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We estimated the risk for gastroesophageal cancers among patients with various histopathological abnormalities in the esophagus, including Barrett\u2019s esophagus, subdivided by histopathological types.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Histopathology data from esophageal biopsies obtained 1979\u20132014 were linked with several national population-based registers in Sweden. Patients were followed from 2\u00a0years after the first biopsy date until cancer, death, emigration, esophagectomy\/gastrectomy or end of follow-up, 31st of December 2016, whichever came first. We estimated standardized incidence ratios (SIRs) as measures of relative risk with the Swedish general population as reference.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In total 367 esophageal adenocarcinoma (EAC) cases were ascertained during 831,394 person-years of follow-up. The incidence rate (IR) for EAC was 0.1 per 1000 person-years for normal morphology, 0.2\u20130.5 for inflammatory changes, and 0.8\u20132.9 for metaplasia. The IR was 1.0 per 1000 person-years (95% confidence interval 0.7\u20131.3) among patients with non-dysplastic intestinal metaplasia, 0.9 (0.8\u20131.1) in non-dysplastic gastric\/glandular metaplasia and 2.9 (2.0\u20134.2) among columnar metaplasia patients with low-grade dysplasia. The SIRs were 11.7 (95% confidence interval 8.6\u201315.5), 12.0 (10.0\u201314.2) and 30.2 (20.5\u201342.8), respectively. The SIRs for gastric cardia adenocarcinoma (GCA) were moderately elevated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>For the first time, we demonstrate that patients with esophageal inflammatory and other metaplastic abnormalities than Barrett\u2019s esophagus have an increased risk of EAC and GCA compared to the general population. Moreover, patients with different histopathologic subtypes of Barrett\u2019s esophagus have a comparable risk for EAC.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10654-021-00833-6","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T08:06:54Z","timestamp":1641197214000},"page":"401-411","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Esophageal abnormalities and the risk for gastroesophageal cancers\u2014a histopathology-register-based study in Sweden"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0445-6630","authenticated-orcid":false,"given":"Isabella","family":"Ekheden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas F.","family":"Ludvigsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Elbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weimin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,3]]},"reference":[{"issue":"8","key":"833_CR1","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s00535-019-01593-7","volume":"54","author":"KEL McColl","year":"2019","unstructured":"McColl KEL. 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