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A total of 120 juvenile\n                    <jats:italic>C. macropomum<\/jats:italic>\n                    (38.91\u2009\u00b1\u20095.57\u00a0g and 13.76\u2009\u00b1\u20090.74\u00a0cm in total length) were distributed in 12 tanks of 150\u00a0L, in a recirculating aquaculture system (RAS). The juveniles were kept in water containing cellulose acetate nanoparticles (CANs) at four different concentrations (treatments): 0 mg L\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u00b9, 0.01 mg L\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u00b9, 0.10 mg L\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u00b9 and 1.00 mg L\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u00b9. Blood samples were collected after 1 and 24\u00a0h of exposure. The juveniles were then relocated to a tank with clean water, where they remained for another 24\u00a0h, after which a new blood sample was collected (24\u00a0h). Hemoglobin, serum protein and globulin were reduced after 1\u00a0h of exposure for the group exposed to 1.00 mg L\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u00b9 of CANs. Glucose levels increased after 24\u00a0h for the groups exposed to 0.10 and 1.00 mg L\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u00b9. Urea increased after 1\u00a0h for the groups exposed to 0.10 and 1.00 mg L\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u00b9. Triglycerides and cholesterol were reduced both after 1\u00a0h and 24\u00a0h of exposure for the 1.00 mg L\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u00b9 group, returning to baseline levels at 24\u00a0h. The activities of aspartate aminotransferase (AST) and alanine aminotransferase were altered after 24\u00a0h. Albumin was lower after 1\u00a0h and 24\u00a0h compared to after 24\u00a0h for the 1.00 mg L\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u00b9 group. Exposure of juvenile\n                    <jats:italic>C. macropomum<\/jats:italic>\n                    to CANs caused transient physiological changes, with partial recovery being observed after transfer to clean water.\n                  <\/jats:p>","DOI":"10.1007\/s10646-026-03174-w","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:34:59Z","timestamp":1792730099000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cellulose acetate nanoparticles: impacts of concentration and exposure time on the biochemistry and hematology of juvenile Colossoma macropomum"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1260-9529","authenticated-orcid":false,"given":"Camila Gomes","family":"de Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6143-5417","authenticated-orcid":false,"given":"T\u00falio Pacheco","family":"Boaventura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5682-8040","authenticated-orcid":false,"given":"F\u00e1bio Aremil Costa","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"de Sena Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2807-2957","authenticated-orcid":false,"given":"Sidney","family":"dos Santos Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imaculada de Morais","family":"Carvalho Ananias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0767-3123","authenticated-orcid":false,"given":"Camila Silva Brey","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1021-5772","authenticated-orcid":false,"given":"Ronald Kennedy","family":"Luz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6046-4056","authenticated-orcid":false,"given":"Rodrigo Lambert","family":"Or\u00e9fice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"3174_CR1","doi-asserted-by":"publisher","first-page":"142643","DOI":"10.1016\/j.chemosphere.2024.142643","volume":"362","author":"M Abbaszadeh","year":"2024","unstructured":"Abbaszadeh M, Sayadi MH, Kharkan J (2024) Impact of polyvinyl chloride microplastic and paraquat herbicide on the blood cells, biochemical parameters, liver enzymes and morphological changes of aqueduct fish. 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