{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:29:34Z","timestamp":1783938574501,"version":"3.55.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF15OC0016932"],"award-info":[{"award-number":["NNF15OC0016932"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF23OC0082015"],"award-info":[{"award-number":["NNF23OC0082015"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF17OC0027864"],"award-info":[{"award-number":["NNF17OC0027864"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF17OC0027594"],"award-info":[{"award-number":["NNF17OC0027594"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021817","name":"Knud og Edith Eriksens Mindefond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021817","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008368","name":"Gigtforeningen","doi-asserted-by":"publisher","award":["A2037"],"award-info":[{"award-number":["A2037"]}],"id":[{"id":"10.13039\/100008368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008368","name":"Gigtforeningen","doi-asserted-by":"publisher","award":["A3570"],"award-info":[{"award-number":["A3570"]}],"id":[{"id":"10.13039\/100008368","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bio- and Genome Bank Denmark"},{"name":"Administrative Regions","award":["02\/2611"],"award-info":[{"award-number":["02\/2611"]}]},{"DOI":"10.13039\/501100004836","name":"Danish Council for Independent Research","doi-asserted-by":"crossref","award":["09\u2013069412"],"award-info":[{"award-number":["09\u2013069412"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Infrastructure of Bio- and Genome Bank Denmark"},{"name":"Department of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital"},{"name":"Rigshospitalet Research Council"},{"DOI":"10.13039\/100008368","name":"Danish Rheumatism Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008368","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Danish Regions"},{"DOI":"10.13039\/501100006356","name":"University of Southern Denmark","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Epidemiol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>The Copenhagen Hospital Biobank-chronic inflammatory disease\u2014inflammatory bowel disease (CHB-CID: IBD) cohort contributes to genetic research in inflammatory bowel disease, including Crohn\u2019s disease and ulcerative colitis. Of the 327,084 enrolled and genotyped individuals in the cohort, 10,626 have been diagnosed with IBD as of May 2023. The CHB-CID: IBD cohort includes both patients without IBD and healthy blood donors as control groups. Clinical data is collected from Danish registries and patient records, including details on hospital contacts, co-morbidities, medication, surgical procedures, and laboratory investigations. The cohort features a wide age range (&gt;\u200918\u00a0years), extensive population coverage representative of Danish adults, and validated IBD diagnoses. Finally, the cohort benefits from continuous recruitment and regular updates of clinical information. The aim is to enhance IBD management and ultimately improve patients\u2019 quality of life.<\/jats:p>","DOI":"10.1007\/s10654-025-01239-4","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T03:10:43Z","timestamp":1749438643000},"page":"721-734","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cohort profile: Copenhagen Hospital Biobank-chronic inflammatory disease\u2014inflammatory bowel disease (CHB-CID:IBD) genetic cohort"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0289-6392","authenticated-orcid":false,"given":"Behrooz","family":"Darbani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4431-9972","authenticated-orcid":false,"given":"Thorsten","family":"Brodersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3937-0095","authenticated-orcid":false,"given":"Anette","family":"Liljens\u00f8e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe Bek","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7195-3074","authenticated-orcid":false,"given":"Josephine Bjergb\u00e6k","family":"Olsson-Svendsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Buil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Kamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Schork","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0314-3467","authenticated-orcid":false,"given":"Anja","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9953-9521","authenticated-orcid":false,"given":"Bertram Dalskov","family":"Kjerulff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8306-1332","authenticated-orcid":false,"given":"Bitten","family":"Aagaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta \u00d8rnfelt","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte Siggaard","family":"Rittig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2945-6197","authenticated-orcid":false,"given":"Christina","family":"Mikkelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Millencourt","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0128-8432","authenticated-orcid":false,"given":"David","family":"Westergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ditte","family":"Rudbeck-Resdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorte Helenius","family":"Mikkelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Else","family":"Randers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank Vinholt","family":"Schi\u00f8dt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6743-7931","authenticated-orcid":false,"given":"Hans J\u00fcrgen","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella Friis","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4203-5442","authenticated-orcid":false,"given":"Ivan","family":"Brandslund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2530-7554","authenticated-orcid":false,"given":"Jacob Broder","family":"Brodersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob Hjorth","family":"von Stemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1159-4003","authenticated-orcid":false,"given":"Jakob Thaning","family":"Bay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8891-8451","authenticated-orcid":false,"given":"Janna","family":"Nissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8139-1642","authenticated-orcid":false,"given":"Jens Kj\u00e6rgaard","family":"Boldsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5381-2633","authenticated-orcid":false,"given":"Joseph","family":"Dowsett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9233-3117","authenticated-orcid":false,"given":"Josephine","family":"Gladov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Banasik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7973-3623","authenticated-orcid":false,"given":"Kathrine Agerg\u00e5rd","family":"Kaspersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3175-3529","authenticated-orcid":false,"given":"Katrine","family":"Carlsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1881-5673","authenticated-orcid":false,"given":"Khoa Manh","family":"Dinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauge","family":"Kellermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5816-6324","authenticated-orcid":false,"given":"Lea Arregui Nordahl","family":"Christoffersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam James Elgaard","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4391-4956","authenticated-orcid":false,"given":"Lise Wegner","family":"Th\u00f8rner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4067-2381","authenticated-orcid":false,"given":"Lone","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-887X","authenticated-orcid":false,"given":"Luise","family":"Aamann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malene Rohr","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4856-496X","authenticated-orcid":false,"given":"Maria","family":"Didriksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Joanna","family":"Alexandraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3645-6689","authenticated-orcid":false,"given":"Marianne Kragh","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3070-8950","authenticated-orcid":false,"given":"Mette","family":"Julsgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4973-8543","authenticated-orcid":false,"given":"Mette","family":"Nyegaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schwinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mie","family":"Topholm-Bruun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0158-3016","authenticated-orcid":false,"given":"Mikael Njai","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3610-6563","authenticated-orcid":false,"given":"Morten Lee","family":"Halling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3199-3474","authenticated-orcid":false,"given":"Ole K.","family":"Bonderup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palle Duun","family":"Rohde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5513-2914","authenticated-orcid":false,"given":"Pernille Dige","family":"Ovesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1497-6309","authenticated-orcid":false,"given":"Ram Benny","family":"Dessau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaz","family":"Saboori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Holm-Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5929-6168","authenticated-orcid":false,"given":"Steffen","family":"Bank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Mikkelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6703-7762","authenticated-orcid":false,"given":"Thomas Folkmann","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Werge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Qvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5002-9077","authenticated-orcid":false,"given":"Erik","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3312-5139","authenticated-orcid":false,"given":"Johan","family":"Burisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4229-6818","authenticated-orcid":false,"given":"Merete Lund","family":"Hetland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8931-8482","authenticated-orcid":false,"given":"Bente","family":"Glintborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6551-6647","authenticated-orcid":false,"given":"Christian","family":"Erikstrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0316-5866","authenticated-orcid":false,"given":"S\u00f8ren","family":"Brunak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Ullum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5288-3851","authenticated-orcid":false,"given":"Sisse Rye","family":"Ostrowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2312-5976","authenticated-orcid":false,"given":"Ole Birger Vesterager","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0127-2863","authenticated-orcid":false,"given":"Vibeke","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"1239_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S2468-1253(19)30333-4","volume":"5","author":"S Alatab","year":"2020","unstructured":"Alatab S, Sepanlou SG, Ikuta K, Vahedi H, Bisignano C, Safiri S, et al. The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990\u20132017: a systematic analysis for the global burden of disease study 2017. Lancet Gastroenterol Hepatol. 2020;5:17\u201330.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"1239_CR2","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1053\/j.gastro.2023.07.003","volume":"165","author":"JD Lewis","year":"2023","unstructured":"Lewis JD, Parlett LE, Funk MLJ, Brensinger C, Pate V, Wu Q, et al. Incidence, prevalence, and racial and ethnic distribution of inflammatory bowel disease in the United States. Gastroenterology. 2023;165:1197-1205.e2.","journal-title":"Gastroenterology"},{"key":"1239_CR3","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","volume":"390","author":"SC Ng","year":"2017","unstructured":"Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017;390:2769\u201378.","journal-title":"Lancet"},{"key":"1239_CR4","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/ajg.2015.50","volume":"110","author":"FT Moller","year":"2015","unstructured":"Moller FT, Andersen V, Wohlfahrt J, Jess T. Familial risk of inflammatory bowel disease: a population-based cohort study 1977\u20132011. Am J Gastroenterol. 2015;110:564\u201371.","journal-title":"Am J Gastroenterol"},{"key":"1239_CR5","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1038\/s41588-022-01156-2","volume":"54","author":"A Sazonovs","year":"2022","unstructured":"Sazonovs A, Stevens CR, Venkataraman GR, Yuan K, Avila B, Abreu MT, et al. Large-scale sequencing identifies multiple genes and rare variants associated with Crohn\u2019s disease susceptibility. Nat Genet. 2022;54:1275\u201383.","journal-title":"Nat Genet"},{"key":"1239_CR6","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/S0140-6736(15)00465-1","volume":"387","author":"I Cleynen","year":"2016","unstructured":"Cleynen I, Boucher G, Jostins L, Schumm LP, Zeissig S, Ahmad T, et al. Inherited determinants of Crohn\u2019s disease and ulcerative colitis phenotypes: a genetic association study. Lancet. 2016;387:156\u201367.","journal-title":"Lancet"},{"key":"1239_CR7","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1038\/s41588-023-01384-0","volume":"55","author":"Z Liu","year":"2023","unstructured":"Liu Z, Liu R, Gao H, Jung S, Gao X, Sun R, et al. Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries. Nat Genet. 2023;55:796\u2013806.","journal-title":"Nat Genet"},{"key":"1239_CR8","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1053\/j.gastro.2017.05.010","volume":"153","author":"P Yadav","year":"2017","unstructured":"Yadav P, Ellinghaus D, R\u00e9my G, Freitag-Wolf S, Cesaro A, Degenhardt F, et al. Genetic factors interact with tobacco smoke to modify risk for inflammatory bowel disease in humans and mice. Gastroenterology. 2017;153:550\u201365.","journal-title":"Gastroenterology"},{"key":"1239_CR9","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/nature11582","volume":"491","author":"L Jostins","year":"2012","unstructured":"Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 2012;491:119\u201324.","journal-title":"Nature"},{"key":"1239_CR10","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1056\/NEJMra2002697","volume":"383","author":"JT Chang","year":"2020","unstructured":"Chang JT. Pathophysiology of inflammatory bowel diseases. N Engl J Med. 2020;383:2652\u201364.","journal-title":"N Engl J Med"},{"key":"1239_CR11","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1016\/j.cgh.2023.01.012","volume":"21","author":"N Narula","year":"2023","unstructured":"Narula N, Chang NH, Mohammad D, Wong ECL, Ananthakrishnan AN, Chan SSM, et al. Food processing and risk of inflammatory bowel disease: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2023;21:2483-2495.e1.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"1239_CR12","doi-asserted-by":"publisher","first-page":"765474","DOI":"10.3389\/fmed.2021.765474","volume":"8","author":"Z Cai","year":"2021","unstructured":"Cai Z, Wang S, Li J. Treatment of inflammatory bowel disease: a comprehensive review. Front Med (Lausanne). 2021;8:765474.","journal-title":"Front Med (Lausanne)"},{"key":"1239_CR13","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1053\/j.gastro.2022.07.062","volume":"163","author":"M Agrawal","year":"2022","unstructured":"Agrawal M, Christensen HS, B\u00f8gsted M, Colombel J-F, Jess T, Allin KH. The rising burden of inflammatory bowel disease in Denmark over two decades: a nationwide cohort study. Gastroenterology. 2022;163:1547-1554.e5.","journal-title":"Gastroenterology"},{"key":"1239_CR14","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2147\/CLEP.S392416","volume":"15","author":"K Laugesen","year":"2023","unstructured":"Laugesen K, Mengel-From J, Christensen K, Olsen J, Hougaard DM, Boding L, et al. A review of major Danish biobanks: advantages and possibilities of health research in Denmark. Clin Epidemiol. 2023;15:213\u201339.","journal-title":"Clin Epidemiol"},{"key":"1239_CR15","doi-asserted-by":"publisher","first-page":"e78","DOI":"10.1016\/S2589-7500(19)30024-X","volume":"1","author":"AB Nielsen","year":"2019","unstructured":"Nielsen AB, Thorsen-Meyer H-C, Belling K, Nielsen AP, Thomas CE, Chmura PJ, et al. Survival prediction in intensive-care units based on aggregation of long-term disease history and acute physiology: a retrospective study of the Danish national patient registry and electronic patient records. Lancet Digit Health. 2019;1:e78-89.","journal-title":"Lancet Digit Health"},{"key":"1239_CR16","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1093\/ije\/dyaa157","volume":"50","author":"E S\u00f8rensen","year":"2021","unstructured":"S\u00f8rensen E, Christiansen L, Wilkowski B, Larsen MH, Burgdorf KS, Th\u00f8rner LW, et al. Data resource profile: the Copenhagen hospital biobank (CHB). Int J Epidemiol. 2021;50:719\u2013720e.","journal-title":"Int J Epidemiol"},{"key":"1239_CR17","doi-asserted-by":"publisher","first-page":"e162","DOI":"10.1093\/ije\/dyac194","volume":"52","author":"C Erikstrup","year":"2023","unstructured":"Erikstrup C, S\u00f8rensen E, Nielsen KR, Bruun MT, Petersen MS, Rostgaard K, et al. Cohort profile: the Danish blood donor study. Int J Epidemiol. 2023;52:e162\u201371.","journal-title":"Int J Epidemiol"},{"key":"1239_CR18","doi-asserted-by":"publisher","first-page":"e028401","DOI":"10.1136\/bmjopen-2018-028401","volume":"9","author":"TF Hansen","year":"2019","unstructured":"Hansen TF, Banasik K, Erikstrup C, Pedersen OB, Westergaard D, Chmura PJ, et al. DBDS genomic cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors. BMJ Open. 2019;9:e028401.","journal-title":"BMJ Open"},{"key":"1239_CR19","doi-asserted-by":"publisher","first-page":"e019325","DOI":"10.1136\/bmjopen-2017-019325","volume":"8","author":"TM Kringelbach","year":"2018","unstructured":"Kringelbach TM, Glintborg B, Hogdall EV, Johansen JS, Hetland ML. Identification of new biomarkers to promote personalised treatment of patients with inflammatory rheumatic disease: protocol for an open cohort study. BMJ Open. 2018;8:e019325.","journal-title":"BMJ Open"},{"key":"1239_CR20","doi-asserted-by":"publisher","first-page":"e003027","DOI":"10.1136\/rmdopen-2023-003027","volume":"9","author":"H Westerlind","year":"2023","unstructured":"Westerlind H, Glintborg B, Hammer HB, Saevarsdottir S, Krogh NS, Hetland ML, et al. Remission, response, retention and persistence to treatment with disease-modifying agents in patients with rheumatoid arthritis: a study of harmonised Swedish, Danish and Norwegian cohorts. RMD Open. 2023;9:e003027.","journal-title":"RMD Open"},{"key":"1239_CR21","doi-asserted-by":"publisher","first-page":"e98815","DOI":"10.1371\/journal.pone.0098815","volume":"9","author":"S Bank","year":"2014","unstructured":"Bank S, Skytt Andersen P, Burisch J, Pedersen N, Roug S, Galsgaard J, et al. Polymorphisms in the inflammatory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG are associated with susceptibility of inflammatory bowel disease in a Danish cohort. PLoS ONE. 2014;9:e98815.","journal-title":"PLoS ONE"},{"key":"1239_CR22","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/tpj.2014.19","volume":"14","author":"S Bank","year":"2014","unstructured":"Bank S, Andersen PS, Burisch J, Pedersen N, Roug S, Galsgaard J, et al. Associations between functional polymorphisms in the NF\u03baB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease. Pharmacogenomics J. 2014;14:526\u201334.","journal-title":"Pharmacogenomics J"},{"key":"1239_CR23","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/tpj.2016.84","volume":"18","author":"S Bank","year":"2018","unstructured":"Bank S, Andersen PS, Burisch J, Pedersen N, Roug S, Galsgaard J, et al. Genetically determined high activity of IL-12 and IL-18 in ulcerative colitis and TLR5 in Crohns disease were associated with non-response to anti-TNF therapy. Pharmacogenomics J. 2018;18:87\u201397.","journal-title":"Pharmacogenomics J"},{"key":"1239_CR24","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1007\/s10654-023-01027-y","volume":"38","author":"MK Pedersen","year":"2023","unstructured":"Pedersen MK, Eriksson R, Reguant R, Collin C, Pedersen HK, S\u00f8rup FKH, et al. A unidirectional mapping of ICD-8 to ICD-10 codes, for harmonized longitudinal analysis of diseases. Eur J Epidemiol. 2023;38:1043\u201352.","journal-title":"Eur J Epidemiol"},{"key":"1239_CR25","doi-asserted-by":"publisher","first-page":"e049709","DOI":"10.1136\/bmjopen-2021-049709","volume":"11","author":"IH Laursen","year":"2021","unstructured":"Laursen IH, Banasik K, Haue AD, Petersen O, Holm PC, Westergaard D, et al. Cohort profile: Copenhagen hospital biobank - cardiovascular disease cohort (CHB-CVDC): construction of a large-scale genetic cohort to facilitate a better understanding of heart diseases. BMJ Open. 2021;11:e049709.","journal-title":"BMJ Open"},{"key":"1239_CR26","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/s41586-022-04965-x","volume":"607","author":"BV Halldorsson","year":"2022","unstructured":"Halldorsson BV, Eggertsson HP, Moore KHS, Hauswedell H, Eiriksson O, Ulfarsson MO, et al. The sequences of 150,119 genomes in the UK biobank. Nature. 2022;607:732\u201340.","journal-title":"Nature"},{"key":"1239_CR27","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1038\/ng.3964","volume":"49","author":"HP Eggertsson","year":"2017","unstructured":"Eggertsson HP, Jonsson H, Kristmundsdottir S, Hjartarson E, Kehr B, Masson G, et al. Graphtyper enables population-scale genotyping using pangenome graphs. Nat Genet. 2017;49:1654\u201360.","journal-title":"Nat Genet"},{"key":"1239_CR28","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s12863-023-01132-7","volume":"24","author":"K Banasik","year":"2023","unstructured":"Banasik K, M\u00f8ller PL, Techlo TR, Holm PC, Walters GB, Ingason A, et al. DanMAC5: a browser of aggregated sequence variants from 8,671 whole genome sequenced Danish individuals. BMC Genomic Data. 2023;24:30.","journal-title":"BMC Genomic Data"},{"key":"1239_CR29","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1093\/bioinformatics\/btq559","volume":"26","author":"A Manichaikul","year":"2010","unstructured":"Manichaikul A, Mychaleckyj JC, Rich SS, Daly K, Sale M, Chen W-M. Robust relationship inference in genome-wide association studies. Bioinformatics. 2010;26:2867\u201373.","journal-title":"Bioinformatics"},{"key":"1239_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-025-02118-0","author":"J Guan","year":"2025","unstructured":"Guan J, Tan T, Nehzati SM, Bennett M, Turley P, Benjamin DJ, et al. Family-based genome-wide association study designs for increased power and robustness. Nat Genet. 2025. https:\/\/doi.org\/10.1038\/s41588-025-02118-0.","journal-title":"Nat Genet"},{"key":"1239_CR31","doi-asserted-by":"publisher","first-page":"449","DOI":"10.2147\/CLEP.S91125","volume":"7","author":"M Schmidt","year":"2015","unstructured":"Schmidt M, Schmidt SAJ, Sandegaard JL, Ehrenstein V, Pedersen L, S\u00f8rensen HT. The Danish national patient registry: a review of content, data quality, and research potential. Clin Epidemiol. 2015;7:449\u201390.","journal-title":"Clin Epidemiol"},{"key":"1239_CR32","doi-asserted-by":"publisher","first-page":"469","DOI":"10.2147\/CLEP.S245060","volume":"12","author":"JFH Arendt","year":"2020","unstructured":"Arendt JFH, Hansen AT, Ladefoged SA, S\u00f8rensen HT, Pedersen L, Adelborg K. Existing data sources in clinical epidemiology: laboratory information system databases in Denmark. Clin Epidemiol. 2020;12:469\u201375.","journal-title":"Clin Epidemiol"},{"key":"1239_CR33","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1136\/annrheumdis-2021-221754","volume":"81","author":"S Saevarsdottir","year":"2022","unstructured":"Saevarsdottir S, Stefansdottir L, Sulem P, Thorleifsson G, Ferkingstad E, Rutsdottir G, et al. Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset. Ann Rheum Dis. 2022;81:1085\u201395.","journal-title":"Ann Rheum Dis"},{"key":"1239_CR34","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/s42003-024-06207-4","volume":"7","author":"ATh Skuladottir","year":"2024","unstructured":"Skuladottir ATh, Stefansdottir L, Halldorsson GH, Stefansson OA, Bjornsdottir A, Jonsson P, et al. GWAS meta-analysis reveals key risk loci in essential tremor pathogenesis. Commun Biol. 2024;7:504.","journal-title":"Commun Biol"},{"key":"1239_CR35","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1038\/s42003-024-07115-3","volume":"7","author":"E Allara","year":"2024","unstructured":"Allara E, Bell S, Smith R, Keene SJ, Gill D, Gaziano L, et al. Novel loci and biomedical consequences of iron homoeostasis variation. Commun Biol. 2024;7:1631.","journal-title":"Commun Biol"},{"key":"1239_CR36","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12881-018-0680-z","volume":"19","author":"J Sode","year":"2018","unstructured":"Sode J, Bank S, Vogel U, Andersen PS, S\u00f8rensen SB, Bojesen AB, et al. Genetically determined high activities of the TNF-alpha, IL23\/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis. BMC Med Genet. 2018;19:165.","journal-title":"BMC Med Genet"},{"key":"1239_CR37","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/tpj.2017.31","volume":"18","author":"ND Loft","year":"2018","unstructured":"Loft ND, Skov L, Iversen L, Gniadecki R, Dam TN, Brandslund I, et al. Associations between functional polymorphisms and response to biological treatment in Danish patients with psoriasis. Pharmacogenomics J. 2018;18:494\u2013500.","journal-title":"Pharmacogenomics J"},{"key":"1239_CR38","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1111\/apt.15187","volume":"49","author":"S Bank","year":"2019","unstructured":"Bank S, Julsgaard M, Abed OK, Burisch J, Broder Brodersen J, Pedersen NK, et al. Polymorphisms in the NFkB, TNF-alpha, IL-1beta, and IL-18 pathways are associated with response to anti-TNF therapy in Danish patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2019;49:890\u2013903.","journal-title":"Aliment Pharmacol Ther"},{"key":"1239_CR39","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.2147\/CLEP.S378003","volume":"14","author":"H Albaek Jacobsen","year":"2022","unstructured":"Albaek Jacobsen H, Jess T, Larsen L. Validity of inflammatory bowel disease diagnoses in the Danish national patient registry: a population-based study from the north Denmark region. Clin Epidemiol. 2022;14:1099\u2013109.","journal-title":"Clin Epidemiol"},{"key":"1239_CR40","doi-asserted-by":"publisher","first-page":"8054","DOI":"10.1038\/s41467-024-52470-8","volume":"15","author":"TA Olafsdottir","year":"2024","unstructured":"Olafsdottir TA, Thorleifsson G, de Lapuente Portilla AL, Jonsson S, Stefansdottir L, Niroula A, et al. Sequence variants influencing the regulation of serum IgG subclass levels. Nat Commun. 2024;15:8054.","journal-title":"Nat Commun"},{"key":"1239_CR41","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","volume":"613","author":"MI Kurki","year":"2023","unstructured":"Kurki MI, Karjalainen J, Palta P, Sipil\u00e4 TP, Kristiansson K, Donner KM, et al. FinnGen provides genetic insights from a well-phenotyped isolated population. Nature. 2023;613:508\u201318.","journal-title":"Nature"},{"key":"1239_CR42","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.annepidem.2023.10.008","volume":"88","author":"F Li","year":"2023","unstructured":"Li F, Ramirez Y, Yano Y, Daniel CR, Sharma SV, Brown EL, et al. The association between inflammatory bowel disease and all-cause and cause-specific mortality in the UK biobank. Ann Epidemiol. 2023;88:15\u201322.","journal-title":"Ann Epidemiol"},{"key":"1239_CR43","doi-asserted-by":"publisher","first-page":"e018166","DOI":"10.1136\/bmjopen-2017-018166","volume":"8","author":"R Christensen","year":"2018","unstructured":"Christensen R, Heitmann BL, Andersen KW, Nielsen OH, S\u00f8rensen SB, Jawhara M, et al. Impact of red and processed meat and fibre intake on treatment outcomes among patients with chronic inflammatory diseases: protocol for a prospective cohort study of prognostic factors and personalised medicine. BMJ Open. 2018;8:e018166.","journal-title":"BMJ Open"},{"key":"1239_CR44","doi-asserted-by":"publisher","first-page":"e035756","DOI":"10.1136\/bmjopen-2019-035756","volume":"10","author":"M Zhao","year":"2020","unstructured":"Zhao M, Bendtsen F, Petersen AM, Larsen L, Dige A, Hvas C, et al. Predictors of response and disease course in patients with inflammatory bowel disease treated with biological therapy\u2014the Danish IBD biobank project: protocol for a multicentre prospective cohort study. BMJ Open. 2020;10:e035756.","journal-title":"BMJ Open"}],"container-title":["European Journal of Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10654-025-01239-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10654-025-01239-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10654-025-01239-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T18:16:57Z","timestamp":1757182617000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10654-025-01239-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["1239"],"URL":"https:\/\/doi.org\/10.1007\/s10654-025-01239-4","relation":{},"ISSN":["0393-2990","1573-7284"],"issn-type":[{"value":"0393-2990","type":"print"},{"value":"1573-7284","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"19 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All personal fees and grants were received outside this work. Anja Poulsen reports research grants and personal fees from Janssen, Takeda, and MSD, personal fees from Bristol Myers Squibb, national coordinator of studies from Agomab, Boehringer Ingelheim and Bristol Myers. Bente Glintborg has received research grants (paid to institution) from AbbVie, Pfizer, BMS, Sandoz. Bente Glintborg chairs the DANBIO steering committee. Jacob Broder Brodersen has received consultation fee from Jansen-Cilag. Johan Burisch reports grants and personal fees from AbbVie, Janssen-Cilag, Takeda, Tillots Pharma, Bristol Myers Squibb, and MSD, personal fees from Celgene, Pfizer, Samsung Bioepis, Pharmacosmos, Ferring, Galapagos, and Eli Lilly, and grants from Novo Nordisk Foundation. Mette Julsgaard has received research grants from Takeda and the Novo Nordisk Foundation (grant no. NNF23OC0081717), has been on the advisory board of PharmaCosmos, has received consultation fee from Ferring and Takeda, and has received speaker\u2019s fees from Tillotts Pharma, MSD, Ferring, and Takeda. Vibeke A ndersen has served as advisory board member for MSD (Merck). S\u00f8ren Brunak has ownerships in Intomics A\/S, Hoba Therapeutics Aps, Novo Nordisk A\/S, Lundbeck A\/S, ALK abello A\/S, Eli Lilly and Co and managing board memberships in Proscion A\/S and Intomics A\/S. Thorsten Brodersen\u2019s spouse currently holds incentive stock options in LEO Pharma A\/S. All other authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"CHB-CID:IBD studies will be conducted in accordance with the Declaration of Helsinki and has been approved by the National and the Capital, Central Denmark, and South Denmark Regional Committees on Health Research Ethics (NVK-1700407, H-18064178, M20100153, S-20120113, and S-20160124), as well as the Data Protection Agency of Capital (P-2019\u201399 and P-2022\u2013876), Central (RM: J. 2010\u201341-4719) and Southern (RSD: 2008\u201358-035) Denmark. All individuals in CHB have been informed about their inclusion into the biobank and the use of their data for research.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"ChatGPT () assisted copy editing was used and authors reviewed and revised the final version, taking full responsibility for the content of the publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Concent for publication"}}]}}