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The Lifelines NEXT is a birth cohort designed to study the effects of intrinsic and extrinsic determinants on health and disease in a four-generation design. It is embedded within the Lifelines cohort study, a prospective three-generation population-based cohort study recording the health and health-related aspects of 167,729 individuals living in Northern Netherlands. In Lifelines NEXT we aim to include 1500 pregnant Lifelines participants and intensively follow them, their partners and their children until at least 1\u00a0year after birth. Longer-term follow-up of physical and psychological health will then be embedded following Lifelines procedures. During the Lifelines NEXT study period biomaterials\u2014including maternal and neonatal (cord) blood, placental tissue, feces, breast milk, nasal swabs and urine\u2014will be collected from the mother and child at 10 time points. We will also collect data on medical, social, lifestyle and environmental factors via questionnaires at 14 different time points and continuous data via connected devices. The extensive collection of different (bio)materials from mother and child during pregnancy and afterwards will provide the means to relate environmental factors including maternal and neonatal microbiome composition) to (epi)genetics, health and developmental outcomes. The nesting of the study within Lifelines enables us to include preconceptional transgenerational data and can be used to identify other extended families within the cohort.<\/jats:p>","DOI":"10.1007\/s10654-020-00614-7","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T03:02:36Z","timestamp":1582599756000},"page":"157-168","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1223-4923","authenticated-orcid":false,"given":"Willemijn D. 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Although Philips is a partner in the Newborn project, the company has no influence on or participation in the analyses and publication of the results of the data from their devices.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Informed consent was obtained from all individuals included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The Lifelines NEXT study was approved by the ethics committee of the University Medical Center Groningen, document number METC UMCG METc2015\/600.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants"}}]}}