{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:09:09Z","timestamp":1764688149720,"version":"3.44.0"},"reference-count":164,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ecotoxicology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s10646-025-02924-6","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T12:01:20Z","timestamp":1751544080000},"page":"1419-1446","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Integrated assessment of water quality: influence of physicochemical parameters and ecotoxicological impacts under different flow conditions of lonqueador river, Southern Brazil"],"prefix":"10.1007","volume":"34","author":[{"given":"Clisley Marielly Ribeiro","family":"Lameira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Karolina Gomes","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Carolina","family":"Antes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassiano Aparecido de","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia Aline","family":"Bressiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariah Pereira Rosa da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina Pires","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula de","family":"Oliveira Schmitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Pokrywiecki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ticiane Sauer","family":"Pokrywiecki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando C\u00e9sar","family":"Manosso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Michel Vieira","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Lingnau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisele","family":"Arruda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franciele An\u00ed Caovilla","family":"Follador","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor Vivian de","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elis\u00e2ngela","family":"D\u00fcsman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"2924_CR1","unstructured":"Ag\u00eancia Nacional De Vigil\u00e2ncia Sanit\u00e1ria (2024) M01 \u2013 malathion. Governo do Brasil. Dispon\u00edvel em. https:\/\/www.gov.br\/anvisa\/pt-br\/setorregulado\/regularizacao\/agrotoxicos\/monografias\/monografias-autorizadas\/m-n-o\/4418json-file-1\/view. Acesso em: 02 fev. 2025."},{"key":"2924_CR2","unstructured":"Ag\u00eancia Nacional De Vigil\u00e2ncia Sanit\u00e1ria (2022) Nota: carcinogenicidade de cinco agrot\u00f3xicos. Governo do Brasil. Atualizado em: 7 nov. 2022. Dispon\u00edvel em: https:\/\/www.gov.br\/anvisa\/pt-br\/assuntos\/noticias-anvisa\/2016\/notacarcinogenicidade-de-cinco-agrotoxicos. Acesso em: 02 fev. 2025."},{"issue":"n. 2","key":"2924_CR3","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ijsrc.2021.09.002","volume":"37","author":"MM Ali","year":"2022","unstructured":"Ali MM, Rahman S, Islam MS, Rakib MRJ, Hossen S, Rahman MZ, Kormoker T, Idris AM, Phoungthong K (2022) Distribution of heavy metals in water and sediment of an urban river in a developing country: A probabilistic risk assessment. Int J Sediment Res 37(n. 2):173\u2013187. https:\/\/doi.org\/10.1016\/j.ijsrc.2021.09.002.","journal-title":"Int J Sediment Res"},{"key":"2924_CR4","doi-asserted-by":"publisher","unstructured":"Annisa A, Mulyawan H, Sunardi S (2024) Evaluation of cytotoxicity and genotoxicity of the upstream Citarum River using Allium cepa assay. In: E3S web of Conferences. EDP Sciences, vol. 495, p 02001. https:\/\/doi.org\/10.1051\/e3sconf\/202449502001.","DOI":"10.1051\/e3sconf\/202449502001"},{"key":"2924_CR5","unstructured":"APHA (American Public Health Association) And WEF (Water Environment Federation)., 1998. Standard methods for the examination of water and wastewater. American Public Health Association, Washington, 20 ed."},{"key":"2924_CR6","unstructured":"APHA (American Public Health Association), AWWA (American Water Works Association) And WEF (Water Environment Federation)., 2012. Standard methods for the examination of water and wastewater, 22nd ed.. American Public Health Association, Washington."},{"key":"2924_CR7","unstructured":"ASSOCIA\u00c7\u00c3O BRASILEIRA DE NORMAS T\u00c9CNICAS. NBR 13373:2010. Ecotoxicologia aqu\u00e1tica \u2013 Toxicidade cr\u00f4nica \u2013 M\u00e9todo de ensaio com Ceriodaphnia spp. (Crustacea, Cladocera). Rio de Janeiro: ABNT, 2010. 26 p."},{"key":"2924_CR8","unstructured":"Associa\u00e7\u00e3o Brasileira De Normas T\u00e9cnicas (2011) NBR 17512-1:2011. Qualidade do solo \u2013 Ensaio de fuga para avaliar a qualidade de solos e efeitos d subst\u00e2ncias qu\u00edmicas no comportamento \u2013 Parte 1: Ensaio com minhocas (Eisenia fetida e Eisenia andrei). Rio de Janeiro."},{"key":"2924_CR9","doi-asserted-by":"publisher","first-page":"18","DOI":"10.5902\/2179460X35495","volume":"40","author":"AR Azevedo","year":"2018","unstructured":"Azevedo AR, Coronas MV (2018) Use of avoidance tests with earthworms eisenia andrei e eisenia fetida for identification of pesticides toxicity in Brazil: a brief review of the literature. Ci\u00ean Nat 40:18\u201326. https:\/\/doi.org\/10.5902\/2179460X35495 Edi\u00e7\u00e3o Especial: II Mostra de Projetos da UFSM - Campus Cachoeira do Sul.","journal-title":"Ci\u00ean Nat"},{"key":"2924_CR10","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1007\/s11157-024-09698-z","volume":"23","author":"T Azevedo","year":"2024","unstructured":"Azevedo T, Gon\u00e7alves M, Silva-Reis R, Medeiros-Fonseca B, Roboredo M, Sousa JR, Oliveira PA, Pinto ML, Peixoto F, Gaiv\u00e3o I, Matos M, Coimbra AM (2024) Do endocrine disrupting compounds impact earthworms? A comprehensive evidence review. Rev Env Sci Biotechnol 23:633\u2013677. https:\/\/doi.org\/10.1007\/s11157-024-09698-z.","journal-title":"Rev Env Sci Biotechnol"},{"issue":"n. 3","key":"2924_CR11","first-page":"53","volume":"11","author":"DNR Barbosa","year":"2017","unstructured":"Barbosa DNR, Vargas RR (2017) Estudo comparativo da DBO e DQO em amostras de \u00e1guas superficiais na microbacia cubas, Guarulhos-SP. Rev Educ-UNG-Ser 11(n. 3):53.","journal-title":"Rev Educ-UNG-Ser"},{"key":"2924_CR12","doi-asserted-by":"publisher","first-page":"224","DOI":"10.5897\/AJEST11.298","volume":"5","author":"G Battala","year":"2012","unstructured":"Battala G, Yadamari T et al. (2012) Study on degradation of malathion and phorate in various environmental matrices. Afr J Env Sci Technol 5:224\u2013228. https:\/\/doi.org\/10.5897\/AJEST11.298.","journal-title":"Afr J Env Sci Technol"},{"key":"2924_CR13","unstructured":"BRASIL. Minist\u00e9rio da Sa\u00fade. Secretaria de Vigil\u00e2ncia em Sa\u00fade. Departamento de Sa\u00fade Ambiental, do Trabalhador e Vigil\u00e2ncia das Emerg\u00eancias em Sa\u00fade P\u00fablica. Manual sobre medidas de prote\u00e7\u00e3o \u00e0 sa\u00fade dos agentes de combate \u00e0s endemias: volume 1 \u2013 arboviroses transmitidas pelo Aedes aegypti [recurso eletr\u00f4nico]. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade, 2019. 1 v.: l. Dispon\u00edvel em: http:\/\/bvsms.saude.gov.br\/bvs\/publicacoes\/manual_protecao_agentes_endemias.pdf. Acesso em: 24 jan. 2025."},{"key":"2924_CR14","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/s1383-5742(02)00009-1","volume":"511","author":"C Bernstein","year":"2002","unstructured":"Bernstein C, Gutteridge JM (2002) DNA repair\/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis. Mutat Res 511:145\u2013178. https:\/\/doi.org\/10.1016\/s1383-5742(02)00009-1.","journal-title":"Mutat Res"},{"key":"2924_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s42452-020-03620-2","volume":"2","author":"AS Bertan","year":"2020","unstructured":"Bertan AS, Teles AGDX, De Oliveira BCT, Ferreira LMR, Thiel NA, Fieira C, D\u00fcsman E (2020) Influence of the seasons on the water quality of the Marmeleiro River (Paran\u00e1, Brazil) using different bioindicators. SN Appl Sci 2:1\u201315. https:\/\/doi.org\/10.1007\/s42452-020-03620-2.","journal-title":"SN Appl Sci"},{"issue":"n. 4","key":"2924_CR16","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1590\/1983-084X\/14_027","volume":"17","author":"AP Berti","year":"2015","unstructured":"Berti AP, Pacheco LS, Rocha CLMSC (2015) Efeito da Aloe arborescens Miller e da Aloe barbadensis Miller sobre o desenvolvimento vegetativo em Aspergillus nidulans. Rev Bras Plant Med 17(n. 4):804\u2013810. https:\/\/doi.org\/10.1590\/1983-084X\/14_027.","journal-title":"Rev Bras Plant Med"},{"key":"2924_CR17","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.ecohyd.2019.05.002","volume":"72","author":"E Bianchi","year":"2017","unstructured":"Bianchi E, Lessing G, Brina KR, Angeli L, Andriguetti NB, Peruzzo JRS, do Nascimento CA, Spilki FR, Ziulkoski AL, Silva LB (2017) Monitoring the genotoxic and cytotoxic potential and the presence of pesticides and hydrocarbons in water of the Sinos River Basin, Southern Brazil. Arch Env Contam Toxicol 72:321\u2013334. https:\/\/doi.org\/10.1016\/j.ecohyd.2019.05.002.","journal-title":"Arch Env Contam Toxicol"},{"issue":"n. 3","key":"2924_CR18","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1590\/S0100-40422007000300027","volume":"30","author":"DM Bila","year":"2007","unstructured":"Bila DM, Dezotti M (2007) Desreguladores end\u00f3crinos no meio ambiente: Efeitos e consequ\u00eancias. Quim Nova 30(n. 3):651\u2013666. https:\/\/doi.org\/10.1590\/S0100-40422007000300027 S\u00e3o Paulo.","journal-title":"Quim Nova"},{"issue":"n. 11","key":"2924_CR19","doi-asserted-by":"publisher","first-page":"e393111133841","DOI":"10.33448\/rsd-v11i11.33841","volume":"11","author":"JK Bohrer","year":"2022","unstructured":"Bohrer JK, Dos Santos AP, Perszel A, Gomes EMV, Berti AP, D\u00fcsman E (2022) Cytotoxicity and mutagenicity of female contraceptives in Allium cepa L. Citotoxicidade e mutagenicidade de contraceptivos femininos em Allium cepa L. Citotoxicidad y mutagenicidad de anticonceptivos femeninos en Allium cepa L. Res Soc Dev 11(n. 11):e393111133841. https:\/\/doi.org\/10.33448\/rsd-v11i11.33841.","journal-title":"Res Soc Dev"},{"key":"2924_CR168","unstructured":"BOHRER, JK (2021) Quantifica\u00e7\u00e3o de horm\u00f4nios estr\u00f3genos em esgoto sanit\u00e1rio por HPLC-UV e avalia\u00e7\u00e3o da degrada\u00e7\u00e3o por processos oxidativos avan\u00e7ados. Disserta\u00e7\u00e3o em Engenharia Ambiental) \u2013 Universidade Tecnol\u00f3gica Federal do Paran\u00e1, Francisco Beltr\u00e3o. [In Portuguese]."},{"issue":"n. 3","key":"2924_CR20","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1080\/00087114.2018.1503496","volume":"71","author":"E Bonciu","year":"2018","unstructured":"Bonciu E (2018) An evaluation for the standardization of the Allium cepa test as cytotoxicity and genotoxicity assay. Caryologia 71(n. 3):191\u2013209. https:\/\/doi.org\/10.1080\/00087114.2018.1503496.","journal-title":"Caryologia"},{"key":"2924_CR22","volume-title":"Coordena\u00e7\u00e3o-geral de vigil\u00e2ncia em sa\u00fade ambiental","author":"Brasil","year":"2005","unstructured":"Brasil (2005) Minist\u00e9rio da sa\u00fade. Secretaria de vigil\u00e2ncia em sa\u00fade. Coordena\u00e7\u00e3o-geral de vigil\u00e2ncia em sa\u00fade ambiental. Editora do Minist\u00e9rio da Sa\u00fade, Bras\u00edlia, Portaria MS n. 518\/2004."},{"key":"2924_CR23","volume-title":"Minist\u00e9rio do meio ambiente","author":"Brasil.","year":"2005","unstructured":"Brasil., 2005. Minist\u00e9rio do meio ambiente. Di\u00e1rio Oficial da Uni\u00e3o, Bras\u00edlia, DF, Resolu\u00e7\u00e3o CONAMA n 357, de 17 de mar\u00e7o de 2005."},{"key":"2924_CR24","doi-asserted-by":"publisher","unstructured":"Brodeur JC, Candioti JV (2017) Impacts of agriculture and pesticides on amphibian terrestrial life stages: potential biomonitor\/bioindicator species for the pampa region of Argentina. In: Ecotoxicology and genotoxicology. p. 163\u2013194. https:\/\/doi.org\/10.1039\/9781788010573-00163.","DOI":"10.1039\/9781788010573-00163"},{"issue":"n. 2","key":"2924_CR25","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.13140\/RG.2.1.4369.0726","volume":"19","author":"RP Calegari","year":"2015","unstructured":"Calegari RP, Boffe PM, Piloto CA, Tessaro D (2015) Caracteriza\u00e7\u00e3o da \u00e1gua da microbacia do Rio Lonqueador avaliada por par\u00e2metros f\u00edsicos, qu\u00edmicos e microbiol\u00f3gicos. Rev Eletr Gest Educ Tecnol Amb 19(n. 2):1284\u20131291. https:\/\/doi.org\/10.13140\/RG.2.1.4369.0726.","journal-title":"Rev Eletr Gest Educ Tecnol Amb"},{"key":"2924_CR26","doi-asserted-by":"publisher","first-page":"87828","DOI":"10.1007\/s11356-022-21865-9","volume":"29","author":"CF Camilo-Cotrim","year":"2022","unstructured":"Camilo-Cotrim CF, De Souza Ondei L, De Almeida EA, Ferreira MFN, Rocha O (2022) As respostas dos biomarcadores dos peixes refletem a perturba\u00e7\u00e3o antr\u00f3pica da paisagem nos riachos da savana. Env Sci Pollut Res Int 29:87828\u201387843. https:\/\/doi.org\/10.1007\/s11356-022-21865-9.","journal-title":"Env Sci Pollut Res Int"},{"issue":"n. 4","key":"2924_CR27","doi-asserted-by":"publisher","first-page":"18127","DOI":"10.34117\/bjdv6n4-108","volume":"6","author":"ACL Carvalho","year":"2020","unstructured":"Carvalho ACL, de Rocha GM (2020) An\u00e1lise dos riscos e da vulnerabilidade socioambiental urbana, face ao desenvolvimento desordenado e \u00e0 press\u00e3o sobre os recursos h\u00eddricos em Bel\u00e9m\u2013PA. Braz J Dev 6(n. 4):18127\u201318142. https:\/\/doi.org\/10.34117\/bjdv6n4-108.","journal-title":"Braz J Dev"},{"key":"2924_CR28","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.envpol.2016.12.012","volume":"221","author":"CS Carvalho","year":"2017","unstructured":"Carvalho CS, Utsunomiya HSM, Pasquoto T, Lima R, Costa MJ, Fernandes MN (2017) Blood cell responses and metallothionein in the liver, kidney and muscles of bullfrog tadpoles, Lithobates catesbeianus, following exposure to different metals. Env Pollut 221:445\u2013452. https:\/\/doi.org\/10.1016\/j.envpol.2016.12.012.","journal-title":"Env Pollut"},{"key":"2924_CR29","doi-asserted-by":"publisher","first-page":"114344","DOI":"10.1016\/j.envpol.2020.114344","volume":"262","author":"M \u010celi\u0107","year":"2020","unstructured":"\u010celi\u0107 M, \u0160krbi\u0107 BD, Insa S, \u017divan\u010dev J, Gros M, Petrovi\u0107 M (2020) Occurrence and assessment of environmental risks of endocrine disrupting compounds in drinking, surface and wastewaters in Serbia. Env Pollut 262:114344. https:\/\/doi.org\/10.1016\/j.envpol.2020.114344.","journal-title":"Env Pollut"},{"key":"2924_CR30","first-page":"59","volume-title":"WHO; UNESCO; UNEP (Org) Water quality assessments: A guide to use of biota, sediments and water in environmental monitoring","author":"D Champman","year":"1996","unstructured":"Champman D, Kimstach V (1996) Selection of water quality variables. WHO; UNESCO; UNEP (Org) Water quality assessments: A guide to use of biota, sediments and water in environmental monitoring. Chapman Edition, E& FN Spon, London, 59\u2013126."},{"key":"2924_CR31","volume-title":"Toxicidade aguda e risco ambiental do malathion \u2013 emuls\u00e3o aquosa, 44% \u2013 utilizado no combate ao mosquito Aedes aegypti para organismos aqu\u00e1ticos","author":"AC Coleone","year":"2017","unstructured":"Coleone, AC, Paganini, WDS, 2017. Toxicidade aguda e risco ambiental do malathion \u2013 emuls\u00e3o aquosa, 44% \u2013 utilizado no combate ao mosquito Aedes aegypti para organismos aqu\u00e1ticos. Anais da ABES, S\u00e3o Paulo."},{"key":"2924_CR33","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s00338-009-0512-x","volume":"28","author":"TF Cooper","year":"2009","unstructured":"Cooper TF, Gilmour JP, Fabricius KE (2009) Bioindicators of changes in water quality on coral reefs: review and recommendations for monitoring programmes. Coral Reefs 28:589\u2013606. https:\/\/doi.org\/10.1007\/s00338-009-0512-x.","journal-title":"Coral Reefs"},{"key":"2924_CR34","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s10646-007-0178-5","volume":"17","author":"MJ Costa","year":"2008","unstructured":"Costa MJ, Monteiro DA, Oliveira-Neto AL, Rantin FT, Kalinin AL (2008) Oxidative stress biomarkers and heart function in bullfrog tadpoles exposed to roundup original\u00ae. Ecotoxicology 17:153\u2013163. https:\/\/doi.org\/10.1007\/s10646-007-0178-5.","journal-title":"Ecotoxicology"},{"key":"2924_CR35","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1590\/1519-6984.08314","volume":"75","author":"MJ Costa","year":"2015","unstructured":"Costa MJ, Ribeiro LR, Salla RF, Gamero FU, Alves LMLM, Silva-Zacarin ECM (2015) Effects of the organophosphorus pesticide folisuper 600 (methyl parathion) on the heart function of bullfrog tadpoles, Lithobates catesbeianus (Shaw, 1802). Braz J Biol 75:163\u2013168. https:\/\/doi.org\/10.1590\/1519-6984.08314.","journal-title":"Braz J Biol"},{"issue":"n. 72","key":"2924_CR36","doi-asserted-by":"publisher","first-page":"102","DOI":"10.5007\/1982-5153.2019v34n72p102","volume":"34","author":"AM Cunha","year":"2019","unstructured":"Cunha AM, Cas\u00e9 M, Lopes DV (2019) Qualidade da \u00e1gua como reflexo de atividades antr\u00f3picas em bacias hidrogr\u00e1ficas do Nordeste, Brasil. Geosul 34(n. 72):102\u2013123. https:\/\/doi.org\/10.5007\/1982-5153.2019v34n72p102.","journal-title":"Geosul"},{"issue":"n. 1","key":"2924_CR37","first-page":"77","volume":"32","author":"FA D\u2019oliveira","year":"2007","unstructured":"D\u2019oliveira FA, Frank AA, Soares EA (2007) The influence of minerals on Parkinson\u2019s disease. Nutrire: Rev da Soc Brasileira de Alimentos e Nutri\u00e7\u00e3o 32(n. 1):77\u201388.","journal-title":"Nutrire: Rev da Soc Brasileira de Alimentos e Nutri\u00e7\u00e3o"},{"key":"2924_CR38","doi-asserted-by":"publisher","first-page":"122846","DOI":"10.1016\/j.envpol.2023.122846","volume":"340","author":"RL da Costa","year":"2024","unstructured":"da Costa RL, Souza IC, Morozesk M, de Carvalho LB, Carvalho CDS, Monferr\u00e1n MV, Wunderlin DA, Fernandes MN, Monteiro DA (2024) Toxic, genotoxic, mutagenic, and bioaccumulative effects of metal mixture from settleable particulate matter on American bullfrog tadpoles (Lithobates catesbeianus). Env Pollut 340:122846. https:\/\/doi.org\/10.1016\/j.envpol.2023.122846.","journal-title":"Env Pollut"},{"key":"2924_CR39","doi-asserted-by":"publisher","unstructured":"da Silva MB, Fraga RE, Nishiyama PB, Costa NLB, Da Silva ISS, Brand\u00e3o DA et al. (2021) In situ assessment of genotoxicity in tadpoles (Amphibia: Anura) in impacted and protected areas of Chapada Diamantina, Brazil. Sci Plena 17(n. 2). https:\/\/doi.org\/10.14808\/sci.plena.2021.021701.","DOI":"10.14808\/sci.plena.2021.021701"},{"issue":"n. 3","key":"2924_CR40","doi-asserted-by":"publisher","first-page":"54","DOI":"10.19177\/rgsa.v9e3202054-72","volume":"9","author":"YR De Mello","year":"2020","unstructured":"De Mello YR, De Freitas LL, DE Oliveira TMN (2020) An\u00e1lise comparativa de par\u00e2metros f\u00edsico-qu\u00edmicos e biol\u00f3gicos nos rios do bra\u00e7o e Mississipe, Nordeste de Santa Catarina. Rev Gest Sustentabilidade Ambient 9(n. 3):54\u201372. https:\/\/doi.org\/10.19177\/rgsa.v9e3202054-72.","journal-title":"Rev Gest Sustentabilidade Ambient"},{"key":"2924_CR41","doi-asserted-by":"publisher","first-page":"95","DOI":"10.21829\/azm.2010.262880","volume":"26","author":"MM de Andr\u00e9a","year":"2010","unstructured":"de Andr\u00e9a MM (2010) O uso de minhocas como bioindicadores de contamina\u00e7\u00e3o de solos. Acta Zool Mex 26:95\u2013107.","journal-title":"Acta Zool Mex"},{"issue":"n. 7","key":"2924_CR42","doi-asserted-by":"publisher","first-page":"863","DOI":"10.51891\/rease.v8i7.6235","volume":"8","author":"BFM de Pereira","year":"2022","unstructured":"de Pereira BFM, Alves BM et al. (2022) Contamina\u00e7\u00e3o no len\u00e7ol fre\u00e1tico, rios, lagos e lagoas do Brasil por agrot\u00f3xicos. Ibero-Am J Hum Sci Educ 8(n. 7):863\u2013874. https:\/\/doi.org\/10.51891\/rease.v8i7.6235.","journal-title":"Ibero-Am J Hum Sci Educ"},{"issue":"n. 6","key":"2924_CR43","first-page":"4575","volume":"17","author":"DAF Dias","year":"2024","unstructured":"Dias DAF, Gon\u00e7alves JAC (2024) \u00cdndice de qualidade da \u00e1gua - IQA no m\u00e9dio curso do rio Piracicaba (MG) para os anos de 2011 e 2020. Rev Bras Geogr F\u00eds 17(n. 6):4575\u20134595.","journal-title":"Rev Bras Geogr F\u00eds"},{"issue":"n. 1","key":"2924_CR44","first-page":"282","volume":"6","author":"EC Dias","year":"2019","unstructured":"Dias EC, Ferrari ALS, Schmidt RB, Silva F, Salvi JO, Salvi JS (2019) Qualidade f\u00edsico-qu\u00edmica, microbiol\u00f3gica e a toxicidade de corpos h\u00eddricos do parque tecnol\u00f3gico vandeci rack em Ji-Paran\u00e1, Rond\u00f4nia. SAJEBTT 6(n. 1):282\u2013296.","journal-title":"SAJEBTT"},{"key":"2924_CR45","doi-asserted-by":"publisher","unstructured":"do Couto MSB, Salla L, Biffi MT et al. (2024) Waters biomonitoring of the Marrecas River (Paran\u00e1, Brazil) at different trophic levels. Pr\u00e9-impress\u00e3o. https:\/\/doi.org\/10.21203\/rs.3.rs-3874191\/v1.","DOI":"10.21203\/rs.3.rs-3874191\/v1"},{"issue":"n. 20","key":"2924_CR46","doi-asserted-by":"publisher","first-page":"57850","DOI":"10.1007\/s11356-023-26539-8","volume":"30","author":"GC Dos Santos Gon\u00e7alves Nascimento","year":"2023","unstructured":"Dos Santos Gon\u00e7alves Nascimento GC, Dusman E, da Silva Gonzalez R, Nicola JV, de Souza Moura MA, de Oliveira KM, Oliveira AKG, Bressani PA, Santo DE, Filipi \u00c1CK, Gomes EMV, Pokrywiecki JC, de Souza DC, Peron AP (2023) Toxicity of methylparaben and its chlorinated derivatives to Allium cepa L. and Eisenia fetida Sav. Env Sci Pollut Res Int 30(n. 20):57850\u201357861. https:\/\/doi.org\/10.1007\/s11356-023-26539-8.","journal-title":"Env Sci Pollut Res Int"},{"key":"2924_CR47","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1007\/s10661-013-3493-8","volume":"186","author":"E D\u00fcsman","year":"2014","unstructured":"D\u00fcsman E, Luzza M, Savegnago L, Lauxen D, Vicentini VEP, Tonial IB, Sauer TP (2014) Allium cepa L. as a bioindicator to measure cytotoxicity of surface water of the Quatorze River, located in Francisco Beltr\u00e3o, Paran\u00e1, Brazil. Env Monit Assess 186:1793\u20131800. https:\/\/doi.org\/10.1007\/s10661-013-3493-8.","journal-title":"Env Monit Assess"},{"issue":"n. 2","key":"2924_CR48","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1897\/07-354R.1","volume":"27","author":"EB Dussault","year":"2008","unstructured":"Dussault EB, Balakrishnan VK, Sverko E, Solomon KR, Sibley PK (2008) Toxicity of human pharmaceuticals and personal care products to benthic invertebrates. Env Toxicol Chem 27(n. 2):425\u2013432. https:\/\/doi.org\/10.1897\/07-354R.1.","journal-title":"Env Toxicol Chem"},{"issue":"n. 1","key":"2924_CR49","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.chemosphere.2012.04.020","volume":"89","author":"YS El-Temsah","year":"2012","unstructured":"El-Temsah YS, Joner EJ (2012) Ecotoxicological effects on earthworms of fresh and aged nano-sized zero-valent iron (nZVI) in soil. Chemosphere 89(n. 1):76\u201382. https:\/\/doi.org\/10.1016\/j.chemosphere.2012.04.020.","journal-title":"Chemosphere"},{"issue":"n. 2","key":"2924_CR50","doi-asserted-by":"publisher","first-page":"95","DOI":"10.2754\/avb201483020095","volume":"83","author":"M Falis","year":"2014","unstructured":"Falis M, \u0160palkov\u00e1 M, Lega\u0165h J (2014) Effects of heavy metals and pesticides on survival of Artemia franciscana. Acta Vet Brno 83(n. 2):95\u201399. https:\/\/doi.org\/10.2754\/avb201483020095.","journal-title":"Acta Vet Brno"},{"key":"2924_CR51","doi-asserted-by":"publisher","first-page":"e63717","DOI":"10.2754\/avb201483020095","volume":"34","author":"A Farias","year":"2022","unstructured":"Farias A, Mendon\u00e7a F (2022) The urban environmental system perspective on socio-environmental risks of urban flooding. Soc Nat 34:e63717. https:\/\/doi.org\/10.2754\/avb201483020095.","journal-title":"Soc Nat"},{"key":"2924_CR52","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1590\/S0100-40422011000900009","volume":"34","author":"AN Fernandes","year":"2011","unstructured":"Fernandes AN, Giovanela M, Almeida CA, Esteve VI, Sierra M, Grassi MT (2011) Remo\u00e7\u00e3o dos horm\u00f4nios 17\u03b2-estradiol e 17\u03b1-etinilestradiol de solu\u00e7\u00f5es aquosas empregando turfa decomposta como material adsorvente. Quim Nova 34:1526\u20131533. https:\/\/doi.org\/10.1590\/S0100-40422011000900009.","journal-title":"Quim Nova"},{"key":"2924_CR53","doi-asserted-by":"publisher","first-page":"130000","DOI":"10.1590\/S0100-40422011000900009","volume":"275","author":"IF Fernandes","year":"2021","unstructured":"Fernandes IF, Utsunomiya HSM, De Lacerda Valverde BS, Ferraz JVC, Fujiwara GH, Gutierres DM, Dos Santos Carvalho C (2021) Ecotoxicological evaluation of water from the Sorocaba River using an integrated analysis of biochemical and morphological biomarkers in bullfrog tadpoles, Lithobates catesbeianus. Chemosphere 275:130000. https:\/\/doi.org\/10.1590\/S0100-40422011000900009.","journal-title":"Chemosphere"},{"key":"2924_CR54","doi-asserted-by":"publisher","first-page":"e0042018","DOI":"10.1590\/1808-1657000042018","volume":"86","author":"RCB Ferreira","year":"2019","unstructured":"Ferreira RCB, Papini S, Luchini LC, Vieira E (2019) Persistence of malathion used in dengue control on household surfaces. Arq Inst Biol 86:e0042018. https:\/\/doi.org\/10.1590\/1808-1657000042018.","journal-title":"Arq Inst Biol"},{"issue":"n. 1","key":"2924_CR55","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/j.1601-5223.1985.tb00471.x","volume":"102","author":"G Fiskesj\u00f6","year":"1985","unstructured":"Fiskesj\u00f6 G (1985) The Allium test as a standard in environmental monitoring. Hereditas 102(n. 1):99\u2013112.","journal-title":"Hereditas"},{"issue":"n. 7","key":"2924_CR56","doi-asserted-by":"publisher","first-page":"153","DOI":"10.3390\/toxics9070153","volume":"9","author":"LFV Francisco","year":"2021","unstructured":"Francisco LFV, Baldivia DDS, Crispim BDA, Klafke SMFF, Castilho PF, Viana LF, Santos ELD, Oliveira KMP, Barufatti A (2021) Acute toxic and genotoxic effects of aluminum and manganese using in vitro models. Toxics 9(n. 7):153. https:\/\/doi.org\/10.3390\/toxics9070153.","journal-title":"Toxics"},{"issue":"n. 1-3","key":"2924_CR57","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.scitotenv.2003.10.014","volume":"323","author":"L Gauthier","year":"2004","unstructured":"Gauthier L, Tardy E, Mouchet F, Marty J (2004) Biomonitoring of the genotoxic potential (micronucleus assay) and detoxifying activity (EROD induction) in the River Dadou (France), using the amphibian Xenopus laevis. Sci Total Environ 323(n. 1-3):47\u201361. https:\/\/doi.org\/10.1016\/j.scitotenv.2003.10.014.","journal-title":"Sci Total Environ"},{"issue":"6","key":"2924_CR58","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1007\/s10653-019-00292-9","volume":"41","author":"RP Gomes","year":"2019","unstructured":"Gomes RP, Silva JAP, Carvalho Junior MC, Alburquerque WCA, Scalize PS, Galv\u00e3o Filho AR, Carneiro LC (2019) Evaluation of the raw water quality: physicochemical and toxicological approaches. Env Geochem Health 41(6):2425\u20132442. https:\/\/doi.org\/10.1007\/s10653-019-00292-9.","journal-title":"Env Geochem Health"},{"key":"2924_CR59","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s00244-019-00647-4","volume":"77","author":"MW Gon\u00e7alves","year":"2019","unstructured":"Gon\u00e7alves MW, De Campos CBM, Godoy FR, Gambale PG, Nunes HF, Nomura F, De Melo E, Silva D (2019) Assessing genotoxicity and mutagenicity of three common amphibian species inhabiting agroecosystem environment. Arch Env Contam Toxicol 77:409\u2013420. https:\/\/doi.org\/10.1007\/s00244-019-00647-4.","journal-title":"Arch Env Contam Toxicol"},{"key":"2924_CR60","doi-asserted-by":"crossref","unstructured":"Grott SC, Rutkoski CF, de Almeida EA (2023) The importance of tadpole staging in ecotoxicological studies. In: TOXICOLOGY OF AMPHIBIAN TADPOLES. 1. ed. Boca Raton: CRC Press, 2023. p. 27\u201335.","DOI":"10.1201\/9781003091394-2"},{"issue":"n. 8","key":"2924_CR61","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1016\/S0045-6535(00)00562-2","volume":"44","author":"R Guerra","year":"2001","unstructured":"Guerra R (2001) Ecotoxicological and chemical evaluation of phenolic compounds in industrial effluents. Chemosphere 44(n. 8):1737\u20131747. https:\/\/doi.org\/10.1016\/S0045-6535(00)00562-2.","journal-title":"Chemosphere"},{"issue":"n. 1\u20133","key":"2924_CR63","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.ygcen.2007.02.011","volume":"154","author":"NS Hogan","year":"2007","unstructured":"Hogan NS, Crump KL, Duarte P, Lean DRS, Trudeau VL (2007) Hormone cross-regulation in the tadpole brain: Developmental expression profiles and effect of T3 exposure on thyroid hormone- and estrogen-responsive genes in Rana pipiens. Gen Comp Endocrinol 154(n. 1\u20133):5\u201315. https:\/\/doi.org\/10.1016\/j.ygcen.2007.02.011.","journal-title":"Gen Comp Endocrinol"},{"issue":"n. 1","key":"2924_CR64","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.envpol.2010.09.005","volume":"159","author":"M Holmstrup","year":"2011","unstructured":"Holmstrup M, S\u00f8rensen JG, Overgaard J, Bayley M, Bindesb\u00f8l A-M, Slotsbo S, Fisker KV, Maraldo K, Waagner D, Labouriau R, Asmund G (2011) Body metal concentrations and glycogen reserves in earthworms (Dendrobaena octaedra) from contaminated and uncontaminated forest soil. Env Pollut 159(n. 1):190\u2013197. https:\/\/doi.org\/10.1016\/j.envpol.2010.09.005.","journal-title":"Env Pollut"},{"issue":"n. 3","key":"2924_CR65","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3112\/erdkunde.2018.03.04","volume":"72","author":"G H\u00fcbner","year":"2018","unstructured":"H\u00fcbner G, Schwandt D (2018) Extreme low flow and water quality \u2013 A long-term view on the River Elbe. Erdkunde 72(n. 3):235\u2013252. https:\/\/doi.org\/10.3112\/erdkunde.2018.03.04.","journal-title":"Erdkunde"},{"key":"2924_CR66","volume-title":"Instituto mineiro de gest\u00e3o das \u00e1guas","author":"IGAM.","year":"2010","unstructured":"IGAM., 2010. Instituto mineiro de gest\u00e3o das \u00e1guas. Relat\u00f3rio monitoramento da qualidade das \u00e1guas superficiais da bacia do rio das velhas 2009, Belo Horizonte, MG."},{"issue":"n. 4","key":"2924_CR67","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S1470-160X(03)00004-9","volume":"2","author":"J Iliopoulou-Georgudaki","year":"2003","unstructured":"Iliopoulou-Georgudaki J, Kantzaris V, Katharios P, Kaspiris P, Georgiadis T, Montesantou B (2003) An application of different bioindicators for assessing water quality: a case study in the rivers Alfeios and Pineios (Peloponnisos, Greece). Ecol Indic 2(n. 4):345\u2013360. https:\/\/doi.org\/10.1016\/S1470-160X(03)00004-9.","journal-title":"Ecol Indic"},{"issue":"n. 132","key":"2924_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fpls.2018.00132","volume":"9","author":"NO Kalinina","year":"2018","unstructured":"Kalinina NO, Makarova S, Makhotenko A, Love AJ, Taliansky M (2018) The multiple functions of the nucleolus in plant development, disease and stress responses. Front Plant Sci 9(n. 132):1\u201319. https:\/\/doi.org\/10.3389\/fpls.2018.00132.","journal-title":"Front Plant Sci"},{"key":"2924_CR69","doi-asserted-by":"publisher","first-page":"e00911","DOI":"10.1016\/j.sciaf.2021.e00911","volume":"13","author":"BA Kassa","year":"2021","unstructured":"Kassa BA (2021) Cytotoxicity and genotoxicity evaluation of municipal wastewater discharged into the head of blue Nile River using the Allium Cepa test. Sci Afr 13:e00911. https:\/\/doi.org\/10.1016\/j.sciaf.2021.e00911.","journal-title":"Sci Afr"},{"key":"2924_CR70","doi-asserted-by":"publisher","first-page":"e01288","DOI":"10.1016\/j.sciaf.2022.e01288","volume":"17","author":"SD Kayode-Afolayan","year":"2022","unstructured":"Kayode-Afolayan SD, Ahuekwe EF, Nwinyi OC (2022) Impacts of pharmaceutical effluents on aquatic ecosystems. Sci Afr 17:e01288. https:\/\/doi.org\/10.1016\/j.sciaf.2022.e01288.","journal-title":"Sci Afr"},{"key":"2924_CR71","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.gexplo.2018.03.013","volume":"190","author":"KC Kinimo","year":"2018","unstructured":"Kinimo KC, Yao KM, Marcotte S, Kouassi NGLB, Trokourey A (2018) Distribution trends and ecological risks of arsenic and trace metals in wetland sediments around gold mining activities in central-southern and southeastern C\u00f4te d\u2019Ivoire. J Geochem Explor 190:265\u2013280. https:\/\/doi.org\/10.1016\/j.gexplo.2018.03.013.","journal-title":"J Geochem Explor"},{"key":"2924_CR72","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.ecoenv.2003.08.010","volume":"57","author":"RG Kuperman","year":"2004","unstructured":"Kuperman RG, Checkai RT, Simini M, Phillips CT (2004) Manganese toxicity in soil for Eisenia fetida, Enchytraeus crypticus (Oligochaeta), and Folsomia candida (Collembola). Ecotoxicol Env Saf 57:48\u201353. https:\/\/doi.org\/10.1016\/j.ecoenv.2003.08.010.","journal-title":"Ecotoxicol Env Saf"},{"key":"2924_CR73","doi-asserted-by":"publisher","first-page":"109036","DOI":"10.1016\/j.cbpc.2021.109036","volume":"245","author":"JI Kwak","year":"2021","unstructured":"Kwak JI, An YJ (2021) Assessing potential indicator of endocrine-disrupting property of chemicals using soil invertebrates. Comp Biochem Physiol C Toxicol Pharm 245:109036. https:\/\/doi.org\/10.1016\/j.cbpc.2021.109036.","journal-title":"Comp Biochem Physiol C Toxicol Pharm"},{"key":"2924_CR74","first-page":"851","volume":"69","author":"LD Lacerda","year":"2009","unstructured":"Lacerda LD, Santos JA, Lopes DV (2009) Destino do cobre em cria\u00e7\u00f5es intensivas de camar\u00e3o: bioacumula\u00e7\u00e3o e deposi\u00e7\u00e3o em sedimentos de lagoas. Rev Bras Biol 69:851\u2013858.","journal-title":"Rev Bras Biol"},{"key":"2924_CR75","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.mrgentox.2014.04.009","volume":"769","author":"RC Lajmanovich","year":"2014","unstructured":"Lajmanovich RC, Cabagna-Zenklusen MC, Attamemo AM, Junges CM, Peltzer PM, Bass\u00f3 A, Lorenzatti E (2014) Induction of micronuclei and nuclear abnormalities in tadpoles of the common toad (Rhinella arenarum) treated with the herbicides Liberty\u00ae and glufosinate-ammonium. Mutat Res Genet Toxicol Env Mutagen 769:7\u201312. https:\/\/doi.org\/10.1016\/j.mrgentox.2014.04.009.","journal-title":"Mutat Res Genet Toxicol Env Mutagen"},{"issue":"n. 1","key":"2924_CR76","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/ejss.12006","volume":"64","author":"D Lang Burak","year":"2013","unstructured":"Lang Burak D, Van Oort F, Becquer T, Foy E, Ferreira Fontes MP (2013) Unravelling zinc and lead distributions in dolomitic and metapelitic soils of the Brazilian central plateau: insight from physical fractionation, optical microscopy and X-ray microfluorescence. Eur J Soil Sci 64(n. 1):131\u2013144. https:\/\/doi.org\/10.1111\/ejss.12006.","journal-title":"Eur J Soil Sci"},{"issue":"n. 10","key":"2924_CR77","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1111\/tmi.13474","volume":"25","author":"AS Leandro","year":"2020","unstructured":"Leandro AS, Rios JA, Britto ADS, Galv\u00e3o SR, Lopes RD, Rivas AV, Martins CA, da Silva I, Delai RM, Gon\u00e7alves DD, da Silva MAN, Palacio-Cort\u00e8s AM, Schuartz V, Sibim AC, de Castro WAC (2020) Malathion insecticide resistance in Aedes aegypti: laboratory conditions and in situ experimental approach through adult entomological surveillance. Trop Med Int Health 25(n. 10):1271\u20131282. https:\/\/doi.org\/10.1111\/tmi.13474.","journal-title":"Trop Med Int Health"},{"key":"2924_CR78","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.chemosphere.2017.05.124","volume":"184","author":"PK Lee","year":"2017","unstructured":"Lee PK, Kang MJ, Yu S, Ko KS, Ha K, Shin SC, Park JH (2017) Enrichment and geochemical mobility of heavy metals in bottom sediment of the Hoedong reservoir, Korea and their source apportionment. Chemosphere 184:74\u201385. https:\/\/doi.org\/10.1016\/j.chemosphere.2017.05.124.","journal-title":"Chemosphere"},{"key":"2924_CR79","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1007\/s11356-016-8001-6","volume":"24","author":"J Liang","year":"2016","unstructured":"Liang J, Xia X, Zhang W, Zaman WQ, Lin K, Hu S, Lin Z (2016) The biochemical and toxicological responses of earthworm (Eisenia fetida) following exposure to nanoscale zerovalent iron in a soil system. Environ Sci Pollut Res 24:2507\u20132514. https:\/\/doi.org\/10.1007\/s11356-016-8001-6.","journal-title":"Environ Sci Pollut Res"},{"issue":"n. 1","key":"2924_CR80","doi-asserted-by":"publisher","first-page":"66","DOI":"10.6008\/CBPC2318-2881.2019.001.0007","volume":"12","author":"JAV Lima","year":"2019","unstructured":"Lima JAV, Stachiw R, Milit\u00e3o JSLT (2019) A problem\u00e1tica ambiental dos poluentes emergentes: poss\u00edveis impactos por horm\u00f4nios sexuais. Nat Conserv 12(n. 1):66\u201374. https:\/\/doi.org\/10.6008\/CBPC2318-2881.2019.001.0007.","journal-title":"Nat Conserv"},{"key":"2924_CR81","doi-asserted-by":"publisher","first-page":"6","DOI":"10.7594\/revbio.14.01.02","volume":"4","author":"LCA Lima","year":"2015","unstructured":"Lima LCA (2015) Resposta a danos no DNA ap\u00f3s exposi\u00e7\u00e3o \u00e0 luz ultravioleta: apagando o fogo antes do inc\u00eandio celular. Rev da Biol 4:6\u201316. https:\/\/doi.org\/10.7594\/revbio.14.01.02.","journal-title":"Rev da Biol"},{"key":"2924_CR82","doi-asserted-by":"publisher","first-page":"134288","DOI":"10.1016\/j.jhazmat.2024.134288","volume":"470","author":"H Lin","year":"2024","unstructured":"Lin H, Zhou L, Lu S, Yang H, Li Y, Yang X (2024) Occurrence and spatiotemporal distribution of natural and synthetic steroid hormones in soil, water, and sediment systems in suburban agricultural area of Guangzhou City, China. J Hazard Mater 470:134288. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.134288.","journal-title":"J Hazard Mater"},{"key":"2924_CR83","first-page":"290","volume":"24","author":"\u00c2ME Lu\u00edz","year":"2012","unstructured":"Lu\u00edz \u00c2ME, Pinto MLC, Scheffer E (2012) Par\u00e2metros de cor e turbidez relacionados aos usos do solo e \u00e0 morfometria da bacia hidrogr\u00e1fica do Rio Taquaral, S\u00e3o Mateus do Sul-Pr. Rev Caminhos da Geogr 24:290\u2013310.","journal-title":"Rev Caminhos da Geogr"},{"issue":"n. 3","key":"2924_CR84","doi-asserted-by":"publisher","first-page":"355","DOI":"10.4257\/oeco.2008.1203.02","volume":"12","author":"D Magalh\u00e3es","year":"2008","unstructured":"Magalh\u00e3es D, Ferr\u00e3o Filho AS (2008) A ecotoxicologia como ferramenta no biomonitoramento de ecossistemas aqu\u00e1ticos. Oecol Bras 12(n. 3):355\u2013381.","journal-title":"Oecol Bras"},{"key":"2924_CR85","doi-asserted-by":"publisher","first-page":"7359","DOI":"10.2147\/IJN.S250467","volume":"15","author":"JS Maziero","year":"2020","unstructured":"Maziero JS, Thipe VC, Rogero SO, Cavalcante AK, Damasceno KC, Ormenio MB, Katti KV (2020) Species-specific in vitro and in vivo evaluation of toxicity of silver nanoparticles stabilized with gum Arabic protein. Int J Nanomed 15:7359\u20137376. https:\/\/doi.org\/10.2147\/IJN.S250467.","journal-title":"Int J Nanomed"},{"issue":"n. 1","key":"2924_CR86","first-page":"35","volume":"29","author":"PRP Medeiros","year":"2015","unstructured":"Medeiros PRP, Segundo GHC, Magalh\u00e3es EMM (2015) Comportamento da turbidez e material em suspens\u00e3o em um rio com vaz\u00e3o regularizada por sistema de barragens em cascata: Rio S\u00e3o Francisco (NE, Brasil). Geochim Bras 29(n. 1):35\u201344.","journal-title":"Geochim Bras"},{"issue":"n. 2","key":"2924_CR87","doi-asserted-by":"publisher","first-page":"43","DOI":"10.18316\/260","volume":"5","author":"BG Mendes","year":"2011","unstructured":"Mendes BG, Budziak D, Stolberg J, Peixer ZI, Dalmarco JB, Simionatto EL, Geremias R (2011) Estudo da qualidade das \u00e1guas do Rio Marombas (SC\/Brasil), utilizando par\u00e2metros f\u00edsico-qu\u00edmicos e bioensaios. Rev Ci\u00eanc Ambient 5(n. 2):43\u201358. https:\/\/doi.org\/10.18316\/260.","journal-title":"Rev Ci\u00eanc Ambient"},{"key":"2924_CR88","doi-asserted-by":"publisher","unstructured":"Morais F, Sousa ES, Bacellar LAP, Cardoso LH (2024) Integra\u00e7\u00e3o de an\u00e1lise hidroqu\u00edmica \u00e0 geof\u00edsica a\u00e9rea para entendimento da hidrodin\u00e2mica no entorno da Lagoa da Confus\u00e3o, Tocantins, Brasil. Northeast Geosci J 10(n. 1). https:\/\/doi.org\/10.21680\/2447-3359.2024v10n1ID30701.","DOI":"10.21680\/2447-3359.2024v10n1ID30701"},{"issue":"n. 6","key":"2924_CR89","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1590\/S1413-81232012000600019","volume":"17","author":"JC Moreira","year":"2012","unstructured":"Moreira JC, Peres F, Sim\u00f5es AC, Pignati WA, Dores ED, Vieira SN, Mott T (2012) Groundwater and rainwater contamination by pesticides in an agricultural region of Mato Grosso state in central Brazil. Cien Saude Colet 17(n. 6):1557. https:\/\/doi.org\/10.1590\/S1413-81232012000600019.","journal-title":"Cien Saude Colet"},{"key":"2924_CR90","doi-asserted-by":"publisher","first-page":"3923","DOI":"10.1007\/s11269-012-0113-2","volume":"26","author":"L Mosley","year":"2012","unstructured":"Mosley L, Zammit B, Leyden E, Heneker T, Hipsey M, Skinner D, Aldridge K (2012) The impact of extreme low flows on the water quality of the lower Murray River and Lakes (South Australia). Water Resour Manag 26:3923\u20133946. https:\/\/doi.org\/10.1007\/s11269-012-0113-2.","journal-title":"Water Resour Manag"},{"key":"2924_CR91","doi-asserted-by":"publisher","first-page":"100356","DOI":"10.1016\/j.enmm.2020.100356","volume":"14","author":"AGC Motta","year":"2020","unstructured":"Motta AGC, do Amaral DF, Benvindo-Souza M, Rocha TL, de Silva DM (2020) Genotoxic and mutagenic effects of zinc oxide nanoparticles and zinc chloride on tadpoles of Lithobates catesbeianus (Anura: Ranidae). Environ Nanotechnol, Monit Manag 14:100356. https:\/\/doi.org\/10.1016\/j.enmm.2020.100356.","journal-title":"Environ Nanotechnol, Monit Manag"},{"key":"2924_CR92","doi-asserted-by":"publisher","first-page":"112241","DOI":"10.1016\/j.fct.2021.112241","volume":"152","author":"P Moyano","year":"2021","unstructured":"Moyano P, Garc\u00eda JM, Garc\u00eda J, Pelayo A, Mu\u00f1oz-Calero P, Frejo MT, Anadon MJ, Naval MV, Flores A, Mirat VA, Del Pino J (2021) Chlorpyrifos induces cell proliferation in MCF-7 and MDA-MB-231 cells, through cholinergic and Wnt\/\u03b2-catenin signaling disruption, AChE-R upregulation and oxidative stress generation after single and repeated treatment. Food Chem Toxicol 152:112241. https:\/\/doi.org\/10.1016\/j.fct.2021.112241.","journal-title":"Food Chem Toxicol"},{"issue":"n. 5","key":"2924_CR93","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1007\/s12665-012-1574-6","volume":"67","author":"DS Mulholland","year":"2012","unstructured":"Mulholland DS, Boaventura GR, Ara\u00fajo DF (2012) Geological and anthropogenic influences on sediment metal composition in the upper Paracatu River Basin, Brazil. Environ Earth Sci 67(n. 5):1307\u20131317. https:\/\/doi.org\/10.1007\/s12665-012-1574-6.","journal-title":"Environ Earth Sci"},{"key":"2924_CR94","doi-asserted-by":"publisher","first-page":"13","DOI":"10.51910\/ijhdr.v21i1.1175","volume":"21","author":"M Nagai","year":"2022","unstructured":"Nagai M, Pinto A, Von Ancken A, Coimbra E, Pinto S, Nowrooz S, Bonamin L (2022) Exposure of Artemia salina to glyphosate and bioremediation by isotherapy. Int J High Dilut Res 21:13\u201313. https:\/\/doi.org\/10.51910\/ijhdr.v21i1.1175.","journal-title":"Int J High Dilut Res"},{"key":"2924_CR95","doi-asserted-by":"publisher","first-page":"20422","DOI":"10.1007\/s11356-017-9717-7","volume":"24","author":"E Nasri","year":"2017","unstructured":"Nasri E, Machreki M, Beltifa A, Aroui S, Ghorbel A, Saad A, Feriani A, Borgi MA, Ghazouani L, Sire O, Balc\u00e1zar JL, Mansour HB (2017) Cytotoxic effects of seven Tunisian hospital wastewaters on the proliferation of human breast cancer cell line MDA-231: correlation with their chemical characterization. Env Sci Pollut Res 24:20422\u201320428. https:\/\/doi.org\/10.1007\/s11356-017-9717-7.","journal-title":"Env Sci Pollut Res"},{"issue":"n. 8","key":"2924_CR96","first-page":"149","volume":"8","author":"JBS Neto","year":"2016","unstructured":"Neto JBS, J\u00fanior MGS, Ucker FE, Alonso RRP, Lima ML (2016) Diagn\u00f3stico dos recursos h\u00eddricos: disponibilidade e demanda para a regi\u00e3o metropolitana de Goi\u00e2nia. RENEFARA 8(n. 8):149\u2013167.","journal-title":"RENEFARA"},{"issue":"n. 3","key":"2924_CR97","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.etap.2013.02.007","volume":"35","author":"E Netto","year":"2013","unstructured":"Netto E, Madeira RA, Silveira FZ, Fiori MA, Angioleto E, Pich CT (2013) Evaluation of the toxic and genotoxic potential of acid mine drainage using physicochemical parameters and bioassays. Env Toxicol Pharm 35(n. 3):511\u2013516. https:\/\/doi.org\/10.1016\/j.etap.2013.02.007.","journal-title":"Env Toxicol Pharm"},{"key":"2924_CR98","unstructured":"OECD (1984) Guideline for testing of chemicals N\u00b0. 207. Earthworm, acute toxicity test. Adopted on April 4."},{"key":"2924_CR99","doi-asserted-by":"publisher","first-page":"148306","DOI":"10.1016\/j.scitotenv.2021.148306","volume":"792","author":"JO Ojoghoro","year":"2021","unstructured":"Ojoghoro JO, Scrimshaw MD, Sumpter JP (2021) Steroid hormones in the aquatic environment. Sci Total Environ 792:148306. https:\/\/doi.org\/10.1016\/j.scitotenv.2021.148306.","journal-title":"Sci Total Environ"},{"key":"2924_CR100","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.chemosphere.2016.01.076","volume":"149","author":"CR Oliveira","year":"2016","unstructured":"Oliveira CR, Fraceto LF, Rizzi GM, Salla RF, Abdalla FC, Costa MJ, Silva-Zacarin ECM (2016) Hepatic effects of the clomazone herbicide in both its free form and associated with chitosan-alginate nanoparticles in bullfrog tadpoles. Chemosphere 149:304\u2013313. https:\/\/doi.org\/10.1016\/j.chemosphere.2016.01.076.","journal-title":"Chemosphere"},{"issue":"n. 10","key":"2924_CR101","doi-asserted-by":"publisher","first-page":"01","DOI":"10.54033\/cadpedv21n10-389","volume":"21","author":"LL Oliveira","year":"2024","unstructured":"Oliveira LL, Silva Tonini G, De Oliveira Faria J, Martins Da Costa Bianchi R (2024) Eisenia fetida como bioindicadora da qualidade de \u00e1guas de a\u00e7udes e residu\u00e1ria. Rev Cad Ped \u2013 Stud 21(n. 10):01\u201324. https:\/\/doi.org\/10.54033\/cadpedv21n10-389.","journal-title":"Rev Cad Ped \u2013 Stud"},{"key":"2924_CR102","unstructured":"Oliveira UD, Marins JF, Chiuchetta SJR (2006) Avalia\u00e7\u00e3o do ciclo celular de Aspergillus nidulans exposto ao extrato da planta Copaifera officinalis. SaBios \u2013 Revista de Sa\u00fade e Biologia,Campo Mour\u00e3o. 1(n. 2):42\u201347."},{"key":"2924_CR103","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1007\/s00244-013-9920-6","volume":"65","author":"NA Ossana","year":"2013","unstructured":"Ossana NA, Casta\u00f1\u00e9 PM, Salibi\u00e1n A (2013) Uso de girinos de Lithobates catesbeianus em uma abordagem de biomarcadores m\u00faltiplos para a avalia\u00e7\u00e3o da qualidade da \u00e1gua do rio reconquista (Argentina). Arch Env Contam Toxicol 65:486\u2013497. https:\/\/doi.org\/10.1007\/s00244-013-9920-6.","journal-title":"Arch Env Contam Toxicol"},{"key":"2924_CR104","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1007\/s13201-015-0334-7","volume":"7","author":"J Pandey","year":"2017","unstructured":"Pandey J, Singh R (2017) Heavy metals in sediments of Ganga River: up- and downstream urban influences. Appl Water Sci 7:1669\u20131678. https:\/\/doi.org\/10.1007\/s13201-015-0334-7.","journal-title":"Appl Water Sci"},{"key":"2924_CR169","unstructured":"PARAN\u00c1. Resolu\u00e7\u00e3o do Conselho Estadual de Recursos H\u00eddricos \u2013 CERH\/PR No 122, de 19 de junho de 2023. Estabelece diretrizes e crit\u00e9rios gerais para reuso de \u00e1gua no Estado do Paran\u00e1. Avaliable in: https:\/\/www.legisweb.com.br\/legislacao\/?d=449325. Accessed 10 Jan 2024. [In Portuguese]."},{"issue":"n. 3","key":"2924_CR105","doi-asserted-by":"publisher","first-page":"103","DOI":"10.46754\/jssm.2021.04.009","volume":"16","author":"C Payus","year":"2021","unstructured":"Payus C, Payus AO, Yan MP (2021) Steroid hormones assay on estrogen and progesterone group occurrences, fate, and pathway distributions in river and coastal environments. J Sustain Sci Manag 16(n. 3):103\u2013115.","journal-title":"J Sustain Sci Manag"},{"key":"2924_CR106","doi-asserted-by":"publisher","first-page":"114434","DOI":"10.1016\/j.envpol.2020.114434","volume":"263","author":"J Peluso","year":"2020","unstructured":"Peluso J, Aronzon CM, R\u00edos De Molina MDC, Rojas DE, Cristos D, P\u00e9rez Coll CS (2020) Integrated analysis of the quality of water bodies from the lower Paran\u00e1 River basin with different productive uses by physicochemical and biological indicators. Env Pollut 263:114434. https:\/\/doi.org\/10.1016\/j.envpol.2020.114434.","journal-title":"Env Pollut"},{"issue":"n. 1","key":"2924_CR107","doi-asserted-by":"publisher","first-page":"384","DOI":"10.55905\/rcssv12n1-023","volume":"12","author":"A Pereira Junior","year":"2023","unstructured":"Pereira Junior A, Morales GP, Beltr\u00e3o NES, Giuliatti NM, Rodrigues ABM (2023) Demanda biol\u00f3gica e qu\u00edmica do oxig\u00eanio no rio Uraim e o processo de urbaniza\u00e7\u00e3o. Rev Caribe\u00f1a Cienc Soc 12(n. 1):384\u2013399. https:\/\/doi.org\/10.55905\/rcssv12n1-023 Miami.","journal-title":"Rev Caribe\u00f1a Cienc Soc"},{"key":"2924_CR108","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.envpol.2018.04.116","volume":"240","author":"I P\u00e9rez-\u00c1lvarez","year":"2018","unstructured":"P\u00e9rez-\u00c1lvarez I, Islas-Flores H, G\u00f3mez-Oliv\u00e1n LM, Barcel\u00f3 D, De Alda ML, Solsona SP, Galar-Mart\u00ednez M (2018) Determination of metals and pharmaceutical compounds released in hospital wastewater from Toluca, Mexico, and evaluation of their toxic impact. Environ Pollut 240:330\u2013341. https:\/\/doi.org\/10.1016\/j.envpol.2018.04.116.","journal-title":"Environ Pollut"},{"key":"2924_CR109","doi-asserted-by":"publisher","first-page":"9852","DOI":"10.1007\/s11356-016-6153-z","volume":"23","author":"JM P\u00e9rez-Iglesias","year":"2016","unstructured":"P\u00e9rez-Iglesias JM, Franco-Belussi L, Moreno L, Tripole S, De Oliveira C, Natale GS (2016) Effects of glyphosate on hepatic tissue evaluating melanomacrophages and erythrocytes responses in neotropical anuran Leptodactylus latinasus. Environ Sci Pollut Res 23:9852\u20139861. https:\/\/doi.org\/10.1007\/s11356-016-6153-z.","journal-title":"Environ Sci Pollut Res"},{"issue":"n. 10","key":"2924_CR110","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.3390\/w13101347","volume":"13","author":"C Pironti","year":"2021","unstructured":"Pironti C, Ricciardi M, Proto A, Bianco PM, Montano L, Motta O (2021) Endocrine-disrupting compounds: An overview on their occurrence in the aquatic environment and human exposure. Water 13(n. 10):1347. https:\/\/doi.org\/10.3390\/w13101347.","journal-title":"Water"},{"key":"2924_CR111","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1080\/17435390.2018.1564079","volume":"13","author":"MV Pomeren","year":"2019","unstructured":"Pomeren MV, Peijnenburg WJGM, Vlieg RC, Noort SJT, Vijve MG (2019) The biodistribution and immuno-responses of differently shaped non-modified gold particles in zebrafish embryos. Nanotoxicology 13:558\u2013571. https:\/\/doi.org\/10.1080\/17435390.2018.1564079.","journal-title":"Nanotoxicology"},{"key":"2924_CR112","unstructured":"Pomp\u00eao M, Moschini-Carlos V, L\u00f3pez-Doval JC (2022) Aspectos da ecotoxicidade em ambientes aqu\u00e1ticos. Instituto de bioci\u00eancias \u2013 IB\/USP. Universidade de S\u00e3o Paulo."},{"key":"2924_CR113","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0065-2660(08)60408-3","volume":"5","author":"G Pontecorvo","year":"1953","unstructured":"Pontecorvo G (1953) The genetics of Aspergillus nidulans. Adv Genet 5:141\u2013238. https:\/\/doi.org\/10.1016\/S0065-2660(08)60408-3.","journal-title":"Adv Genet"},{"key":"2924_CR114","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1007\/s10646-016-1707-x","volume":"25","author":"MD Proki\u0107","year":"2016","unstructured":"Proki\u0107 MD, Borkovi\u0107-Miti\u0107 SS, Krizmani\u0107 II, Muti\u0107 JJ, Trifkovi\u0107 J\u0110, Gavri\u0107 JP, Sai\u010di\u0107 ZS (2016) Bioaccumulation and effects of metals on oxidative stress and neurotoxicity parameters in the frogs from the Pelophylax esculentus complex. Ecotoxicology 25:1531\u20131542. https:\/\/doi.org\/10.1007\/s10646-016-1707-x.","journal-title":"Ecotoxicology"},{"issue":"n. 11","key":"2924_CR115","doi-asserted-by":"publisher","first-page":"e7699","DOI":"10.1371\/journal.pone.0007699","volume":"4","author":"A Quaranta","year":"2009","unstructured":"Quaranta A, Bellantuono V, Cassano G, Lippe C (2009) Why amphibians are more sensitive than mammals to xenobiotics. PLoS ONE 4(n. 11):e7699. https:\/\/doi.org\/10.1371\/journal.pone.0007699.","journal-title":"PLoS ONE"},{"key":"2924_CR116","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s40199-015-0105-x","volume":"23","author":"S Rajabi","year":"2015","unstructured":"Rajabi S, Ramazani A, Hamidi M, Naji T (2015) Artemia salina as a model organism in toxicity assessment of nanoparticles. Daru 23:20. https:\/\/doi.org\/10.1186\/s40199-015-0105-x.","journal-title":"Daru"},{"key":"2924_CR117","doi-asserted-by":"publisher","first-page":"22625","DOI":"10.1007\/s11356-019-05438-x","volume":"26","author":"S Ray","year":"2019","unstructured":"Ray S, Gautam A, Ray A, Das S, Ray M (2019) Analysis of oxidative stress and cellular aggregation in the coelomocytes of earthworms collected from metal contaminated sites of industrial and agricultural soils of West Bengal, India. Environ Sci Pollut Res 26:22625\u201322640. https:\/\/doi.org\/10.1007\/s11356-019-05438-x.","journal-title":"Environ Sci Pollut Res"},{"key":"2924_CR118","doi-asserted-by":"publisher","first-page":"e6138","DOI":"10.7717\/peerj.6138","volume":"6","author":"R Rekulapally","year":"2019","unstructured":"Rekulapally R, Murthy Chavali LN, Idris MM, Singh S (2019) Toxicity of TiO2, SiO2, ZnO, CuO, Au and Ag engineered nanoparticles on hatching and early nauplii of Artemia sp. Peer J 6:e6138. https:\/\/doi.org\/10.7717\/peerj.6138.","journal-title":"Peer J"},{"issue":"n. 4","key":"2924_CR119","doi-asserted-by":"publisher","first-page":"e2360","DOI":"10.4136\/ambi-agua.2360","volume":"14","author":"JCPS Restrepo","year":"2019","unstructured":"Restrepo JCPS, Antonelo DI, Pokrywiecki TS, Tonial IB, Manosso FC, Almeida IG, Vicentini VEP, D\u00fcsman E (2019) Changes in physicochemical and toxicological parameters of waters of Trincheira\u2019s River caused by road construction. Rev Ambient \u00c1gua 14(n. 4):e2360. https:\/\/doi.org\/10.4136\/ambi-agua.2360.","journal-title":"Rev Ambient \u00c1gua"},{"issue":"n. 3","key":"2924_CR120","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1007\/s00244-015-0134-y","volume":"68","author":"PS Rezende","year":"2015","unstructured":"Rezende PS, Costa LM, Windm\u00f6ller CC (2015) Arsenic mobility in sediments from Paracatu River basin, MG, Brazil. Arch Env Contam Toxicol 68(n. 3):588\u2013602. https:\/\/doi.org\/10.1007\/s00244-015-0134-y.","journal-title":"Arch Env Contam Toxicol"},{"issue":"n. 1","key":"2924_CR121","first-page":"7","volume":"7","author":"LGG Ribeiro","year":"2017","unstructured":"Ribeiro LGG, Rolim ND (2017) Planeta \u00e1gua de quem e para quem: uma an\u00e1lise da \u00e1gua doce como direito fundamental e sua valora\u00e7\u00e3o mercadol\u00f3gica. Rev Dir Amb e Soc 7(n. 1):7\u201333.","journal-title":"Rev Dir Amb e Soc"},{"issue":"n. 3-6","key":"2924_CR122","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1080\/02772248.2019.1692019","volume":"101","author":"MJ Rocha","year":"2019","unstructured":"Rocha MJ, Madureira TV, Venade CS, Martins I, Campos J, Rocha E (2019) Presence of estrogenic endocrine disruptors in three European estuaries in the Northwest Iberian Peninsula (Portugal). Env Toxicol Chem 101(n. 3-6):244\u2013264. https:\/\/doi.org\/10.1080\/02772248.2019.1692019.","journal-title":"Env Toxicol Chem"},{"key":"2924_CR123","doi-asserted-by":"publisher","first-page":"e76","DOI":"10.5902\/2179460X41818","volume":"42","author":"GZP Rodrigues","year":"2020","unstructured":"Rodrigues GZP, Machado AB, Finkler M, Berleze DB, Gehlen G (2020) Environmental assessment of Luiz Rau stream (Brazil) utilizing Allium cepa test. Ci\u00eanc Nat 42:e76. https:\/\/doi.org\/10.5902\/2179460X41818.","journal-title":"Ci\u00eanc Nat"},{"key":"2924_CR124","doi-asserted-by":"publisher","unstructured":"SALIBI\u00c1N A (2006) Ecotoxicological assessment of the highly polluted reconquista river of Argentina. In: Ware GW, Nigg HN, Doerge DR (eds) Reviews of environmental contamination and toxicology, vol 185. Springer, New York, NY, pp 25\u201352. https:\/\/doi.org\/10.1007\/0-387-30638-2_2.","DOI":"10.1007\/0-387-30638-2_2"},{"key":"2924_CR125","doi-asserted-by":"publisher","first-page":"21742","DOI":"10.1007\/s11356-020-12026-x","volume":"28","author":"D Santos","year":"2021","unstructured":"Santos D, Mizobata A, Suyama G, Cenci G, Follador F, Arruda G, Hellmann L, Gomes E, De Oliveira Schmitz A, Pokrywiecki J, Lingnau R, Manosso F, Pokrywiecki T, D\u00fcsman E (2021) Cytotoxicity and mutagenicity of the waters of the Marrecas River (Paran\u00e1, Brazil) to bullfrogs (Lithobates catesbeianus). Environ Sci Pollut Res 28:21742\u201321753. https:\/\/doi.org\/10.1007\/s11356-020-12026-x.","journal-title":"Environ Sci Pollut Res"},{"issue":"n. 24-25","key":"2924_CR126","doi-asserted-by":"publisher","first-page":"46","DOI":"10.21527\/2176-7114.2013.24-25.46-53","volume":"13","author":"RS Santos","year":"2013","unstructured":"Santos RS, Mohr T (2013) Sa\u00fade e qualidade da \u00e1gua: An\u00e1lises microbiol\u00f3gicas e f\u00edsico-qu\u00edmicas em \u00e1guas subterr\u00e2neas. Rev Contexto Sa\u00fade 13(n. 24-25):46\u201353. https:\/\/doi.org\/10.21527\/2176-7114.2013.24-25.46-53.","journal-title":"Rev Contexto Sa\u00fade"},{"key":"2924_CR127","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1590\/S0100-40422009000800003","volume":"32","author":"VK Saraiva","year":"2009","unstructured":"Saraiva VK, Nascimento MRLD, Palmieri HEL, Jacomino VMF (2009) Evaluation of sediment quality: case study\u2014sub-watershed of Esp\u00edrito Santo stream, affluent of the S\u00e3o Francisco river. Quim Nova 32:1995\u20132002. https:\/\/doi.org\/10.1590\/S0100-40422009000800003.","journal-title":"Quim Nova"},{"issue":"n. 1","key":"2924_CR128","first-page":"e35695","volume":"15","author":"M Schafaschek","year":"2024","unstructured":"Schafaschek M, Deniz JP, da Pires TCS, da Pires YMS (2024) Avalia\u00e7\u00e3o f\u00edsico-qu\u00edmica e microbiol\u00f3gica da qualidade da \u00e1gua consumida em escolas do interior de Santa Catarina. Rev Casos Consult 15(n. 1):e35695. ISSN 2237-7417.","journal-title":"Rev Casos Consult"},{"key":"2924_CR129","doi-asserted-by":"publisher","first-page":"164564","DOI":"10.1016\/j.scitotenv.2023.164564","volume":"892","author":"DL Schutz","year":"2023","unstructured":"Schutz DL, De Marco IG, Teles AGDX, Schmitz APO, Gomes EMV, Manosso FC, Tonial IB, Pokrywiecki JC, Lingnau R, Pokrywieki TS, Modenes AN, Qui\u00f1ones FRE, D\u00fcsman E (2023) Soil toxicity in a protected area in Brazil: Cytotoxic, genotoxic, and toxic effects. Sci Total Environ 892:164564. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.164564.","journal-title":"Sci Total Environ"},{"key":"2924_CR130","doi-asserted-by":"publisher","unstructured":"Sieklicki J, Bione NCP, Oliveira PC, Souza VF, Martins KG (2018) Relationships between land use and water quality obtained for the evaluation of genotoxic effects in plant bioindicators. Environ Water 14(n. 2). https:\/\/doi.org\/10.4136\/ambi-agua.2299.","DOI":"10.4136\/ambi-agua.2299"},{"issue":"n. 10","key":"2924_CR131","doi-asserted-by":"publisher","first-page":"01","DOI":"10.54033\/cadpedv21n10-389","volume":"21","author":"ASA Silva","year":"2024","unstructured":"Silva ASA, de Ara\u00fajo SB, da Silva MVC, de Ara\u00fajo NC, Carneiro MVD (2024) Eisenia fetida como bioindicadora da qualidade de \u00e1guas de a\u00e7udes e residu\u00e1ria. Rev Cad Ped \u2013 Stud 21(n. 10):01\u201324. https:\/\/doi.org\/10.54033\/cadpedv21n10-389.","journal-title":"Rev Cad Ped \u2013 Stud"},{"key":"2924_CR133","unstructured":"Silva GR, Carvalho A (2023) Rela\u00e7\u00f5es entre a\u00e7\u00f5es antr\u00f3picas e taxas de turbidez na bacia hidrogr\u00e1fica do Rio Maracuj\u00e1, Amarantina-MG. Revista Geoaraguaia, [S. l.], vol 13, (n. 2). Barra do Gar\u00e7as, MT, pp 1\u201321."},{"issue":"n. 1-2","key":"2924_CR134","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.marpolbul.2017.04.007","volume":"120","author":"K Smolarz","year":"2017","unstructured":"Smolarz K, Hallmann A, Zabrzanska S, Pietrasik A (2017) Elevated gonadal atresia as biomarker of endocrine disruptors: Field and experimental studies using Mytilus trossulus (L.) and 17-alpha ethinylestradiol (EE2). Mar Pollut Bull 120(n. 1-2):58\u201367. https:\/\/doi.org\/10.1016\/j.marpolbul.2017.04.007.","journal-title":"Mar Pollut Bull"},{"key":"2924_CR135","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1016\/j.toxicon.2008.03.002","volume":"51","author":"G Souid-Mensi","year":"2008","unstructured":"Souid-Mensi G, Moukha S, Mobio TA, Maaroufi KE, Creppy EE (2008) The cytotoxicity and genotoxicity of okadaic acid are cell-line dependent. Toxicon 51:1338\u20131344. https:\/\/doi.org\/10.1016\/j.toxicon.2008.03.002.","journal-title":"Toxicon"},{"key":"2924_CR136","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s00244-019-00603-2","volume":"76","author":"JCV Sposito","year":"2019","unstructured":"Sposito JCV, Francisco LFV, Do Amaral Crispim B et al. (2019) Influence of land use and cover on the toxicogenetic potential of surface waters in rivers of the Brazilian Midwest. Arch Env Contam Toxicol 76:483\u2013495. https:\/\/doi.org\/10.1007\/s00244-019-00603-2.","journal-title":"Arch Env Contam Toxicol"},{"key":"2924_CR137","doi-asserted-by":"publisher","first-page":"120310","DOI":"10.1016\/j.watres.2023.120310","volume":"243","author":"Z Tang","year":"2023","unstructured":"Tang Z, Liu Z, Wang H, Wan Y, Dang Z, Guo P, Song Y, Chen S (2023) Twelve natural estrogens and ten bisphenol analogues in eight drinking water treatment plants: Analytical method, their occurrence and risk evaluation. Water Res 243:120310. https:\/\/doi.org\/10.1016\/j.watres.2023.120310.","journal-title":"Water Res"},{"key":"2924_CR138","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1016\/j.scitotenv.2017.11.081","volume":"619\u2013620","author":"TJ Thrupp","year":"2018","unstructured":"Thrupp TJ, Runnalls TJ, Scholze M, Kugathas S, Kortenkamp A, Sumpter JP (2018) The consequences of exposure to mixtures of chemicals: Something from \u2018nothing\u2019 and \u2018a lot from a little\u2019 when fish are exposed to steroid hormones. Sci Total Environ 619\u2013620:1482\u20131492. https:\/\/doi.org\/10.1016\/j.scitotenv.2017.11.081.","journal-title":"Sci Total Environ"},{"key":"2924_CR139","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.actbio.2017.07.006","volume":"59","author":"M Tootoonchi","year":"2017","unstructured":"Tootoonchi M, Hashempour M, Blackwelder PL, Fraker CA (2017) Manganese oxide particles as cytoprotective, oxygen generating agents. Acta Biomater 59:327\u2013337. https:\/\/doi.org\/10.1016\/j.actbio.2017.07.006.","journal-title":"Acta Biomater"},{"issue":"n. 2","key":"2924_CR140","first-page":"145","volume":"73","author":"KC Trapp","year":"2020","unstructured":"Trapp KC, Hister CAL, Laughinghouse IVHD, Boligon AA, Tedesco SB (2020) Determination of phenolic compounds and evaluation of cytotoxicity in Plectranthus barbatus using the Allium cepa test. Caryologia 73(n. 2):145\u2013153.","journal-title":"Caryologia"},{"key":"2924_CR141","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1590\/1519-6984.0113","volume":"75","author":"L Trintinaglia","year":"2015","unstructured":"Trintinaglia L, Bianchi E, Silva LB, Nascimento CA, Spilki FR, Ziulkoski AL (2015) Cytotoxicity assays as tools to assess water quality in the Sinos River basin. Braz J Biol 75:75\u201380. https:\/\/doi.org\/10.1590\/1519-6984.0113.","journal-title":"Braz J Biol"},{"issue":"n. 7","key":"2924_CR142","doi-asserted-by":"publisher","first-page":"691","DOI":"10.3109\/17435390.2011.604440","volume":"6","author":"L Truong","year":"2012","unstructured":"Truong L, Zaikova T, Richman EK, Hutchison JE, Tanguay RL (2012) Media ionic strength impacts embryonic responses to engineered nanoparticle exposure. Nanotoxicology 6(n. 7):691\u2013699. https:\/\/doi.org\/10.3109\/17435390.2011.604440.","journal-title":"Nanotoxicology"},{"key":"2924_CR143","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jhazmat.2012.07.007","volume":"233\u2013234","author":"V Tsarpali","year":"2012","unstructured":"Tsarpali V, Kamilari M, Dailianis S (2012) Seasonal alterations of landfill leachate composition and toxic potency in semi-arid regions. J Hazard Mater 233\u2013234:163\u2013171. https:\/\/doi.org\/10.1016\/j.jhazmat.2012.07.007.","journal-title":"J Hazard Mater"},{"key":"2924_CR144","unstructured":"UTFPR (2025) E-Clima: Sistema de monitoramento meteorol\u00f3gico da UTFPR \u2013 campus Francisco Beltr\u00e3o. Dispon\u00edvel em: https:\/\/www.e-clima.fb.utfpr.edu.br\/index.php. Acesso em: 10 fev."},{"key":"2924_CR145","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.etap.2017.08.001","volume":"55","author":"H Uwizeyimana","year":"2017","unstructured":"Uwizeyimana H, Wang M, Chen W, Khan K (2017) The eco-toxic effects of pesticide and heavy metal mixtures towards earthworms in soil. Env Toxicol Pharm 55:20\u201329. https:\/\/doi.org\/10.1016\/j.etap.2017.08.001.","journal-title":"Env Toxicol Pharm"},{"key":"2924_CR146","doi-asserted-by":"publisher","first-page":"110060","DOI":"10.1016\/j.ecoenv.2019.110060","volume":"189","author":"M Varol","year":"2020","unstructured":"Varol M, Canpolat \u00d6, Eri\u015f KK, \u00c7a\u011flar M (2020) Trace metals in core sediments from a deep lake in eastern Turkey: Vertical concentration profiles, eco-environmental risks and possible sources. Ecotoxicol Env Saf 189:110060. https:\/\/doi.org\/10.1016\/j.ecoenv.2019.110060.","journal-title":"Ecotoxicol Env Saf"},{"key":"2924_CR147","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.chemosphere.2014.07.088","volume":"120","author":"C Ventura","year":"2015","unstructured":"Ventura C, Venturino A, Miret N, Randi A, Rivera E, N\u00fa\u00f1ez M, Cocca C (2015) Chlorpyrifos inhibits cell proliferation through ERK1\/2 phosphorylation in breast cancer cell lines. Chemosphere 120:343\u2013350. https:\/\/doi.org\/10.1016\/j.chemosphere.2014.07.088.","journal-title":"Chemosphere"},{"key":"2924_CR148","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.jsbmb.2018.09.021","volume":"186","author":"C Ventura","year":"2019","unstructured":"Ventura C, Zappia CD, Lasagna M, Pavicic W, Richard S, Bolzan AD, Monczor F, N\u00fa\u00f1ez M, Cocca C (2019) Effects of the pesticide chlorpyrifos on breast cancer disease. Implication of epigenetic mechanisms. J Steroid Biochem Mol Biol 186:96\u2013104. https:\/\/doi.org\/10.1016\/j.jsbmb.2018.09.021.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2924_CR149","unstructured":"Veolia Water Technologies & Solutions (2022) Handbook of industrial water treatment. [S. l.]: Veolia. Dispon\u00edvel em: https:\/\/www.watertechnologies.com\/handbook\/handbook-industrial-water-treatment. Acesso em: 22 abr. 2025."},{"key":"2924_CR150","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.aquatox.2016.02.011","volume":"174","author":"A Veronez","year":"2016","unstructured":"Veronez A, Salla R, Baroni V, Barcarolli I, Bianchini A, Martinez C, Chiparri-Gomes A (2016) Efeitos gen\u00e9ticos e bioqu\u00edmicos induzidos pela exposi\u00e7\u00e3o ao min\u00e9rio de ferro, Fe e Mn em girinos de Lithobates catesbeianus. Aquat Toxicol 174:101\u2013108. https:\/\/doi.org\/10.1016\/j.aquatox.2016.02.011.","journal-title":"Aquat Toxicol"},{"issue":"n. 2","key":"2924_CR151","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1590\/0001-3765201720150536","volume":"89","author":"ACD Wandscheer","year":"2017","unstructured":"Wandscheer ACD, Marchesan E, Tedesco SB, Frescura VD, Soares CF, Londero GP, Tel\u00f3 GM, Hansel DSS (2017) Cytogenotoxicity of rice crop water after application of the tricyclazole fungicide. Acad Bras Cienc 89(n. 2):1251\u20131258. https:\/\/doi.org\/10.1590\/0001-3765201720150536.","journal-title":"Acad Bras Cienc"},{"key":"2924_CR152","doi-asserted-by":"publisher","first-page":"147819","DOI":"10.1016\/j.scitotenv.2021.147819","volume":"788","author":"H Wang","year":"2021","unstructured":"Wang H, Xi H, Xu L, Jin M, Zhao W, Liu H (2021) Ecotoxicological effects, environmental fate and risks of pharmaceutical and personal care products in the water environment: a review. Sci Total Env 788:147819. https:\/\/doi.org\/10.1016\/j.scitotenv.2021.147819.","journal-title":"Sci Total Env"},{"key":"2924_CR153","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.jes.2024.02.025","volume":"150","author":"Y Wang","year":"2025","unstructured":"Wang Y, Zhang C, Lin D, Zhang J (2025) Metabolomic and gut-microbial responses of earthworms exposed to microcystins and nano zero-valent iron in soil. J Environ Sci 150:340\u2013348. https:\/\/doi.org\/10.1016\/j.jes.2024.02.025.","journal-title":"J Environ Sci"},{"key":"2924_CR154","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.mrgentox.2007.01.010","volume":"689","author":"MJ Winter","year":"2007","unstructured":"Winter MJ, Ellis LCJ, Hutchinson TH (2007) Formation of micronuclei in erythrocytes of the fathead minnow (Pimephales promelas) after acute treatment with mitomycin C or cyclophosphamide. Mutat Res Genet Toxicol Environ Mutagen 689:89\u201399. https:\/\/doi.org\/10.1016\/j.mrgentox.2007.01.010.","journal-title":"Mutat Res Genet Toxicol Environ Mutagen"},{"key":"2924_CR155","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1007\/s11356-019-05055-8","volume":"20","author":"J Wu","year":"2013","unstructured":"Wu J, Zhang C, Xiao L, Moteleica-Heino M, Ren Z, Deng T, Dai J (2013) Impacts of earthworm species on soil acidification, Al fractions, and base cation release in a subtropical soil from China. Environ Sci Pollut Res 20:1135\u20131141. https:\/\/doi.org\/10.1007\/s11356-019-05055-8.","journal-title":"Environ Sci Pollut Res"},{"key":"2924_CR156","doi-asserted-by":"publisher","first-page":"141873","DOI":"10.1016\/j.scitotenv.2020.141873","volume":"754","author":"X Yan","year":"2021","unstructured":"Yan X, Wang J, Zhu L, Wang J, Li S, Kim YM (2021) Oxidative stress, growth inhibition, and DNA damage in earthworms induced by the combined pollution of typical neonicotinoid insecticides and heavy metals. Sci Total Environ 754:141873. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.141873.","journal-title":"Sci Total Environ"},{"issue":"n. 3","key":"2924_CR157","first-page":"317","volume":"7","author":"W Yanhua","year":"2012","unstructured":"Yanhua W, Weihua Y, Lizhi Y, Tao C, Ruixian Y, Qiang W, Xueping Z (2012) Acute toxicity of twenty-two commonly used herbicides to earthworm (Eisenia fetida). Asian J Ecotoxicol 7(n. 3):317\u2013325.","journal-title":"Asian J Ecotoxicol"},{"key":"2924_CR158","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.envint.2018.05.026","volume":"118","author":"B Yao","year":"2018","unstructured":"Yao B, Li R, Yan S, Chan S-A, Song W (2018) Occurrence and estrogenic activity of steroid hormones in Chinese streams: A nationwide study based on a combination of chemical and biological tools. Env Int 118:1\u20138. https:\/\/doi.org\/10.1016\/j.envint.2018.05.026.","journal-title":"Env Int"},{"key":"2924_CR159","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.3390\/w15061062","volume":"15","author":"MM Yaqoob","year":"2023","unstructured":"Yaqoob MM, Somlyai I, Berta C, B\u00e1csi I, Al-Tayawi AN, Al-Ahmady KK, Mohammed RH, Alalami O, Grigorszky I (2023) The impacts of land use and seasonal effects on phytoplankton taxa and physical-chemical variables in the Tigris River within the city of Mosul. Water 15:1062. https:\/\/doi.org\/10.3390\/w15061062.","journal-title":"Water"},{"key":"2924_CR160","doi-asserted-by":"publisher","first-page":"127316","DOI":"10.1016\/j.jhazmat.2021.127316","volume":"424","author":"J \u017daltauskait\u0117","year":"2022","unstructured":"\u017daltauskait\u0117 J, Kniuipyt\u0117 I, Praspaliauskas M (2022) Earthworm Eisenia fetida potential for sewage sludge amended soil valorization by heavy metal remediation and soil quality improvement. J Hazard Mater 424:127316. https:\/\/doi.org\/10.1016\/j.jhazmat.2021.127316.","journal-title":"J Hazard Mater"},{"key":"2924_CR161","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1007\/s11356-012-0969-y","volume":"20","author":"J Zhang","year":"2013","unstructured":"Zhang J, Yu J, Ouyang Y, Xu H (2013) Responses of earthworm to aluminum toxicity in latosol. Environ Sci Pollut Res 20:1135\u20131141. https:\/\/doi.org\/10.1007\/s11356-012-0969-y.","journal-title":"Environ Sci Pollut Res"},{"key":"2924_CR162","doi-asserted-by":"publisher","first-page":"143562","DOI":"10.1016\/j.scitotenv.2020.143562","volume":"755","author":"Q Zhang","year":"2021","unstructured":"Zhang Q, Webber JS, Moyer DL, Chanat JG (2021a) An approach for decomposing river water-quality trends into different flow classes. Sci Total Environ 755:143562. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.143562.","journal-title":"Sci Total Environ"},{"key":"2924_CR163","doi-asserted-by":"publisher","unstructured":"Zhang Q, Webber J, Moyer D, Chanat J (2021b) Estimating river water-quality trends under different flow conditions. In: EGU general assembly conference abstracts. v. EGU21-595. https:\/\/doi.org\/10.5194\/egusphere-egu21-595.","DOI":"10.5194\/egusphere-egu21-595"},{"key":"2924_CR165","doi-asserted-by":"publisher","first-page":"126982","DOI":"10.1016\/j.chemosphere.2020.126982","volume":"255","author":"L Zhu","year":"2020","unstructured":"Zhu L, Li B, Wu R, Li W, Wang J, Wang J, Du Z, Juhasz A, Zhu L (2020) Acute toxicity, oxidative stress and DNA damage of chlorpyrifos to earthworms (Eisenia fetida): The difference between artificial and natural soils. Chemosphere 255:126982. https:\/\/doi.org\/10.1016\/j.chemosphere.2020.126982.","journal-title":"Chemosphere"},{"issue":"n. 2","key":"2924_CR166","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s40071-016-0147-9","volume":"24","author":"PRG Zimmermann","year":"2016","unstructured":"Zimmermann PRG, Dalzochio T, Gehlen G (2016) The use of biomarkers to assess the health of aquatic ecosystems in Brazil: a review. Acta Toxicol 24(n. 2):97\u2013104. https:\/\/doi.org\/10.1007\/s40071-016-0147-9.","journal-title":"Acta Toxicol"},{"key":"2924_CR167","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1508\/cytologia.65.403","volume":"65","author":"PC Zonetti","year":"2000","unstructured":"Zonetti PC, Rocha CLS (2000) Mutagenicity of benlate in methG1 system in Aspergillus (=Emericella) nidulans. Cytology 65:403\u2013408. https:\/\/doi.org\/10.1508\/cytologia.65.403.","journal-title":"Cytology"}],"container-title":["Ecotoxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10646-025-02924-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10646-025-02924-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10646-025-02924-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:21:53Z","timestamp":1758979313000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10646-025-02924-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,3]]},"references-count":164,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["2924"],"URL":"https:\/\/doi.org\/10.1007\/s10646-025-02924-6","relation":{},"ISSN":["0963-9292","1573-3017"],"issn-type":[{"type":"print","value":"0963-9292"},{"type":"electronic","value":"1573-3017"}],"subject":[],"published":{"date-parts":[[2025,7,3]]},"assertion":[{"value":"16 June 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The project has approval of the Committee on Ethics in the Use of Animals of the State University of Western Paran\u00e1 (Protocol 19.473.178-7).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors certify that they have participated in the conception of this work and take public responsibility for its content.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors attest that they participated in the design of this work and accept the publication of data.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}