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To this end, 36 German Academic Medical Centers started to collaborate on 13 projects, with the largest being the\n                    <jats:italic>National Pandemic Cohort Network<\/jats:italic>\n                    (NAPKON). The NAPKON\u2019s goal is creating the most comprehensive\n                    <jats:italic>Coronavirus Disease 2019<\/jats:italic>\n                    (COVID-19) cohort in Germany. Within NAPKON, adult and pediatric patients are observed in three complementary cohort platforms (Cross-Sectoral, High-Resolution and Population-Based) from the initial infection until up to three years of follow-up. Study procedures comprise comprehensive clinical and imaging diagnostics, quality-of-life assessment, patient-reported outcomes and biosampling. The three cohort platforms build on four infrastructure core units (Interaction, Biosampling, Epidemiology, and Integration) and collaborations with NUM projects. Key components of the data capture, regulatory, and data privacy are based on the\n                    <jats:italic>German Centre for Cardiovascular Research.<\/jats:italic>\n                    By April 01, 2022, 34 university and 40 non-university hospitals have enrolled 5298 patients with local data quality reviews performed on 4727 (89%). 47% were female, the median age was 52 (IQR 36\u201362-) and 50 pediatric cases were included. 44% of patients were hospitalized, 15% admitted to an intensive care unit, and 12% of patients deceased while enrolled. 8845 visits with biosampling in 4349 patients were conducted by April 03, 2022. In this overview article, we summarize NAPKON\u2019s design, relevant milestones including first study population characteristics, and outline the potential of NAPKON for German and international research activities.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Trial registration<\/jats:italic>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04768998\" ext-link-type=\"uri\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04768998<\/jats:ext-link>\n                    <jats:underline>.<\/jats:underline>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04747366\" ext-link-type=\"uri\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04747366<\/jats:ext-link>\n                    <jats:underline>.<\/jats:underline>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04679584\" ext-link-type=\"uri\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04679584<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1007\/s10654-022-00896-z","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T09:25:57Z","timestamp":1659086757000},"page":"849-870","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["The German National Pandemic Cohort Network (NAPKON): rationale, study design and baseline 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Dr. Bahmer reports grants from the German Center for Lung Research (DZL) and fees for lecturing, advice and travel expenses from AstraZeneca, GlaxoSmithKline. Novartis, Chiesi, Boehringer Ingelheim, MSD, Roche. Dr. Bellinghausen reports grants or contracts from Gilead Sciences. Dr. Hanses reports having received fees for presentations and lectures for DGINA, Akademie f\u00fcr Infektionsmedizin, and participation on the advisory boards for MSD, GSK and Sobi. Dr. Herold reports grants or contracts from the German Research Foundation (DFG), Ministry of Research and Education (BMBF), consulting fees from Janssen, Sanofi and AstraZeneca, participation on a data safety monitoring board or advisory Board for Atriva. Dr. Keil reports grants from European Union; German Research Foundation; German Federal Ministry of Research and Education; Innovationsfonds by the Federal Joint Committee (G-BA); and the Bavarian State Ministry of Health and Care. Dr. Pape reports having received support for attending ECCMID 2021 from Advanz Pharma Germany. Dr. P\u00fcntmann reports honoraria for presentations for Byer AG and Siemens AG, and being involved in the ACC Taskforce on long-term sequela of COVID-19 infection. Dr. St\u00f6rk reports grants from Federal Ministry of Education and Research for the Comprehensive Heart Failure Center W\u00fcrzburg. Dr. Nagel reports grants from Byer AG and NeoSoft Ltd., consulting fees from Bayer AG, honoraria for presentations for Byer AG, Pfizer AG and Siemens Healthineers. He has received payments for expert testimony by Bayer AG, participates in the Advisory board CMR-ICD: NCT04558723, has patents issued and received equipment from MEDIS and NeoSoft. Dr. Thibeault reports grants from the Deutsche Forschungsgemeinschaft. Dr. Witzenrath reports grants from Deutsche Forschungsgemeinschaft, Bundesministerium f\u00fcr Bildung und Forschung, Deutsche Gesellschaft f\u00fcr Pneumologie, European Respiratory Society, Marie Curie Foundation, Else Kr\u00f6ner Fresenius Stiftung, Capnetz Stiftung, International Max Planck Research School, Vaxxilon, Actelion, Bayer Health Care, Biotest, Boehringer Ingelheim. He received consulting fees from Noxxon, Pantherna, Vaxxilon, Aptarion, Glaxo Smith Kline, Sinoxa, Biotest, Thieme, and received honoraria for presentations from Astra Zeneca, Berlin Chemie, Chiesi, Novartis, Actelion, Boehringer Ingelheim, Glaxo Smith Kline, Biotest, Bayer Health Care. He has issued several patents. Dr. Vehreschild reports to have received honoraria for presentations from Merck \/ MSD, Gilead, Pfizer, Astellas Pharma, Basilea, German Centre for Infection Research (DZIF), University Hospital Freiburg\/Congress and Communication, Academy for Infectious Medicine, University Manchester, German Society for Infectious Diseases (DGI), \u00c4rztekammer Nordrhein, University Hospital Aachen, Back Bay Strategies, German Society for Internal Medicine (DGIM), Shionogi, Molecular Health, Netzwerk Universit\u00e4tsmedizin, Janssen, NordForsk. He received research funding from Merck \/ MSD, Gilead, Pfizer, Astellas Pharma, Basilea, German Centre for Infection Research (DZIF), German Federal Ministry of Education and Research (BMBF), (PJ-T: DLR), University of Bristol, Rigshospitalet Copenhagen. All other authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript, except for the Network University Medicine.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No identifying information is included in this article.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"NAPKON\u2019s study protocols have been approved at institutional review boards\/ethics committees of all participating study sites.","order":4,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}