{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:12:37Z","timestamp":1773270757549,"version":"3.50.1"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Sichuan Provincial Special Project for Central Government Guiding Local Science and Technology Development","award":["2023ZYD0288"],"award-info":[{"award-number":["2023ZYD0288"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Geochem Health"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10653-026-03056-4","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T11:11:45Z","timestamp":1771585905000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deciphering the air pollution-osteoarthritis relationship: insights from network toxicology, integrated machine learning, and molecular docking"],"prefix":"10.1007","volume":"48","author":[{"given":"Yue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinghong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dexin","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"issue":"12","key":"3056_CR1","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1016\/S2213-2600(17)30396-X","volume":"5","author":"HR Anderson","year":"2017","unstructured":"Anderson, H. R. (2017). Implications for the science of air pollution and health. The Lancet Respiratory Medicine, 5(12), 916\u2013918.","journal-title":"The Lancet Respiratory Medicine"},{"issue":"10134","key":"3056_CR2","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1016\/S0140-6736(18)31064-X","volume":"391","author":"R Barnett","year":"2018","unstructured":"Barnett, R. (2018). Osteoarthritis. Lancet, 391(10134), 1985.","journal-title":"Lancet"},{"issue":"9","key":"3056_CR3","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.tins.2009.05.009","volume":"32","author":"ML Block","year":"2009","unstructured":"Block, M. L., & Calder\u00f3n-Garcidue\u00f1as, L. (2009). Air pollution: Mechanisms of neuroinflammation and CNS disease. Trends in Neurosciences, 32(9), 506\u2013516.","journal-title":"Trends in Neurosciences"},{"issue":"11","key":"3056_CR4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167076","volume":"11","author":"MG Broeren","year":"2016","unstructured":"Broeren, M. G., de Vries, M., Bennink, M. B., van Lent, P. L., van der Kraan, P. M., Koenders, M. I., Thurlings, R. M., & van de Loo, F. A. (2016). Functional tissue analysis reveals successful cryopreservation of human osteoarthritic synovium. PLoS ONE, 11(11), e0167076.","journal-title":"PLoS ONE"},{"key":"3056_CR5","doi-asserted-by":"crossref","unstructured":"Chan YC, Huang YW, Chuang SH, Kuo YJ, Chen YP: A decade of exposure: Long-term air pollution and its impact on osteoarthritis: A nationwide cohort study in Taiwan. Osteoarthritis Cartilage 2025.","DOI":"10.1016\/j.joca.2025.09.004"},{"key":"3056_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113341","volume":"153","author":"H Chen","year":"2022","unstructured":"Chen, H., Wang, J., Zhang, C., Ding, P., Tian, S., Chen, J., Ji, G., & Wu, T. (2022). Sphingosine 1-phosphate receptor, a new therapeutic direction in different diseases. Biomedicine & Pharmacotherapy, 153, 113341.","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"1","key":"3056_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67730-y","volume":"10","author":"CH Chou","year":"2020","unstructured":"Chou, C. H., Jain, V., Gibson, J., Attarian, D. E., Haraden, C. A., Yohn, C. B., Laberge, R. M., Gregory, S., & Kraus, V. B. (2020). Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis. Scientific Reports, 10(1), 10868.","journal-title":"Scientific Reports"},{"issue":"6","key":"3056_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/ar4380","volume":"15","author":"CH Chou","year":"2013","unstructured":"Chou, C. H., Wu, C. C., Song, I. W., Chuang, H. P., Lu, L. S., Chang, J. H., Kuo, S. Y., Lee, C. H., Wu, J. Y., Chen, Y. T., et al. (2013). Genome-wide expression profiles of subchondral bone in osteoarthritis. Arthritis Research & Therapy, 15(6), R190.","journal-title":"Arthritis Research & Therapy"},{"issue":"W1","key":"3056_CR9","doi-asserted-by":"publisher","first-page":"W357","DOI":"10.1093\/nar\/gkz382","volume":"47","author":"A Daina","year":"2019","unstructured":"Daina, A., Michielin, O., & Zoete, V. (2019). SwissTargetPrediction: Updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Research, 47(W1), W357-w364.","journal-title":"Nucleic Acids Research"},{"issue":"9","key":"3056_CR10","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nrc3572","volume":"13","author":"L Fajersztajn","year":"2013","unstructured":"Fajersztajn, L., Veras, M., Barrozo, L. V., & Saldiva, P. (2013). Air pollution: A potentially modifiable risk factor for lung cancer. Nature Reviews Cancer, 13(9), 674\u2013678.","journal-title":"Nature Reviews Cancer"},{"issue":"9991","key":"3056_CR11","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","volume":"386","author":"S Glyn-Jones","year":"2015","unstructured":"Glyn-Jones, S., Palmer, A. J., Agricola, R., Price, A. J., Vincent, T. L., Weinans, H., & Carr, A. J. (2015). Osteoarthritis. Lancet, 386(9991), 376\u2013387.","journal-title":"Lancet"},{"issue":"Suppl 1","key":"3056_CR12","doi-asserted-by":"publisher","first-page":"S63","DOI":"10.1007\/s00011-007-0631-1","volume":"57","author":"A Grzybowska-Kowalczyk","year":"2008","unstructured":"Grzybowska-Kowalczyk, A., Maslinska, D., Wojciechowska, M., Szukiewicz, D., Wojtecka-Lukasik, E., Paradowska, A., Maldyk, P., & Maslinski, S. (2008). Expression of histamine H4 receptor in human osteoarthritic synovial tissue. Inflammation Research, 57(Suppl 1), S63-64.","journal-title":"Inflammation Research"},{"issue":"1","key":"3056_CR13","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1093\/rheumatology\/key261","volume":"58","author":"YJ Ha","year":"2019","unstructured":"Ha, Y. J., Choi, Y. S., Han, D. W., Kang, E. H., Yoo, I. S., Kim, J. H., Kang, S. W., Lee, E. Y., Song, Y. W., & Lee, Y. J. (2019). PIM-1 kinase is a novel regulator of proinflammatory cytokine-mediated responses in rheumatoid arthritis fibroblast-like synoviocytes. Rheumatology , 58(1), 154\u2013164.","journal-title":"Rheumatology"},{"issue":"Pt 1","key":"3056_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2022.114340","volume":"215","author":"S Han","year":"2022","unstructured":"Han, S., Zhang, F., Yu, H., Wei, J., Xue, L., Duan, Z., & Niu, Z. (2022). Systemic inflammation accelerates the adverse effects of air pollution on metabolic syndrome: Findings from the China health and retirement longitudinal study (CHARLS). Environmental Research, 215(Pt 1), 114340.","journal-title":"Environmental Research"},{"key":"3056_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2024.142711","volume":"363","author":"J He","year":"2024","unstructured":"He, J., Zhu, X., Xu, K., Li, Y., & Zhou, J. (2024). Network toxicological and molecular docking to investigate the mechanisms of toxicity of agricultural chemical Thiabendazole. Chemosphere, 363, 142711.","journal-title":"Chemosphere"},{"issue":"3","key":"3056_CR16","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.jcmgh.2021.12.002","volume":"13","author":"CH Hong","year":"2022","unstructured":"Hong, C. H., Ko, M. S., Kim, J. H., Cho, H., Lee, C. H., Yoon, J. E., Yun, J. Y., Baek, I. J., Jang, J. E., Lee, S. E., et al. (2022). Sphingosine 1-phosphate receptor 4 promotes nonalcoholic steatohepatitis by activating NLRP3 inflammasome. Cellular and Molecular Gastroenterology and Hepatology, 13(3), 925\u2013947.","journal-title":"Cellular and Molecular Gastroenterology and Hepatology"},{"key":"3056_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.871008","volume":"13","author":"X Hu","year":"2022","unstructured":"Hu, X., Ni, S., Zhao, K., Qian, J., & Duan, Y. (2022). Bioinformatics-led discovery of osteoarthritis biomarkers and inflammatory infiltrates. Frontiers in Immunology, 13, 871008.","journal-title":"Frontiers in Immunology"},{"issue":"7","key":"3056_CR18","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1164\/rccm.202011-4063OC","volume":"204","author":"Y Huang","year":"2021","unstructured":"Huang, Y., Zhu, M., Ji, M., Fan, J., Xie, J., Wei, X., Jiang, X., Xu, J., Chen, L., Yin, R., et al. (2021). Air pollution, genetic factors, and the risk of lung cancer: A prospective study in the UK Biobank. American Journal of Respiratory and Critical Care Medicine, 204(7), 817\u2013825.","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"46","key":"3056_CR19","doi-asserted-by":"publisher","first-page":"17690","DOI":"10.1021\/acs.est.3c00653","volume":"57","author":"X Jia","year":"2023","unstructured":"Jia, X., Wang, T., & Zhu, H. (2023). Advancing computational toxicology by interpretable machine learning. Environmental Science & Technology, 57(46), 17690\u201317706.","journal-title":"Environmental Science & Technology"},{"key":"3056_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.117014","volume":"284","author":"Y Jiang","year":"2024","unstructured":"Jiang, Y., Li, G., Wu, S., Duan, F., Liu, S., & Liu, Y. (2024). Assessment of short-term effects of ambient air pollution exposure on osteoarthritis outpatient visits. Ecotoxicology and Environmental Safety, 284, 117014.","journal-title":"Ecotoxicology and Environmental Safety"},{"issue":"9","key":"3056_CR21","doi-asserted-by":"publisher","first-page":"2817","DOI":"10.1007\/s00204-024-03785-4","volume":"98","author":"L Kazensky","year":"2024","unstructured":"Kazensky, L., Matkovi\u0107, K., Geri\u0107, M., \u017degura, B., Pehnec, G., & Gajski, G. (2024). Impact of indoor air pollution on DNA damage and chromosome stability: A systematic review. Archives of Toxicology, 98(9), 2817\u20132841.","journal-title":"Archives of Toxicology"},{"issue":"2","key":"3056_CR22","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nbt1284","volume":"25","author":"MJ Keiser","year":"2007","unstructured":"Keiser, M. J., Roth, B. L., Armbruster, B. N., Ernsberger, P., Irwin, J. J., & Shoichet, B. K. (2007). Relating protein pharmacology by ligand chemistry. Nature Biotechnology, 25(2), 197\u2013206.","journal-title":"Nature Biotechnology"},{"issue":"1","key":"3056_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01101-y","volume":"7","author":"KW Kim","year":"2017","unstructured":"Kim, K. W., Kim, B. M., Lee, K. A., Lee, S. H., Firestein, G. S., & Kim, H. R. (2017). Histamine and histamine H4 receptor promotes osteoclastogenesis in rheumatoid arthritis. Scientific Reports, 7(1), 1197.","journal-title":"Scientific Reports"},{"key":"3056_CR24","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1146\/annurev-publhealth-052120-103607","volume":"43","author":"RJ Laumbach","year":"2022","unstructured":"Laumbach, R. J., & Cromar, K. R. (2022). Personal interventions to reduce exposure to outdoor air pollution. Annual Review of Public Health, 43, 293\u2013309.","journal-title":"Annual Review of Public Health"},{"issue":"1","key":"3056_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-13868-6","volume":"15","author":"J Lee","year":"2025","unstructured":"Lee, J., Choi, H. K., Park, S. H., Lee, Y. G., & Park, J. H. (2025). Epigenome-wide association study of BMI and waist-to-hip ratio and their associations with dietary patterns in Korean adults. Scientific Reports, 15(1), 28681.","journal-title":"Scientific Reports"},{"key":"3056_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.118255","volume":"297","author":"G Li","year":"2025","unstructured":"Li, G., Li, C., Liu, H., Song, Y., Zhang, Y., Chen, P., Zhang, H., & Wu, S. (2025a). Association of ambient air pollution with hospital admissions for major osteoarthritis diseases: A national case-crossover study in China. Ecotoxicology and Environmental Safety, 297, 118255.","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"3056_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.721258","volume":"12","author":"S Li","year":"2021","unstructured":"Li, S., Wang, H., Zhang, Y., Qiao, R., Xia, P., Kong, Z., Zhao, H., & Yin, L. (2021). COL3A1 and MMP9 serve as potential diagnostic biomarkers of osteoarthritis and are associated with immune cell infiltration. Frontiers in Genetics, 12, 721258.","journal-title":"Frontiers in Genetics"},{"key":"3056_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.119480","volume":"343","author":"X Li","year":"2025","unstructured":"Li, X., Lin, L., Pang, L., Pu, K., Fu, J., Shen, Y., Zhang, W., Xu, H., & Niu, Y. (2025d). Application and development trends of network toxicology in the safety assessment of traditional Chinese medicine. Journal of Ethnopharmacology, 343, 119480.","journal-title":"Journal of Ethnopharmacology"},{"key":"3056_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2025.108918","volume":"135","author":"Y Li","year":"2025","unstructured":"Li, Y., Liu, Z., Zhou, T., Zhu, X., Wu, Q., Zeng, Y., Yang, J., Meng, C., & Deng, Q. (2025b). Integrating network toxicology and Mendelian randomization to uncover the role of AHR in linking air pollution to male reproductive health. Reproductive Toxicology, 135, 108918.","journal-title":"Reproductive Toxicology"},{"key":"3056_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.117966","volume":"292","author":"Y Li","year":"2025","unstructured":"Li, Y., Zhou, T., Liu, Z., Zhu, X., Wu, Q., Meng, C., & Deng, Q. (2025c). Air pollution and prostate cancer: Unraveling the connection through network toxicology and machine learning. Ecotoxicology and Environmental Safety, 292, 117966.","journal-title":"Ecotoxicology and Environmental Safety"},{"issue":"1","key":"3056_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28421-6","volume":"13","author":"Z Liu","year":"2022","unstructured":"Liu, Z., Liu, L., Weng, S., Guo, C., Dang, Q., Xu, H., Wang, L., Lu, T., Zhang, Y., Sun, Z., et al. (2022). Machine learning-based integration develops an immune-derived lncRNA signature for improving outcomes in colorectal cancer. Nature Communications, 13(1), 816.","journal-title":"Nature Communications"},{"issue":"1","key":"3056_CR32","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13018-021-02208-9","volume":"16","author":"S Luo","year":"2021","unstructured":"Luo, S., Li, W., Wu, W., & Shi, Q. (2021). Elevated expression of MMP8 and MMP9 contributes to diabetic osteoarthritis progression in a rat model. Journal of Orthopaedic Surgery and Research, 16(1), 64.","journal-title":"Journal of Orthopaedic Surgery and Research"},{"key":"3056_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.72","volume":"2","author":"J Martel-Pelletier","year":"2016","unstructured":"Martel-Pelletier, J., Barr, A. J., Cicuttini, F. M., Conaghan, P. G., Cooper, C., Goldring, M. B., Goldring, S. R., Jones, G., Teichtahl, A. J., & Pelletier, J. P. (2016). Osteoarthritis. Nature Reviews Disease Primers, 2, 16072.","journal-title":"Nature Reviews Disease Primers"},{"issue":"2","key":"3056_CR34","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/s41576-024-00767-1","volume":"26","author":"MJ Meier","year":"2025","unstructured":"Meier, M. J., Harrill, J., Johnson, K., Thomas, R. S., Tong, W., Rager, J. E., & Yauk, C. L. (2025). Progress in toxicogenomics to protect human health. Nature Reviews Genetics, 26(2), 105\u2013122.","journal-title":"Nature Reviews Genetics"},{"issue":"1\u20132","key":"3056_CR35","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.drudis.2009.09.010","volume":"15","author":"C Merlot","year":"2010","unstructured":"Merlot, C. (2010). Computational toxicology\u2013a tool for early safety evaluation. Drug Discovery Today, 15(1\u20132), 16\u201322.","journal-title":"Drug Discovery Today"},{"key":"3056_CR36","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.freeradbiomed.2020.01.004","volume":"151","author":"MR Miller","year":"2020","unstructured":"Miller, M. R. (2020). Oxidative stress and the cardiovascular effects of air pollution. Free Radical Biology & Medicine, 151, 69\u201387.","journal-title":"Free Radical Biology & Medicine"},{"issue":"4","key":"3056_CR37","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1007\/s40572-017-0168-6","volume":"4","author":"H Orru","year":"2017","unstructured":"Orru, H., Ebi, K. L., & Forsberg, B. (2017). The interplay of climate change and air pollution on health. Current Environmental Health Reports, 4(4), 504\u2013513.","journal-title":"Current Environmental Health Reports"},{"key":"3056_CR38","doi-asserted-by":"crossref","unstructured":"Qi W, Kong M, Meng X, Sun Z, Mei Z, Pu Y, Zhou X, Wang Q, Qiu JG, Jiang BH et al: The Role of Gut Microbiota in the Association Between Air Pollution and Cognitive Function in Older Adults. Environmental Health Perspect 2025.","DOI":"10.1289\/EHP16515"},{"key":"3056_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.118233","volume":"297","author":"L Qi","year":"2025","unstructured":"Qi, L., Yang, J., Niu, Q., & Li, J. (2025b). Exploring pesticide risk in autism via integrative machine learning and network toxicology. Ecotoxicology and Environmental Safety, 297, 118233.","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"3056_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.117770","volume":"290","author":"J Qian","year":"2025","unstructured":"Qian, J., Zhu, J., Wang, Y., Dai, R., Miao, J., Yang, Y., Zhao, W., Wang, J., Ding, L., Zhou, D., et al. (2025). Associations and potential epigenetic changes between air pollution and osteoarthritis risk and survival: Insights from a prospective cohort study. Ecotoxicology and Environmental Safety, 290, 117770.","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"3056_CR41","doi-asserted-by":"crossref","unstructured":"Qiao PY, Yang YL, Zhao JK, Wang PZ, Wei JC, Zhang LY: Methodological gaps in air pollution and osteoarthritis risk research. Osteoarthritis Cartilage 2025.","DOI":"10.1016\/j.joca.2025.06.010"},{"issue":"1","key":"3056_CR42","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1183\/09031936.00128106","volume":"31","author":"I Romieu","year":"2008","unstructured":"Romieu, I., Castro-Giner, F., Kunzli, N., & Sunyer, J. (2008). Air pollution, oxidative stress and dietary supplementation: A review. European Respiratory Journal, 31(1), 179\u2013197.","journal-title":"European Respiratory Journal"},{"issue":"12","key":"3056_CR43","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1513\/AnnalsATS.201907-538CME","volume":"16","author":"DE Schraufnagel","year":"2019","unstructured":"Schraufnagel, D. E., Balmes, J. R., De Matteis, S., Hoffman, B., Kim, W. J., Perez-Padilla, R., Rice, M., Sood, A., Vanker, A., & Wuebbles, D. J. (2019). Health benefits of air pollution reduction. Annals of the American Thoracic Society, 16(12), 1478\u20131487.","journal-title":"Annals of the American Thoracic Society"},{"key":"3056_CR44","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1016\/j.envpol.2019.07.054","volume":"253","author":"A Shepherd","year":"2019","unstructured":"Shepherd, A., & Mullins, J. T. (2019). Arthritis diagnosis and early-life exposure to air pollution. Environmental Pollution, 253, 1030\u20131037.","journal-title":"Environmental Pollution"},{"key":"3056_CR45","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.scitotenv.2018.11.381","volume":"656","author":"A Shukla","year":"2019","unstructured":"Shukla, A., Bunkar, N., Kumar, R., Bhargava, A., Tiwari, R., Chaudhury, K., Goryacheva, I. Y., & Mishra, P. K. (2019). Air pollution associated epigenetic modifications: Transgenerational inheritance and underlying molecular mechanisms. Science of the Total Environment, 656, 760\u2013777.","journal-title":"Science of the Total Environment"},{"issue":"7","key":"3056_CR46","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1111\/j.1440-1843.2012.02213.x","volume":"17","author":"MP Sierra-Vargas","year":"2012","unstructured":"Sierra-Vargas, M. P., & Teran, L. M. (2012). Air pollution: Impact and prevention. Respirology, 17(7), 1031\u20131038.","journal-title":"Respirology"},{"key":"3056_CR47","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jot.2023.11.005","volume":"44","author":"H Tang","year":"2024","unstructured":"Tang, H., Gong, X., Dai, J., Gu, J., Dong, Z., Xu, Y., Hu, Z., Zhao, C., Deng, J., & Dong, S. (2024). The IRF1\/GBP5 axis promotes osteoarthritis progression by activating chondrocyte pyroptosis. Journal of Orthopaedic Translation, 44, 47\u201359.","journal-title":"Journal of Orthopaedic Translation"},{"key":"3056_CR48","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2024-011088","author":"RE Tay","year":"2025","unstructured":"Tay, R. E., Ho, C. M., Ang, N. D. Z., Tay, H. C., Lopez, D. Z., Na, Q. R., Tan, Y. W., Koh, S. M., Tan, K. P., Lee, W., et al. (2025). Serotonin receptor 5-HT(2A) as a potential target for HCC immunotherapy. Journal for ImmunoTherapy of Cancer. https:\/\/doi.org\/10.1136\/jitc-2024-011088","journal-title":"Journal for ImmunoTherapy of Cancer"},{"issue":"1","key":"3056_CR49","doi-asserted-by":"publisher","DOI":"10.5334\/aogh.4363","volume":"90","author":"D Vilcins","year":"2024","unstructured":"Vilcins, D., Christofferson, R. C., Yoon, J. H., Nazli, S. N., Sly, P. D., Cormier, S. A., & Shen, G. (2024). Updates in air pollution: Current research and future challenges. Annals of Global Health, 90(1), 9.","journal-title":"Annals of Global Health"},{"issue":"8","key":"3056_CR50","doi-asserted-by":"publisher","first-page":"5150","DOI":"10.1097\/JS9.0000000000002638","volume":"111","author":"F Wang","year":"2025","unstructured":"Wang, F., Cheng, B., Wu, W., Chen, Y., Dai, J., & Li, Y. (2025). Mechanistic insights into PFOS-induced inflammatory bowel disease: A network toxicology and molecular docking study. International Journal of Surgery, 111(8), 5150\u20135161.","journal-title":"International Journal of Surgery"},{"issue":"4","key":"3056_CR51","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/s41423-023-00982-6","volume":"20","author":"Z Wang","year":"2023","unstructured":"Wang, Z., Yan, C., Du, Q., Huang, Y., Li, X., Zeng, D., Mao, R., Gurram, R. K., Cheng, S., Gu, W., et al. (2023). HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation. Cellular & Molecular Immunology, 20(4), 404\u2013418.","journal-title":"Cellular & Molecular Immunology"},{"issue":"2","key":"3056_CR52","doi-asserted-by":"publisher","DOI":"10.1186\/ar4526","volume":"16","author":"D Woetzel","year":"2014","unstructured":"Woetzel, D., Huber, R., Kupfer, P., Pohlers, D., Pfaff, M., Driesch, D., H\u00e4upl, T., Koczan, D., Stiehl, P., Guthke, R., et al. (2014). Identification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation. Arthritis Research & Therapy, 16(2), R84.","journal-title":"Arthritis Research & Therapy"},{"issue":"1","key":"3056_CR53","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-024-01352-w","volume":"24","author":"C Xiang","year":"2024","unstructured":"Xiang, C., Hong, S. M., Zhao, B., Pi, H., Du, F., Lu, X., Tang, Y., Shen, N., Yang, C., & Wang, R. (2024). Fibroblast expression of neurotransmitter receptor HTR2A associates with inflammation in rheumatoid arthritis joint. Clinical and Experimental Medicine, 24(1), 84.","journal-title":"Clinical and Experimental Medicine"},{"key":"3056_CR54","doi-asserted-by":"publisher","first-page":"205","DOI":"10.2147\/IJGM.S447035","volume":"17","author":"L Xu","year":"2024","unstructured":"Xu, L., Wang, Z., & Wang, G. (2024). Screening of biomarkers associated with osteoarthritis aging genes and immune correlation studies. International Journal of General Medicine, 17, 205\u2013224.","journal-title":"International Journal of General Medicine"},{"issue":"5","key":"3056_CR55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194226","volume":"13","author":"Y Xue","year":"2018","unstructured":"Xue, Y., Cheng, L., Chen, X., Zhai, X., Wang, W., Zhang, W., Bai, Y., Tian, H., Nie, L., Zhang, S., et al. (2018). Emission characteristics of harmful air pollutants from cremators in Beijing, China. PLoS ONE, 13(5), e0194226.","journal-title":"PLoS ONE"},{"key":"3056_CR56","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2024.117313","volume":"190","author":"M Yan","year":"2025","unstructured":"Yan, M., Cai, L., Duan, X., Tycksen, E. D., & Rai, M. F. (2025). Carbonic anhydrase 2 is important for articular chondrocyte function and metabolic homeostasis. Bone, 190, 117313.","journal-title":"Bone"},{"key":"3056_CR57","doi-asserted-by":"publisher","first-page":"1380210","DOI":"10.3389\/fmed.2024.1380210","volume":"11","author":"J Yang","year":"2024","unstructured":"Yang, J., Zhong, J., Du, Y., Wang, Z., Jiang, L., Li, Z., & Liu, Y. (2024). Bioinformatics and systems biology approaches to identify potential common pathogeneses for sarcopenia and osteoarthritis. Front Med (Lausanne), 11, 1380210.","journal-title":"Front Med (Lausanne)"},{"issue":"5","key":"3056_CR58","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s10822-016-9915-2","volume":"30","author":"ZJ Yao","year":"2016","unstructured":"Yao, Z. J., Dong, J., Che, Y. J., Zhu, M. F., Wen, M., Wang, N. N., Wang, S., Lu, A. P., & Cao, D. S. (2016). TargetNet: A web service for predicting potential drug-target interaction profiling via multi-target SAR models. Journal of Computer-Aided Molecular Design, 30(5), 413\u2013424.","journal-title":"Journal of Computer-Aided Molecular Design"},{"issue":"5","key":"3056_CR59","doi-asserted-by":"publisher","DOI":"10.1093\/toxres\/tfae147","volume":"13","author":"F Yarmohammadi","year":"2024","unstructured":"Yarmohammadi, F., Hayes, A. W., & Karimi, G. (2024). Research trends of computational toxicology: A bibliometric analysis. Toxicology Research, 13(5), tfae147.","journal-title":"Toxicology Research"},{"issue":"7","key":"3056_CR60","doi-asserted-by":"publisher","first-page":"4087","DOI":"10.1007\/s10653-023-01495-x","volume":"45","author":"RD Zhang","year":"2023","unstructured":"Zhang, R. D., Chen, C., Wang, P., Fang, Y., Jiang, L. Q., Fang, X., Zhao, Y., Ni, J., Wang, D. G., & Pan, H. F. (2023a). Air pollution exposure and auto-inflammatory and autoimmune diseases of the musculoskeletal system: A review of epidemiologic and mechanistic evidence. Environmental Geochemistry and Health, 45(7), 4087\u20134105.","journal-title":"Environmental Geochemistry and Health"},{"issue":"1","key":"3056_CR61","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04313-1","volume":"21","author":"Z Zhang","year":"2023","unstructured":"Zhang, Z., Xie, S., Qian, J., Gao, F., Jin, W., Wang, L., Yan, L., Chen, H., Yao, W., Li, M., et al. (2023b). Targeting macrophagic PIM-1 alleviates osteoarthritis by inhibiting NLRP3 inflammasome activation via suppressing mitochondrial ROS\/Cl(-) efflux signaling pathway. Journal of Translational Medicine, 21(1), 452.","journal-title":"Journal of Translational Medicine"},{"key":"3056_CR62","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1054451","volume":"13","author":"J Zhao","year":"2022","unstructured":"Zhao, J., Xu, L., Chang, C., Jiang, P., Wei, K., Shi, Y., Xu, L., Zheng, Y., Shan, Y., Bian, Y., et al. (2022). Circulating methylation level of HTR2A is associated with inflammation and disease activity in rheumatoid arthritis. Frontiers in Immunology, 13, 1054451.","journal-title":"Frontiers in Immunology"},{"issue":"1","key":"3056_CR63","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03596-5","volume":"22","author":"H Zhou","year":"2024","unstructured":"Zhou, H., Hong, F., Wang, L., Tang, X., Guo, B., Luo, Y., Yu, H., Mao, D., Liu, T., Feng, Y., et al. (2024). Air pollution and risk of 32 health conditions: Outcome-wide analyses in a population-based prospective cohort in Southwest China. BMC Medicine, 22(1), 370.","journal-title":"BMC Medicine"},{"key":"3056_CR64","doi-asserted-by":"crossref","unstructured":"Zhu Y, Liu J, Wang F: Investigating the mechanisms of pazopanib-induced hepatotoxicity: Insights from network toxicology, microarray analysis, and machine learning. Current Medicinal Chemistry\u00a0\u00a02025.","DOI":"10.2174\/0109298673367311250508082747"}],"container-title":["Environmental Geochemistry and Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10653-026-03056-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10653-026-03056-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10653-026-03056-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T08:02:22Z","timestamp":1773216142000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10653-026-03056-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":64,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["3056"],"URL":"https:\/\/doi.org\/10.1007\/s10653-026-03056-4","relation":{},"ISSN":["0269-4042","1573-2983"],"issn-type":[{"value":"0269-4042","type":"print"},{"value":"1573-2983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"26 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have reported that they have no relationships relevant to the contents of this paper to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"179"}}