{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:20:36Z","timestamp":1788430836031,"version":"build-2803163510"},"reference-count":119,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ecotoxicology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s10646-026-03117-5","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:24:25Z","timestamp":1783013065000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In vivo effects of lead on sea urchin Paracentrotus lividus: toxicity, bioconcentration and oxidative stress response"],"prefix":"10.1007","volume":"35","author":[{"given":"Faiza","family":"TALBI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5211-825X","authenticated-orcid":false,"given":"Nedjoua","family":"ZAIDI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amel","family":"HAMDANI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noomene","family":"SLEIMI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"issue":"1","key":"3117_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1080\/24750263.2024.2434122","volume":"92","author":"R Agaguena","year":"2025","unstructured":"Agaguena R, Zaidi N, Brunelli E, Hamdani A, Macirella R (2025) Sub-lethal effects of acetamiprid on the gills of the bleak Alburnus alburnus: histopathological and molecular alterations. Eur Zoological J 92(1):61\u201373. https:\/\/doi.org\/10.1080\/24750263.2024.2434122","journal-title":"Eur Zoological J"},{"issue":"1","key":"3117_CR2","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0304-4165(00)00098-2","volume":"1523","author":"I Ahmad","year":"2000","unstructured":"Ahmad I, Hamid T, Fatima M, Chand HS, Jain SK, Athar M, Raisuddin S (2000) Induction of hepatic antioxidants in freshwater catfish (Channa punctatus Bloch) is a biomarker of paper mill effluent exposure. Biochim et Biophys Acta (BBA)-General Subj 1523(1):37\u201348","journal-title":"Biochim et Biophys Acta (BBA)-General Subj"},{"issue":"6","key":"3117_CR3","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s10661-019-7505-1","volume":"20","author":"T Alharbi","year":"2019","unstructured":"Alharbi T, El-Sorogy A (2019) Assessment of seawater pollution of the Al-Khafji coastal area, Arabian Gulf, Saudi Arabia. Environ Monit Assess 20(6):383. https:\/\/doi.org\/10.1007\/s10661-019-7505-1","journal-title":"Environ Monit Assess"},{"issue":"4","key":"3117_CR4","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.crte.2018.02.002","volume":"350","author":"A Amira","year":"2018","unstructured":"Amira A, Merad I, Almeida CMR, Guimar\u00e3es L, Soltani N (2018) Seasonal variation in biomarker responses of Donax trunculus from the Gulf of Annaba (Algeria): Implication of metal accumulation in sediments. Comptes Rendus G\u00e9oscience 350(4):173\u2013179. https:\/\/doi.org\/10.1016\/j.crte.2018.02.002","journal-title":"ComptesRendus G\u00e9oscience"},{"issue":"1\u20132","key":"3117_CR5","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.marpolbul.2017.06.079","volume":"122","author":"S Amri","year":"2017","unstructured":"Amri S, Samar MF, Sellem F, Ouali K (2017) Seasonal antioxidant responses in the sea urchin Paracentrotus lividus (Lamarck 1816) used as a bioindicator of the environmental contamination in the South-East Mediterranean. Mar Pollut Bull 122(1\u20132):392\u2013402. https:\/\/doi.org\/10.1016\/j.marpolbul.2017.06.079","journal-title":"Mar Pollut Bull"},{"key":"3117_CR122","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1016\/j.ecoenv.2011.07.037","volume":"74","author":"HMR Van den Anselmo","year":"2011","unstructured":"Anselmo HMR, Koerting L, Devito S, Van den Berg JHJ, Dubbeldam M, Kwadijk C, Murk AJ (2011) Early life developmental effects of marine persistent organic pollutants on the sea urchin Psammechinus miliaris. Ecotoxicol Environ Saf 74:2182\u20132192. https:\/\/doi.org\/10.1016\/j.ecoenv.2011.07.037","journal-title":"Ecotoxicol Environ Saf"},{"issue":"1","key":"3117_CR127","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1476-5926-2-4","volume":"2","author":"A Arukwe","year":"2003","unstructured":"Arukwe A, Goks\u00f8yr A (2003) Eggshell and egg yolk proteins in fish: Hepatic proteins for the next generation: Oogenetic, population, and evolutionary implications of endocrine disruption. Comp Hepatol 2(1):4. https:\/\/doi.org\/10.1186\/1476-5926-2-4","journal-title":"Comp Hepatol"},{"issue":"6","key":"3117_CR6","first-page":"180","volume":"6","author":"PD Arya","year":"2018","unstructured":"Arya PD, Joseph ML, Angel M (2018) Determination of lc50 of lead acetate for a fish Oreochromis mossambicus (Peters). International Journal of Fisheries and Aquatic Studies 6(6): 180\u2013182","journal-title":"International Journal of Fisheries and Aquatic Studies"},{"issue":"6","key":"3117_CR7","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1093\/etojnl\/vgaf080","volume":"44","author":"D de Asnicar","year":"2025","unstructured":"Asnicar D, Jonah L, de Jourdan B, Hamoutene D (2025) Exploring cumulative effects of aquaculture chemicals in sediment on adult sea urchin behavioral, immunological, and metabolomic endpoints. Environmental Toxicology and Chemistry. 44(6):1686\u20131695","journal-title":"Environmental Toxicology and Chemistry"},{"issue":"6","key":"3117_CR8","doi-asserted-by":"publisher","first-page":"660","DOI":"10.14202\/vetworld","volume":"9","author":"MA Assi","year":"2016","unstructured":"Assi MA, Hezmee MNM, Haron AW, Sabri MYM, Rajion MA (2016) The detrimental effects of lead on human and animal health. Veterinary World 9(6):660\u2013671. https:\/\/doi.org\/10.14202\/vetworld","journal-title":"Veterinary World"},{"issue":"1","key":"3117_CR9","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ecoenv.2003.10.003","volume":"60","author":"A Avci","year":"2005","unstructured":"Avci A, Ka\u00e7maz M, Durak \u0130 (2005) Peroxidation in muscle and liver tissues from fish in a contaminated river due to a petroleum refinery industry. Ecotoxicol Environ Saf 60(1):101\u2013105","journal-title":"Ecotoxicol Environ Saf"},{"issue":"13","key":"3117_CR11","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.4236\/jwarp.2015.713082","volume":"7","author":"K Baghdad","year":"2015","unstructured":"Baghdad K, Bendraoua A, Hasnaoui AM (2015) Assessment of Marine Pollution at Bay of Oran, Algeria. J Water Resour Prot 7(13):1010\u20131016","journal-title":"J Water Resour Prot"},{"issue":"2","key":"3117_CR10","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.brainres.2005.06.002","volume":"1052","author":"TV Bagnyukova","year":"2005","unstructured":"Bagnyukova TV, Vasylkiv OY, Storey KB, Lushchak VI (2005) Catalase inhibition by amino triazole induces oxidative stress in goldfish brain. Brain Res 1052(2):180\u2013186","journal-title":"Brain Res"},{"key":"3117_CR12","doi-asserted-by":"publisher","first-page":"643972","DOI":"10.3389\/fphar.2021.643972","volume":"12","author":"M Balali-Mood","year":"2021","unstructured":"Balali-Mood M, Naseri K, Tahergorabi Z, Reza Khazdair M, Sadeghi M (2021) Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic. Front Pharmacol 12:643972. https:\/\/doi.org\/10.3389\/fphar.2021.643972","journal-title":"Front Pharmacol"},{"key":"3117_CR13","doi-asserted-by":"publisher","unstructured":"Bankaji I, Kouki R, Dridi N, Ferreira R, Hidouri S, Duarte B, Sleimi N, Ca\u00e7ador I (2023) Comparison of digestion methods using atomic absorption spectrometry for the determination of metal levels in plants. Separations 10(40). https:\/\/doi.org\/10.3390\/separations10010040","DOI":"10.3390\/separations10010040"},{"issue":"4\u20135","key":"3117_CR14","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1080\/13547500400017820","volume":"9","author":"MJ Bebianno","year":"2004","unstructured":"Bebianno MJ, G\u00e9ret F, Hoarau P, Serafim MA, Coelho MR, Gnassia-barelli M, Rom\u00e9o M (2004) Biomarkers in Ruditapes decussatus A potential bioindicator species. Biomarkers 9(4\u20135):305\u2013330. https:\/\/doi.org\/10.1080\/13547500400017820","journal-title":"Biomarkers"},{"issue":"12","key":"3117_CR15","first-page":"11715","volume":"31","author":"S Belabed","year":"2022","unstructured":"Belabed S, Soltani N (2022) Cadmium exposure on Donax trunculus (Mollusca, Bivalvia) lethality parameters and biomarkers responses. Fresenius Environ Bull 31(12):11715\u201311725","journal-title":"Fresenius Environ Bull"},{"issue":"7","key":"3117_CR16","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s10661-022-10059-y","volume":"194","author":"Z Bencheikh","year":"2022","unstructured":"Bencheikh Z, Refes W, Brito PM, Prodocimo MM, Paloma Kachel Gusso-Choueri PK, Choueri RB, Ciro Alberto de Oliveira Ribeiro CAO (2022) Chemical pollution impairs the health of fish species and fishery activities along the Algeria coastline, Mediterranean Sea. Environmental Monitoring and Assessment. 194(7):497. https:\/\/doi.org\/10.1007\/s10661-022-10059-y","journal-title":"Environmental Monitoring and Assessment"},{"key":"3117_CR17","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s40710-015-0075-5","volume":"2","author":"R Benfares","year":"2015","unstructured":"Benfares R, Seridi H, Belkacem Y, Inal A (2015) Heavy Metal Bioaccumulation in Brown Algae Cystoseira compressa in Algerian Coasts. Mediterranean Sea Environ Processes 2:429\u2013439","journal-title":"Mediterranean Sea Environ Processes"},{"issue":"2","key":"3117_CR18","doi-asserted-by":"publisher","first-page":"38","DOI":"10.5281\/zenodo.10936274","volume":"8","author":"D Berdi","year":"2024","unstructured":"Berdi D, Nassouhi D, \u00c7iftci E, G\u00fcner B, Trampac\u0131 B, G\u00fclsoy S, Alt\u0131nda\u011f A (2024) Acute Toxicity of Lead on the Survival of Macrobiotus Hufelandi (Eutardigrada: Parachela: Macrobiotidae). J Wildl Biodivers 8(2):38\u201354. https:\/\/doi.org\/10.5281\/zenodo.10936274","journal-title":"J Wildl Biodivers"},{"key":"3117_CR133","unstructured":"Boletin Oficial del Estado (BOE) or Official Gazette of the State (1991) Normas microbiologicas, limites de contenido en rnetales pesados y metodos analiticos para la determination de etales pesados para os productos de la pesca y de la agricultura. Madrid, Spain: Ed. BOE: 5937-5941."},{"key":"3117_CR120","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3354\/meps07976","volume":"382","author":"C Di Bonaviri","year":"2009","unstructured":"Bonaviri C, Vega Fern\u00e1ndez T, Badalamenti F, Gianguzza P, Di Lorenzo M, Riggio S (2009) Fish versus starfish predat, ion in controlling sea urchin populations in Mediterranean rocky shores. Mar Ecol Prog Ser 382:129\u2013138","journal-title":"Mar Ecol Prog Ser"},{"issue":"2","key":"3117_CR19","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1007\/s10646-021-02504-4","volume":"31","author":"A Bott\u00e9","year":"2022","unstructured":"Bott\u00e9 A, Seguin C, Nahrgang J, Zaidi M, Guery J, Leignel V (2022) Lead in the marine environment: Concentrations and effects on invertebrates. Ecotoxicology 31(2):194\u2013207. https:\/\/doi.org\/10.1007\/s10646-021-02504-4","journal-title":"Ecotoxicology"},{"issue":"5","key":"3117_CR134","first-page":"46","volume":"10","author":"S Boucetta","year":"2016","unstructured":"Boucetta S, Beldi H, Draredja B (2016) Effects of metal pollution on the activities of Acetylcholinesterase and glutathione -S -transferase in Phorcus (Osilinus) turbinatus (Gastropoda, Trochidae) of the coast East-Algerian. Adv Environ Biology 10(5):46\u201360","journal-title":"Adv Environ Biology"},{"issue":"2","key":"3117_CR21","doi-asserted-by":"publisher","first-page":"170","DOI":"10.15421\/012318","volume":"31","author":"K Boudeffa","year":"2023","unstructured":"Boudeffa K, Fekrache F, Bouhayene S, Bouchareb N, Zaoui L, Benselhoub A, Bellucci S (2023) Assessment of metal trace elements in the echinoderm Paracentrotus lividus from the North-Eastern coast of Algeria. Biosystems Divers 31(2):170\u2013176. https:\/\/doi.org\/10.15421\/012318","journal-title":"Biosystems Divers"},{"key":"3117_CR20","first-page":"297","volume":"38","author":"CF Boudouresque","year":"2013","unstructured":"Boudouresque CF, Verlaque M (2013) Paracentrotus lividus, Biology and EcologyIn: JM Lawrence (Ed)Developments in aquaculture and fisheries science. Elsevier 38:297\u2013327","journal-title":"Elsevier"},{"key":"3117_CR22","doi-asserted-by":"publisher","first-page":"169492","DOI":"10.1016\/j.scitotenv.2023.169492","volume":"915","author":"S Bouiba","year":"2024","unstructured":"Bouiba S, Bendimerad MEA, Rouane-Hacene O, Ahmed Boualga A, Richir J (2024) Metallic trace element dynamics in Paracentrotus lividus from Algeria: Environmental large-scale survey and human health risk assessmen. Sci Total Environ 915:169492. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.169492","journal-title":"Sci Total Environ"},{"key":"3117_CR23","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/bf00282901","volume":"57\u201358","author":"BP Bourgoin","year":"1991","unstructured":"Bourgoin BP, Risk MJ, Evans RD, Cornett RJ (1991) Relationships between the Partitioning of Lead in Sediments and Its Accumulation in the Marine Mussel, Mytilus edulis near a Lead Smelter. Water Air Soil Pollut 57\u201358:377\u2013386. https:\/\/doi.org\/10.1007\/bf00282901","journal-title":"Water Air Soil Pollut"},{"key":"3117_CR24","doi-asserted-by":"publisher","first-page":"116006","DOI":"10.1016\/j.marpolbul.2023.116006","volume":"199","author":"H Bouzahouane","year":"2024","unstructured":"Bouzahouane H, Kouki R, Amri S, Barour C, Sleimi N, Ouali K (2024) Investigating seasonal metal impact on Stramonita haemastoma gastropod along the Algerian East Coast: Understanding through various pollution indicators. Mar Pollut Bull 199:116006. https:\/\/doi.org\/10.1016\/j.marpolbul.2023.116006","journal-title":"Mar Pollut Bull"},{"key":"3117_CR25","first-page":"12749","volume":"30","author":"R Bouzenda","year":"2021","unstructured":"Bouzenda R, Soltani N, Khebbeb MEH (2021) Spatio-temporal variation in biomarker responses and biochemical composition in the fish Liza aurata from the gulf of Annaba (Algeria): Relation with the environmental pollution. Fresenius Environ Bull 30:12749\u201312758","journal-title":"Fresenius Environ Bull"},{"key":"3117_CR26","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254. https:\/\/doi.org\/10.1016\/0003-2697(76)90527-3","journal-title":"Anal Biochem"},{"key":"3117_CR27","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.marenvres.2015.06.015","volume":"111","author":"P Buri\u0107","year":"2015","unstructured":"Buri\u0107 P, Jak\u0161i\u0107 \u017d, \u0160tajner L, Dutour Sikiri\u0107 M, Jura\u0161in D, Cascio C, Calzolai L, Lyons DM (2015) Effect of silver nanoparticles on Mediterranean sea urchin embryonal development is species specific and depends on moment of first exposure. Mar Environ Res 111:50\u201359. https:\/\/doi.org\/10.1016\/j.marenvres.2015.06.015","journal-title":"Mar Environ Res"},{"issue":"1","key":"3117_CR28","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1080\/10807039.2014.890480","volume":"21","author":"J Cabral-Oliveira","year":"2015","unstructured":"Cabral-Oliveira J, Pratas J, Mendes S, Pardal MA (2015) Trace elements in edible rocky shore species: Effect of sewage discharges and human health risk implications. Hum Ecol Risk Assess 21(1):135\u2013145. https:\/\/doi.org\/10.1080\/10807039.2014.890480","journal-title":"Hum Ecol Risk Assess"},{"issue":"1","key":"3117_CR29","first-page":"1","volume":"26","author":"JE Celis","year":"2015","unstructured":"Celis JE, Espejo W, Barra R, Gonzalez-Acu\u00f1a D, Gonzalez F, Jara S (2015) Assessment of trace metals in droppings of Ad\u00e9lie penguins (Pygoscelisadeliae) from different locations of the Antarctic Peninsula area. Adv Polar Sci 26(1):1\u20137. https:\/\/doi.org\/10.13679\/j","journal-title":"Adv Polar Sci"},{"issue":"S1","key":"3117_CR30","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3989\/scimar.2004.68s1205","volume":"68","author":"A Cesar","year":"2004","unstructured":"Cesar A, Mar\u00edn-Guirao L, Vita R, Mar\u00edn A (2004) Amphipod and sea urchin tests to assess the toxicity of Mediterranean sediments: The case of Portm\u00e1n Bay. Scientia Mar 68(S1):205\u2013213","journal-title":"Scientia Mar"},{"key":"3117_CR31","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1007\/s13762-013-0310-4","volume":"11","author":"S Chakraborty","year":"2013","unstructured":"Chakraborty S, Owens G (2013) Metal distributions in seawater, sediment and marine benthic macroalgae from the South Australian coastline. Int J Environ Sci Technol 11:1259\u20131270. https:\/\/doi.org\/10.1007\/s13762-013-0310-4","journal-title":"Int J Environ Sci Technol"},{"key":"3117_CR32","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.envpol.2019.04.140","volume":"251","author":"CY Chan","year":"2019","unstructured":"Chan CY, Wang WX (2019) Biomarker responses in oysters Crassostrea hongkongensis in relation to metal contamination patterns in the Pearl River estuary, southern China. Environ Pollut 251:264\u2013276. https:\/\/doi.org\/10.1016\/j.envpol.2019.04.140","journal-title":"Environ Pollut"},{"issue":"7","key":"3117_CR33","first-page":"681","volume":"109","author":"AO Cheek","year":"2001","unstructured":"Cheek AO, Brouwer TH, Carroll S, Manning S, McLachlan JA, Brouwer M (2001) Experimental evaluation of vitellogenin as a predictive biomarker for reproductive disruption. Environmental Health Perspectives 109(7):681-690.","journal-title":"EnvironmentalHealth Perspect"},{"issue":"4","key":"3117_CR123","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/s12192-019-01010-1","volume":"24","author":"R Chiarelli","year":"2019","unstructured":"Chiarelli R, Martino C, Roccheri MC (2019) Cadmium stress effects indicating marine pollution in different species of sea urchin employed as environmental bioindicators. Cell Stress Chaperones 24(4):675\u2013687. https:\/\/doi.org\/10.1007\/s12192-019-01010-1","journal-title":"Cell Stress Chaperones"},{"key":"3117_CR35","unstructured":"Cossu C, Doyotte A, Jacquin MC, Vasseur P (1997) Biomarqueurs du stress oxydant chez les animaux aquatiques. In:  Biomarqueurs en \u00e9cotoxicology - Aspects fondamentaux(eds. Lagadic L, Caquet T, Amiart JC, Ramade F), pp. 149\u2013163, Paris"},{"issue":"12","key":"3117_CR36","doi-asserted-by":"publisher","first-page":"875","DOI":"10.3390\/toxics12120875","volume":"12","author":"S Davidova","year":"2024","unstructured":"Davidova S, Milushev V, Satchanska G (2024) The Mechanisms of Cadmium Toxicity in Living Organisms. Toxics 12(12):875","journal-title":"Toxics"},{"key":"3117_CR37","first-page":"165","volume":"3","author":"S Dermeche","year":"2012","unstructured":"Dermeche S, Chahrour F, Boutiba Z (2012) Evaluation of the toxicity of metal pollutants on embryonic development of the sea urchin Paracentrotus lividus (Lamarck, 1816) (Echinodermata Echinoidea). Biodivers J 3:165\u2013172","journal-title":"Biodivers J"},{"key":"3117_CR38","doi-asserted-by":"publisher","first-page":"616488","DOI":"10.3389\/fmars.2021.616488","volume":"8","author":"C Di Bella","year":"2021","unstructured":"Di Bella C, Calagna A, Cammilleri G, Schembri P, Lo Monaco D, Cipr\u00ec V, Battaglia L, Barbera G, Ferrantelli V, Sadok S, Tliba I (2021) Risk assessment of cadmium, lead, and mercury on human health in relation to the consumption of farmed sea bass in Italy: ameta-analytical approach. Front Mar Sci 8:616488","journal-title":"Front Mar Sci"},{"key":"3117_CR39","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1007\/BF01225012","volume":"18","author":"P Dinnel","year":"1989","unstructured":"Dinnel P, Link J, Stober Q, Letourneau M, Roberts W (1989) Comparative sensitivity of sea urchin sperm bioassays to metals and pesticides. Arch Environ Contam Toxicol 18:748\u2013755. https:\/\/doi.org\/10.1007\/BF01225012","journal-title":"Arch Environ Contam Toxicol"},{"key":"3117_CR40","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.sajb.2022.08.047","volume":"150","author":"N Dridi","year":"2022","unstructured":"Dridi N, Bouslimi H, Ca\u00e7ador I, Sleimi N (2022) Lead tolerance, accumulation and translocation in two Asteraceae plants: Limbarda crithmoides and Helianthus annuus. South Afr J Bot 150:986\u2013996. https:\/\/doi.org\/10.1016\/j.sajb.2022.08.047","journal-title":"South Afr J Bot"},{"issue":"3","key":"3117_CR41","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.15244\/pjoes\/67529","volume":"26","author":"Z Drira","year":"2017","unstructured":"Drira Z, Sahnoun H, Ayadi H (2017) Spatial distribution and source identification of heavy metals in surface waters of three coastal areas of Tunisia. Pol J Environ Stud 26(3):1057\u20131069. https:\/\/doi.org\/10.15244\/pjoes\/67529","journal-title":"Pol J Environ Stud"},{"key":"3117_CR42","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.freeradbiomed.2013.05.023","volume":"63","author":"C Du","year":"2013","unstructured":"Du C, Anderson A, Lortie M, Parsons R, Bodnar A (2013) Oxidative damage and cellular defense mechanisms in sea urchin models of aging. Free Radic Biol Med 63:254\u2013263. https:\/\/doi.org\/10.1016\/j","journal-title":"Free Radic Biol Med"},{"key":"3117_CR43","doi-asserted-by":"publisher","first-page":"114092","DOI":"10.1016\/j.marpolbul.2022.114092","volume":"183","author":"O El Idrissi","year":"2022","unstructured":"El Idrissi O, Santini J, Bonnin M, Demolliens SM, Aiello M, Gobert AS, Pasqualini SV, Ternengo VS S (2022) Stress response to trace elements mixture of different embryo-larval stages of Paracentrotus lividus. Mar Pollut Bull 183:114092. https:\/\/doi.org\/10.1016\/j.marpolbul.2022.114092","journal-title":"Mar Pollut Bull"},{"key":"3117_CR44","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.etap.2013.04.019","volume":"36","author":"C Ensibi","year":"2013","unstructured":"Ensibi C, Pe \u0301rez-Lo \u0301pez M, Soler Rodr\u0131 \u0301guez F, M\u0131 \u0301guez-Santiya \u0301n MP, Daly Yahia MN, Hern\u00e1ndez -Moreno D (2013) Effects of deltamethrin on biometric parameters and liver biomarkers in common carp (Cyprinus carpio L.). Environmental Toxicology and Pharmacology 36:384\u2013391","journal-title":"Environmental Toxicology and Pharmacology"},{"key":"3117_CR45","unstructured":"Fabre MC, Descamps M, Baert J-L (1992) Identification and partial characterization of vitellin and vitellogenin from Scolopendra cingulata LATREILLE (Myriapoda Chilopoda). In: Meyer E, Thaler K, Schedl W (Eds) Advances in Myriapodology 117\u2013121"},{"issue":"4","key":"3117_CR46","first-page":"51","volume":"11","author":"BA Falusi","year":"2007","unstructured":"Falusi BA, Olanipekun EO (2007) Bioconcentration factors of heavy metals in tropical crab (Carcinus sp) from River Aponwe, Ado-Ekiti. Nigeria Appl Sci Environ Manage 11(4):51\u201354. https:\/\/tspace.library.utoronto.ca\/handle\/1807\/51574","journal-title":"Nigeria Appl Sci Environ Manage"},{"key":"3117_CR47","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1023\/A:1016703116830","volume":"10","author":"N Fern\u00e1ndez","year":"2001","unstructured":"Fern\u00e1ndez N, Beiras R (2001) Combined toxicity of dissolved mercury with copper, lead and cadmium on embryogenesis and early larval growth of the Paracentrotus Lividus sea-urchin. Ecotoxicology 10:263\u2013271. https:\/\/doi.org\/10.1023\/A:1016703116830","journal-title":"Ecotoxicology"},{"key":"3117_CR48","doi-asserted-by":"publisher","first-page":"139896","DOI":"10.1016\/j.chemosphere.2023.139896","volume":"340","author":"CS Ferreira","year":"2023","unstructured":"Ferreira CS, Ribeiro YM, Moreira DP, Paschoalini AL, Bazzoli N, Rizzo E (2023) Reproductive toxicity induced by lead exposure: Effects on gametogenesis and sex steroid signaling in teleost fish. Chemosphere 340:139896. https:\/\/doi.org\/10.1016\/j","journal-title":"Chemosphere"},{"key":"3117_CR49","first-page":"92","volume":"3","author":"P Galle","year":"1980","unstructured":"Galle P, Berry JP (1980) The role of acid phosphatases in the concentration of some mineral elements in lysosomes. Electron Microsc 3:92\u201393","journal-title":"Electron Microsc"},{"issue":"1","key":"3117_CR51","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1006\/eesa","volume":"46","author":"A Gomot-De Vaufleury","year":"2000","unstructured":"Gomot-De Vaufleury A (2000) Standardized growth toxicity testing (Cu, Zn, Pb, and pentachlorophenol) with Helix aspersa. Ecotoxicology and. Environ Saf 46(1):41\u201350. https:\/\/doi.org\/10.1006\/eesa","journal-title":"Environ Saf"},{"key":"3117_CR52","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0891-5849(87)80012-6","volume":"3","author":"R Greenwald","year":"1987","unstructured":"Greenwald R (1987) CRC Handbook of methods for oxygen radical research. Free Radic Biol Med 3:161. https:\/\/doi.org\/10.1016\/S0891-5849(87)80012-6","journal-title":"Free Radic Biol Med"},{"key":"3117_CR53","doi-asserted-by":"publisher","first-page":"711","DOI":"10.3390\/w13050711","volume":"13","author":"C Gregorin","year":"2021","unstructured":"Gregorin C, Albarano L, Somma E, Costantini M, Zupo V (2021) Assessing the ecotoxicity of copper and polycyclic aromatic hydrocarbons: comparison of effects on Paracentrotus lividus and Botryllus schlosseri, as alternative bioassay methods. Water 13:711. https:\/\/doi.org\/10.3390\/w13050711","journal-title":"Water"},{"key":"3117_CR54","doi-asserted-by":"publisher","first-page":"113831","DOI":"10.1016\/j.marpolbul.2022.113831","volume":"181","author":"H Grini","year":"2022","unstructured":"Grini H, Metallaoui S, Gonz\u00e1lez-Fern\u00e1ndez D, Bensouilah M (2022) First evidence of plastic pollution in beach sediments of the Skikda coast (northeast of Algeria). Mar Pollut Bull 181:113831. https:\/\/doi.org\/10.1016\/j.marpolbul.2022.113831","journal-title":"Mar Pollut Bull"},{"key":"3117_CR55","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.tox.2003.09.009","volume":"195","author":"H Gurer-Orhan","year":"2004","unstructured":"Gurer-Orhan H, Sabir HU, Ozgunes H (2004) Correlation between clinical indicators of lead poisoning and oxidative stress parameters in controls and lead-exposed workers. Toxicology 195:147\u2013154","journal-title":"Toxicology"},{"key":"3117_CR56","doi-asserted-by":"publisher","first-page":"33","DOI":"10.26471\/cjees\/2024\/019\/278","volume":"19","author":"A Hafsi","year":"2024","unstructured":"Hafsi A, Ahcene B, Kessasra F, Abdellah B (2024) Environmental assessment of pollution in an industrial environment using heavy metal pollution indices and stable isotopes, case study of the industrial zone of Skikda, North-East of Algeria. Carpathian J Earth Environ Sci 19:33\u201350. https:\/\/doi.org\/10.26471\/cjees\/2024\/019\/278","journal-title":"Carpathian J Earth Environ Sci"},{"key":"3117_CR57","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1073\/pnas","volume":"104","author":"A Hamdoun","year":"2007","unstructured":"Hamdoun A, Epel D (2007) Embryo stability and vulnerability in an always changing world. Proc Natl Acad Sci USA 104:1745\u20131750. https:\/\/doi.org\/10.1073\/pnas","journal-title":"Proc Natl Acad Sci USA"},{"key":"3117_CR58","doi-asserted-by":"publisher","first-page":"1140001","DOI":"10.1080\/23311843.2016.1140001","volume":"2","author":"MR Hasan","year":"2016","unstructured":"Hasan MR, Khan MZH, Khan M, Aktar S, Rahman M, Hossain F, Hasan ASMM (2016) Heavy metals distribution and contamination in surface water of the Bay of Bengal coast. Cogent Environ Sci 2:1140001. https:\/\/doi.org\/10.1080\/23311843.2016.1140001","journal-title":"Cogent Environ Sci"},{"key":"3117_CR59","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.sajce.2021.04.002","volume":"37","author":"CW Hee","year":"2021","unstructured":"Hee CW, Shing WL, Chi CK (2021) Effect of Lead (Pb) exposure towards green microalgae (Chlorella vulgaris) on the changes of physicochemical parameters in water. S Afr J Chem Eng 37:252\u2013255. https:\/\/doi.org\/10.1016\/j.sajce.2021.04.002","journal-title":"S Afr J Chem Eng"},{"issue":"1","key":"3117_CR124","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/s0300-483x(02)00380-3","volume":"180","author":"PC Hsu","year":"2002","unstructured":"Hsu PC, Guo YL (2002) Antioxidant nutrients and lead toxicity. Toxicology 180(1):33\u201344. https:\/\/doi.org\/10.1016\/s0300-483x(02)00380-3","journal-title":"Toxicology"},{"issue":"4","key":"3117_CR131","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ajme.2017.09.001","volume":"54","author":"OM Ighodaro","year":"2018","unstructured":"Ighodaro OM, Akinloye OA (2018) First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): their fundamental role in the entire antioxidant defence grid. Alexandria J Med 54(4):287\u2013293. https:\/\/doi.org\/10.1016\/j.ajme.2017.09.001","journal-title":"Alexandria J Med"},{"issue":"1","key":"3117_CR60","first-page":"107","volume":"31","author":"RN Jackson","year":"2005","unstructured":"Jackson RN, Baird D, Els S (2005) The effect of the heavy metals lead (Pb2+) and zinc (Zn2+) onthe brood and larval development of the burrowing crustacean. Callianassa kraussi. Water Sa 31(1):107\u2013116","journal-title":"Callianassakraussi Water Sa"},{"key":"3117_CR61","doi-asserted-by":"publisher","unstructured":"Jozefczak M, Remans T, Vangronsveld J, Cuypers A (2012) Glutathione is a key player in metal-induced oxidative stress defenses. Int J Mol Sci 13(3). https:\/\/doi.org\/10.3390\/ijms13033145","DOI":"10.3390\/ijms13033145"},{"key":"3117_CR62","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1080\/09593330.2004.9619399","volume":"25","author":"M Kehal","year":"2004","unstructured":"Kehal M, Mennour A, Reinert L, Fuzellier H (2004) Heavy metals in water of the Skikda Bay. Environ Technol 25:1059\u20131065. https:\/\/doi.org\/10.1080\/09593330.2004.9619399","journal-title":"Environ Technol"},{"key":"3117_CR63","first-page":"102943","volume":"62","author":"B Khellaf","year":"2023","unstructured":"Khellaf B, Bouayad L, Benouadah A, Hamdi TM, Chekri R, Jitaru P (2023) Arsenic, mercury, cadmium and lead contents in Algerian continental and marine farming fish and human health risk assessment due to their consumption. Reg Stud Mar Sci 62:102943. https:\/\/doi.org\/10.1016\/j","journal-title":"Reg Stud Mar Sci"},{"issue":"4","key":"3117_CR64","doi-asserted-by":"publisher","first-page":"865","DOI":"10.31396\/Biodiv","volume":"12","author":"N Kheroufi","year":"2021","unstructured":"Kheroufi N, Hamdani A, Soltani N (2021) Acute exposure of cadmium on Donax trunculus Linnaeus, 1758 (Mollusca Bivalvia) during the vitellogenesis process: Histological and biochemical aspects. Biodivers J 12(4):865\u2013873. https:\/\/doi.org\/10.31396\/Biodiv","journal-title":"Biodivers J"},{"key":"3117_CR119","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.chemosphere.2016.12.094","volume":"171","author":"J-H Kim","year":"2017","unstructured":"Kim J-H, Kang J-C (2017) Effects of sub-chronic exposure to lead (Pb) and ascorbic acid in juvenile rockfish: Antioxidant responses, MT gene expression, and neurotransmitters. Chemosphere 171:520\u2013527. https:\/\/doi.org\/10.1016\/j.chemosphere.2016.12.094","journal-title":"Chemosphere"},{"issue":"2","key":"3117_CR65","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s13530-016-0270-4","volume":"8","author":"H Kim","year":"2016","unstructured":"Kim H, Lim B, Kim B- (2016) Effects of heavy metals on transcription and enzyme activity of Na+\/K+-ATPase in the monogonont rotifer, Brachionus koreanus. Toxicol Environ Health Sci 8(2):128\u2013134. https:\/\/doi.org\/10.1007\/s13530-016-0270-4","journal-title":"Toxicol Environ Health Sci"},{"issue":"4","key":"3117_CR72","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1007\/s11356-013-2184-x","volume":"21","author":"E \u0141uszczek-Trojnar","year":"2014","unstructured":"\u0141uszczek-Trojnar E, Dr\u0105g-Kozak E, Szczerbik P, Socha M, Popek W (2014) Effect of long-term dietary lead exposure on some maturation and reproductive parameters of a female Prussian carp (Carassius gibelio B). Environ Sci Pollut Res 21(4):2465\u20132478. https:\/\/doi.org\/10.1007\/s11356-013-2184-x","journal-title":"Environ Sci Pollut Res"},{"key":"3117_CR117","unstructured":"Lamarck JB (1816) Histoire naturelle des animaux sans vert\u00e8bres. Verdiere, Librarie, Quai des Augustins, Paris."},{"key":"3117_CR67","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.etap.2019.03.010","volume":"68","author":"JW Lee","year":"2019","unstructured":"Lee JW, Choi H, Hwang UK, Kang JC, KangYJ,Kim K, Kim JH (2019) Toxic effects of lead exposure on bioaccumulation, oxidative stress, neurotoxicity, and immune responses in fish: A review. Environ Toxicol Pharmacol 68:101\u2013108","journal-title":"Environ Toxicol Pharmacol"},{"issue":"2","key":"3117_CR68","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/BF00224804","volume":"26","author":"P Lemaire","year":"1994","unstructured":"Lemaire P, Matthews A, F\u00f6rlin L, Livingstone DR (1994) Stimulation of oxyradical production of hepatic microsomes of flounder (Platichthysflesus) and perch (Perca fluviatilis) by model and pollutant xenobiotics. Arch Environ Contam Toxicol 26(2):191\u2013200. https:\/\/doi.org\/10.1007\/BF00224804","journal-title":"Arch Environ Contam Toxicol"},{"key":"3117_CR69","doi-asserted-by":"publisher","first-page":"118631","DOI":"10.1016\/j.ecoenv.2025.118631","volume":"302","author":"F Liu","year":"2025","unstructured":"Liu F, Reinardy HC, Last KS, Henry TB (2025) Environmentally-Relevant Hydrogen Peroxide Exposure Induces DNA Damage and Elevates Coelomocyte Concentrations in the Sea Urchin Paracentrotus lividusas. Ecotoxicol Environ Saf 302:118631. https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118631","journal-title":"Ecotoxicol Environ Saf"},{"key":"3117_CR70","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0048-9697(01)00822-1","volume":"280","author":"P Lopes","year":"2002","unstructured":"Lopes P, Pinheiro T, Santos M, Mathias MdaL, Collares-Pereira M, Viegas-Crespo A (2002) Response of antioxidant enzymes in freshwater fish populations (Leuciscus alburnides complex) to inorganic pollutants exposure. Sci Total Environ 280:153\u2013163. https:\/\/doi.org\/10.1016\/S0048-9697(01)00822-1","journal-title":"Sci Total Environ"},{"key":"3117_CR71","doi-asserted-by":"publisher","first-page":"151070","DOI":"10.1016\/j.scitotenv.2021.151070","volume":"807","author":"M Luo","year":"2022","unstructured":"Luo M, Zhang Y, Li H, Hu W, Xiao K, Yu S, Zheng C, Wang X (2022) Pollution assessment and sources of dissolved heavy metals in coastal water of a highly urbanized coastal area: The role of groundwater discharge. Sci Total Environ 807:151070","journal-title":"Sci Total Environ"},{"key":"3117_CR126","doi-asserted-by":"publisher","first-page":"118426","DOI":"10.1016\/j.marpolbul.2025.118426","volume":"220","author":"MM Mahmoud","year":"2025","unstructured":"Mahmoud MM, Elshebrawy HA, Sallam KI (2025) Health risk assessment of heavy metals-contaminated marine fishes from the Mediterranean Sea at Damietta city coast, Egypt. Mar Pollut Bull 220:118426. https:\/\/doi.org\/10.1016\/j.marpolbul.2025.118426","journal-title":"Mar Pollut Bull"},{"issue":"3\u20134","key":"3117_CR74","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1515\/bnm-2013-0016","volume":"14","author":"D Manno","year":"2013","unstructured":"Manno D, Serra A, Buccolieri A, Panzarini E, Carata E, Tenuzzo B, Izzo D, Vergallo C, Rossi M, Dini L (2013) Silver and carbon nanoparticles toxicity in sea urchin Paracentrotus lividus embryos. Bio Nano Materials 14(3\u20134):229\u2013238. https:\/\/doi.org\/10.1515\/bnm-2013-0016","journal-title":"BioNanoMaterials"},{"issue":"9","key":"3117_CR75","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.marpolbul.2004.02.037","volume":"48","author":"MG Marin","year":"2004","unstructured":"Marin MG, Matozzo V (2004) Vitellogenin induction as a biomarker of exposure to estrogenic compounds in aquatic environments. Mar Pollut Bull 48(9):835\u2013839","journal-title":"Mar Pollut Bull"},{"key":"3117_CR76","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.envint.2007.09.008","volume":"34","author":"V Matozzo","year":"2008","unstructured":"Matozzo V, Gagn\u00e9 F, Marin M, Ricciardi F, Blaise C (2008) Vitellogenin as a biomarker of exposure to estrogenic compounds in aquatic invertebrates. Environ Int 34:531\u2013545. https:\/\/doi.org\/10.1016\/j","journal-title":"Environ Int"},{"issue":"11","key":"3117_CR77","doi-asserted-by":"publisher","first-page":"4965","DOI":"10.3390\/app11114965","volume":"11","author":"C Merola","year":"2021","unstructured":"Merola C, Bisegna A, Angelozzi G, Conte A, Abete MC, Stella C, Pederiva S, Faggio C, Riganelli N, Perugini M (2021) Study of heavy metals pollution and vitellogenin levels in brown trout (Salmo trutta trutta) wild fish populations. Appl Sci 11(11):4965. https:\/\/doi.org\/10.3390\/app11114965","journal-title":"Appl Sci"},{"key":"3117_CR78","doi-asserted-by":"publisher","first-page":"125337","DOI":"10.1016\/j.chemosphere.2019.125337","volume":"243","author":"X Miao","year":"2020","unstructured":"Miao X, Hao Y, Tang X, Xie Z, Liu L, Luo S, Huang Q, Zou S, Zhang C, Li J (2020) Analysis and health risk assessment of toxic and essential elements of the wild fish caught by anglers in Liuzhou as a large industrial city of China. Chemosphere 243:125337. https:\/\/doi.org\/10.1016\/j","journal-title":"Chemosphere"},{"key":"3117_CR130","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s00128-019-02693-z","volume":"103","author":"MS Mnkandla","year":"2019","unstructured":"Mnkandla MS, Basopo N, Siwela AH (2019) The Effect of Persistent Heavy Metal Exposure on Some Antioxidant Enzyme Activities and Lipid Peroxidation of the Freshwater snail, Lymnaea natalensis. Bull Environ Contam Toxicol 103:515\u2013558. https:\/\/doi.org\/10.1007\/s00128-019-02693-z","journal-title":"Bull Environ Contam Toxicol"},{"key":"3117_CR80","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.aquatox.2017.02.011","volume":"185","author":"AM Moncaleano-Ni\u00f1o","year":"2017","unstructured":"Moncaleano-Ni\u00f1o AM, Barrios-Latorre SA, Poloche-Hern\u00e1ndez JF, Becquet V, Huet V, Villamil L, Thomas-Guyon H, Ahrens MJ, Luna-Acosta A (2017) Alterations of tissue metallothionein and vitellogenin concentrations in tropical cup oysters (Saccostrea sp.) following short-term (96\u00a0h) exposure to cadmium. Aquat Toxicol 185:160\u2013170. http:\/\/dx.doi.org\/10.1016\/j","journal-title":"Aquat Toxicol"},{"issue":"2","key":"3117_CR81","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.cbpc.2013.04.004","volume":"158","author":"SR Nadella","year":"2013","unstructured":"Nadella SR, Tellis M, Diamond RSS, Bianchini A, Wood CM (2013) Toxicity of lead and zinc to developing mussel and sea urchin embryos: Critical tissue residues and effects of dissolved organic matter and salinity. Comp Biochem Physiol C: Toxicol Pharmacol 158(2):72\u201383. https:\/\/doi.org\/10.1016\/j.cbpc.2013.04.004","journal-title":"Comp Biochem Physiol C: Toxicol Pharmacol"},{"issue":"1\u20132","key":"3117_CR129","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0166-445X(01)00226-0","volume":"58","author":"A Orbea","year":"2002","unstructured":"Orbea A, Ortiz-Zarragoitia M, Sole M, Porte C, Cajaraville MP (2002) Antioxidant enzymes and peroxisome proliferation in relation to contaminant body burdens of PAHs and PCBs in bivalve molluscs, crabs and fish from the Urdaibai and Plentzia estuaries (Bay of Biscay). Aquat Toxicol 58(1\u20132):75\u201398","journal-title":"Aquat Toxicol"},{"issue":"1","key":"3117_CR82","first-page":"49","volume":"3","author":"Y Ozvarol","year":"2009","unstructured":"Ozvarol Y, Turna II (2009) Determination of Some Biological Properties of Paracentrotus lividus(Lamarck, 1816) in Antalya Gulf Shores. J Appl Biol Sci 3(1):49\u201352","journal-title":"J Appl Biol Sci"},{"issue":"1","key":"3117_CR125","first-page":"55","volume":"5","author":"E Parvin","year":"2011","unstructured":"Parvin E, Kawser Ahmed M, Monirul Islam M, Akter MS, Kabir MA (2011) Preliminary acute toxicity bioassays of lead and cadmiumon fresh water climbing perch, Anabas testudineus (Bloch). Terr Aquat Environ Toxicol 5(1):55\u201358","journal-title":"Terr Aquat Environ Toxicol"},{"key":"3117_CR84","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.envpol.2018.01.041","volume":"237","author":"A Rabei","year":"2018","unstructured":"Rabei A, Hichami A, Beldi H, Bellenger S, Khan NA, Soltani N (2018) Fatty acid composition, enzyme activities and metallothioneins in Donax trunculus (Mollusca, Bivalvia) from polluted and reference sites in the Gulf of Annaba (Algeria): Pattern of recovery during transplantation. Environ Pollut 237:900\u2013907. https:\/\/doi.org\/10.16\/j","journal-title":"Environ Pollut"},{"issue":"3","key":"3117_CR85","first-page":"184","volume":"21","author":"MA Randhawa","year":"2009","unstructured":"Randhawa MA (2009) Calculation of LD50 values from the method of Miller and Tainter, 1944. J Ayub Med Coll Abbottabad 21(3):184\u2013185","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"3117_CR118","doi-asserted-by":"publisher","first-page":"115744","DOI":"10.1016\/j.envpol.2020.115744","volume":"269","author":"F Rendell-Bhatti","year":"2021","unstructured":"Rendell-Bhatti F, Paganos P, Pouch A, Mitchell C, D'Aniello S, Godley BJ, Pazdro K, Arnone MI, Jimenez-Guri E (2021) Developmental toxicity of plastic leachates on the sea urchin Paracentrotus lividus. Environ Pollut 269:115744. https:\/\/doi.org\/10.1016\/j.envpol.2020.115744","journal-title":"Environ Pollut"},{"issue":"2\u20133","key":"3117_CR128","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0166-445X(99)00039-9","volume":"48","author":"M Rom\u00e9o","year":"2000","unstructured":"Rom\u00e9o M, Bennani N, Gnassia-Barelli M, Lafaurie M, Girard JP (2000) Cadmium and copper display different responses towards oxidative stress in the kidney of the sea bass Dicentrarchus labrax. Aquat Toxicol 48(2\u20133):185\u2013194","journal-title":"Aquat Toxicol"},{"key":"3117_CR86","doi-asserted-by":"publisher","first-page":"11238","DOI":"10.1007\/s11356-017-8946-0","volume":"25","author":"O Rouane-Hacene","year":"2018","unstructured":"Rouane-Hacene O, Boutiba Z, Benaissa M, Belhaouari B, Francour P, Guibbolini-Sabatier ME, Risso-De Faverney C (2018) Seasonal assessment of biological indices, bioaccumulation,and bioavailability of heavy metals in sea urchins Paracentrotus lividus from Algerian west coast, applied to environmental monitoring. Environ Sci Pollut Res 25:11238\u201311251. https:\/\/doi.org\/10.1007\/s11356-017-8946-0","journal-title":"Environ Sci Pollut Res"},{"issue":"1","key":"3117_CR88","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1515\/REVEH.2009.24.1.15","volume":"24","author":"T Sanders","year":"2009","unstructured":"Sanders T, Liu Y, Buchner V, Tchounwou PB (2009) Neurotoxiceffects and biomarkers of lead exposure: a review. Rev Environ Health 24(1):15\u201346","journal-title":"Rev Environ Health"},{"issue":"2","key":"3117_CR90","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S0147-6513(03)00009-5","volume":"56","author":"I Sayeed","year":"2003","unstructured":"Sayeed I, Parvez S, Pandey S, Bin-Hafeez B, Haque R, Raisuddin (2003) Oxidative stress biomarkers of exposure to deltamethrin in freshwater fish, Channa punctatus Bloch. Ecotoxicol Environ Saf 56(2):295\u2013301.","journal-title":"Ecotoxicol Environ Saf"},{"issue":"1","key":"3117_CR91","doi-asserted-by":"publisher","first-page":"113","DOI":"10.15421\/012312","volume":"31","author":"A Sebbih","year":"2023","unstructured":"Sebbih A, Moumeni N, Belfetmi NZ, Daas T, Maamcha O (2023) Marine pollution effects on the reproduction process of Perinereis cultrifera (Annelida, Polychaeta) in Algeria. Biosystems Divers 31(1):113\u2013122. https:\/\/doi.org\/10.15421\/012312","journal-title":"Biosystems Divers"},{"key":"3117_CR92","doi-asserted-by":"publisher","first-page":"3865","DOI":"10.1073\/pnas.83.11.3865","volume":"83","author":"A-B Shyu","year":"1986","unstructured":"Shyu A-B, Raff RA, Blumenthal T (1986) Expression of the vitellogenin gene in female and male sea urchin. Proc Natl Acad Sci USA 83:3865\u20133869. https:\/\/doi.org\/10.1073\/pnas.83.11.3865","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"3117_CR93","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.chemosphere.2007.11.025","volume":"71","author":"I Sioen","year":"2008","unstructured":"Sioen I, Van Camp J, Verdonck F, Verbeke W, Vanhonacker F, Willems J, De Henauw S (2008) Probabilistic intake assessment of multiple compounds as a tool to quantify the nutritional-toxicological conflict related to seafood consumption. Chemosphere 71(6):1056\u20131066. https:\/\/doi.org\/10.1016\/j.chemosphere.2007.11.025","journal-title":"Chemosphere"},{"issue":"3","key":"3117_CR94","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.3390\/su14031428","volume":"14","author":"N Sleimi","year":"2022","unstructured":"Sleimi N, Bankaji I, Kouki R, Dridi N, Duarte BCa\u00e7adorI (2022) Assessment of extraction methods of trace metallic elements in plants: approval of a common method. Sustain (Switzerland) 14(3):1428. https:\/\/doi.org\/10.3390\/su14031428","journal-title":"Sustain (Switzerland)"},{"issue":"1\u20134","key":"3117_CR95","first-page":"51","volume":"137","author":"N Soltani","year":"2012","unstructured":"Soltani N, Amira A, Sifi K, Beldi H (2012) Environmental monitoring of the Annaba gulf (Algeria): Measurement of biomarkers in Donax trunculus and metallic pollution. Bull Soc zool Fr 137(1\u20134):51\u201360","journal-title":"Bull Soc zool Fr"},{"issue":"4","key":"3117_CR96","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1007\/s11356-012-1459-y","volume":"20","author":"K Srikanth","year":"2013","unstructured":"Srikanth K, Pereira E, Duarte AC, Ahmad I (2013) Glutathione and its dependent enzymes\u2019 modulatory responses to toxic metals and metalloids in fish A review. Environ Sci Pollut Res 20(4):2133\u20132149. https:\/\/doi.org\/10.1007\/s11356-012-1459-y","journal-title":"Environ Sci Pollut Res"},{"issue":"1\u20132","key":"3117_CR132","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.marpolbul.2015.07.013","volume":"98","author":"A Tayeb","year":"2015","unstructured":"Tayeb A, Chellalib MR, Hamoub A, Debbahe S (2015) Impact of urban and industrial effluents on the coastal marine environment in Oran, Algeria. Mar Pollut Bull 98(1\u20132):281\u2013288. http:\/\/dx.doi.org\/10.1016\/j.marpolbul.2015.07.013","journal-title":"Mar Pollut Bull"},{"key":"3117_CR98","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/978-981-99-5340-0_10","volume-title":"Vitellogenin in Fishes- Diversification, Biological Properties, and Future Perspectives","author":"R Thirumalaivasn","year":"2023","unstructured":"Thirumalaivasn R, Devaprakash M, Sivakumar N (2023) Vitellogenin Is a Biomarker. In: Baskaralingam V, Vanichviriyakit R (eds) Vitellogenin in Fishes- Diversification, Biological Properties, and Future Perspectives. Springer, Singapore, pp 139\u2013166. https:\/\/doi.org\/10.1007\/978-981-99-5340-0_10"},{"key":"3117_CR99","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/j.envpol.2019.02.056","volume":"248","author":"TKA Tran","year":"2019","unstructured":"Tran TKA, Yu RMK, Islam R, Nguyen THT, Bui TLH, Kong RYC, O\u2019Connor WA, Leusch FD, Andrew-Priestley M, MacFarlane GR (2019) The utility of vitellogenin as a biomarker of estrogenic endocrine disrupting chemicals in molluscs. Environ Pollut 248:1067\u20131078. 10.1016\/j","journal-title":"Environ Pollut"},{"issue":"2","key":"3117_CR100","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.ecoenv.2005.03.013","volume":"64","author":"A Valavanidis","year":"2006","unstructured":"Valavanidis A, Vlahogianni T, Dassenakis M, Scoullos M (2006) Molecular biomarkers of oxidative stress in aquatic organisms in relation to toxic environmental pollutants. Ecotoxicol Environ Saf 64(2):178\u2013189","journal-title":"Ecotoxicol Environ Saf"},{"issue":"1","key":"3117_CR101","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pestbp.2011.05.005","volume":"101","author":"OY Vasylkiv","year":"2011","unstructured":"Vasylkiv OY, Kubrak OI, Storey KB, LushchakVI (2011) Catalase activity as a potential vital biomarker of fish intoxication by the herbicide aminotriazole. Pestic Biochem Physiol 101(1):1\u20135. https:\/\/doi.org\/10.1016\/j","journal-title":"Pestic Biochem Physiol"},{"key":"3117_CR102","doi-asserted-by":"publisher","first-page":"116374","DOI":"10.1016\/j.marpolbul.2024.116374","volume":"202","author":"D Vidyalakshmi","year":"2024","unstructured":"Vidyalakshmi D, Yesudas A, Sivan G, Akhil Prakash E, Priyaja P (2024) Heavy metal accumulation analysis using bivalve, sponge, sea urchin, and gastropod species as bioindicators. Mar Pollut Bull 202:116374. https:\/\/doi.org\/10.1016\/j.marpolbul.2024.116374","journal-title":"Mar Pollut Bull"},{"issue":"6","key":"3117_CR103","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1897\/05-299R.1","volume":"25","author":"TJ Ward","year":"2006","unstructured":"Ward TJ, Kramer JR, Boeri RL, Gorsuch JW (2006) Chronic toxicity of silver to the sea urchin (Arbacia punctulata). Environ Toxicol Chem 25(6):1568\u20131573. https:\/\/doi.org\/10.1897\/05-299R.1","journal-title":"Environ Toxicol Chem"},{"key":"3117_CR104","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1007\/BF00197237","volume":"53","author":"M Warnau","year":"1994","unstructured":"Warnau M, Pagano G (1994) Developmental toxicity of PbCl2 in the echinoid Paracentrotus lividus (Echinodermata). Bull Environ Contam Toxicol 53:434\u2013441. https:\/\/doi.org\/10.1007\/BF00197237","journal-title":"Bull Environ Contam Toxicol"},{"key":"3117_CR105","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0304-3835(88)90084-5","volume":"40","author":"G Weckbecker","year":"1988","unstructured":"Weckbecker G, Cory J (1988) Ribonucleotide reductase activity and growth of glutathione-depleted mouse leukemia L1210 cells in vitro. Cancer Lett 40:257\u2013264. https:\/\/doi.org\/10.1016\/0304-3835(88)90084-5","journal-title":"Cancer Lett"},{"key":"3117_CR107","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/0304-4165(95)00033-8","volume":"1244","author":"J Yamamura","year":"1995","unstructured":"Yamamura J, Adachi T, Aoki N, Nakajima H, Nakamura R, Matsuda T (1995) Precursor-product relationship between chicken vitellogenin and the yolk proteins: The 40\u00a0kDa yolk plasma glycoprotein is derived from the C-terminal cysteine-rich domain of vitellogenin II. Biochim Biophys Acta 1244:384\u2013394. https:\/\/doi.org\/10.1016\/0304-4165(95)00033-8","journal-title":"Biochim Biophys Acta"},{"key":"3117_CR110","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1086\/BBL","volume":"230","author":"V Zazueta","year":"2016","unstructured":"Zazueta V, Onorato T, Reyes G, Oulhen N, Wessel G (2016) Complexity of yolk proteins and their dynamics in the sea star Patiria miniata. Biol Bull 230:209\u2013219. https:\/\/doi.org\/10.1086\/BBL","journal-title":"Biol Bull"},{"issue":"4","key":"3117_CR109","doi-asserted-by":"publisher","first-page":"453","DOI":"10.21608\/ejabf.2024.368403","volume":"28","author":"F Zeghdoudi","year":"2024","unstructured":"Zeghdoudi F, Ouali N, Allalgua A, Haddidi I, Heramza K (2024) Trace Metal Elements Contents of the Waters and Fish on El-Kala Coastline(El-Tarf- Eastern Algeria). Egypt J Aquat Biology Fisheries 28(4):453\u2013468","journal-title":"Egypt J Aquat Biology Fisheries"},{"issue":"2","key":"3117_CR111","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/s00128-020-02916-8","volume":"105","author":"D Zezza","year":"2020","unstructured":"Zezza D, Bisegna A, Angelozzi G, Merola C, Conte A, Amorena M, Perugini M (2020) Impact of endocrine disruptors on vitellogenin concentrations in Wild Brown Trout (Salmo trutta trutta). Bull Environ Contam Toxicol 105(2):218\u2013223. https:\/\/doi.org\/10.1007\/s00128-020-02916-8","journal-title":"Bull Environ Contam Toxicol"},{"issue":"1","key":"3117_CR113","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12302-020-00318-5","volume":"32","author":"J Zhang","year":"2020","unstructured":"Zhang J, Yu Z (2020) Transgenerational effects of different sequential exposure to 2,2\u2032,4,4\u2032-tetra-brominated diphenyl ether (BDE47) and lead (Pb) on Caenorhabditis elegans. Environ Sci Europe 32(1):44. https:\/\/doi.org\/10.1186\/s12302-020-00318-5","journal-title":"Environ Sci Europe"},{"issue":"5","key":"3117_CR112","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s10661-016-5314-3","volume":"188","author":"L Zhang","year":"2016","unstructured":"Zhang L, Shi Z, Zhang J, Jiang Z, Wang F, Huang X (2016) Toxic heavy metals in sediments, seawater, and molluscs in the eastern and western coastal waters of Guangdong Province, South China. Environ Monit Assess 188(5):313. https:\/\/doi.org\/10.1007\/s10661-016-5314-3","journal-title":"Environ Monit Assess"}],"container-title":["Ecotoxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10646-026-03117-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10646-026-03117-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10646-026-03117-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:03:26Z","timestamp":1788429806000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10646-026-03117-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":119,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["3117"],"URL":"https:\/\/doi.org\/10.1007\/s10646-026-03117-5","relation":{},"ISSN":["0963-9292","1573-3017"],"issn-type":[{"value":"0963-9292","type":"print"},{"value":"1573-3017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]},"assertion":[{"value":"4 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The current study was approved by the Committee of the Laboratory for the Optimization of Agricultural Production in Subhumid Areas, University of Skikda (Ref. 02\/2023; Date: 02\/12\/2023). The experimental studies were performed according to the ARRIVE guidelines (2010) (\n                      \n                      Table\u00a01).","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors approved this submission.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Conflict of interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"139"}}