{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:41:05Z","timestamp":1782297665327,"version":"3.54.5"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Geochem Health"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s10653-025-02922-x","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T04:40:35Z","timestamp":1765428035000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Estimating macrolide antibiotics use in a typical region of Taihu Lake Basin, China through wastewater-based epidemiology"],"prefix":"10.1007","volume":"48","author":[{"given":"Tao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liulin","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"2922_CR1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000320320","volume":"81","author":"J Altenburg","year":"2011","unstructured":"Altenburg, J., de Graaff, C. S., van der Werf, T. S., & Boersma, W. G. (2011). Immunomodulatory effects of macrolide antibiotics \u2013 Part 2: Advantages and disadvantages of long-term, low-dose macrolide therapy. Respiration, 81, 75\u201387.","journal-title":"Respiration"},{"key":"2922_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2020.116125","author":"N Alygizakis","year":"2021","unstructured":"Alygizakis, N., Markou, A. N., Rousis, N. I., Galani, A., Avgeris, M., Adamopoulos, P. G., Scorilas, A., Lianidou, E. S., Paraskevis, D., Tsiodras, S., Tsakris, A., Dimopoulos, M.-A., & Thomaidis, N. S. (2021). Analytical methodologies for the detection of SARS-CoV-2 in wastewater: Protocols and future perspectives. Trends in Analytical Chemistry. https:\/\/doi.org\/10.1016\/j.trac.2020.116125","journal-title":"Trends in Analytical Chemistry"},{"key":"2922_CR3","doi-asserted-by":"crossref","first-page":"8162","DOI":"10.1021\/es5008388","volume":"48","author":"F Been","year":"2014","unstructured":"Been, F., Rossi, L., Ort, C., Rudaz, S., Del\u00e9mont, O., & Esseiva, P. (2014). Population normalization with ammonium in wastewater-based epidemiology: Application to illicit drug monitoring. Environmental Science & Technology, 48, 8162\u20138169.","journal-title":"Environmental Science & Technology"},{"key":"2922_CR4","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.envres.2018.11.040","volume":"169","author":"Y Ben","year":"2019","unstructured":"Ben, Y., Fu, C., Hu, M., Liu, L., Wong, M. H., & Zheng, C. (2019). Human health risk assessment of antibiotic resistance associated with antibiotic residues in the environment: A review. Environmental Research, 169, 483\u2013493.","journal-title":"Environmental Research"},{"key":"2922_CR5","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.drugalcdep.2016.01.002","volume":"160","author":"T Boogaerts","year":"2016","unstructured":"Boogaerts, T., Covaci, A., Kinyua, J., Neels, H., & van Nuijs, A. L. N. (2016). Spatial and temporal trends in alcohol consumption in Belgian cities: A wastewater-based approach. Drug and Alcohol Dependence, 160, 170\u2013176.","journal-title":"Drug and Alcohol Dependence"},{"key":"2922_CR6","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1021\/es302722f","volume":"47","author":"S Castiglioni","year":"2013","unstructured":"Castiglioni, S., Bijlsma, L., Covaci, A., Emke, E., Hern\u00e1ndez, F., Reid, M., Ort, C., Thomas, K. V., van Nuijs, A. L. N., de Voogt, P., & Zuccato, E. (2013). Evaluation of uncertainties associated with the determination of community drug use through the measurement of sewage drug biomarkers. Environmental Science & Technology, 47, 1452\u20131460.","journal-title":"Environmental Science & Technology"},{"key":"2922_CR7","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1136\/tobaccocontrol-2014-051553","volume":"24","author":"S Castiglioni","year":"2015","unstructured":"Castiglioni, S., Senta, I., Borsotti, A., Davoli, E., & Zuccato, E. (2015). A novel approach for monitoring tobacco use in local communities by wastewater analysis. Tobacco Control, 24, 38\u201342.","journal-title":"Tobacco Control"},{"key":"2922_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2020.115653","author":"E Castrignan\u00f2","year":"2020","unstructured":"Castrignan\u00f2, E., Yang, Z., Feil, E. J., Bade, R., Castiglioni, S., Causanilles, A., Gracia-Lor, E., Hernandez, F., Pl\u00f3sz, B. G., Ramin, P., Rousis, N. I., Ryu, Y., Thomas, K. V., de Voogt, P., Zuccato, E., & Kasprzyk-Hordern, B. (2020). Enantiomeric profiling of quinolones and quinolones resistance gene qnrS in European wastewaters. Water Research. https:\/\/doi.org\/10.1016\/j.watres.2020.115653","journal-title":"Water Research"},{"key":"2922_CR9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.envint.2018.08.009","volume":"120","author":"PM Choi","year":"2018","unstructured":"Choi, P. M., O\u2019Brien, J. W., Li, J., Jiang, G., Thomas, K. V., & Mueller, J. F. (2018). Population histamine burden assessed using wastewater-based epidemiology: The association of 1,4-methylimidazole acetic acid and fexofenadine. Environment International, 120, 172\u2013180.","journal-title":"Environment International"},{"key":"2922_CR10","volume-title":"Status Report on Antimicrobial Administration and Antimicrobial Resistance in China (2023)","author":"NH Commission","year":"2023","unstructured":"Commission, N. H. (2023). Status Report on Antimicrobial Administration and Antimicrobial Resistance in China (2023). Peking Union Medical College Press."},{"key":"2922_CR11","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.scitotenv.2018.07.065","volume":"645","author":"Q Dai","year":"2018","unstructured":"Dai, Q., Ma, W., Huang, H., Xu, K., Qi, X., Yu, H., Deng, F., Bao, C., & Huo, X. (2018). The effect of ambient temperature on the activity of influenza and influenza like illness in Jiangsu Province, China. Science of the Total Environment, 645, 684\u2013691.","journal-title":"Science of the Total Environment"},{"key":"2922_CR12","volume-title":"Illicit drugs in municipal sewage: Proposed new nonintrusive tool to heighten public awareness of societal use of illicit-abused drugs and their potential for ecological consequences","author":"CG Daughton","year":"2001","unstructured":"Daughton, C. G. (2001). Illicit drugs in municipal sewage: Proposed new nonintrusive tool to heighten public awareness of societal use of illicit-abused drugs and their potential for ecological consequences. American Chemical Society."},{"key":"2922_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106404","author":"M Escol\u00e0 Casas","year":"2021","unstructured":"Escol\u00e0 Casas, M., Schr\u00f6ter, N. S., Zammit, I., Casta\u00f1o-Trias, M., Rodriguez-Mozaz, S., Gago-Ferrero, P., & Corominas, L. (2021). Showcasing the potential of wastewater-based epidemiology to track pharmaceuticals consumption in cities: Comparison against prescription data collected at fine spatial resolution. Environment International. https:\/\/doi.org\/10.1016\/j.envint.2021.106404","journal-title":"Environment International"},{"key":"2922_CR14","first-page":"730","volume":"66","author":"DC Fiore","year":"2017","unstructured":"Fiore, D. C., Fettic, L. P., Wright, S. D., & Ferrara, B. R. (2017). Antibiotic overprescribing: Still a major concern. The Journal of Family Practice, 66, 730\u2013736.","journal-title":"The Journal of Family Practice"},{"key":"2922_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.154171","author":"J Gao","year":"2022","unstructured":"Gao, J., Li, L., Duan, L., Yang, M., Zhou, X., Zheng, Q., Ou, Y., Li, Z., & Lai, F. Y. (2022). Exploring antibiotic consumption between urban and sub-urban catchments using both parent drugs and related metabolites in wastewater-based epidemiology. Science of the Total Environment. https:\/\/doi.org\/10.1016\/j.scitotenv.2022.154171","journal-title":"Science of the Total Environment"},{"key":"2922_CR16","doi-asserted-by":"crossref","first-page":"5516","DOI":"10.1007\/s11356-022-24268-y","volume":"30","author":"Z Gao","year":"2023","unstructured":"Gao, Z., Li, P., Lin, H., Lin, W., & Ren, Y. (2023). Biomarker selection strategies based on compound stability in wastewater-based epidemiology. Environmental Science and Pollution Research, 30, 5516\u20135529.","journal-title":"Environmental Science and Pollution Research"},{"key":"2922_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.168056","author":"S Gholipour","year":"2024","unstructured":"Gholipour, S., Shamsizadeh, Z., Halabowski, D., Gwenzi, W., & Nikaeen, M. (2024). Combating antibiotic resistance using wastewater surveillance: Significance, applications, challenges, and future directions. Science of the Total Environment. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.168056","journal-title":"Science of the Total Environment"},{"key":"2922_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.154116","author":"S Han","year":"2022","unstructured":"Han, S., Wang, Z., Huang, H., Wang, T., Zhou, Z., Bai, Y., Du, P., & Li, X. (2022). Estimating antibiotics use in major cities in China through wastewater-based epidemiology. Science of the Total Environment. https:\/\/doi.org\/10.1016\/j.scitotenv.2022.154116","journal-title":"Science of the Total Environment"},{"key":"2922_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.143578","author":"A Hata","year":"2021","unstructured":"Hata, A., Hara-Yamamura, H., Meuchi, Y., Imai, S., & Honda, R. (2021). Detection of SARS-CoV-2 in wastewater in Japan during a COVID-19 outbreak. Science of the Total Environment. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.143578","journal-title":"Science of the Total Environment"},{"key":"2922_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.129001","author":"E Holton","year":"2022","unstructured":"Holton, E., Sims, N., Jagadeesan, K., Standerwick, R., & Kasprzyk-Hordern, B. (2022). Quantifying community-wide antimicrobials usage via wastewater-based epidemiology. Journal of Hazardous Materials. https:\/\/doi.org\/10.1016\/j.jhazmat.2022.129001","journal-title":"Journal of Hazardous Materials"},{"key":"2922_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.143480","author":"CZ Hou","year":"2021","unstructured":"Hou, C. Z., Chu, T. T., Chen, M. Y., Hua, Z. D., Xu, P., Xu, H., Wang, Y. M., Liao, J., & Di, B. (2021). Application of multi-parameter population model based on endogenous population biomarkers and flow volume in wastewater epidemiology. Science of the Total Environment. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.143480","journal-title":"Science of the Total Environment"},{"key":"2922_CR22","doi-asserted-by":"crossref","first-page":"4379","DOI":"10.1128\/AAC.04652-14","volume":"59","author":"BD Jamieson","year":"2015","unstructured":"Jamieson, B. D., Ciric, S., & Fernandes, P. (2015). Safety and pharmacokinetics of Solithromycin in subjects with hepatic impairment. Antimicrobial Agents and Chemotherapy, 59, 4379\u20134386.","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"2922_CR23","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.scitotenv.2014.01.043","volume":"487","author":"U Khan","year":"2014","unstructured":"Khan, U., van Nuijs, A. L. N., Li, J., Maho, W., Du, P., Li, K., Hou, L., Zhang, J., Meng, X., Li, X., & Covaci, A. (2014). Application of a sewage-based approach to assess the use of ten illicit drugs in four Chinese megacities. Science of the Total Environment, 487, 710\u2013721.","journal-title":"Science of the Total Environment"},{"key":"2922_CR24","volume":"115","author":"EY Klein","year":"2018","unstructured":"Klein, E. Y., Van Boeckel, T. P., Martinez, E. M., Pant, S., Gandra, S., Levin, S. A., Goossens, H., & Laxminarayan, R. (2018). Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proceedings of the National Academy of Sciences of the United States of America, 115, Article E3463-E3470.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"2922_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22557-7","author":"\u00c9 Kocsm\u00e1r","year":"2021","unstructured":"Kocsm\u00e1r, \u00c9., Buz\u00e1s, G. M., Szirtes, I., Kocsm\u00e1r, I., Kramer, Z., Szij\u00e1rt\u00f3, A., Fadgyas-Freyler, P., Sz\u00e9n\u00e1s, K., Rugge, M., Fassan, M., Kiss, A., Schaff, Z., R\u00f6st, G., & Lotz, G. (2021). Primary and secondary clarithromycin resistance in Helicobacter pylori and mathematical modeling of the role of macrolides. Nature Communications. https:\/\/doi.org\/10.1038\/s41467-021-22557-7","journal-title":"Nature Communications"},{"key":"2922_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.126351","author":"P Kovalakova","year":"2020","unstructured":"Kovalakova, P., Cizmas, L., McDonald, T. J., Marsalek, B., Feng, M., & Sharma, V. K. (2020). Occurrence and toxicity of antibiotics in the aquatic environment: A review. Chemosphere. https:\/\/doi.org\/10.1016\/j.chemosphere.2020.126351","journal-title":"Chemosphere"},{"key":"2922_CR27","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s40121-022-00591-2","volume":"11","author":"AJ Kunz Coyne","year":"2022","unstructured":"Kunz Coyne, A. J., El Ghali, A., Holger, D., Rebold, N., & Rybak, M. J. (2022). Therapeutic strategies for emerging multidrug-resistant Pseudomonas aeruginosa. Infectious Diseases and Therapy, 11, 661\u2013682.","journal-title":"Infectious Diseases and Therapy"},{"key":"2922_CR28","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1021\/es503474d","volume":"49","author":"FY Lai","year":"2014","unstructured":"Lai, F. Y., Anuj, S., Bruno, R., Carter, S., Gartner, C., Hall, W., Kirkbride, K. P., Mueller, J. F., O\u2019Brien, J. W., Prichard, J., Thai, P. K., & Ort, C. (2014). Systematic and day-to-day effects of chemical-derived population estimates on wastewater-based drug epidemiology. Environmental Science & Technology, 49, 999\u20131008.","journal-title":"Environmental Science & Technology"},{"key":"2922_CR29","first-page":"3395","volume":"20","author":"TH Le","year":"2022","unstructured":"Le, T. H., Truong, T., Tran, L. T., Nguyen, D. H., Pham, T. P. T., & Ng, C. (2022). Antibiotic resistance in the aquatic environments: The need for an interdisciplinary approach. International Journal of Environmental Science and Technology, 20, 3395\u20133408.","journal-title":"International Journal of Environmental Science and Technology"},{"key":"2922_CR30","volume":"254","author":"T Li","year":"2020","unstructured":"Li, T., Wang, C., Xu, Z., & Chakraborty, A. (2020). A coupled method of on-line solid phase extraction with the UHPLC-MS\/MS for detection of sulfonamides antibiotics residues in aquaculture. Chemosphere, 254, Article 126765.","journal-title":"Chemosphere"},{"key":"2922_CR31","doi-asserted-by":"crossref","first-page":"59052","DOI":"10.1007\/s11356-022-20070-y","volume":"29","author":"DK Lim","year":"2022","unstructured":"Lim, D. K., Kim, Jw., & Kim, J. K. (2022). Effects of climatic factors on the prevalence of influenza virus infection in Cheonan, Korea. Environmental Science and Pollution Research, 29, 59052\u201359059.","journal-title":"Environmental Science and Pollution Research"},{"key":"2922_CR32","volume":"254","author":"X Luo","year":"2024","unstructured":"Luo, X., Han, S., Wang, Y., Du, P., Li, X., & Thai, P. K. (2024). Significant differences in usage of antibiotics in three Chinese cities measured by wastewater-based epidemiology. Water Research, 254, Article 121335.","journal-title":"Water Research"},{"key":"2922_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2020.116559","author":"K Mao","year":"2021","unstructured":"Mao, K., Yang, Z., Zhang, H., Li, X., & Cooper, J. M. (2021). Paper-based nanosensors to evaluate community-wide illicit drug use for wastewater-based epidemiology. Water Research. https:\/\/doi.org\/10.1016\/j.watres.2020.116559","journal-title":"Water Research"},{"key":"2922_CR34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coesh.2020.04.006","volume":"17","author":"K Mao","year":"2020","unstructured":"Mao, K., Zhang, K., Du, W., Ali, W., Feng, X., & Zhang, H. (2020). The potential of wastewater-based epidemiology as surveillance and early warning of infectious disease outbreaks. Current Opinion in Environmental Science & Health, 17, 1\u20137.","journal-title":"Current Opinion in Environmental Science & Health"},{"key":"2922_CR35","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1021\/acs.estlett.0c00357","volume":"7","author":"G Medema","year":"2020","unstructured":"Medema, G., Heijnen, L., Elsinga, G., Italiaander, R., & Brouwer, A. (2020). Presence of SARS-Coronavirus-2 RNA in sewage and correlation with reported COVID-19 prevalence in the early stage of the epidemic in The Netherlands. Environmental Science & Technology Letters, 7, 511\u2013516.","journal-title":"Environmental Science & Technology Letters"},{"key":"2922_CR36","doi-asserted-by":"crossref","unstructured":"Medina, W.R.M.; D\u2019Elia, S.; Fahrenfeld, N.L. Accumulation of SARS-CoV-2 RNA in Sewer Biofilms. ACS EST Water 2022;","DOI":"10.1021\/acsestwater.1c00345"},{"key":"2922_CR37","doi-asserted-by":"crossref","unstructured":"Moriyama M, Hugentobler WJ, Iwasaki A, (2020) Seasonality of Respiratory Viral Infections in Enquist L Ed. Annual Review of Virology. 7 (1): 83-101","DOI":"10.1146\/annurev-virology-012420-022445"},{"key":"2922_CR38","first-page":"1640","volume":"20","author":"M Nkoom","year":"2018","unstructured":"Nkoom, M., Lu, G., & Liu, J. (2018). Occurrence and ecological risk assessment of pharmaceuticals and personal care products in Taihu Lake, China: A review. Environmental Science: Processes & Impacts, 20, 1640\u20131648.","journal-title":"Environmental Science: Processes & Impacts"},{"key":"2922_CR39","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/add.12405","volume":"109","author":"C Ort","year":"2014","unstructured":"Ort, C., Eppler, J. M., Scheidegger, A., Rieckermann, J., Kinzig, M., & S\u00f6rgel, F. (2014). Challenges of surveying wastewater drug loads of small populations and generalizable aspects on optimizing monitoring design. Addiction, 109, 472\u2013481.","journal-title":"Addiction"},{"key":"2922_CR40","volume":"15","author":"H Patel","year":"2020","unstructured":"Patel, H., DiDomenico, R. J., Suda, K. J., Schumock, G. T., Calip, G. S., & Lee, T. A. (2020). Risk of cardiac events with azithromycin\u2014A prediction model. PLoS ONE, 15, Article e0240379.","journal-title":"PLoS ONE"},{"key":"2922_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jece.2018.03.004","author":"NA Sabri","year":"2020","unstructured":"Sabri, N. A., Schmitt, H., Van der Zaan, B., Gerritsen, H. W., Zuidema, T., Rijnaarts, H. H. M., & Langenhoff, A. A. M. (2020). Prevalence of antibiotics and antibiotic resistance genes in a wastewater effluent-receiving river in the Netherlands. Journal of Environmental Chemical Engineering. https:\/\/doi.org\/10.1016\/j.jece.2018.03.004","journal-title":"Journal of Environmental Chemical Engineering"},{"key":"2922_CR42","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.emcon.2019.08.001","volume":"5","author":"DND Samaraweera","year":"2019","unstructured":"Samaraweera, D. N. D., Liu, X., Zhong, G., Priyadarshana, T., Naseem Malik, R., Zhang, G., Khorram, M. S., Zhu, Z., & Peng, X. (2019). Antibiotics in two municipal sewage treatment plants in Sri Lanka: Occurrence, consumption and removal efficiency. Emerging Contaminants, 5, 272\u2013278.","journal-title":"Emerging Contaminants"},{"key":"2922_CR43","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/03611981231224747","volume":"2678","author":"T Scheffler","year":"2024","unstructured":"Scheffler, T., & Heinen, E. (2024). Impact of settlement size and regional density on the frequency of different holiday types. Transportation Research Record, 2678, 37\u201349.","journal-title":"Transportation Research Record"},{"key":"2922_CR44","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1001\/jama.2018.19283","volume":"321","author":"ES Shenoy","year":"2019","unstructured":"Shenoy, E. S., Macy, E., Rowe, T., & Blumenthal, K. G. (2019). Evaluation and management of penicillin allergy: A review. JAMA, 321, 188\u2013199.","journal-title":"JAMA"},{"key":"2922_CR45","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.jclepro.2019.06.243","volume":"234","author":"R Singh","year":"2019","unstructured":"Singh, R., Singh, A. P., Kumar, S., Giri, B. S., & Kim, K.-H. (2019). Antibiotic resistance in major rivers in the world: A systematic review on occurrence, emergence, and management strategies. Journal of Cleaner Production, 234, 1484\u20131505.","journal-title":"Journal of Cleaner Production"},{"key":"2922_CR46","doi-asserted-by":"crossref","first-page":"1067973","DOI":"10.3389\/fphar.2023.1067973","volume":"14","author":"D Sokolovi\u0107","year":"2023","unstructured":"Sokolovi\u0107, D., Drakul, D., Vuji\u0107-Aleksi\u0107, V., Joksimovi\u0107, B., Mari\u0107, S., & Ne\u017ei\u0107, L. (2023). Antibiotic consumption and antimicrobial resistance in the SARS-CoV-2 pandemic: A single-center experience. Frontiers in Pharmacology, 14, 1067973.","journal-title":"Frontiers in Pharmacology"},{"key":"2922_CR47","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3109\/03009734.2014.905664","volume":"119","author":"C St\u00e5lsby Lundborg","year":"2014","unstructured":"St\u00e5lsby Lundborg, C., & Tamhankar, A. J. (2014). Understanding and changing human behaviour\u2014antibiotic mainstreaming as an approach to facilitate modification of provider and consumer behaviour. Upsala Journal of Medical Sciences, 119, 125\u2013133.","journal-title":"Upsala Journal of Medical Sciences"},{"key":"2922_CR48","volume":"12","author":"N Sun","year":"2021","unstructured":"Sun, N., Gong, Y., Liu, J., Wu, J., An, R., Dong, Y., Zhu, Y., Mu, K., Zhang, G., & Yin, X. (2021). Prevalence of antibiotic purchase online and associated factors among Chinese residents: A nationwide community survey of 2019. Frontiers in Pharmacology, 12, Article 761086.","journal-title":"Frontiers in Pharmacology"},{"key":"2922_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2022.118800","author":"LE Tomsone","year":"2022","unstructured":"Tomsone, L. E., Perkons, I., Sukajeva, V., Neilands, R., Kokina, K., Bartkevics, V., & Pugajeva, I. (2022). Consumption trends of pharmaceuticals and psychoactive drugs in Latvia determined by the analysis of wastewater. Water Research. https:\/\/doi.org\/10.1016\/j.watres.2022.118800","journal-title":"Water Research"},{"key":"2922_CR50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2017.05.002","volume":"809","author":"V Waetzig","year":"2017","unstructured":"Waetzig, V., Riffert, J., Cordt, J., Reinecke, K., Haeusgen, W., Boehm, R., Cascorbi, I., & Herdegen, T. (2017). Neurodegenerative effects of azithromycin in differentiated PC12 cells. European Journal of Pharmacology, 809, 1\u201312.","journal-title":"European Journal of Pharmacology"},{"key":"2922_CR51","doi-asserted-by":"publisher","DOI":"10.3390\/v15030594","author":"D Wang","year":"2023","unstructured":"Wang, D., Lei, H., Wang, D., Shu, Y., & Xiao, S. (2023). Association between temperature and influenza activity across different regions of China during 2010\u20132017. Viruses. https:\/\/doi.org\/10.3390\/v15030594","journal-title":"Viruses"},{"key":"2922_CR52","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.ijantimicag.2017.04.009","volume":"50","author":"X Wang","year":"2017","unstructured":"Wang, X., Peng, D., Wang, W., Xu, Y., Zhou, X., & Hesketh, T. (2017). Massive misuse of antibiotics by university students in all regions of China: Implications for national policy. International Journal of Antimicrobial Agents, 50, 441\u2013446.","journal-title":"International Journal of Antimicrobial Agents"},{"key":"2922_CR53","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.2c00193","author":"CMJ Wesseling","year":"2022","unstructured":"Wesseling, C. M. J., & Martin, N. I. (2022). Synergy by perturbing the Gram-negative outer membrane: Opening the door for Gram-positive specific antibiotics. ACS Infectious Diseases. https:\/\/doi.org\/10.1021\/acsinfecdis.2c00193","journal-title":"ACS Infectious Diseases"},{"key":"2922_CR54","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.scitotenv.2014.07.114","volume":"497-498","author":"J Xu","year":"2014","unstructured":"Xu, J., Zhang, Y., Zhou, C., Guo, C., Wang, D., Du, P., Luo, Y., Wan, J., & Meng, W. (2014). Distribution, sources and composition of antibiotics in sediment, overlying water and pore water from Taihu Lake, China. Science of the Total Environment, 497\u2013498, 267\u2013273.","journal-title":"Science of the Total Environment"},{"key":"2922_CR55","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.scitotenv.2018.06.175","volume":"643","author":"Z Xu","year":"2018","unstructured":"Xu, Z., Li, T., Bi, J., & Wang, C. (2018). Spatiotemporal heterogeneity of antibiotic pollution and ecological risk assessment in Taihu Lake Basin, China. Science of the Total Environment, 643, 12\u201320.","journal-title":"Science of the Total Environment"},{"key":"2922_CR56","first-page":"225","volume":"17","author":"H Zhang","year":"2015","unstructured":"Zhang, H., Du, M., Jiang, H., Zhang, D., Lin, L., Ye, H., & Zhang, X. J. E. S. P. (2015a). Occurrence, seasonal variation and removal efficiency of antibiotics and their metabolites in wastewater treatment plants, Jiulongjiang River Basin, South China. Environmental Science: Processes & Impacts, 17, 225\u2013234.","journal-title":"Environmental Science: Processes & Impacts"},{"key":"2922_CR57","doi-asserted-by":"crossref","first-page":"6772","DOI":"10.1021\/acs.est.5b00729","volume":"49","author":"Q-Q Zhang","year":"2015","unstructured":"Zhang, Q.-Q., Ying, G.-G., Pan, C.-G., Liu, Y.-S., & Zhao, J.-L. (2015b). Comprehensive evaluation of antibiotics emission and fate in the river basins of China: Source analysis, multimedia modeling, and linkage to bacterial resistance. Environmental Science & Technology, 49, 6772\u20136782.","journal-title":"Environmental Science & Technology"},{"key":"2922_CR58","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.envint.2019.01.061","volume":"125","author":"YZ Zhang","year":"2019","unstructured":"Zhang, Y. Z., Duan, L., Wang, B., Du, Y. L., Cagnetta, G., Huang, J., Blaney, L., & Yu, G. (2019). Wastewater-based epidemiology in Beijing, China: Prevalence of antibiotic use in flu season and association of pharmaceuticals and personal care products with socioeconomic characteristics. Environment International, 125, 152\u2013160.","journal-title":"Environment International"},{"key":"2922_CR59","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.scitotenv.2017.02.214","volume":"590-591","author":"Q-D Zheng","year":"2017","unstructured":"Zheng, Q.-D., Lin, J.-G., Pei, W., Guo, M.-X., Wang, Z., & Wang, D.-G. (2017). Estimating nicotine consumption in eight cities using sewage epidemiology based on ammonia nitrogen equivalent population. Science of the Total Environment, 590\u2013591, 226\u2013232.","journal-title":"Science of the Total Environment"},{"key":"2922_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.145124","author":"Y Zhu","year":"2021","unstructured":"Zhu, Y., Oishi, W., Maruo, C., Saito, M., Chen, R., Kitajima, M., & Sano, D. (2021). Early warning of COVID-19 via wastewater-based epidemiology: Potential and bottlenecks. Science of the Total Environment. https:\/\/doi.org\/10.1016\/j.scitotenv.2021.145124","journal-title":"Science of the Total Environment"}],"container-title":["Environmental Geochemistry and Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10653-025-02922-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10653-025-02922-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10653-025-02922-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T18:03:48Z","timestamp":1767636228000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10653-025-02922-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,11]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["2922"],"URL":"https:\/\/doi.org\/10.1007\/s10653-025-02922-x","relation":{},"ISSN":["0269-4042","1573-2983"],"issn-type":[{"value":"0269-4042","type":"print"},{"value":"1573-2983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,11]]},"assertion":[{"value":"4 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}],"article-number":"41"}}