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A random sample of 45,000 participants between 45 and 74\u00a0years of age from the general population of Hamburg, Germany, are taking part in an extensive baseline assessment at one dedicated study center. Participants undergo 13 validated and 5 novel examinations primarily targeting major organ system function and structures including extensive imaging examinations. The protocol includes validate self-reports via questionnaires regarding lifestyle and environmental conditions, dietary habits, physical condition and activity, sexual dysfunction, professional life, psychosocial context and burden, quality of life, digital media use, occupational, medical and family history as well as healthcare utilization. The assessment is completed by genomic and proteomic characterization. Beyond the identification of classical risk factors for major chronic diseases and survivorship, the core intention is to gather valid prevalence and incidence, and to develop complex models predicting health outcomes based on a multitude of examination data, imaging, biomarker, psychosocial and behavioral assessments. Participants at risk for coronary artery disease, atrial fibrillation, heart failure, stroke and dementia are invited for a visit to conduct an additional MRI examination of either heart or brain. Endpoint assessment of the overall sample will be completed through repeated follow-up examinations and surveys as well as related individual routine data from involved health and pension insurances. 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Gerhard Adam: Nothing to disclose. Sven Anders: received research funding from German Ministry of Science and Education (BMBF) and Rickertsen Foundation. Matthias Augustin: Nothing to disclose. Ramona Bei der Kellen: Nothing to disclose. Thomas Beikler: Nothing to disclose. Christian-Alexander Behrendt: has received research funding from the German Federal Joint Committee (Grant No. 01VSF16008 and 01VSF18035). Christian S. Betz: Nothing to disclose relating to HCHS. Carsten Bokemeyer: Nothing to disclose. Katrin Borof: Nothing to disclose. Peer Briken: Nothing to disclose. Chia-Jung Busch: Has received project related funding by the DKFZ. Christian B\u00fcchel: Nothing to disclose. Stefanie Brassen: Nothing to disclose. Sebastian Debus received institutional Grants from COOK, Vascutek and Bayer. He has also received honoraria as member of Bayer Advisory boards. Larissa Eggers: Nothing to disclose. Jens Fiehler: received research funding from German Ministry of Science and Education (BMBF), German Ministry of Economy and Innovation (BMWi), German Research Foundation (DFG), European Union (EU), Hamburgische Investitions- und F\u00f6rderbank (IFB), Medtronic, Microvention, Philips, Stryker; received honoraria as consultant or speaker for Acandis, Boehringer Ingelheim, Cerenovus, Covidien, Evasc Neurovascular, MD Clinicals, Medtronic, Medina, Microvention, Penumbra, Route92, Stryker, Transverse Medical. J\u00fcrgen Gallinat: has received research funding from the German Federal Ministry of Education and Research, German Science Foundation, and speaker fees from Lundbeck, Janssen-Cilag, Lilly and Otsuka. Christian Gerloff: received funding from German Research Council (DFG), European Union, Federal Ministery of Education and Research (BMBF), German Statutory Pension Insurance Scheme (RV Nord), National Innovation Fond, Wegener Foundation, and Schilling Foundation; received honoraria as speaker or consultant from Abbott, Amgen, Bayer Vital, Bristol-Myers-Squibb, Boehringer Ingelheim, Sanofi Aventis, and Prediction Biosciences. Evaldas Girdauskas: Nothing to disclose. Martin Gosau: Nothing to disclose. Uwe Koch- Gromus: Nothing to disclose. Markus Graefen: Nothing to disclose. Martin H\u00e4rter: received funding from the Federal Ministery of Education and Research (BMBF) for the project PERGOLA. Volker Harth: received funding from European Union, Federal Ministery of Education and Research (BMBF), Federal Ministery of Health (BMG), and Deutsche Gesetzliche Unfallversicherung (DGUV). Christoph Heidemann: Nothing to disclose. Guido Heydecke: Nothing to disclose. Tobias Huber: Nothing to disclose relating to HCHS. Yassin Hussein: Nothing to disclose. Annika Jagodzinski: Has received project related funding by Amgen and an unrestricted Grant by Bayer. Christoffer Johansen: Nothing to disclose. Marvin O. Kampf: Nothing to disclose. Olaf von dem Knesebeck: Nothing to disclose. Alexander Konnopka: Nothing to disclose. Hans-Helmut K\u00f6nig: Nothing to disclose. Robert Kromer: received funding from the Federal Ministry of Economics and Technology, European Union, Santen and StullnPharma;\u00a0received honoraria as\u00a0speaker from Bayer, Novartis, Santen and Topcon. Christian Kubisch: Nothing to disclose. Simone K\u00fchn: has been funded by the German Science Foundation, the European Union (ERC-2016-StG-Self-Control-677804) and a Fellowship from the Jacobs Foundation. Sonja Loges: Nothing to disclose with regards to this publication. Bernd L\u00f6we: Nothing to disclose. Gunnar Lund: Nothing to disclose. Christian Meyer: is supported by the German Center for Cardiovascular Research (DZHK, 81Z0710112). Lina Nagel: Nothing to disclose Albert Nienhaus: Received funds from the German Ministry of Health (BMG), the European Union Social Dialog Fund, Institution for Statutory Accident Insurance and Prevention in the Health and Welfare Services, and ZEIT-Stiftung. Klaus Pantel: Nothing to disclose. Elina Petersen: Nothing to disclose. Klaus P\u00fcschel: Nothing to disclose. Hermann Reichenspurner: received honoraria as consultant for Abiomed und Medtronic. Guido Sauter: Nothing to disclose. Martin Scherer: Nothing to disclose. Katharina Scherschel: is supported by the German Center for Cardiovascular Research (DZHK, 81Z0710112). Ulrich Schiffner: has received honoraria for lectures from 3\u00a0M, CP Gaba, and DMG. Renate Schnabel: has received funding from the European Research Council (ERC) under the European Union\u2019s Horizon 2020 research and innovation programme (Grant Agreement No 648131), German Ministry of Research and Education (BMBF 01ZX1408A) and German Center for Cardiovascular Research (DZHK e.V.) (81Z1710103). Holger Schulz: Nothing to disclose. Ralf Smeets: Nothing to disclose. Vladislavs Sokalskis: Nothing to disclose. Martin S. Spitzer has received research funding from Novartis, Clanotech, Croma Pharma Topcon and Flouron. He received honoraria for lectures from Novartis, Bayer, Alcon, Allergan, Alimera Sciences and for consulting from Bayer, SHS and Altacor. Claudia Tersch\u00fcren: received funding from Deutsche Gesetzliche Unfallversicherung (DGUV). Imke Thederan: Nothing to disclose. G\u00f6tz Thomalla: received funding from the German Research Council (DFG), European Union\u2019s Horizon 2020 research and innovation programme, German Federal Ministry for Economic Affairs and Energy (BMWi), Germany\u2019s Federal Joint Committee (G-BA) Innovation Fund (Innovationsfonds), and has received honoraria as speaker or consultant from Acandis, Bayer Vital, Bristol-Myers-Squibb\/Pfizer, Boehringer Ingelheim, Daiichi Sankyo and Stryker. Benjamin Waschki: Nothing to disclose. Karl Wegscheider: Nothing to disclose. Jan-Per Wenzel: Nothing to disclose. Susanne Wiese: Nothing to disclose. Birgit-Christiane Zyriax: has received project related funding by BASF, Unilever and DIFE. Tanja Zeller: is supported by the German Center for Cardiovascular Research (DZHK, 81Z0710102). This project has received funding from the European Union\u00b4s Horizon 2020 research and innovation programme under Grant Agreement No. 825903, the Innovative medicine initiative (IMI) under Grant No. 116074 and the Fondation Leducq under Grant Number 16 CVD 03. Stefan Blankenberg: is supported by the Innovative medicine initiative (IMI) under Grant No. 116074, the Fondation Leducq under Grant Number 16 CVD 03, Siemens, Bayer, Astra Zeneca, Deutsche Gesetzliche Unfallversicherung (DGUV) and Novartis for project related analyses.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}]}}