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However, long-term donor prognosis is debated, necessitating high-quality studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A follow-up study of 761 living kidney donors was conducted, who visited the outpatient clinic and were propensity score matched and compared to 1522 non-donors from population-based cohort studies. Primary outcome was kidney function. Secondary outcomes were BMI (kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), incidences of hypertension, diabetes, cardiovascular events, cardiovascular and overall mortality, and quality of life.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median follow-up after donation was 8.0\u00a0years. Donors had an increase in serum creatinine of 26\u00a0\u03bcmol\/l (95% CI 24\u201328), a decrease in eGFR of 27\u00a0ml\/min\/1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      (95% CI \u2212\u200929 to \u2212\u200926), and an eGFR decline of 32% (95% CI 30\u201333) as compared to non-donors. There was no difference in outcomes between the groups for ESRD, microalbuminuria, BMI, incidence of diabetes or cardiovascular events, and mortality. A lower risk of new-onset hypertension (OR 0.45, 95% CI 0.33\u20130.62) was found among donors. The EQ-5D health-related scores were higher among donors, whereas the SF-12 physical and mental component scores were lower.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Loss of kidney mass after live donation does not translate into negative long-term outcomes in terms of morbidity and mortality compared to non-donors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>Dutch Trial Register NTR3795.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10654-020-00647-y","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T15:02:36Z","timestamp":1590073356000},"page":"699-707","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Long-term prognosis after kidney donation: a propensity score matched comparison of living donors and non-donors from two population cohorts"],"prefix":"10.1007","volume":"35","clinical-trial-number":[{"clinical-trial-number":"ntr3795","registry":"10.18810\/dutch-trial-register"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9515-6774","authenticated-orcid":false,"given":"Shiromani","family":"Janki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6403-016X","authenticated-orcid":false,"given":"Abbas","family":"Dehghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9117-2630","authenticated-orcid":false,"given":"Jacqueline","family":"van de Wetering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7787-0122","authenticated-orcid":false,"given":"Ewout W.","family":"Steyerberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3001-1328","authenticated-orcid":false,"given":"Karel W. 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