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We created The Danish Infection Cohort by linking Danish National Health Survey data (including self-reported behavioral, health, and other information) to data on diagnoses and medications in Danish national health registries. We included individuals\u2009\u2265\u200918 years of age in surveys from 2010, 2013, 2017, and 2021. We identified evidence of infection in the 365 days post-survey by using two definitions: hospital-diagnosed infections, via primary or secondary discharge diagnoses in the Danish National Patient Registry (containing all Danish hospital-based outpatient, emergency, and inpatient encounters); and community-treated infections, via systemic anti-infective prescription redemptions at community pharmacies in the Danish National Prescription Registry. Overall, among 609,224 individuals, 196,980 (32.3%) had one or more infections within 365 days post-survey: 11,850 hospital-diagnosed and 185,130 community-treated. Because more than one infection occurred in some individuals, the total number of infections was 315,689: 25,385 hospital-diagnosed and 290,304 community-treated. The most common diagnoses were respiratory infections (34.9%), and the most common anti-infectives were antibiotics (80.6%). This cohort, with nearly 200,000 individuals with infections, and more than 315,000 infections overall, includes data on smoking, weight, physical activity, diet, alcohol use, and other factors, enabling a wide range of investigations including infectious disease patterns and etiologies over time.<\/jats:p>","DOI":"10.1007\/s10654-026-01410-5","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T07:23:51Z","timestamp":1779866631000},"page":"681-691","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Danish Infection Cohort: a resource for population based infectious disease epidemiology"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7090-2761","authenticated-orcid":false,"given":"Noelle M.","family":"Cocoros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Oren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianka","family":"Darvalics","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi Amalie Rosendahl","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Holm","family":"Eliasen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Toft","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"1410_CR1","unstructured":"World Health Organization. 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The Department of Clinical Epidemiology, Aarhus University, receives funding for other studies in the form of institutional research grants to (and administered by) Aarhus University. The Department of Clinical Epidemiology, Aarhus University, confirms that none of these studies have any relation to the present study. Henrik Toft S\u00f8rensen has made paid evaluations for University of Oslo, the Norwegian Research Council, the Independent Research Fund Denmark, and the European Research Council. Noelle M. Cocoros is an employee of the Harvard Pilgrim Health Care Institute, a non-profit organization that conducts work for government and private organizations, including pharmaceutical companies; none of these studies are relevant to the present study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was registered with the Danish Data Protection Agency through Aarhus University (AU Registration number: 2022-0367531, serial number 3229). According to Danish law, no further approvals were required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}