{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:20:28Z","timestamp":1792412428378,"version":"4.4.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100013955","name":"Astellas Pharma, Netherlands","doi-asserted-by":"publisher","award":["TransplantLines Biobank"],"award-info":[{"award-number":["TransplantLines Biobank"]}],"id":[{"id":"10.13039\/501100013955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013955","name":"Astellas Pharma, Netherlands","doi-asserted-by":"publisher","award":["Cohort study"],"award-info":[{"award-number":["Cohort study"]}],"id":[{"id":"10.13039\/501100013955","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chiesi Pharmaceuticals BV","award":["PA-SP\/PRJ-2020-9136"],"award-info":[{"award-number":["PA-SP\/PRJ-2020-9136"]}]},{"name":"DSM, Animal Nutrition and Health","award":["project code: 14939"],"award-info":[{"award-number":["project code: 14939"]}]},{"DOI":"10.13039\/501100016238","name":"Ministerie van Economische Zaken en Klimaat","doi-asserted-by":"publisher","award":["project code: PPP-2019-032"],"award-info":[{"award-number":["project code: PPP-2019-032"]}],"id":[{"id":"10.13039\/501100016238","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016238","name":"Ministerie van Economische Zaken en Klimaat","doi-asserted-by":"publisher","award":["PPP-2022-015"],"award-info":[{"award-number":["PPP-2022-015"]}],"id":[{"id":"10.13039\/501100016238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Epidemiol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The TransplantLines Biobank and Cohort Study (NCT03272841) is an ongoing prospective study conducted at the University Medical Centre Groningen, The Netherlands. TransplantLines aims to identify risk factors and biomarkers associated with health problems following solid organ transplantation and donation. Additionally, the study seeks to develop new interventions to reduce symptom burden and improve long-term outcomes, including health-related quality of life, cardiovascular complications, graft failure, and mortality. It includes recipients of (combined) heart, liver, lung, kidney, pancreas, and small bowel transplants, as well as living liver and kidney donors, and deceased (multi-)organ donors. The biobank contains a wide range of biomaterials including whole blood, serum, EDTA-plasma, buffy coat, 24-h urine samples, faeces, hair, nails, and tissues. Data collection includes physical and cognitive assessments, extensive laboratory analysis, metagenomic sequencing, and questionnaires. TransplantLines, initiated in 2015, consists of 5143 participants as of October 2024, among 2312 (45%) females. The mean age was\u00a050 (\u00b1\u200916) years at transplantation, 55 (\u00b1\u200911) years at living donation and 56 (\u00b1\u200915) years at deceased donation. Both cross-sectional and longitudinal biomaterials and data are included. For recipients, longitudinal biomaterials and\u00a0data were collected at: pre-transplantation, at transplantation, and at 3, 6, 12, 24, and 60\u00a0months post-transplantation. For living donors, data were collected at pre-donation, donation, 3\u00a0months post-donation, and\/or 5 or 10\u00a0years post-donation.<\/jats:p>","DOI":"10.1007\/s10654-025-01258-1","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:42:38Z","timestamp":1751416958000},"page":"969-979","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["TransplantLines, a biobank and cohort study of solid organ transplant recipients and donors"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6520-6830","authenticated-orcid":false,"given":"Anna M.","family":"Posthumus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3246-3192","authenticated-orcid":false,"given":"Tim J.","family":"Knobbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0011-115X","authenticated-orcid":false,"given":"Daan","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4398-4877","authenticated-orcid":false,"given":"Antonio W.","family":"Gomes-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8270-1926","authenticated-orcid":false,"given":"Isabelle J. C.","family":"Dielwart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9548-4985","authenticated-orcid":false,"given":"Jip","family":"Jonker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8036-520X","authenticated-orcid":false,"given":"Caecilia S. E.","family":"Doorenbos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2484-6233","authenticated-orcid":false,"given":"Michele F.","family":"Eisenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7145-3240","authenticated-orcid":false,"given":"Marco","family":"van Londen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2517-5769","authenticated-orcid":false,"given":"Rianne M.","family":"Douwes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1159-787X","authenticated-orcid":false,"given":"Lianne M.","family":"Nieuwenhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8663-2145","authenticated-orcid":false,"given":"Coby","family":"Annema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0634-4740","authenticated-orcid":false,"given":"Marieke T.","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4127-8733","authenticated-orcid":false,"given":"Martin H.","family":"de Borst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0190-2228","authenticated-orcid":false,"given":"Kevin","family":"Damman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2236-5233","authenticated-orcid":false,"given":"Robert A.","family":"Pol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1310-4189","authenticated-orcid":false,"given":"C. Tji","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6807-6744","authenticated-orcid":false,"given":"Erik A. M.","family":"Verschuuren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4240-7506","authenticated-orcid":false,"given":"Hans","family":"Blokzijl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7900-5917","authenticated-orcid":false,"given":"Vincent E.","family":"de Meijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3356-6791","authenticated-orcid":false,"given":"Stephan J. L.","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"TransplantLines Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coby","family":"Annema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan P.","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Blokzijl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A. J. A.","family":"Bodewes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke T.","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Damman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin H.","family":"de Borst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan","family":"Diepstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Dijkstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianne M.","family":"Douwes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caecilia S. E.","family":"Doorenbos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele F.","family":"Eisenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel E.","family":"Erasmus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Tji","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio W.","family":"Gomes-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eelko","family":"Hak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bouke G.","family":"Hepkema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius C.","family":"van den Heuvel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jip","family":"Jonker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Klont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim J.","family":"Knobbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daan","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coretta","family":"van Leer-Buter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri G. D.","family":"Leuvenink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"van Londen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem S.","family":"Lexmond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent E.","family":"de Meijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert G. M.","family":"Niesters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gertrude J.","family":"Nieuwenhuis-Moeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Joost","family":"van Pelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Pol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Posthumus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelita V.","family":"Ranchor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Stephan F.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion J.","family":"Siebelink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riemer J. H. J. A.","family":"Slart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Cas","family":"Swarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daan J.","family":"Touw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte A.","family":"Velde-Keyzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik A. M.","family":"Verschuuren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel J.","family":"Vos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinse K.","family":"Weersma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan J. L.","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"1258_CR1","doi-asserted-by":"publisher","unstructured":"Carbone M, M. Neuberger J. Solid Organ Transplantation. Regenerative Medicine Applications in Organ Transplantation, Elsevier; 2014, https:\/\/doi.org\/10.1016\/B978-0-12-398523-1.00002-1.","DOI":"10.1016\/B978-0-12-398523-1.00002-1"},{"key":"1258_CR2","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1093\/ndt\/gfad148","volume":"39","author":"TJ Knobbe","year":"2023","unstructured":"Knobbe TJ, Kremer D, Eisenga MF, et al. Sleep quality, fatigue, societal participation and health-related quality of life in kidney transplant recipients: a cross-sectional and longitudinal cohort study. Nephrol Dial Transplant. 2023;39:74\u201383. https:\/\/doi.org\/10.1093\/ndt\/gfad148.","journal-title":"Nephrol Dial Transplant"},{"key":"1258_CR3","doi-asserted-by":"publisher","first-page":"16208","DOI":"10.1038\/s41598-022-19952-5","volume":"12","author":"TJ Knobbe","year":"2022","unstructured":"Knobbe TJ, Kremer D, Eisenga MF, et al. Hand dexterity, daily functioning and health-related quality of life in kidney transplant recipients. Sci Rep. 2022;12:16208. https:\/\/doi.org\/10.1038\/s41598-022-19952-5.","journal-title":"Sci Rep"},{"key":"1258_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2023.10951","author":"NL Riemersma","year":"2023","unstructured":"Riemersma NL, Kremer D, Knobbe TJ, et al. Tremor, daily functioning, and health-related quality of life in solid organ transplant recipients. Transplant Int. 2023. https:\/\/doi.org\/10.3389\/ti.2023.10951.","journal-title":"Transplant Int"},{"key":"1258_CR5","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1053\/j.ajkd.2022.12.012","volume":"82","author":"TJ Knobbe","year":"2023","unstructured":"Knobbe TJ, Kremer D, Douwes RM, et al. Proton pump inhibitor use, fatigue, and health-related quality of life in kidney transplant recipients: results from the transplantlines biobank and cohort study. Am J Kidney Dis. 2023;82:189-201.e1. https:\/\/doi.org\/10.1053\/j.ajkd.2022.12.012.","journal-title":"Am J Kidney Dis"},{"key":"1258_CR6","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-024502","volume":"8","author":"MF Eisenga","year":"2018","unstructured":"Eisenga MF, Gomes-Neto AW, van Londen M, et al. Rationale and design of TransplantLines: a prospective cohort study and biobank of solid organ transplant recipients. BMJ Open. 2018;8: e024502. https:\/\/doi.org\/10.1136\/bmjopen-2018-024502.","journal-title":"BMJ Open"},{"key":"1258_CR7","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1016\/j.numecd.2024.04.008","volume":"34","author":"FG Rodrigues","year":"2024","unstructured":"Rodrigues FG, Bruins MSM, Vliegenthart R, et al. Phase angle and donor type are determinants of coronary artery calcification in stable kidney transplant recipients at twelve months after transplantation. Nutr Metab Cardiovasc Dis. 2024;34:1912\u201321. https:\/\/doi.org\/10.1016\/j.numecd.2024.04.008.","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"1258_CR8","doi-asserted-by":"publisher","first-page":"7968","DOI":"10.1038\/s41467-023-43431-8","volume":"14","author":"JC Swarte","year":"2023","unstructured":"Swarte JC, Knobbe TJ, Bj\u00f6rk JR, et al. Health-related quality of life is linked to the gut microbiome in kidney transplant recipients. Nat Commun. 2023;14:7968. https:\/\/doi.org\/10.1038\/s41467-023-43431-8.","journal-title":"Nat Commun"},{"key":"1258_CR9","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.01312-23","author":"S Zhang","year":"2024","unstructured":"Zhang S, Swarte JC, Gacesa R, et al. The gut microbiome in end-stage lung disease and lung transplantation. MSystems. 2024. https:\/\/doi.org\/10.1128\/msystems.01312-23.","journal-title":"MSystems"},{"key":"1258_CR10","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1136\/gutjnl-2023-331441","volume":"73","author":"JC Swarte","year":"2024","unstructured":"Swarte JC, Zhang S, Nieuwenhuis LM, et al. Multiple indicators of gut dysbiosis predict all-cause and cause-specific mortality in solid organ transplant recipients. Gut. 2024;73:1650\u201361. https:\/\/doi.org\/10.1136\/gutjnl-2023-331441.","journal-title":"Gut"},{"key":"1258_CR11","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3390\/jcm9020386","volume":"9","author":"JC Swarte","year":"2020","unstructured":"Swarte JC, Douwes RM, Hu S, et al. Characteristics and dysbiosis of the gut microbiome in renal transplant recipients. J Clin Med. 2020;9:386. https:\/\/doi.org\/10.3390\/jcm9020386.","journal-title":"J Clin Med"},{"key":"1258_CR12","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16412","author":"AMM van der Stouwe","year":"2024","unstructured":"van der Stouwe AMM, Riemersma NL, Knobbe TJ, et al. Tremor after solid organ transplantation: results from the transplantlines biobank and cohort study. Eur J Neurol. 2024. https:\/\/doi.org\/10.1111\/ene.16412.","journal-title":"Eur J Neurol"},{"key":"1258_CR13","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.2215\/CJN.05560522","volume":"17","author":"TJ Knobbe","year":"2022","unstructured":"Knobbe TJ, Kremer D, Abma FI, et al. Employment status and work functioning among kidney transplant recipients. Clin J Am Soc Nephrol. 2022;17:1506\u201314. https:\/\/doi.org\/10.2215\/CJN.05560522.","journal-title":"Clin J Am Soc Nephrol"},{"key":"1258_CR14","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1093\/ndt\/gfac035","volume":"38","author":"AL Ziengs","year":"2023","unstructured":"Ziengs AL, Buunk AM, van Sonderen L, et al. Long-term cognitive impairments in kidney transplant recipients: impact on participation and quality of life. Nephrol Dial Transplant. 2023;38:491\u20138. https:\/\/doi.org\/10.1093\/ndt\/gfac035.","journal-title":"Nephrol Dial Transplant"},{"key":"1258_CR15","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1039\/D3AN01874A","volume":"149","author":"F Klont","year":"2024","unstructured":"Klont F, Nijdam FB, Bakker SJL, et al. High-abundance peaks and peak clusters associate with pharmaceutical polymers and excipients in urinary untargeted clinical metabolomics data: exploration of their origin and possible impact on label-free quantification. Analyst. 2024;149:1061\u20137. https:\/\/doi.org\/10.1039\/D3AN01874A.","journal-title":"Analyst"},{"key":"1258_CR16","doi-asserted-by":"publisher","first-page":"942","DOI":"10.3390\/metabo12100942","volume":"12","author":"F Klont","year":"2022","unstructured":"Klont F, Sosnowski P, Kremer D, et al. Assessing the potential of untargeted SWATH mass spectrometry-based metabolomics to differentiate closely related exposures in observational studies. Metabolites. 2022;12:942. https:\/\/doi.org\/10.3390\/metabo12100942.","journal-title":"Metabolites"},{"key":"1258_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2023.123709","volume":"1222","author":"TR Zijp","year":"2023","unstructured":"Zijp TR, Knobbe TJ, van Hateren K, et al. Expeditious quantification of plasma tacrolimus with liquid chromatography tandem mass spectrometry in solid organ transplantation. J Chromatogr B. 2023;1222: 123709. https:\/\/doi.org\/10.1016\/j.jchromb.2023.123709.","journal-title":"J Chromatogr B"},{"key":"1258_CR18","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvae055","author":"A van der Vaart","year":"2024","unstructured":"van der Vaart A, Kremer D, Niekolaas T, et al. Time-updated fibroblast growth factor 23 is predictive for posttransplant diabetes mellitus in kidney transplant recipients. J Endocr Soc. 2024. https:\/\/doi.org\/10.1210\/jendso\/bvae055.","journal-title":"J Endocr Soc"},{"key":"1258_CR19","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.clinbiochem.2022.01.009","volume":"102","author":"M B\u00f6hler","year":"2022","unstructured":"B\u00f6hler M, van den Berg EH, Almanza MCT, et al. Branched chain amino acids are associated with metabolic complications in liver transplant recipients. Clin Biochem. 2022;102:26\u201333. https:\/\/doi.org\/10.1016\/j.clinbiochem.2022.01.009.","journal-title":"Clin Biochem"},{"key":"1258_CR20","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1093\/ndt\/gfac332","volume":"38","author":"D Kremer","year":"2023","unstructured":"Kremer D, Alkaff FF, Post A, et al. Plasma endotrophin, reflecting tissue fibrosis, is associated with graft failure and mortality in KTRs: results from two prospective cohort studies. Nephrol Dial Transplant. 2023;38:1041\u201352. https:\/\/doi.org\/10.1093\/ndt\/gfac332.","journal-title":"Nephrol Dial Transplant"},{"key":"1258_CR21","doi-asserted-by":"publisher","first-page":"6031","DOI":"10.3390\/ijms25116031","volume":"25","author":"MC Trillos-Almanza","year":"2024","unstructured":"Trillos-Almanza MC, Chvatal-Medina M, Connelly MA, et al. Circulating trimethylamine-n-oxide is elevated in liver transplant recipients. Int J Mol Sci. 2024;25:6031. https:\/\/doi.org\/10.3390\/ijms25116031.","journal-title":"Int J Mol Sci"},{"key":"1258_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2024.12.036","author":"RR Aleksandrova","year":"2025","unstructured":"Aleksandrova RR, Nieuwenhuis LM, Karmi N, et al. Gut microbiome dysbiosis is not associated with portal vein thrombosis in patients with end-stage liver disease: a cross-sectional study. J Thromb Haemost. 2025. https:\/\/doi.org\/10.1016\/j.jtha.2024.12.036.","journal-title":"J Thromb Haemost"},{"key":"1258_CR23","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1111\/liv.15310","volume":"43","author":"EH van den Berg","year":"2023","unstructured":"van den Berg EH, Flores-Guerrero JL, Garcia E, et al. High plasma levels of betaine, a trimethylamine <scp>N-Oxide<\/scp> -related metabolite, are associated with the severity of cirrhosis. Liver Int. 2023;43:424\u201333. https:\/\/doi.org\/10.1111\/liv.15310.","journal-title":"Liver Int"},{"key":"1258_CR24","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3390\/ijms26020459","volume":"26","author":"Y Li","year":"2025","unstructured":"Li Y, Chvatal-Medina M, Trillos-Almanza MC, et al. Plasma GlycA, a glycoprotein marker of chronic inflammation, and all-cause mortality in cirrhotic patients and liver transplant recipients. Int J Mol Sci. 2025;26:459. https:\/\/doi.org\/10.3390\/ijms26020459.","journal-title":"Int J Mol Sci"},{"key":"1258_CR25","doi-asserted-by":"publisher","first-page":"12806","DOI":"10.3390\/ijms252312806","volume":"25","author":"Y Li","year":"2024","unstructured":"Li Y, Chvatal-Medina M, Trillos-Almanza MC, et al. Circulating citrate is reversibly elevated in patients with end-stage liver disease: association with all-cause mortality. Int J Mol Sci. 2024;25:12806. https:\/\/doi.org\/10.3390\/ijms252312806.","journal-title":"Int J Mol Sci"},{"key":"1258_CR26","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1053\/j.ajkd.2021.10.009","volume":"80","author":"CG Sotomayor","year":"2022","unstructured":"Sotomayor CG, Giubergia F, Groothof D, et al. Plasma lead concentration and risk of late kidney allograft failure: findings from the transplantlines biobank and cohort studies. Am J Kidney Dis. 2022;80:87-97.e1. https:\/\/doi.org\/10.1053\/j.ajkd.2021.10.009.","journal-title":"Am J Kidney Dis"},{"key":"1258_CR27","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1002\/jcsm.12999","volume":"13","author":"JSJ Vinke","year":"2022","unstructured":"Vinke JSJ, Wouters HJCM, Stam SP, et al. Decreased haemoglobin levels are associated with lower muscle mass and strength in kidney transplant recipients. J Cachexia Sarcopenia Muscle. 2022;13:2044\u201353. https:\/\/doi.org\/10.1002\/jcsm.12999.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"1258_CR28","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.1002\/jcsm.13070","volume":"13","author":"IMY van Vliet","year":"2022","unstructured":"van Vliet IMY, Post A, Kremer D, et al. Muscle mass, muscle strength and mortality in kidney transplant recipients: results of the TransplantLines Biobank and Cohort Study. J Cachexia Sarcopenia Muscle. 2022;13:2932\u201343. https:\/\/doi.org\/10.1002\/jcsm.13070.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"1258_CR29","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1007\/s40262-023-01259-x","volume":"62","author":"JV Koomen","year":"2023","unstructured":"Koomen JV, Knobbe TJ, Zijp TR, et al. A joint pharmacokinetic model for the simultaneous description of plasma and whole blood tacrolimus concentrations in kidney and lung transplant recipients. Clin Pharmacokinet. 2023;62:1117\u201328. https:\/\/doi.org\/10.1007\/s40262-023-01259-x.","journal-title":"Clin Pharmacokinet"},{"key":"1258_CR30","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1111\/tri.14110","volume":"34","author":"RM Douwes","year":"2021","unstructured":"Douwes RM, Vinke JSJ, Gomes-Neto AW, et al. Type of proton-pump inhibitor and risk of iron deficiency in kidney transplant recipients \u2013 results from the transplantlines biobank and cohort study. Transpl Int. 2021;34:2305\u201316. https:\/\/doi.org\/10.1111\/tri.14110.","journal-title":"Transpl Int"},{"key":"1258_CR31","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfae065","author":"J van der Weijden","year":"2024","unstructured":"van der Weijden J, Kremer D, Westenberg LB, et al. Pre-donation assessment of cystatin c to improve prediction of pre- and post-donation GFR in potential living kidney donors. Nephrol Dial Transplant. 2024. https:\/\/doi.org\/10.1093\/ndt\/gfae065.","journal-title":"Nephrol Dial Transplant"},{"key":"1258_CR32","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3390\/jcm10010155","volume":"10","author":"LB Westenberg","year":"2021","unstructured":"Westenberg LB, van Londen M, Sotomayor CG, et al. The association between body composition measurements and surgical complications after living kidney donation. J Clin Med. 2021;10:155. https:\/\/doi.org\/10.3390\/jcm10010155.","journal-title":"J Clin Med"},{"key":"1258_CR33","doi-asserted-by":"publisher","first-page":"503","DOI":"10.2215\/CJN.0000000000000403","volume":"19","author":"LB Westenberg","year":"2024","unstructured":"Westenberg LB, Pol RA, van der Weijden J, et al. Central body fat distribution and kidney function after living kidney donation. Clin J Am Soc Nephrol. 2024;19:503\u201313. https:\/\/doi.org\/10.2215\/CJN.0000000000000403.","journal-title":"Clin J Am Soc Nephrol"},{"key":"1258_CR34","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.ajt.2022.12.015","volume":"23","author":"C Eelderink","year":"2023","unstructured":"Eelderink C, Kremer D, Riphagen IJ, et al. Effect of vitamin K supplementation on serum calcification propensity and arterial stiffness in vitamin K-deficient kidney transplant recipients: a double-blind, randomized, placebo-controlled clinical trial. Am J Transplant. 2023;23:520\u201330. https:\/\/doi.org\/10.1016\/j.ajt.2022.12.015.","journal-title":"Am J Transplant"}],"container-title":["European Journal of Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10654-025-01258-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10654-025-01258-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10654-025-01258-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T07:44:25Z","timestamp":1755935065000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10654-025-01258-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["1258"],"URL":"https:\/\/doi.org\/10.1007\/s10654-025-01258-1","relation":{},"ISSN":["0393-2990","1573-7284"],"issn-type":[{"value":"0393-2990","type":"print"},{"value":"1573-7284","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,2]]},"assertion":[{"value":"23 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"MB reports a grant from CSL Vifor, outside the submitted work. Additionally, MB reports consulting fees paid to his institution by Astellas, Astra Zeneca, Bayer, Boehringer Ingelheim, CSL Vifor, Kyowa Kirin Pharma, Lilly and Sanofi Genzyme. KD reports consulting fees from Abbot, Astra Zeneca, Boehringer Ingelheim, Novartis, Echosense, FIRE1 and Reprieve paid to his institution. TG reports participation on a data safety monitoring board or advisory board from Chiesi pharmaceuticals, payments paid to his institution. VM reports a VENI research grant by the Dutch Research Council (NWO; grant #09150161810030), a Research grant from the Dutch Ministry of Economic Affairs (Health\u2009~\u2009Holland Public Private Partnership grant #PPP31 2019\u2013024), and a Research grant from the Dutch Society for Gastroenterology (NVGE #01\u20132021), all outside the submitted work. VM further reports speakers fees paid to his institution by Astellas, Chiesi, and XVIVO.\u00a0All above reported conflict of interest are not directly involved in this manuscript. The remaining authors do not have conflicts of interests to report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study protocol has been approved by the local Institutional Review Board (METc 2014\/077), adheres to the UMCG Biobank Regulation, and complies with the WMA Declaration of Helsinki and the Declaration of Istanbul [\n                      \n                      ].","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all participants prior to inclusion for all recipients and living donors. For deceased donors, informed consent was obtained from their relatives, following the applicable regulations and agreements of the Dutch Transplant Foundation (NTS) regarding participation and use in scientific research.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Coby Annema, Stefan P Berger, Hans Blokzijl, Frank AJA Bodewes, Marieke T de Boer, Kevin Damman, Martin H de Borst, Arjan Diepstra, Gerard Dijkstra, Rianne M Douwes, Caecilia SE Doorenbos, Michele F Eisenga, Michiel E Erasmus, C Tji Gan, Antonio W Gomes-Neto, Eelko Hak, Bouke G Hepkema, Marius C van den Heuvel, Jip Jonker, Frank Klont, Tim J Knobbe, Daan Kremer, Coretta van Leer-Buter, Henri GD Leuvenink, Marco van Londen, Willem S Lexmond, Vincent E de Meijer, Hubert GM Niesters, Gertrude J Nieuwenhuis-Moeke, L Joost van Pelt, Robert A Pol, Anna M Posthumus, Adelita V Ranchor, Jan Stephan F Sanders, Marion J Siebelink, Riemer JHJA Slart, J Cas Swarte, Daan J Touw, Charlotte A te Velde-Keyzer, Erik AM Verschuuren, Michel J Vos, Rinse K Weersma, Stephan JL Bakker.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"TransplantLines Investigators"}}]}}