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The Swiss Personalized Health Network Cohort Consortium (SPHN-CC) was established to address these limitations by creating the first coordinated network of Swiss cohort studies within the internationally recognized Maelstrom Research catalogue. Participating cohorts were invited in 2021\u20132022, including longitudinal and cross-sectional studies with 1010\u201321,993 participants. Data collected include questionnaires, physical and cognitive assessments, administrative records, and biological samples. Variables were classified into 18 domains and 134 subdomains, and an online metadata catalogue was implemented to document study designs, explore variable content, and assess harmonization potential. The catalogue enables researchers to identify study-specific and harmonized variables for co-analysis. Core variables, such as age, sex\/gender, anthropometrics, and medication use, are widely available, while other variables vary across cohorts. Harmonization assessments demonstrate that several key variables can be co-analyzed across multiple studies, supporting collaborative research with over 37,000 participants. A use case illustrates the potential for harmonizing and co-analyzing data across studies. The SPHN-CC strengthens Swiss cohort research by enhancing data discoverability, supporting harmonization, and facilitating cross-cohort and international research, providing a model for more efficient use of high-value longitudinal data.<\/jats:p>","DOI":"10.1007\/s10654-026-01411-4","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T10:36:30Z","timestamp":1782470190000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cohort profile: Swiss personalized health network cohort consortium"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5727-0218","authenticated-orcid":false,"given":"Murielle","family":"Bochud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel El Bouza\u00efdi","family":"Tiali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4250-3983","authenticated-orcid":false,"given":"Jan","family":"Armida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Wissa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3248-7899","authenticated-orcid":false,"given":"Sabine","family":"\u00d6sterle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Pierre","family":"Ghobril","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Henchoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Pittet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Benkert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Kuhle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Castelao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Preisig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Chizzolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huldrych F.","family":"G\u00fcnthard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Kusejko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Medea","family":"Imboden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Probst-Hensch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Koller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Marques-Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vollenweider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno","family":"Pruijm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andri","family":"Rauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camillo","family":"Ribi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almut","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Tellenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belen","family":"Ponte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Vaucher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Fortier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"issue":"1","key":"1411_CR1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1093\/ije\/dyab141","volume":"51","author":"AU Scherrer","year":"2022","unstructured":"Scherrer AU, et al. 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H. F. G. has received research grants from the Swiss National Science Foundation, Swiss HIV Cohort Study, Yvonne Jacob Foundation, NIH, Gilead, ViiV, and is a subcontractor to a Bill and Melinda Gates foundation grant, paid to his institution; personal honoraria for data safety monitoring board or advisory board consultations from Merck, ViiV healthcare, Gilead Sciences, Janssen, Johnson and Johnson, Novartis, and GSK. AR reports support to his institution for advisory boards and\/or travel grants from MSD, Gilead Sciences, ViiV and Moderna, and an investigator initiated trial (IIT) grant from Gilead Sciences. All remuneration went to his home institution and not to AR personally, and all remuneration was provided outside the submitted work. MPRE has received unrestricted research grants from GlaxoSmithKline and the Swiss National Science Foundation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All participating studies received ethical approvals from their respective institutions and informed consent from participants. Investigators requiring access to study-specific data need to obtain ethical approval from their home institution and follow study-specific data access rules and procedures. Not applicable. This article describes the cohort framework and metadata only, without presenting individual-level results. All data used in this article is already available online at:\n                      \n                      .","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable. This article describes the cohort framework and metadata only, without presenting individual-level results. All data used in this article is already available online at:\n                      \n                      .","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"Grammar proofreading was supported by ChatGPT-4 (OpenAI).","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Use of artificial intelligence"}}]}}