.1007\/s11356-019-07592-8","volume":"27","author":"L Lomba","year":"2020","unstructured":"Lomba L, Lape\u00f1a D, Ros N, Aso E, Cannav\u00f2 M, Errazquin D, Giner B (2020) Ecotoxicological study of six drugs in Aliivibrio fischeri, Daphnia magna and Raphidocelis subcapitata. Environ Sci Pollut Res 27(9):9891\u20139900. https:\/\/doi.org\/10.1007\/s11356-019-07592-8.","journal-title":"Environ Sci Pollut Res"},{"issue":"1","key":"2885_CR48","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s43705-022-00147-y","volume":"2","author":"J Lu","year":"2022","unstructured":"Lu J, Ding P, Wang Y, Guo J (2022) Antidepressants promote the spread of extracellular antibiotic resistance genes via transformation. ISME Commun 2(1):63. https:\/\/doi.org\/10.1038\/s43705-022-00147-y.","journal-title":"ISME Commun"},{"issue":"4","key":"2885_CR49","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s00244-014-0119-2","volume":"68","author":"TO Luna","year":"2015","unstructured":"Luna TO, Plautz SC, Salice CJ (2015) Chronic effects of 17\u03b1-ethinylestradiol, fluoxetine, and the mixture on individual and population-level end points in Daphnia magna. Arch Environ Contam Toxicol 68(4):603\u2013611. https:\/\/doi.org\/10.1007\/s00244-014-0119-2.","journal-title":"Arch Environ Contam Toxicol"},{"key":"2885_CR50","doi-asserted-by":"publisher","first-page":"111428","DOI":"10.1016\/j.ecoenv.2020.111428","volume":"208","author":"M Markovic","year":"2021","unstructured":"Markovic M, Neale PA, Nidumolu B, Kumar A (2021) Combined toxicity of therapeutic pharmaceuticals to duckweed, Lemna minor. Ecotoxicol Environ Saf 208:111428. https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111428.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"4","key":"2885_CR51","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1001\/archinte.163.4.402","volume":"163","author":"PA Masters","year":"2003","unstructured":"Masters PA, O\u2019Bryan TA, Zurlo J, Miller DQ, Joshi N (2003) Trimethoprim-sulfamethoxazole revisited. Arch Intern Med 163(4):402\u2013410.","journal-title":"Arch Intern Med"},{"issue":"4","key":"2885_CR52","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s00128-023-03809-2","volume":"111","author":"M M\u00e9ndez-Rivera","year":"2023","unstructured":"M\u00e9ndez-Rivera M, Montiel-Mora JR, Ram\u00edrez-Morales D, Mas\u00eds-Mora M, Rodr\u00edguez-Rodr\u00edguez CE (2023) On-farm occurrence of pharmaceuticals and their environmental hazard: case study of a tropical dairy farm. Bull Environ Contamination Toxicol 111(4):51. https:\/\/doi.org\/10.1007\/s00128-023-03809-2.","journal-title":"Bull Environ Contamination Toxicol"},{"issue":"6","key":"2885_CR53","doi-asserted-by":"publisher","first-page":"4992","DOI":"10.1007\/s11356-014-3662-5","volume":"23","author":"L Minguez","year":"2016","unstructured":"Minguez L, Pedelucq J, Farcy E, Ballandonne C, Budzinski H, Halm-Lemeille M-P (2016) Toxicities of 48 pharmaceuticals and their freshwater and marine environmental assessment in northwestern France. Environ Sci Pollut Res 23(6):4992\u20135001. https:\/\/doi.org\/10.1007\/s11356-014-3662-5.","journal-title":"Environ Sci Pollut Res"},{"key":"2885_CR54","doi-asserted-by":"publisher","unstructured":"Montiel-Mora, JR, M\u00e9ndez-Rivera, M, Ram\u00edrez-Morales, D, Cambronero-Heinrichs, JC, & Rodr\u00edguez-Rodr\u00edguez, CE (2024). Toxicity of selected pharmaceuticals and their mixtures to the aquatic indicators Daphnia magna and Aliivibrio fischeri. Ecotoxicology. https:\/\/doi.org\/10.1007\/s10646-024-02798-0","DOI":"10.1007\/s10646-024-02798-0"},{"issue":"1","key":"2885_CR55","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s10646-007-0173-x","volume":"17","author":"M Munkegaard","year":"2008","unstructured":"Munkegaard M, Abbaspoor M, Cedergreen N (2008) Organophosphorous insecticides as herbicide synergists on the green algae Pseudokirchneriella subcapitata and the aquatic plant Lemna minor. Ecotoxicology 17(1):29\u201335. https:\/\/doi.org\/10.1007\/s10646-007-0173-x.","journal-title":"Ecotoxicology"},{"key":"2885_CR56","doi-asserted-by":"publisher","unstructured":"OECD (2006). Test No. 221: Lemna sp. Growth Inhibition Test. OECD Guidelines for the Testing of Chemicals, Section 2. OECD Publishing. Paris. https:\/\/doi.org\/10.1787\/9789264016194-en","DOI":"10.1787\/9789264016194-en"},{"key":"2885_CR57","unstructured":"OECD. (2011). Test No. 201: Freshwater Alga and Cyanobacteria, Growth Inhibition Test. Organisation for Economic Co-operation and Development. https:\/\/www.oecd-ilibrary.org\/environment\/test-no-201-alga-growth-inhibition-test_9789264069923-en"},{"key":"2885_CR58","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.scitotenv.2013.02.064","volume":"454","author":"F Orias","year":"2013","unstructured":"Orias F, Perrodin Y (2013) Characterisation of the ecotoxicity of hospital effluents: a review. Sci Total Environ 454:250\u2013276. https:\/\/doi.org\/10.1016\/j.scitotenv.2013.02.064.","journal-title":"Sci Total Environ"},{"issue":"2","key":"2885_CR59","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.3390\/su15021613","volume":"15","author":"B Paw\u0142owska","year":"2023","unstructured":"Paw\u0142owska B, Telesi\u0144ski A, Sysa M, Godela A, \u0160\u010durek R, Biczak R (2023) Ibuprofen and Ketoprofen\u2014Inert Drugs or Potential Environmental Hazard?. Sustainability 15(2):1613. https:\/\/doi.org\/10.3390\/su15021613.","journal-title":"Sustainability"},{"issue":"3","key":"2885_CR60","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.chemosphere.2008.06.029","volume":"73","author":"ARR P\u00e9ry","year":"2008","unstructured":"P\u00e9ry ARR, Gust M, Vollat B, Mons R, Ramil M, Fink G, Ternes T, Garric J (2008) Fluoxetine effects assessment on the life cycle of aquatic invertebrates. Chemosphere 73(3):300\u2013304. https:\/\/doi.org\/10.1016\/j.chemosphere.2008.06.029.","journal-title":"Chemosphere"},{"issue":"10","key":"2885_CR61","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1016\/j.chemosphere.2011.07.061","volume":"85","author":"YL Phyu","year":"2011","unstructured":"Phyu YL, Palmer CG, Warne MS, Hose GC, Chapman JC, Lim RP (2011) A comparison of mixture toxicity assessment: examining the chronic toxicity of atrazine, permethrin and chlorothalonil in mixtures to Ceriodaphnia cf. dubia. Chemosphere 85(10):1568\u20131573. https:\/\/doi.org\/10.1016\/j.chemosphere.2011.07.061.","journal-title":"Chemosphere"},{"issue":"4","key":"2885_CR62","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.aquatox.2004.02.001","volume":"67","author":"F Pomati","year":"2004","unstructured":"Pomati F, Netting AG, Calamari D, Neilan BA (2004) Effects of erythromycin, tetracycline and ibuprofen on the growth of Synechocystis sp. And Lemna minor. Aquat Toxicol 67(4):387\u2013396. https:\/\/doi.org\/10.1016\/j.aquatox.2004.02.001.","journal-title":"Aquat Toxicol"},{"issue":"3","key":"2885_CR63","doi-asserted-by":"publisher","first-page":"343","DOI":"10.2754\/avb201382030343","volume":"82","author":"E Pr\u00e1\u0161kov\u00e1","year":"2013","unstructured":"Pr\u00e1\u0161kov\u00e1 E, \u0160t\u011bp\u00e1nov\u00e1 S, Chromcov\u00e1 L, Plhalov\u00e1 L, Vosl\u00e1\u0159ov\u00e1 E, Pi\u0161t\u011bkov\u00e1 V, Proke\u0161 M, Svobodov\u00e1 Z (2013) The effects of subchronic exposure to ketoprofen on early developmental stages of common carp. Acta Veterinaria Brno 82(3):343\u2013347. https:\/\/doi.org\/10.2754\/avb201382030343.","journal-title":"Acta Veterinaria Brno"},{"issue":"5","key":"2885_CR64","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1007\/s10646-022-02537-3","volume":"31","author":"D Ram\u00edrez-Morales","year":"2022","unstructured":"Ram\u00edrez-Morales D, Fajardo-Romero D, Rodr\u00edguez-Rodr\u00edguez CE, Cedergreen N (2022) Single and mixture toxicity of selected pharmaceuticals to the aquatic macrophyte Lemna minor. Ecotoxicology 31(5):714\u2013724. https:\/\/doi.org\/10.1007\/s10646-022-02537-3.","journal-title":"Ecotoxicology"},{"key":"2885_CR65","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2023.140443","volume":"346","author":"D Ram\u00edrez-Morales","year":"2024","unstructured":"Ram\u00edrez-Morales D, Mas\u00eds-Mora M, Montiel-Mora JR, M\u00e9ndez-Rivera M, Guti\u00e9rrez-Quir\u00f3s JA, Brenes-Alfaro L, Rodr\u00edguez-Rodr\u00edguez CE (2024) Pharmaceuticals, hazard and ecotoxicity in surface and wastewater in a tropical dairy production area in Latin America. Chemosphere 346: 140443. https:\/\/doi.org\/10.1016\/j.chemosphere.2023.140443.","journal-title":"Chemosphere"},{"key":"2885_CR66","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2024.106924","volume":"271","author":"D Ram\u00edrez-Morales","year":"2024","unstructured":"Ram\u00edrez-Morales D, Rojas-Jim\u00e9nez K, Castro-Guti\u00e9rrez V, Rodr\u00edguez-Saravia S, Vaglio-Garro A, Araya-Valverde E, Rodr\u00edguez-Rodr\u00edguez CE (2024) Ecotoxicological effects of ketoprofen and fluoxetine and their mixture in an aquatic microcosm. Aquat Toxicol 271: 106924. https:\/\/doi.org\/10.1016\/j.aquatox.2024.106924.","journal-title":"Aquat Toxicol"},{"key":"2885_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2021.129574","volume":"272","author":"D Ram\u00edrez-Morales","year":"2021","unstructured":"Ram\u00edrez-Morales D, Mas\u00eds-Mora M, Beita-Sand\u00ed W, Montiel-Mora JR, Fern\u00e1ndez-Fern\u00e1ndez E, M\u00e9ndez-Rivera M, Arias-Mora V, Leiva-Salas A, Brenes-Alfaro L, Rodr\u00edguez-Rodr\u00edguez CE (2021) Pharmaceuticals in farms and surrounding surface water bodies: hazard and ecotoxicity in a swine production area in Costa Rica. Chemosphere 272: 129574. https:\/\/doi.org\/10.1016\/j.chemosphere.2021.129574.","journal-title":"Chemosphere"},{"key":"2885_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.141200","volume":"746","author":"D Ram\u00edrez-Morales","year":"2020","unstructured":"Ram\u00edrez-Morales D, Mas\u00eds-Mora M, Montiel-Mora JR, Cambronero-Heinrichs JC, Brice\u00f1o-Guevara S, Rojas-S\u00e1nchez CE, M\u00e9ndez-Rivera M, Arias-Mora V, Tormo-Budowski R, Brenes-Alfaro L, Rodr\u00edguez-Rodr\u00edguez CE (2020) Occurrence of pharmaceuticals, hazard assessment and ecotoxicological evaluation of wastewater treatment plants in Costa Rica. Sci Total Environ 746: 141200. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.141200.","journal-title":"Sci Total Environ"},{"issue":"12","key":"2885_CR69","doi-asserted-by":"publisher","first-page":"e0146021","DOI":"10.1371\/journal.pone.0146021","volume":"10","author":"C Ritz","year":"2015","unstructured":"Ritz C, Baty F, Streibig JC, Gerhard D (2015) Dose-Response Analysis Using R. PLoS ONE 10(12):e0146021\u2013e0146021. https:\/\/doi.org\/10.1371\/journal.pone.0146021.","journal-title":"PLoS ONE"},{"issue":"7","key":"2885_CR70","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1016\/j.chemosphere.2013.07.059","volume":"93","author":"J Rivera-Utrilla","year":"2013","unstructured":"Rivera-Utrilla J, S\u00e1nchez-Polo M, Ferro-Garc\u00eda M\u00c1, Prados-Joya G, Ocampo-P\u00e9rez R (2013) Pharmaceuticals as emerging contaminants and their removal from water. A review. Chemosphere 93(7):1268\u20131287. https:\/\/doi.org\/10.1016\/j.chemosphere.2013.07.059.","journal-title":"Chemosphere"},{"key":"2885_CR71","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2023.139746","volume":"339","author":"CE Rodr\u00edguez-Rodr\u00edguez","year":"2023","unstructured":"Rodr\u00edguez-Rodr\u00edguez CE, Ram\u00edrez-Morales D, Masis-Mora M, Montiel-Mora JR, Soto-Garita C, Araya-Valverde E, Cambronero-Heinrichs JC, S\u00e0nchez-Melsi\u00f3 A, Brice\u00f1o-Guevara S, Mendez-Rivera M, Balc\u00e1zar JL (2023) Occurrence and risk assessment of pharmaceuticals in hospital wastewater in Costa Rica. Chemosphere 339: 139746. https:\/\/doi.org\/10.1016\/j.chemosphere.2023.139746.","journal-title":"Chemosphere"},{"issue":"3","key":"2885_CR72","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/s0378-4274(03)00257-1","volume":"144","author":"H Sanderson","year":"2003","unstructured":"Sanderson H, Johnson DJ, Wilson CJ, Brain RA, Solomon KR (2003) Probabilistic hazard assessment of environmentally occurring pharmaceuticals toxicity to fish, daphnids and algae by ECOSAR screening. Toxicol Lett 144(3):383\u2013395. https:\/\/doi.org\/10.1016\/s0378-4274(03)00257-1.","journal-title":"Toxicol Lett"},{"issue":"1-3","key":"2885_CR73","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jhazmat.2009.10.100","volume":"175","author":"LHMLM Santos","year":"2010","unstructured":"Santos LHMLM, Ara\u00fajo AN, Fachini A, Pena A, Delerue-Matos C, Montenegro MCBSM (2010) Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment. J Hazard Mater 175(1-3):45\u201395. https:\/\/doi.org\/10.1016\/j.jhazmat.2009.10.100.","journal-title":"J Hazard Mater"},{"issue":"4","key":"2885_CR74","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s10651-007-0022-3","volume":"14","author":"H S\u00f8rensen","year":"2007","unstructured":"S\u00f8rensen H, Cedergreen N, Skovgaard IM, Streibig JC (2007) An isobole-based statistical model and test for synergism\/antagonism in binary mixture toxicity experiments. Environ Ecol Stat 14(4):383\u2013397. https:\/\/doi.org\/10.1007\/s10651-007-0022-3.","journal-title":"Environ Ecol Stat"},{"issue":"20","key":"2885_CR75","doi-asserted-by":"publisher","first-page":"6709","DOI":"10.1016\/j.watres.2011.10.004","volume":"45","author":"AL Spongberg","year":"2011","unstructured":"Spongberg AL, Witter JD, Acu\u00f1a J, Vargas J, Murillo M, Uma\u00f1a G, G\u00f3mez E, Perez G (2011) Reconnaissance of selected PPCP compounds in Costa Rican surface waters. Water Res 45(20):6709\u20136717. https:\/\/doi.org\/10.1016\/j.watres.2011.10.004.","journal-title":"Water Res"},{"issue":"1","key":"2885_CR76","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3390\/antibiotics2010115","volume":"2","author":"JO Straub","year":"2013","unstructured":"Straub JO (2013) An environmental risk assessment for human-use trimethoprim in European surface waters. Antibiotics 2(1):115\u2013162. https:\/\/doi.org\/10.3390\/antibiotics2010115.","journal-title":"Antibiotics"},{"key":"2885_CR77","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.128210","volume":"410","author":"R Tormo-Budowski","year":"2021","unstructured":"Tormo-Budowski R, Cambronero-Heinrichs JC, Dur\u00e1n JE, Mas\u00eds-Mora M, Ram\u00edrez-Morales D, Quir\u00f3s-Fournier JP, Rodr\u00edguez-Rodr\u00edguez CE (2021) Removal of pharmaceuticals and ecotoxicological changes in wastewater using Trametes versicolor: a comparison of fungal stirred tank and trickle-bed bioreactors. Chem Eng J 410: 128210. https:\/\/doi.org\/10.1016\/j.cej.2020.128210.","journal-title":"Chem Eng J"},{"key":"2885_CR78","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1200108","volume":"14","author":"E Tyumina","year":"2023","unstructured":"Tyumina E, Subbotina M, Polygalov M, Tyan S, Ivshina I (2023) Ketoprofen as an emerging contaminant: Occurrence, ecotoxicity and (bio)removal. Front Microbiol 14: 1200108. https:\/\/doi.org\/10.3389\/fmicb.2023.1200108.","journal-title":"Front Microbiol"},{"key":"2885_CR79","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jhazmat.2014.06.069","volume":"279","author":"MI Vasquez","year":"2014","unstructured":"Vasquez MI, Lambrianides A, Schneider M, K\u00fcmmerer K, Fatta-Kassinos D (2014) Environmental side effects of pharmaceutical cocktails: what we know and what we should know J Hazard Mater 279:169\u2013189. https:\/\/doi.org\/10.1016\/j.jhazmat.2014.06.069","journal-title":"J Hazard Mater"},{"key":"2885_CR80","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.ecoenv.2015.11.009","volume":"124","author":"J Villain","year":"2016","unstructured":"Villain J, Minguez L, Halm-Lemeille M-P, Durrieu G, Bureau R (2016) Acute toxicities of pharmaceuticals toward green algae. Mode of action, biopharmaceutical drug disposition classification system and quantile regression models. Ecotoxicol Environ Saf 124:337\u2013343. https:\/\/doi.org\/10.1016\/j.ecoenv.2015.11.009.","journal-title":"Ecotoxicol Environ Saf"},{"key":"2885_CR81","doi-asserted-by":"publisher","first-page":"114533","DOI":"10.1016\/j.envpol.2020.114533","volume":"263","author":"H Wang","year":"2020","unstructured":"Wang H, Jin M, Xu L, Xi H, Wang B, Du S, Liu H, Wen Y (2020) Effects of ketoprofen on rice seedlings: Insights from photosynthesis, antioxidative stress, gene expression patterns, and integrated biomarker response analysis. Environ Pollut 263:114533. https:\/\/doi.org\/10.1016\/j.envpol.2020.114533.","journal-title":"Environ Pollut"},{"issue":"8","key":"2885_CR82","doi-asserted-by":"publisher","first-page":"21825","DOI":"10.1007\/s11356-022-23716-z","volume":"30","author":"H Wang","year":"2023","unstructured":"Wang H, Li Z, Chen H, Jin J, Zhang P, Shen L, Hu S, Liu H (2023) Metabolomic analysis reveals the impact of ketoprofen on carbon and nitrogen metabolism in rice (Oryza sativa L.) seedling leaves. Environ Sci Pollut Res 30(8):21825\u201321837. https:\/\/doi.org\/10.1007\/s11356-022-23716-z.","journal-title":"Environ Sci Pollut Res"}],"container-title":["Ecotoxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10646-025-02885-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10646-025-02885-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10646-025-02885-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T12:22:35Z","timestamp":1757161355000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10646-025-02885-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,27]]},"references-count":82,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["2885"],"URL":"https:\/\/doi.org\/10.1007\/s10646-025-02885-w","relation":{},"ISSN":["0963-9292","1573-3017"],"issn-type":[{"value":"0963-9292","type":"print"},{"value":"1573-3017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,27]]},"assertion":[{"value":"6 April 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}