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To survive in the stomach <jats:italic>H. pylori<\/jats:italic> increases the pH locally by producing ammonia which binds to H<jats:sup>+<\/jats:sup> becoming ammonium. This work investigated the effects on the <jats:italic>in-vitro<\/jats:italic> growth of <jats:italic>H. pylori<\/jats:italic> of a natural cation-exchanger mainly composed (\u224870%) of clinoptilolite and mordenite. The zeolitized material from Cuba was evaluated in its original form (<jats:italic>M<\/jats:italic>), as well as in its Na- (<jats:italic>M-Na<\/jats:italic>) and Zn-exchanged (<jats:italic>M-Zn<\/jats:italic>) counterparts. In the preliminary agar cup diffusion test, <jats:italic>H. pylori<\/jats:italic> revealed susceptibility only to <jats:italic>M-Zn<\/jats:italic>, with a direct relationship between concentration and width of inhibition halo. Further experiments evidenced that bacterium replication increases when ammonium is supplied to the growth medium and decreases when zeolites subtract NH<jats:sub>4<\/jats:sub><jats:sup>+<\/jats:sup> via ion exchange. Due to the multi-cationic population of its zeolites <jats:italic>M<\/jats:italic> was not effective enough in removing ammonium and, in the Minimum Inhibitory Concentration (MIC) test, allowed bacterial growth even at a concentration of 50\u00a0mg\/mL. Inhibition was achieved with <jats:italic>M-Na<\/jats:italic> because it contained sodium zeolites capable of maximizing NH<jats:sub>4<\/jats:sub><jats:sup>+<\/jats:sup> subtraction, although the MIC was high (30\u00a0mg\/mL). <jats:italic>M-Zn<\/jats:italic> evidenced a more effective inhibitory capacity, with a MIC of 4\u00a0mg\/mL. Zinc has antimicrobial properties and <jats:italic>H. pylori<\/jats:italic> growth was affected by Zn<jats:sup>2+<\/jats:sup> released from clinoptilolite and mordenite. These zeolites, being more selective towards NH<jats:sub>4<\/jats:sub><jats:sup>+<\/jats:sup> than Zn<jats:sup>2+<\/jats:sup>, can also subtract ammonium to the bacterium, thus enhancing the efficacy of <jats:italic>M-Zn<\/jats:italic>.<\/jats:p>","DOI":"10.1007\/s10653-020-00781-2","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T18:34:18Z","timestamp":1606415658000},"page":"2037-2048","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Antibacterial activity of Zn-loaded Cuban zeolite against Helicobacter pylori in comparison to its Na-loaded and unmodified counterparts"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6685-3351","authenticated-orcid":false,"given":"Guido","family":"Cerri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4573-9522","authenticated-orcid":false,"given":"Mauro","family":"Farina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3908-6097","authenticated-orcid":false,"given":"Antonio","family":"Brundu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0499-9419","authenticated-orcid":false,"given":"Elisabetta","family":"Gavini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6651-5937","authenticated-orcid":false,"given":"Andrea","family":"Salis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6894-4898","authenticated-orcid":false,"given":"Wilfried","family":"Dathe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,26]]},"reference":[{"key":"781_CR1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jgar.2018.03.005","volume":"14","author":"ATB Abadi","year":"2018","unstructured":"Abadi, A. T. B., & Yamaoka, Y. (2018). Helicobacter pylori therapy and clinical perspective. Journal of Global Antimicrobial Resistance, 14, 111\u2013117.","journal-title":"Journal of Global Antimicrobial Resistance"},{"key":"781_CR2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1039\/f19767200661","volume":"72","author":"RM Barrer","year":"1976","unstructured":"Barrer, R. M., & Townsend, R. P. (1976). Transition metal ion exchange in zeolites. Part 1. Thermodynamics of exchange of hydrated Mn2+, Co2+, Ni2+, Cu2+, and Zn2+ ions in ammonium mordenite. Journal of the Chemical Society, Faraday Transactions I, 72, 661\u2013673.","journal-title":"Journal of the Chemical Society, Faraday Transactions I"},{"key":"781_CR3","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/B978-0-08-098258-8.00026-2","volume-title":"Handbook of clay science. Developments in clay science","author":"DL Bish","year":"2013","unstructured":"Bish, D. L. (2013). 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