{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:14:00Z","timestamp":1761905640952,"version":"build-2065373602"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"1\u00b73\u00b75 project for disciplines of excellence from West China Hospital of Sichuan University","award":["ZYGD23010"],"award-info":[{"award-number":["ZYGD23010"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Geochem Health"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s10653-025-02776-3","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T15:43:14Z","timestamp":1760715794000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of environmental factors and biological metrics with lung health: an environment\u2010wide association study"],"prefix":"10.1007","volume":"47","author":[{"given":"Zongyuan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueli","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kejia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Pu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3964-5378","authenticated-orcid":false,"given":"Lunxu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"issue":"4","key":"2776_CR1","doi-asserted-by":"publisher","first-page":"2300239","DOI":"10.1183\/13993003.00239-2023","volume":"61","author":"A Agust\u00ed","year":"2023","unstructured":"Agust\u00ed, A., Celli, B. R., Criner, G. J., Halpin, D., Anzueto, A., Barnes, P., et al. (2023). Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary. The European Respiratory Journal, 61(4), 2300239. https:\/\/doi.org\/10.1183\/13993003.00239-2023","journal-title":"The European Respiratory Journal"},{"issue":"9","key":"2776_CR2","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1164\/rccm.201610-2089OC","volume":"195","author":"LR Benck","year":"2017","unstructured":"Benck, L. R., Cuttica, M. J., Colangelo, L. A., Sidney, S., Dransfield, M. T., Mannino, D. M., et al. (2017). Association between cardiorespiratory fitness and lung health from young adulthood to middle age. American Journal of Respiratory and Critical Care Medicine, 195(9), 1236\u20131243. https:\/\/doi.org\/10.1164\/rccm.201610-2089OC","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"2","key":"2776_CR3","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1378\/chest.121.2.609","volume":"121","author":"DM Biskobing","year":"2002","unstructured":"Biskobing, D. M. (2002). COPD and osteoporosis. Chest, 121(2), 609\u2013620. https:\/\/doi.org\/10.1378\/chest.121.2.609","journal-title":"Chest"},{"issue":"4","key":"2776_CR4","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1093\/ije\/dyy101","volume":"47","author":"J Bowden","year":"2018","unstructured":"Bowden, J., Spiller, W., Del Greco M, F., Sheehan, N., Thompson, J., Minelli, C., & Davey Smith, G. (2018). Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the radial plot and radial regression. International Journal of Epidemiology, 47(4), 1264\u20131278. https:\/\/doi.org\/10.1093\/ije\/dyy101","journal-title":"International Journal of Epidemiology"},{"issue":"2","key":"2776_CR5","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/j.2517-6161.1964.tb00553.x","volume":"26","author":"GEP Box","year":"1964","unstructured":"Box, G. E. P., & Cox, D. R. (1964). An Analysis of Transformations. Journal of the Royal Statistical Society, 26(2), 211\u2013243. https:\/\/doi.org\/10.1111\/j.2517-6161.1964.tb00553.x","journal-title":"Journal of the Royal Statistical Society"},{"issue":"5","key":"2776_CR6","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1210\/jc.2013-3819","volume":"99","author":"N Campos-Obando","year":"2014","unstructured":"Campos-Obando, N., Castano-Betancourt, M. C., Oei, L., Franco, O. H., Stricker, B. H. C., Brusselle, G. G., et al. (2014). Bone mineral density and chronic lung disease mortality: The rotterdam study. The Journal of Clinical Endocrinology and Metabolism, 99(5), 1834\u20131842. https:\/\/doi.org\/10.1210\/jc.2013-3819","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"6","key":"2776_CR7","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/j.chest.2023.02.046","volume":"163","author":"L Dauchet","year":"2023","unstructured":"Dauchet, L. (2023). Propylene oxide, lung function, and oxidative stress: What are the public health implications? Chest, 163(6), 1344\u20131345. https:\/\/doi.org\/10.1016\/j.chest.2023.02.046","journal-title":"Chest"},{"issue":"1","key":"2776_CR8","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.chest.2021.03.024","volume":"160","author":"DL DeMeo","year":"2021","unstructured":"DeMeo, D. L. (2021). Sex and gender omic biomarkers in men and women with COPD: Considerations for precision medicine. Chest, 160(1), 104\u2013113. https:\/\/doi.org\/10.1016\/j.chest.2021.03.024","journal-title":"Chest"},{"issue":"1","key":"2776_CR9","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s12199-021-01033-0","volume":"26","author":"MO Feiler","year":"2021","unstructured":"Feiler, M. O., Pavia, C. J., Frey, S. M., Parsons, P. J., Thevenet-Morrison, K., Canfield, R. L., & Jusko, T. A. (2021). Early life blood lead levels and asthma diagnosis at age 4\u20136 years. Environmental Health and Preventive Medicine, 26(1), 108. https:\/\/doi.org\/10.1186\/s12199-021-01033-0","journal-title":"Environmental Health and Preventive Medicine"},{"issue":"10440","key":"2776_CR10","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1016\/S0140-6736(24)00757-8","volume":"403","author":"GBD 2021 Diseases and Injuries Collaborators","year":"2024","unstructured":"GBD 2021 Diseases and Injuries Collaborators. (2024). Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990\u20132021: A systematic analysis for the Global Burden of Disease Study 2021. The Lancet, 403(10440), 2133\u20132161. https:\/\/doi.org\/10.1016\/S0140-6736(24)00757-8","journal-title":"The Lancet"},{"key":"2776_CR11","doi-asserted-by":"publisher","first-page":"101936","DOI":"10.1016\/j.eclinm.2023.101936","volume":"59","author":"GBD","year":"2019","unstructured":"GBD. (2019). Chronic Respiratory Diseases Collaborators (2023) Global burden of chronic respiratory diseases and risk factors, 1990\u20132019: an update from the Global Burden of Disease Study 2019. EClinicalMedicine, 59, 101936. https:\/\/doi.org\/10.1016\/j.eclinm.2023.101936","journal-title":"EClinicalMedicine"},{"issue":"172","key":"2776_CR12","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0057-2024","volume":"33","author":"CM Greene","year":"2024","unstructured":"Greene, C. M., & Riha, R. L. (2024). Environment and lung health in a rapidly changing world. European Respiratory Review, 33(172), Article 240057. https:\/\/doi.org\/10.1183\/16000617.0057-2024","journal-title":"European Respiratory Review"},{"key":"2776_CR13","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.envres.2016.06.042","volume":"152","author":"E Ha","year":"2017","unstructured":"Ha, E., Basu, N., Bose-O\u2019Reilly, S., D\u00f3rea, J. G., McSorley, E., Sakamoto, M., & Chan, H. M. (2017). Current progress on understanding the impact of mercury on human health. Environmental Research, 152, 419\u2013433. https:\/\/doi.org\/10.1016\/j.envres.2016.06.042","journal-title":"Environmental Research"},{"issue":"2","key":"2776_CR14","doi-asserted-by":"publisher","first-page":"1701374","DOI":"10.1183\/13993003.01374-2017","volume":"51","author":"RJ Hancox","year":"2018","unstructured":"Hancox, R. J., & Rasmussen, F. (2018). Does physical fitness enhance lung function in children and young adults? The European Respiratory Journal, 51(2), 1701374. https:\/\/doi.org\/10.1183\/13993003.01374-2017","journal-title":"The European Respiratory Journal"},{"key":"2776_CR15","doi-asserted-by":"publisher","first-page":"e34408","DOI":"10.7554\/eLife.34408","volume":"7","author":"G Hemani","year":"2018","unstructured":"Hemani, G., Zheng, J., Elsworth, B., Wade, K. H., Haberland, V., Baird, D., et al. (2018). The MR-Base platform supports systematic causal inference across the human phenome. eLife, 7, e34408. https:\/\/doi.org\/10.7554\/eLife.34408","journal-title":"eLife"},{"issue":"7414","key":"2776_CR16","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JPT Higgins","year":"2003","unstructured":"Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003). Measuring inconsistency in meta-analyses. BMJ (Clinical Research Ed), 327(7414), 557\u2013560. https:\/\/doi.org\/10.1136\/bmj.327.7414.557","journal-title":"BMJ (Clinical Research Ed)"},{"issue":"5","key":"2776_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155818","volume":"11","author":"X Huang","year":"2016","unstructured":"Huang, X., Xie, J., Cui, X., Zhou, Y., Wu, X., Lu, W., et al. (2016). Association between Concentrations of Metals in Urine and Adult Asthma: A case-control study in Wuhan, China. PLoS ONE, 11(5), Article e0155818. https:\/\/doi.org\/10.1371\/journal.pone.0155818","journal-title":"PLoS ONE"},{"issue":"7","key":"2776_CR18","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1136\/thoraxjnl-2020-214713","volume":"76","author":"CL Jackson","year":"2021","unstructured":"Jackson, C. L., Umesi, C., Gaston, S. A., Azarbarzin, A., Lunyera, J., McGrath, J. A., et al. (2021). Multiple, objectively measured sleep dimensions including hypoxic burden and chronic kidney disease: Findings from the Multi-Ethnic Study of Atherosclerosis. Thorax, 76(7), 704\u2013713. https:\/\/doi.org\/10.1136\/thoraxjnl-2020-214713","journal-title":"Thorax"},{"key":"2776_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2024.143086","volume":"364","author":"A Li","year":"2024","unstructured":"Li, A., Chen, Y., Du, M., Deng, K., Cui, X., Lin, C., et al. (2024). Healthy lifestyles ameliorate an increased risk of periodontitis associated with polycyclic aromatic hydrocarbons. Chemosphere, 364, Article 143086. https:\/\/doi.org\/10.1016\/j.chemosphere.2024.143086","journal-title":"Chemosphere"},{"issue":"5","key":"2776_CR20","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.4577","volume":"170","author":"TA Manuck","year":"2016","unstructured":"Manuck, T. A., Levy, P. T., Gyamfi-Bannerman, C., Jobe, A. H., & Blaisdell, C. J. (2016). Prenatal and perinatal determinants of lung health and disease in early life: A National Heart, Lung, and Blood Institute workshop report. JAMA Pediatrics, 170(5), Article e154577. https:\/\/doi.org\/10.1001\/jamapediatrics.2015.4577","journal-title":"JAMA Pediatrics"},{"issue":"10277","key":"2776_CR21","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/S0140-6736(21)00458-X","volume":"397","author":"J Meghji","year":"2021","unstructured":"Meghji, J., Mortimer, K., Agusti, A., Allwood, B. W., Asher, I., Bateman, E. D., et al. (2021). Improving lung health in low-income and middle-income countries: From challenges to solutions. Lancet (London, England), 397(10277), 928\u2013940. https:\/\/doi.org\/10.1016\/S0140-6736(21)00458-X","journal-title":"Lancet (London, England)"},{"issue":"2","key":"2776_CR22","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1183\/09031936.05.00034805","volume":"26","author":"MR Miller","year":"2005","unstructured":"Miller, M. R., Hankinson, J., Brusasco, V., Burgos, F., Casaburi, R., Coates, A., et al. (2005). Standardisation of spirometry. The European Respiratory Journal, 26(2), 319\u2013338. https:\/\/doi.org\/10.1183\/09031936.05.00034805","journal-title":"The European Respiratory Journal"},{"issue":"12","key":"2776_CR23","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1001\/jama.2020.14545","volume":"324","author":"P Muntner","year":"2020","unstructured":"Muntner, P., Hardy, S. T., Fine, L. J., Jaeger, B. C., Wozniak, G., Levitan, E. B., & Colantonio, L. D. (2020). Trends in blood pressure control among US adults with hypertension, 1999\u20132000 to 2017\u20132018. JAMA, 324(12), 1190\u20131200. https:\/\/doi.org\/10.1001\/jama.2020.14545","journal-title":"JAMA"},{"issue":"5","key":"2776_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010746","volume":"5","author":"CJ Patel","year":"2010","unstructured":"Patel, C. J., Bhattacharya, J., & Butte, A. J. (2010). An environment-wide association study (EWAS) on type 2 diabetes mellitus. PLoS ONE, 5(5), Article e10746. https:\/\/doi.org\/10.1371\/journal.pone.0010746","journal-title":"PLoS ONE"},{"issue":"5","key":"2776_CR25","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s00439-012-1258-z","volume":"132","author":"CJ Patel","year":"2013","unstructured":"Patel, C. J., Chen, R., Kodama, K., Ioannidis, J. P. A., & Butte, A. J. (2013a). Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus. Human Genetics, 132(5), 495\u2013508. https:\/\/doi.org\/10.1007\/s00439-012-1258-z","journal-title":"Human Genetics"},{"issue":"6","key":"2776_CR26","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1093\/ije\/dyt208","volume":"42","author":"CJ Patel","year":"2013","unstructured":"Patel, C. J., Rehkopf, D. H., Leppert, J. T., Bortz, W. M., Cullen, M. R., Chertow, G. M., & Ioannidis, J. P. (2013b). Systematic evaluation of environmental and behavioural factors associated with all-cause mortality in the United States National Health and Nutrition Examination Survey. International Journal of Epidemiology, 42(6), 1795\u20131810. https:\/\/doi.org\/10.1093\/ije\/dyt208","journal-title":"International Journal of Epidemiology"},{"issue":"6","key":"2776_CR27","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1183\/09031936.00080312","volume":"40","author":"PH Quanjer","year":"2012","unstructured":"Quanjer, P. H., Stanojevic, S., Cole, T. J., Baur, X., Hall, G. L., Culver, B. H., et al. (2012). Multi-ethnic reference values for spirometry for the 3\u201395-yr age range: The global lung function 2012 equations. The European Respiratory Journal, 40(6), 1324\u20131343. https:\/\/doi.org\/10.1183\/09031936.00080312","journal-title":"The European Respiratory Journal"},{"key":"2776_CR28","doi-asserted-by":"crossref","unstructured":"Quartagno, M., Grund, S., & Carpenter, J. (2019). jomo: A Flexible Package for Two-level Joint Modelling Multiple Imputation. R Journal, 9(1). https:\/\/journal.r-project.org\/archive\/2019\/RJ-2019-034\/RJ-2019-034.pdf. Accessed 11 November 2024","DOI":"10.32614\/RJ-2019-028"},{"issue":"5","key":"2776_CR29","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1093\/jssam\/smz036","volume":"8","author":"M Quartagno","year":"2020","unstructured":"Quartagno, M., Carpenter, J. R., & Goldstein, H. (2020). Multiple imputation with survey weights: A multilevel approach. Journal of Survey Statistics and Methodology, 8(5), 965\u2013989.","journal-title":"Journal of Survey Statistics and Methodology"},{"issue":"1","key":"2776_CR30","doi-asserted-by":"publisher","first-page":"2102730","DOI":"10.1183\/13993003.02730-2021","volume":"59","author":"HK Reddel","year":"2022","unstructured":"Reddel, H. K., Bacharier, L. B., Bateman, E. D., Brightling, C. E., Brusselle, G. G., Buhl, R., et al. (2022). Global initiative for asthma strategy 2021: Executive summary and rationale for key changes. The European Respiratory Journal, 59(1), 2102730. https:\/\/doi.org\/10.1183\/13993003.02730-2021","journal-title":"The European Respiratory Journal"},{"issue":"2","key":"2776_CR31","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1289\/ehp.0901234","volume":"118","author":"S Satarug","year":"2010","unstructured":"Satarug, S., Garrett, S. H., Sens, M. A., & Sens, D. A. (2010). Cadmium, environmental exposure, and health outcomes. Environmental Health Perspectives, 118(2), 182\u2013190. https:\/\/doi.org\/10.1289\/ehp.0901234","journal-title":"Environmental Health Perspectives"},{"issue":"4","key":"2776_CR32","doi-asserted-by":"publisher","first-page":"254","DOI":"10.2471\/BLT.12.116152","volume":"92","author":"MC Sheehan","year":"2014","unstructured":"Sheehan, M. C., Burke, T. A., Navas-Acien, A., Breysse, P. N., McGready, J., & Fox, M. A. (2014). Global methylmercury exposure from seafood consumption and risk of developmental neurotoxicity: A systematic review. Bulletin of the World Health Organization, 92(4), 254-269F. https:\/\/doi.org\/10.2471\/BLT.12.116152","journal-title":"Bulletin of the World Health Organization"},{"issue":"9","key":"2776_CR33","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/S2213-2600(13)70118-8","volume":"1","author":"J Stocks","year":"2013","unstructured":"Stocks, J., Hislop, A., & Sonnappa, S. (2013). Early lung development: Lifelong effect on respiratory health and disease. The Lancet Respiratory Medicine, 1(9), 728\u2013742. https:\/\/doi.org\/10.1016\/S2213-2600(13)70118-8","journal-title":"The Lancet Respiratory Medicine"},{"issue":"26","key":"2776_CR34","doi-asserted-by":"publisher","first-page":"809","DOI":"10.15585\/mmwr.mm6926a13","volume":"69","author":"G Syamlal","year":"2020","unstructured":"Syamlal, G., Bhattacharya, A., & Dodd, K. E. (2020). Medical expenditures attributed to asthma and chronic obstructive pulmonary disease among workers - United States, 2011\u20132015. MMWR: Morbidity and Mortality Weekly Report, 69(26), 809\u2013814. https:\/\/doi.org\/10.15585\/mmwr.mm6926a13","journal-title":"MMWR: Morbidity and Mortality Weekly Report"},{"issue":"6","key":"2776_CR35","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1007\/s00408-016-9948-2","volume":"194","author":"C Trevisan","year":"2016","unstructured":"Trevisan, C., Vianello, A., Veronese, N., Carraro, S., Pizzato, S., Lucato, P., et al. (2016). The association between bone mineral density and airflow limitation in a cohort of fit elderly women. Lung, 194(6), 897\u2013904. https:\/\/doi.org\/10.1007\/s00408-016-9948-2","journal-title":"Lung"},{"issue":"21","key":"2776_CR36","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1161\/CIRCULATIONAHA.112.114058","volume":"126","author":"I Tzoulaki","year":"2012","unstructured":"Tzoulaki, I., Patel, C. J., Okamura, T., Chan, Q., Brown, I. J., Miura, K., et al. (2012). A nutrient-wide association study on blood pressure. Circulation, 126(21), 2456\u20132464. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.112.114058","journal-title":"Circulation"},{"issue":"3","key":"2776_CR37","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.chest.2021.03.056","volume":"160","author":"TD Wu","year":"2021","unstructured":"Wu, T. D., Fawzy, A., Brigham, E., McCormack, M. C., Rosas, I., Villareal, D. T., & Hanania, N. A. (2021). Association of triglyceride-glucose index and lung health: A population-based study. Chest, 160(3), 1026\u20131034. https:\/\/doi.org\/10.1016\/j.chest.2021.03.056","journal-title":"Chest"},{"issue":"13","key":"2776_CR38","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1097\/CM9.0000000000000851","volume":"133","author":"A Yorgancioglu","year":"2020","unstructured":"Yorgancioglu, A., Khaltaev, N., Bousquet, J., & Varghese, C. (2020). The global alliance against chronic respiratory diseases: Journey so far and way ahead. Chinese Medical Journal, 133(13), 1513\u20131515. https:\/\/doi.org\/10.1097\/CM9.0000000000000851","journal-title":"Chinese Medical Journal"},{"issue":"1","key":"2776_CR39","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1186\/s12890-019-1008-2","volume":"19","author":"X Zeng","year":"2019","unstructured":"Zeng, X., Liu, D., Zhao, X., Chao, L., Li, Y., Li, H., et al. (2019). Association of bone mineral density with lung function in a Chinese general population: The Xinxiang rural cohort study. Bmc Pulmonary Medicine, 19(1), 239. https:\/\/doi.org\/10.1186\/s12890-019-1008-2","journal-title":"Bmc Pulmonary Medicine"},{"key":"2776_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2020.109275","volume":"183","author":"Y Zheng","year":"2020","unstructured":"Zheng, Y., Chen, Z., Pearson, T., Zhao, J., Hu, H., & Prosperi, M. (2020). Design and methodology challenges of environment-wide association studies: A systematic review. Environmental Research, 183, Article 109275. https:\/\/doi.org\/10.1016\/j.envres.2020.109275","journal-title":"Environmental Research"},{"key":"2776_CR41","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.envint.2018.05.046","volume":"118","author":"X Zhuang","year":"2018","unstructured":"Zhuang, X., Guo, Y., Ni, A., Yang, D., Liao, L., Zhang, S., et al. (2018). Toward a panoramic perspective of the association between environmental factors and cardiovascular disease: An environment-wide association study from National Health and Nutrition Examination Survey 1999\u20132014. Environment International, 118, 146\u2013153. https:\/\/doi.org\/10.1016\/j.envint.2018.05.046","journal-title":"Environment International"},{"key":"2776_CR42","first-page":"1","volume":"56","author":"G Zipf","year":"2013","unstructured":"Zipf, G., Chiappa, M., Porter, K. S., Ostchega, Y., Lewis, B. G., & Dostal, J. (2013). National health and nutrition examination survey: Plan and operations, 1999\u20132010. Vital and Health Statistics. Ser. 1. Programs and Collection Procedures, 56, 1\u201337.","journal-title":"Programs and Collection Procedures"}],"container-title":["Environmental Geochemistry and Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10653-025-02776-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10653-025-02776-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10653-025-02776-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:11:52Z","timestamp":1761905512000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10653-025-02776-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,17]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["2776"],"URL":"https:\/\/doi.org\/10.1007\/s10653-025-02776-3","relation":{},"ISSN":["0269-4042","1573-2983"],"issn-type":[{"type":"print","value":"0269-4042"},{"type":"electronic","value":"1573-2983"}],"subject":[],"published":{"date-parts":[[2025,10,17]]},"assertion":[{"value":"11 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"505"}}