{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:15:30Z","timestamp":1792782930513,"version":"4.5.0"},"reference-count":106,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2022YFF0606703"],"award-info":[{"award-number":["2022YFF0606703"]}]},{"name":"Foundation of Zhejiang Province","award":["LQ22B070001"],"award-info":[{"award-number":["LQ22B070001"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["22206179"],"award-info":[{"award-number":["22206179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["U20A20133"],"award-info":[{"award-number":["U20A20133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ecotoxicology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s10646-026-03060-5","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:00:25Z","timestamp":1773831625000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Advancing environmental toxicology with lipidomics: from toxicity evaluation to mechanistic understanding"],"prefix":"10.1007","volume":"35","author":[{"given":"Fanglin","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Hong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"3060_CR1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s13361-014-1013-x","volume":"26","author":"R Almeida","year":"2015","unstructured":"Almeida R, Pauling JK, Sokol E, Hannibal-Bach HK, Ejsing CS (2015) Comprehensive lipidome analysis by shotgun lipidomics on a hybrid quadrupole-orbitrap-linear ion trap mass spectrometer. J Am Soc Mass Spectrom 26:133\u2013148","journal-title":"J Am Soc Mass Spectrom"},{"key":"3060_CR2","doi-asserted-by":"publisher","first-page":"115165","DOI":"10.1016\/j.watres.2019.115165","volume":"168","author":"H Arambourou","year":"2020","unstructured":"Arambourou H, Llorente L, Moreno-Ocio I, Herrero \u00d3, Barata C, Fuertes I et al (2020) Exposure to heavy metal-contaminated sediments disrupts gene expression, lipid profile, and life history traits in the midge Chironomus riparius. Water Res 168:115165","journal-title":"Water Res"},{"key":"3060_CR107","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.coesh.2020.04.004","volume":"15","author":"JJ Aristizabal-Henao","year":"2020","unstructured":"Aristizabal-Henao JJ, Ahmadireskety A, Griffin EK, Silva BFD, Bowden JA et al (2020) Lipidomics and environmental toxicology:recent trends. Curr Opin Environ Sci Health 15:26\u201331","journal-title":"Curr Opin Environ Sci Health"},{"key":"3060_CR4","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/s41370-022-00410-3","volume":"32","author":"P Ashrap","year":"2022","unstructured":"Ashrap P, Aung MT, Watkins DJ, Mukherjee B, Rosario-Pab\u00f3n Z, V\u00e9lez-Vega CM et al (2022) Maternal urinary phthalate metabolites are associated with lipidomic signatures among pregnant women in Puerto Rico. J Exposure Sci Environ Epidemiol 32:384\u2013391","journal-title":"J Exposure Sci Environ Epidemiol"},{"key":"3060_CR5","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.cca.2020.06.049","volume":"510","author":"HF Avela","year":"2020","unstructured":"Avela HF, Sir\u00e9n H (2020) Advances in lipidomics. Clin Chim Acta 510:123\u2013141","journal-title":"Clin Chim Acta"},{"key":"3060_CR10","doi-asserted-by":"publisher","first-page":"150328","DOI":"10.1016\/j.scitotenv.2021.150328","volume":"806","author":"W Cheng","year":"2022","unstructured":"Cheng W, Li X, Zhou Y, Yu H, Xie Y, Guo H et al (2022) Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids. Sci Total Environ 806:150328","journal-title":"Sci Total Environ"},{"key":"3060_CR6","doi-asserted-by":"publisher","first-page":"122015","DOI":"10.1016\/j.envpol.2023.122015","volume":"333","author":"H Chen","year":"2023","unstructured":"Chen H, Deng Y, Wang Q, Chen W, Liu Z, Tan H et al (2023a) Large polystyrene microplastics results in hepatic lipotoxicity in mice. Environ Pollut 333:122015","journal-title":"Environ Pollut"},{"key":"3060_CR7","doi-asserted-by":"publisher","first-page":"8438","DOI":"10.1021\/acs.est.1c08875","volume":"56","author":"H Chen","year":"2022","unstructured":"Chen H, Qiu W, Yang X, Chen F, Chen J, Tang L et al (2022) Perfluorooctane sulfonamide (PFOSA) induces cardiotoxicity via aryl hydrocarbon receptor activation in zebrafish. Environ Sci Technol 56:8438\u20138448","journal-title":"Environ Sci Technol"},{"issue":"29","key":"3060_CR8","doi-asserted-by":"publisher","first-page":"10542","DOI":"10.1021\/acs.est.3c01746","volume":"57","author":"J Chen","year":"2023","unstructured":"Chen J, Xie P, Wu P, Lin Z, He Y, Cai Z (2023b) Spatial metabolomics and lipidomics reveal the mechanisms of the enhanced growth of breast cancer cell spheroids exposed to triclosan. Environ Sci Technol 57(29):10542\u201310553","journal-title":"Environ Sci Technol"},{"issue":"29","key":"3060_CR9","doi-asserted-by":"publisher","first-page":"15550","DOI":"10.1021\/acs.analchem.5c01863","volume":"97","author":"Y Chen","year":"2025","unstructured":"Chen Y, Wang X, Xu G, Zhong R, Wang Z, Fan Z, Liu T et al (2025) Novel equivalent carbon number strategy for large-scale lipidomics data analysis via ultrahigh\u2013performance liquid chromatography\u2013orbitrap astral mass spectrometry. Anal Chem 97(29):15550\u201315555","journal-title":"Anal Chem"},{"issue":"7","key":"3060_CR11","first-page":"1136","volume":"62","author":"JP Cherry","year":"1981","unstructured":"Cherry JP, Gray MS (1981) Methylene chloride extraction of gossypol from cottonseed products. J Food Sci 62(7):1136\u20131138","journal-title":"J Food Sci"},{"key":"3060_CR12","doi-asserted-by":"publisher","first-page":"115924","DOI":"10.1016\/j.trac.2020.115924","volume":"128","author":"J Deng","year":"2020","unstructured":"Deng J, Yang Y, Luo L, Xiao Y, Luan T (2020a) Lipid analysis and lipidomics investigation by ambient mass spectrometry. Trends Anal Chem 128:115924","journal-title":"Trends Anal Chem"},{"key":"3060_CR13","doi-asserted-by":"publisher","first-page":"115301","DOI":"10.1016\/j.taap.2020.115301","volume":"409","author":"P Deng","year":"2020","unstructured":"Deng P, Wang C, Wahlang B, Sexton T, Morris AJ, Hennig B (2020b) Co-exposure to PCB126 and PFOS increases biomarkers associated with cardiovascular disease risk and liver injury in mice. Toxicol Appl Pharmcol 409:115301","journal-title":"Toxicol Appl Pharmcol"},{"issue":"22","key":"3060_CR14","doi-asserted-by":"publisher","first-page":"15805","DOI":"10.1021\/acs.est.1c07933","volume":"56","author":"Y Deng","year":"2022","unstructured":"Deng Y, Chen H, Huang Y, Zhang Y, Ren H, Fang M et al (2022) Long-term exposure to environmentally relevant doses of large polystyrene microplastics disturbs lipid homeostasis via bowel function interference. Environ Sci Technol 56(22):15805\u201315817","journal-title":"Environ Sci Technol"},{"key":"3060_CR15","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1158\/0008-5472.CAN-11-2465","volume":"72","author":"LS Eberlin","year":"2012","unstructured":"Eberlin LS, Norton I, Dill AL, Golby AJ, Ligon KL, Santagata S et al (2012) Classifying human brain tumors by lipid imaging with mass spectrometry. Cancer Res 72:645\u2013654","journal-title":"Cancer Res"},{"key":"3060_CR16","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1093\/bioinformatics\/bty679","volume":"35","author":"E Fahy","year":"2019","unstructured":"Fahy E, Alvarez-Jarreta J, Brasher CJ, Nguyen A, Hawksworth JI, Rodrigues P et al (2019) LipidFinder on LIPID MAPS: peak filtering, MS searching and statistical analysis for lipidomics. Bioinformatics 35:685\u2013687","journal-title":"Bioinformatics"},{"key":"3060_CR17","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","volume":"226","author":"J Folch","year":"1957","unstructured":"Folch J, Lees M, Sloane Stanley GH (1957a) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chemistr 226:497\u2013509","journal-title":"J Biol Chemistr"},{"key":"3060_CR18","doi-asserted-by":"publisher","first-page":"118904","DOI":"10.1016\/j.envpol.2022.118904","volume":"299","author":"Z Gao","year":"2022","unstructured":"Gao Z, Pan L, Xu R, Zhou Y, Li D (2022) Insights into disruption of lipid metabolism in digestive gland of female scallop Chlamys farreri under B[a]P exposure. Environ Pollut 299:118904","journal-title":"Environ Pollut"},{"key":"3060_CR19","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.ecoenv.2018.12.040","volume":"170","author":"D Geng","year":"2018","unstructured":"Geng D, Musse AA, Wigh V, Carlsson C, Engwall M, Ore\u0161i\u010d M et al (2018) Effect of perfluorooctanesulfonic acid (PFOS) on the liver lipid metabolism of the developing chicken embryo. Ecotoxicol Environ Saf 170:691\u2013698","journal-title":"Ecotoxicol Environ Saf"},{"key":"3060_CR20","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.aca.2018.06.082","volume":"1034","author":"M Ghidotti","year":"2018","unstructured":"Ghidotti M, Fabbri D, Torri C, Piccinini S (2018) Determination of volatile fatty acids in digestate by solvent extraction with dimethyl carbonate and gas chromatography-mass spectrometry. Anal Chim Acta 1034:92\u2013101","journal-title":"Anal Chim Acta"},{"key":"3060_CR21","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.cmet.2012.04.001","volume":"15","author":"CK Glass","year":"2012","unstructured":"Glass CK, Olefsky JM (2012) Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab 15:635\u2013645","journal-title":"Cell Metab"},{"key":"3060_CR22","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.tibtech.2004.03.007","volume":"22","author":"R Goodacre","year":"2004","unstructured":"Goodacre R, Vaidyanathan S, Dunn WB, Harrigan GG, Kell DB (2004) Metabolomics by numbers: acquiring and understanding global metabolite data. Trends Biotechnol 22:245\u2013252","journal-title":"Trends Biotechnol"},{"key":"3060_CR23","doi-asserted-by":"publisher","first-page":"129740","DOI":"10.1016\/j.chemosphere.2021.129740","volume":"271","author":"Y Gu","year":"2021","unstructured":"Gu Y, Gao M, Zhang W, Yan L, Shao F, Zhou J (2021) Exposure to phthalates DEHP and DINP may lead to oxidative damage and lipidomic disruptions in mouse kidney. Chemosphere 271:129740","journal-title":"Chemosphere"},{"key":"3060_CR24","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1194\/jlr.R300004-JLR200","volume":"44","author":"X Han","year":"2003","unstructured":"Han X, Gross RW (2003) Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics. J Lipid Res 44:1071\u20131079","journal-title":"J Lipid Res"},{"issue":"12","key":"3060_CR25","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1038\/nmeth.4470","volume":"14","author":"J Hartler","year":"2017","unstructured":"Hartler J, Triebl A, Ziegl A, Tr\u00f6tzm\u00fcller M, Rechberger GN, Zeleznik OA et al (2017) Deciphering lipid structures based on platform-independent decision rules. Nat Methods 14(12):1171\u20131174","journal-title":"Nat Methods"},{"issue":"1","key":"3060_CR26","doi-asserted-by":"publisher","first-page":"R8","DOI":"10.1186\/gb-2011-12-1-r8","volume":"12","author":"R Herzog","year":"2011","unstructured":"Herzog R, Schwudke D, Schuhmann K, Sampaio JL, Bornstein SR, Schroeder M et al (2011) A novel informatics concept for high-throughput shotgun lipidomics based on the molecular fragmentation query language. Genome Biol 12(1):R8","journal-title":"Genome Biol"},{"key":"3060_CR27","doi-asserted-by":"publisher","first-page":"12812","DOI":"10.1021\/acs.est.9b04369","volume":"53","author":"Y Huang","year":"2019","unstructured":"Huang Y, Sun F, Tan H, Deng Y, Sun Z, Chen H et al (2019) DEHP and DINP induce tissue- and gender-specific disturbances in fatty acid and lipidomic profiles in neonatal mice: a comparative study. Environ Sci Technol 53:12812\u201312822","journal-title":"Environ Sci Technol"},{"issue":"11","key":"3060_CR28","doi-asserted-by":"publisher","first-page":"e79736","DOI":"10.1371\/journal.pone.0079736","volume":"8","author":"P Husen","year":"2013","unstructured":"Husen P, Tarasov K, Katafiasz M, Sokol E, Vogt J, Baumgart J et al (2013) Analysis of lipid experiments (ALEX): a software framework for analysis of high-resolution shotgun lipidomics data. PLoS ONE 8(11):e79736","journal-title":"PLoS ONE"},{"key":"3060_CR29","first-page":"296","volume":"3","author":"RG Jensen","year":"1984","unstructured":"Jensen RG, Clark RM (1984) Methods of Lipid Analysis. J Pediatr Gastroenterol Nutr 3:296\u2013299","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"3060_CR30","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0022-2275(20)34412-6","volume":"26","author":"MA Kaluzny","year":"1985","unstructured":"Kaluzny MA, Duncan LA, Merritt MV, Epps DE (1985) Rapid separation of lipid classes in high yield and purity using bonded phase columns. J Lipid Res 26(1):135\u2013140","journal-title":"J Lipid Res"},{"key":"3060_CR31","doi-asserted-by":"publisher","first-page":"105705","DOI":"10.1016\/j.envint.2020.105705","volume":"139","author":"TP Keerthisinghe","year":"2020","unstructured":"Keerthisinghe TP, Wang F, Wang M, Yang Q, Li J, Yang J et al (2020) Long-term exposure to TET increases body weight of juvenile zebrafish as indicated in host metabolism and gut microbiome. Environ Int 139:105705","journal-title":"Environ Int"},{"key":"3060_CR106","doi-asserted-by":"crossref","unstructured":"Kim C, Ashrap P, Watkins DJ, Mukherjee B, Rosario-Pab\u00f3n ZY, V\u00e9lez-Vega CM, Alshawabkeh AN, Cordero JF, Meeker JD (2022) Maternal Metals\/Metalloid Blood Levels Are Associated With Lipidomic Profiles Among Pregnant Women in Puerto Rico. Front Public Health 9:754706","DOI":"10.3389\/fpubh.2021.754706"},{"key":"3060_CR33","doi-asserted-by":"publisher","first-page":"135500","DOI":"10.1016\/j.scitotenv.2019.135500","volume":"703","author":"HM Kim","year":"2020","unstructured":"Kim HM, Long NP, Yoon SJ, Anh NH, Kim SJ, Park JH et al (2020) Omics approach reveals perturbation of metabolism and phenotype in Caenorhabditis elegans triggered by perfluorinated compounds. Sci Total Environ 703:135500","journal-title":"Sci Total Environ"},{"key":"3060_CR34","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.cbi.2010.01.029","volume":"184","author":"TH Kim","year":"2010","unstructured":"Kim TH, Kim YW, Shin SM, Kim CW, Yu IJ, Kim SG (2010) Synergistic hepatotoxicity of N,N-dimethylformamide with carbon tetrachloride in association with endoplasmic reticulum stress. Chemico-Biol Interact 184:492\u2013501","journal-title":"Chemico-Biol Interact"},{"issue":"8","key":"3060_CR32","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/nmeth.2551","volume":"10","author":"T Kind","year":"2013","unstructured":"Kind T, Liu KH, Lee DY, DeFelice B, Meissen JK, Fiehn O (2013) LipidBlast in silico tandem mass spectrometry database for lipid identification. Nat Methods 10(8):755\u2013758","journal-title":"Nat Methods"},{"issue":"5","key":"3060_CR35","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s11306-020-01665-3","volume":"16","author":"JP Koelmel","year":"2020","unstructured":"Koelmel JP, Napolitano MP, Ulmer CZ, Vasiliou V, Garrett TJ, Yost RA et al (2020) Environmental lipidomics: understanding the response of organisms and ecosystems to a changing world. Metabolomics 16(5):56","journal-title":"Metabolomics"},{"issue":"11","key":"3060_CR36","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1093\/bioinformatics\/btx046","volume":"33","author":"JE Kyle","year":"2017","unstructured":"Kyle JE, Crowell KL, Casey CP, Fujimoto GM, Kim S, Dautel S et al (2017) LIQUID: an-open source software for identifying lipids in LC-MS\/MS-based lipidomics data. Bioinformatics 33(11):1744\u20131746","journal-title":"Bioinformatics"},{"issue":"18","key":"3060_CR37","doi-asserted-by":"publisher","first-page":"10111","DOI":"10.3390\/ijms221810111","volume":"22","author":"S Lagies","year":"2021","unstructured":"Lagies S, Pichler R, Vladimirov G, Gawron J, B\u00e4zner F, Schreiner A et al (2021) Metabolic and lipidomic assessment of kidney cells exposed to nephrotoxic vancomycin dosages. Int J Mol Sci 22(18):10111","journal-title":"Int J Mol Sci"},{"key":"3060_CR38","doi-asserted-by":"publisher","first-page":"8782","DOI":"10.1021\/acs.est.7b02102","volume":"51","author":"KP Lai","year":"2017","unstructured":"Lai KP, Lee JC, Wan HT, Li JW, Wong AY, Chan TF et al (2017) Effects of in utero PFOS exposure on transcriptome, lipidome, and function of mouse testis. Environ Sci Technol 51:8782\u20138794","journal-title":"Environ Sci Technol"},{"key":"3060_CR39","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1111\/raq.12346","volume":"12","author":"VA Laudicella","year":"2019","unstructured":"Laudicella VA, Whitfield PD, Carboni S, Doherty MK, Hughes AD (2019) Application of lipidomics in bivalve aquaculture, a review. Reviews Aquaculture 12:678\u2013702","journal-title":"Reviews Aquaculture"},{"issue":"10","key":"3060_CR40","doi-asserted-by":"publisher","first-page":"e0204829","DOI":"10.1371\/journal.pone.0204829","volume":"13","author":"S-H Lee","year":"2018","unstructured":"Lee S-H, Hong S-H, Tang C-H, Ling YS, Chen K-H, Liang H-J et al (2018) Mass spectrometry-based lipidomics to explore the biochemical effects of naphthalene toxicity or tolerance in a mouse model. PLoS ONE 13(10):e0204829","journal-title":"PLoS ONE"},{"key":"3060_CR41","doi-asserted-by":"publisher","first-page":"135603","DOI":"10.1016\/j.scitotenv.2019.135603","volume":"707","author":"S-H Lee","year":"2019","unstructured":"Lee S-H, Lee P-H, Liang H-J, Tang C-H, Chen T-F, Cheng T-J et al (2019) Brain lipid profiles in the spontaneously hypertensive rat after subchronic real-world exposure to ambient fine particulate matter. Sci Total Environ 707:135603","journal-title":"Sci Total Environ"},{"key":"3060_CR42","doi-asserted-by":"publisher","first-page":"159755","DOI":"10.1016\/j.scitotenv.2022.159755","volume":"858","author":"Y Lei","year":"2022","unstructured":"Lei Y, Li F, Mortimer M, Li Z, Peng B-X, Li M et al (2022) Antibiotics disrupt lipid metabolism in zebrafish (Danio rerio) larvae and 3T3-L1 preadipocytes. Sci Total Environ 858:159755","journal-title":"Sci Total Environ"},{"key":"3060_CR43","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/BF02532113","volume":"2","author":"GA Leveille","year":"1967","unstructured":"Leveille GA, Pardini RS, Tillotson JA (1967) Influence of medium-chain triglycerides on lipid metabolism in the rat. Lipids 2:287\u2013294","journal-title":"Lipids"},{"key":"3060_CR48","doi-asserted-by":"publisher","first-page":"143976","DOI":"10.1016\/j.scitotenv.2020.143976","volume":"757","author":"Y Liang","year":"2021","unstructured":"Liang Y, Zhang H, Cai Z (2021) New insights into the cellular mechanism of triclosan-induced dermal toxicity from a combined metabolomic and lipidomic approach. Sci Total Environ 757:143976","journal-title":"Sci Total Environ"},{"key":"3060_CR49","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1194\/jlr.S120001025","volume":"61","author":"G Liebisch","year":"2020","unstructured":"Liebisch G, Fahy E, Aoki J, Dennis EA, Durand T, Ejsing CS et al (2020) Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures. J Lipid Res 61:1539\u20131555","journal-title":"J Lipid Res"},{"key":"3060_CR44","doi-asserted-by":"publisher","first-page":"7361","DOI":"10.1039\/D3CC00878A","volume":"59","author":"J Li","year":"2023","unstructured":"Li J, Pan L, Pan W, Li N, Tang B (2023) Recent progress of oxidative stress associated biomarker detection. Chem Commun 59:7361\u20137374","journal-title":"Chem Commun"},{"key":"3060_CR50","doi-asserted-by":"publisher","first-page":"147018","DOI":"10.1016\/j.scitotenv.2021.147018","volume":"784","author":"CY Lin","year":"2021","unstructured":"Lin CY, Chen WL, Chen TZ, Lee SH, Liang HJ, Chou CC et al (2021) Lipid changes in extrapulmonary organs and serum of rats after chronic exposure to ambient fine particulate matter. Sci Total Environ 784:147018","journal-title":"Sci Total Environ"},{"key":"3060_CR45","doi-asserted-by":"publisher","first-page":"127062","DOI":"10.1016\/j.chemosphere.2020.127062","volume":"256","author":"R Li","year":"2020","unstructured":"Li R, Guo C, Lin X, Chan TF, Lai KP, Chen J (2020a) Integrative omics analyses uncover the mechanism underlying the immunotoxicity of perfluorooctanesulfonate in human lymphocytes. Chemosphere 256:127062","journal-title":"Chemosphere"},{"key":"3060_CR46","doi-asserted-by":"publisher","first-page":"114668","DOI":"10.1016\/j.envpol.2020.114668","volume":"262","author":"R Li","year":"2020","unstructured":"Li R, Wang Y, Hou B, Lam SM, Zhang W, Chen R et al (2020b) Lipidomics insight into chronic exposure to ambient air pollution in mice. Environ Pollut 262:114668","journal-title":"Environ Pollut"},{"key":"3060_CR51","doi-asserted-by":"publisher","first-page":"131918","DOI":"10.1016\/j.jhazmat.2023.131918","volume":"458","author":"M Liu","year":"2023","unstructured":"Liu M, Mu J, Wang M, Hu C, Ji J, Wen C et al (2023) Impacts of polypropylene microplastics on lipid profiles of mouse liver uncovered by lipidomics analysis and Raman spectroscopy. J Hazard Mater 458:131918","journal-title":"J Hazard Mater"},{"key":"3060_CR47","doi-asserted-by":"publisher","first-page":"122150","DOI":"10.1016\/j.talanta.2021.122150","volume":"226","author":"X Li","year":"2021","unstructured":"Li X, Li T, Wang Z, Wei J, Liu J, Zhang Y et al (2021) Distribution of perfluorooctane sulfonate in mice and its effect on liver lipidomic. Talanta 226:122150","journal-title":"Talanta"},{"key":"3060_CR52","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.aca.2016.09.014","volume":"943","author":"MA L\u00f3pez-Basc\u00f3n","year":"2016","unstructured":"L\u00f3pez-Basc\u00f3n MA, Calder\u00f3n-Santiago M, Priego-Capote F (2016) Confirmatory and quantitative analysis of fatty acid esters of hydroxy fatty acids in serum by solid phase extraction coupled to liquid chromatography tandem mass spectrometry. Anal Chim Acta 943:82\u201388","journal-title":"Anal Chim Acta"},{"key":"3060_CR53","doi-asserted-by":"publisher","first-page":"115238","DOI":"10.1016\/j.ecoenv.2023.115238","volume":"263","author":"M Lu","year":"2023","unstructured":"Lu M, Deng P, Yang L, Wang X, Mei X, Zhou C et al (2023) Manganese overexposure induces Parkinson-like symptoms, altered lipid signature and oxidative stress in C57BL\/6 J mouse. Ecotoxicol Environ Saf 263:115238","journal-title":"Ecotoxicol Environ Saf"},{"key":"3060_CR54","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s00109-023-02308-5","volume":"101","author":"M Luo","year":"2023","unstructured":"Luo M, Li T, Sang H (2023) The role of hypoxia-inducible factor 1\u03b1 in hepatic lipid metabolism. J Mol Med (Berlin) 101:487\u2013500","journal-title":"J Mol Med (Berlin)"},{"key":"3060_CR55","doi-asserted-by":"publisher","first-page":"130120","DOI":"10.1016\/j.chemosphere.2021.130120","volume":"276","author":"SA Maggio","year":"2021","unstructured":"Maggio SA, Janney PK, Jenkins JJ (2021) Neurotoxicity of chlorpyrifos and chlorpyrifos-oxon to Daphnia magna. Chemosphere 276:130120","journal-title":"Chemosphere"},{"issue":"5","key":"3060_CR56","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1194\/jlr.D700041-JLR200","volume":"49","author":"V Matyash","year":"2008","unstructured":"Matyash V, Liebisch G, Kurzchalia TV, Shevchenko A, Schwudke D (2008) Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics. J Lipid Res 49(5):1137\u20131146","journal-title":"J Lipid Res"},{"issue":"1","key":"3060_CR57","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.pharmthera.2014.02.001","volume":"143","author":"PJ Meikle","year":"2014","unstructured":"Meikle PJ, Wong G, Barlow CK, Kingwell BA (2014) Lipidomics: potential role in risk prediction and therapeutic monitoring for diabetes and cardiovascular disease. Pharmacol Ther 143(1):12\u201323","journal-title":"Pharmacol Ther"},{"key":"3060_CR58","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.scitotenv.2018.11.113","volume":"654","author":"SD Melvin","year":"2018","unstructured":"Melvin SD, Lanct\u00f4t CM, Doriean NJC, Bennett WW, Carroll AR (2018) NMR-based lipidomics of fish from a metal(loid) contaminated wetland show differences consistent with effects on cellular membranes and energy storage. Sci Total Environ 654:284\u2013291","journal-title":"Sci Total Environ"},{"key":"3060_CR59","doi-asserted-by":"publisher","first-page":"126777","DOI":"10.1016\/j.jhazmat.2021.126777","volume":"421","author":"A Men\u00e9ndez-Pedriza","year":"2021","unstructured":"Men\u00e9ndez-Pedriza A, Jaumot J, Bedia C (2021) Lipidomic analysis of single and combined effects of polyethylene microplastics and polychlorinated biphenyls on human hepatoma cells. J Hazard Mater 421:126777","journal-title":"J Hazard Mater"},{"issue":"15","key":"3060_CR60","doi-asserted-by":"publisher","first-page":"3810","DOI":"10.3390\/ijms20153810","volume":"20","author":"F Mesa-Herrera","year":"2019","unstructured":"Mesa-Herrera F, Taoro-Gonz\u00e1lez L, Vald\u00e9s-Baizabal C, Diaz M, Mar\u00edn R (2019) Lipid and lipid raft alteration in aging and neurodegenerative diseases: a window for the development of new biomarkers. Int J Mol Sci 20(15):3810","journal-title":"Int J Mol Sci"},{"key":"3060_CR61","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/s41581-023-00741-w","volume":"19","author":"A Mitrofanova","year":"2023","unstructured":"Mitrofanova A, Merscher S, Fornoni A (2023) Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease. Nat Rev Nephrol 19:629\u2013645","journal-title":"Nat Rev Nephrol"},{"key":"3060_CR62","doi-asserted-by":"publisher","first-page":"2596","DOI":"10.1021\/acs.jproteome.2c00297","volume":"21","author":"N Munjoma","year":"2022","unstructured":"Munjoma N, Isaac G, Muazzam A, Cexus O, Azhar F, Pandha H et al (2022) High throughput LC-MS platform for large scale screening of bioactive polar lipids in human plasma and serum. J Proteome Res 21:2596\u20132608","journal-title":"J Proteome Res"},{"key":"3060_CR63","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1007\/s12665-013-2572-z","volume":"71","author":"S Naseem","year":"2013","unstructured":"Naseem S, Hamza S, Nawaz-ul-Huda S, Bashir E, ul-Haq Q (2013) Geochemistry of Cd in groundwater of Winder, Balochistan and suspected health problems. Environ Earth Sci 71:1683\u20131690","journal-title":"Environ Earth Sci"},{"key":"3060_CR64","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.scitotenv.2017.08.205","volume":"612","author":"G Ning","year":"2018","unstructured":"Ning G, Wang S, Ma M, Ni C, Shang Z, Wang J et al (2018) Characteristics of air pollution in different zones of Sichuan Basin, China. Sci Total Environ 612:975\u2013984","journal-title":"Sci Total Environ"},{"key":"3060_CR65","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.scitotenv.2018.09.011","volume":"650","author":"B Petrie","year":"2019","unstructured":"Petrie B, Lopardo L, Proctor K, Youdan J, Barden R, Kasprzyk-Hordern B (2019) Assessment of bisphenol-a in the urban water cycle. Sci Total Environ 650:900\u2013907","journal-title":"Sci Total Environ"},{"key":"3060_CR66","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/0076-6879(82)86218-6","volume":"86","author":"WS Powell","year":"1982","unstructured":"Powell WS (1982) Rapid extraction of arachidonic acid metabolites from biological samples using octadecylsilyl silica. Methods Enzymol 86:467\u2013477","journal-title":"Methods Enzymol"},{"key":"3060_CR67","doi-asserted-by":"publisher","first-page":"130304","DOI":"10.1016\/j.chemosphere.2021.130304","volume":"277","author":"JY Qin","year":"2021","unstructured":"Qin JY, Ru S, Wang W, Hao L, Wei S, Zhang J et al (2021) Unraveling the mechanism of long-term bisphenol S exposure disrupted ovarian lipids metabolism, oocytes maturation, and offspring development of zebrafish. Chemosphere 277:130304","journal-title":"Chemosphere"},{"key":"3060_CR68","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1021\/acs.chemrestox.8b00038","volume":"31","author":"S Rebollo-Ramirez","year":"2018","unstructured":"Rebollo-Ramirez S, Krokowski S, Lobato-M\u00e1rquez D, Thomson M, Pennisi I, Mostowy S et al (2018) Intact Cell Lipidomics Reveal Changes to the Ratio of Cardiolipins to Phosphatidylinositols in Response to Kanamycin in HeLa and Primary Cells. Chem Res Toxicol 31:688\u2013696","journal-title":"Chem Res Toxicol"},{"key":"3060_CR69","doi-asserted-by":"publisher","first-page":"43761","DOI":"10.1038\/srep43761","volume":"7","author":"T Sadowski","year":"2017","unstructured":"Sadowski T, Klose C, Gerl MJ, W\u00f3jcik-Maciejewicz A, Herzog R, Simons K et al (2017) Large-scale human skin lipidomics by quantitative, high-throughput shotgun mass spectrometry. Sci Rep 7:43761","journal-title":"Sci Rep"},{"key":"3060_CR70","doi-asserted-by":"publisher","first-page":"12752","DOI":"10.1021\/acs.analchem.8b03118","volume":"90","author":"MA Samaraweera","year":"2018","unstructured":"Samaraweera MA, Hall LM, Hill DW, Grant DF (2018) Evaluation of an artificial neural network retention index model for chemical structure identification in nontargeted metabolomics. Anal Chem 90:12752\u201312760","journal-title":"Anal Chem"},{"key":"3060_CR71","doi-asserted-by":"publisher","first-page":"4083","DOI":"10.1021\/ac062455y","volume":"79","author":"D Schwudke","year":"2007","unstructured":"Schwudke D, Hannich JT, Surendranath V, Grimard V, Moehring T, Burton L et al (2007) Top-down lipidomic screens by multivariate analysis of high-resolution survey mass spectra. Anal Chem 79:4083\u20134093","journal-title":"Anal Chem"},{"key":"3060_CR72","first-page":"a004614","volume":"39","author":"D Schwudke","year":"2011","unstructured":"Schwudke D, Schuhmann K, Herzog R, Bornstein SR, Shevchenko AJCSH (2011) Shotgun lipidomics on high resolution mass spectrometers. Cold Spring Harb Perspect Biol 39:a004614","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"3060_CR73","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.envpol.2016.06.031","volume":"216","author":"M Shao","year":"2016","unstructured":"Shao M, Ding G, Zhang J, Wei L, Xue H, Zhang N et al (2016) Occurrence and distribution of perfluoroalkyl substances (PFASs) in surface water and bottom water of the Shuangtaizi Estuary, China. Environ Pollut 216:675\u2013681","journal-title":"Environ Pollut"},{"key":"3060_CR74","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.foodchem.2016.02.151","volume":"205","author":"Q Shen","year":"2016","unstructured":"Shen Q, Dai Z, Huang Y-W, Cheung H-Y (2016) Lipidomic profiling of dried seahorses by hydrophilic interaction chromatography coupled to mass spectrometry. Food Chem 205:89\u201396","journal-title":"Food Chem"},{"key":"3060_CR75","doi-asserted-by":"publisher","first-page":"27003","DOI":"10.1289\/EHP3730","volume":"127","author":"H Shoaito","year":"2019","unstructured":"Shoaito H, Petit J, Chissey A, Auzeil N, Guibourdenche J, Gil S et al (2019) The role of peroxisome proliferator\u2013activated receptor gamma (PPAR\u03b3) in mono(2-ethylhexyl) phthalate (MEHP)-mediated cytotrophoblast differentiation. Environ Health Perspect 127:27003","journal-title":"Environ Health Perspect"},{"key":"3060_CR76","doi-asserted-by":"publisher","first-page":"110896","DOI":"10.1016\/j.ecoenv.2020.110896","volume":"202","author":"JC Shon","year":"2020","unstructured":"Shon JC, Lee SM, Jung JH, Wu Z, Kwon YS, Sim HJ et al (2020) Integrated metabolomics and lipidomics reveals high accumulation of polyunsaturated lysoglycerophospholipids in human lung fibroblasts exposed to fine particulate matter. Ecotoxicol Environ Saf 202:110896","journal-title":"Ecotoxicol Environ Saf"},{"key":"3060_CR78","doi-asserted-by":"publisher","first-page":"D527","DOI":"10.1093\/nar\/gkl838","volume":"35","author":"M Sud","year":"2007","unstructured":"Sud M, Fahy E, Cotter D, Brown A, Dennis EA, Glass CK et al (2007) LMSD: LIPID MAPS structure database. Nucleic Acids Res 35:D527\u2013532","journal-title":"Nucleic Acids Res"},{"key":"3060_CR79","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.talanta.2017.03.023","volume":"168","author":"JH Suh","year":"2017","unstructured":"Suh JH, Niu YS, Hung W-L, Ho C-T, Wang Y (2017) Lipidomic analysis for carbonyl species derived from fish oil using liquid chromatography-tandem mass spectrometry. Talanta 168:31\u201342","journal-title":"Talanta"},{"key":"3060_CR77","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1089\/ars.2017.7066","volume":"28","author":"H Su","year":"2018","unstructured":"Su H, Wan C, Lei CT, Zhang CY, Ye C, Tang H et al (2018) Lipid deposition in kidney diseases: interplay among redox, lipid mediators, and renal impairment. Antioxid Redox Signal 28:1027\u20131043","journal-title":"Antioxid Redox Signal"},{"key":"3060_CR80","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1194\/jlr.M700421-JLR200","volume":"49","author":"N Tahallah","year":"2008","unstructured":"Tahallah N, Brunelle A, De La Porte S, Lapr\u00e9vote O (2008) Lipid mapping in human dystrophic muscle by cluster-time-of-flight secondary ion mass spectrometry imaging. J Lipid Res 49:438\u2013454","journal-title":"J Lipid Res"},{"key":"3060_CR81","doi-asserted-by":"publisher","first-page":"117654","DOI":"10.1007\/s11356-023-30447-2","volume":"30","author":"P Tsiantas","year":"2023","unstructured":"Tsiantas P, Karasali H, Pavlidis G, Kavasilis S, Doula M (2023) The status of organochlorine pesticide contamination in Greek agricultural soils: the ghost of traditional agricultural history. Environ Sci Pollut Res Int 30:117654\u2013117675","journal-title":"Environ Sci Pollut Res Int"},{"key":"3060_CR82","doi-asserted-by":"publisher","first-page":"112935","DOI":"10.1016\/j.ecoenv.2021.112935","volume":"228","author":"C Wang","year":"2021","unstructured":"Wang C, Deng H, Wang D, Wang J, Huang H, Qiu J et al (2021a) Changes in metabolomics and lipidomics in brain tissue and their correlations with the gut microbiome after chronic food-derived arsenic exposure in mice. Ecotoxicol Environ Saf 228:112935","journal-title":"Ecotoxicol Environ Saf"},{"key":"3060_CR83","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.aca.2017.09.046","volume":"1000","author":"J Wang","year":"2018","unstructured":"Wang J, Wang C, Han X (2018) Enhanced coverage of lipid analysis and imaging by matrix-assisted laser desorption\/ionization mass spectrometry via a strategy with an optimized mixture of matrices. Anal Chim Acta 1000:155\u2013162","journal-title":"Anal Chim Acta"},{"key":"3060_CR84","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1002\/mas.21492","volume":"36","author":"M Wang","year":"2017","unstructured":"Wang M, Wang C, Han X (2017) Selection of internal standards for accurate quantification of complex lipid species in biological extracts by electrospray ionization mass spectrometry\u2014what, how and why? Mass Spectrom Rev 36:693\u2013714","journal-title":"Mass Spectrom Rev"},{"key":"3060_CR85","doi-asserted-by":"publisher","first-page":"136591","DOI":"10.1016\/j.chemosphere.2022.136591","volume":"308","author":"Q Wang","year":"2022","unstructured":"Wang Q, Wu Y, Zhang W, Shen T, Li H, Wu J et al (2022) Lipidomics and transcriptomics insight into impacts of microplastics exposure on hepatic lipid metabolism in mice. Chemosphere 308:136591","journal-title":"Chemosphere"},{"key":"3060_CR86","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1021\/acs.chemrestox.1c00015","volume":"34","author":"X Wang","year":"2021","unstructured":"Wang X, Song Y, Hu D, Wang F, Cai Z (2021b) Metabolic and lipid alterations in mice brain cortex after PM(2.5) exposure. Chem Res Toxicol 34:1250\u20131255","journal-title":"Chem Res Toxicol"},{"key":"3060_CR87","first-page":"771","volume":"39","author":"X Wang","year":"2023","unstructured":"Wang X, Wang L, Luo M, Bu Q, Liu C, Jiang L et al (2023) Integrated lipidomic and transcriptomic analysis reveals clarithromycin-induced alteration of glycerophospholipid metabolism in the cerebral cortex of mice. Chem Res Toxicol 39:771\u2013793","journal-title":"Chem Res Toxicol"},{"key":"3060_CR88","first-page":"108788","volume":"235","author":"X Wang","year":"2020","unstructured":"Wang X, Xu Y, Jia Q, Song X, Zhang L, Zhang W et al (2020) Perturbations in glycerophospholipid levels of PC12 cells after exposure to PCB95 based on targeted lipidomics analysis. Comp Biochem Physiol Part C: Toxicol Pharmacol 235:108788","journal-title":"Comp Biochem Physiol Part C: Toxicol Pharmacol"},{"key":"3060_CR89","doi-asserted-by":"publisher","first-page":"138777","DOI":"10.1016\/j.jhazmat.2025.138777","volume":"494","author":"W Waqas","year":"2025","unstructured":"Waqas W, Yuan Y, Xue Y, Wang L, Chen Y, Zhang J et al (2025) Lipidomics: an emerging tool in aquatic toxicology research. J Hazard Mater 494:138777","journal-title":"J Hazard Mater"},{"key":"3060_CR90","doi-asserted-by":"publisher","first-page":"121451","DOI":"10.1016\/j.jhazmat.2019.121451","volume":"390","author":"J Wei","year":"2020","unstructured":"Wei J, Li X, Xiang L, Song Y, Liu Y, Jiang Y et al (2020) Metabolomics and lipidomics study unveils the impact of polybrominated diphenyl ether-47 on breast cancer mice. J Hazard Mater 390:121451","journal-title":"J Hazard Mater"},{"key":"3060_CR91","doi-asserted-by":"publisher","first-page":"2819","DOI":"10.1111\/liv.15059","volume":"41","author":"SA Willis","year":"2021","unstructured":"Willis SA, Bawden SJ, Malaikah S, Sargeant JA, Stensel DJ, Aithal GP et al (2021) The role of hepatic lipid composition in obesity-related metabolic disease. Liver Int 41:2819\u20132835","journal-title":"Liver Int"},{"key":"3060_CR92","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.cbi.2016.06.025","volume":"256","author":"X Wu","year":"2016","unstructured":"Wu X, Zhu JC, Zhang Y, Li WM, Rong XL, Feng YF (2016) Lipidomics study of plasma phospholipid metabolism in early type 2 diabetes rats with ancient prescription Huang-Qi-San intervention by UPLC\/Q-TOF-MS and correlation coefficient. Chem - Biol Interact 256:71\u201384","journal-title":"Chem - Biol Interact"},{"issue":"1","key":"3060_CR95","doi-asserted-by":"publisher","first-page":"4566","DOI":"10.1038\/s41467-025-59683-5","volume":"16","author":"H Xu","year":"2025","unstructured":"Xu H, Jiang T, Lin Y, Zhang L, Yang H, Huang X et al (2025) LipidIN: a comprehensive repository for flash platform-independent annotation and reverse lipidomics. Nat Commun 16(1):4566","journal-title":"Nat Commun"},{"key":"3060_CR93","doi-asserted-by":"publisher","first-page":"17005","DOI":"10.1289\/EHP9373","volume":"130","author":"M Xu","year":"2022","unstructured":"Xu M, Li Y, Wang X, Zhang Q, Wang L, Zhang X et al (2022) Role of hepatocyte- and macrophage-specific PPAR\u03b3 in hepatotoxicity induced by diethylhexyl phthalate in mice. Environ Health Perspect 130:17005","journal-title":"Environ Health Perspect"},{"key":"3060_CR94","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.aca.2020.09.060","volume":"1137","author":"T Xu","year":"2020","unstructured":"Xu T, Hu C, Xuan Q, Xu G (2020) Recent advances in analytical strategies for mass spectrometry-based lipidomics. Anal Chim Acta 1137:156\u2013169","journal-title":"Anal Chim Acta"},{"key":"3060_CR97","doi-asserted-by":"publisher","first-page":"150350","DOI":"10.1016\/j.scitotenv.2021.150350","volume":"806","author":"C Yang","year":"2021","unstructured":"Yang C, Wei J, Cao G, Cai Z (2021) Lipid metabolism dysfunction and toxicity of BDE-47 exposure in white adipose tissue revealed by the integration of lipidomics and metabolomics. Sci Total Environ 806:150350","journal-title":"Sci Total Environ"},{"key":"3060_CR96","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1016\/j.scitotenv.2018.07.432","volume":"649","author":"Z Yan","year":"2019","unstructured":"Yan Z, Huang X, Xie Y, Song M, Zhu K, Ding S (2019) Macrolides induce severe cardiotoxicity and developmental toxicity in zebrafish embryos. Sci Total Environ 649:1414\u20131421","journal-title":"Sci Total Environ"},{"key":"3060_CR98","doi-asserted-by":"publisher","first-page":"162039","DOI":"10.1016\/j.scitotenv.2023.162039","volume":"871","author":"F Yu","year":"2023","unstructured":"Yu F, Pei Y, Zhang X, Wu X, Zhang G, Ma J (2023) Occurrence and distribution characteristics of aged microplastics in the surface water, sediment, and crabs of the aquaculture pond in the Yangtze River Delta of China. Sci Total Environ 871:162039","journal-title":"Sci Total Environ"},{"key":"3060_CR99","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.chemosphere.2012.10.078","volume":"90","author":"J Zhang","year":"2013","unstructured":"Zhang J, Zuo Z, Xiong J, Sun P, Chen Y, Wang C (2013) Tributyltin exposure causes lipotoxicity responses in the ovaries of rockfish, Sebastiscus marmoratus. Chemosphere 90:1294\u20131299","journal-title":"Chemosphere"},{"key":"3060_CR100","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1093\/toxsci\/kfw120","volume":"153","author":"L Zhang","year":"2016","unstructured":"Zhang L, Krishnan P, Ehresman DJ, Smith PB, Dutta M, Bagley BD et al (2016) Editor\u2019s highlight: perfluorooctane sulfonate-choline ion pair formation: a potential mechanism modulating hepatic steatosis and oxidative stress in mice. Toxicol Sci 153 186\u2013197","journal-title":"Toxicol Sci"},{"key":"3060_CR101","doi-asserted-by":"publisher","first-page":"165821","DOI":"10.1016\/j.scitotenv.2023.165821","volume":"900","author":"R Zhang","year":"2023","unstructured":"Zhang R, Tu L, Yang Y, Sun J, Liang T, Li Y et al (2023) Altered generation pattern of reactive oxygen species triggering DNA and plasma membrane damages to human liver cells treated with arsenite. Sci Total Environ 900:165821","journal-title":"Sci Total Environ"},{"issue":"1","key":"3060_CR102","first-page":"20","volume":"261","author":"C Zhao","year":"2023","unstructured":"Zhao C, Cai Z (2023) Mass spectrometry-based omics and imaging technique: a novel tool for molecular toxicology and health impacts. Rev Environ Contam Toxicol 261(1):20","journal-title":"Rev Environ Contam Toxicol"},{"key":"3060_CR103","doi-asserted-by":"publisher","first-page":"11420","DOI":"10.1021\/acs.est.8b07314","volume":"53","author":"C Zhao","year":"2019","unstructured":"Zhao C, Tang Z, Xie P, Lin K, Chung ACK, Cai Z (2019) Immunotoxic potential of bisphenol F mediated through lipid signaling pathways on macrophages. Environ Sci Technol 53:11420\u201311428","journal-title":"Environ Sci Technol"},{"issue":"15","key":"3060_CR104","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.scitotenv.2017.03.035","volume":"592","author":"C Zhao","year":"2017","unstructured":"Zhao C, Tang Z, Yan J, Fang J, Wang H, Cai Z (2017) Bisphenol S exposure modulate macrophage phenotype as defined by cytokines profiling, global metabolomics and lipidomics analysis. Sci Total Environ 592(15):357\u2013365","journal-title":"Sci Total Environ"},{"key":"3060_CR105","doi-asserted-by":"publisher","first-page":"3196","DOI":"10.1021\/acs.analchem.7b04540","volume":"90","author":"C Zhao","year":"2018","unstructured":"Zhao C, Xie P, Yong T, Wang H, Chung ACK, Cai Z (2018) MALDI-MS imaging reveals asymmetric spatial distribution of lipid metabolites from bisphenol S-induced nephrotoxicity. Anal Chem 90:3196\u20133204","journal-title":"Anal Chem"}],"container-title":["Ecotoxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10646-026-03060-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10646-026-03060-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10646-026-03060-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T05:01:59Z","timestamp":1776574919000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10646-026-03060-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,18]]},"references-count":106,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["3060"],"URL":"https:\/\/doi.org\/10.1007\/s10646-026-03060-5","relation":{},"ISSN":["0963-9292","1573-3017"],"issn-type":[{"value":"0963-9292","type":"print"},{"value":"1573-3017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,18]]},"assertion":[{"value":"28 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}],"article-number":"84"}}