{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T17:43:52Z","timestamp":1776879832877,"version":"3.51.2"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,10,13]],"date-time":"2006-10-13T00:00:00Z","timestamp":1160697600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Familial Cancer"],"published-print":{"date-parts":[[2007,2,13]]},"DOI":"10.1007\/s10689-006-9104-x","type":"journal-article","created":{"date-parts":[[2006,10,12]],"date-time":"2006-10-12T14:14:10Z","timestamp":1160662450000},"page":"53-62","source":"Crossref","is-referenced-by-count":63,"title":["Very high incidence of familial colorectal cancer in Newfoundland: a comparison with Ontario and 13 other population-based studies"],"prefix":"10.1007","volume":"6","author":[{"given":"R. C.","family":"Green","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"Buehler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Robb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Daftary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gallinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. S.","family":"Parfrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. B.","family":"Younghusband","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,10,13]]},"reference":[{"key":"9104_CR1","unstructured":"National Cancer Institute of Canada (2003) Canadian cancer statistics 2003. Toronto, Canada"},{"key":"9104_CR2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1056\/NEJMra012242","volume":"348","author":"HT Lynch","year":"2003","unstructured":"Lynch HT, De La CA (2003) Hereditary colorectal cancer. N Engl J Med 348:919\u2013932","journal-title":"N Engl J Med"},{"key":"9104_CR3","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/0092-8674(93)90538-2","volume":"75","author":"L Spirio","year":"1993","unstructured":"Spirio L, Olschwang S, Groden J, Robertson M, Samowitz W, Joslyn G et al (1993) Alleles of the APC gene: an attenuated form of familial polyposis. Cell 75:951\u2013957","journal-title":"Cell"},{"key":"9104_CR4","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1093\/oxfordjournals.hmg.a018912","volume":"9","author":"H Lamlum","year":"2000","unstructured":"Lamlum H, Al Tassan N, Jaeger E, Frayling I, Sieber O, Reza FB et al (2000) Germline APC variants in patients with multiple colorectal adenomas, with evidence for the particular importance of E1317Q. Hum Mol Genet 9:2215\u20132221","journal-title":"Hum Mol Genet"},{"key":"9104_CR5","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1200\/JCO.2003.04.060","volume":"21","author":"P Peltomaki","year":"2003","unstructured":"Peltomaki P (2003) Role of DNA mismatch repair defects in the pathogenesis of human cancer. J Clin Oncol 21:1174\u20131179","journal-title":"J Clin Oncol"},{"key":"9104_CR6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1476-4598-2-41","volume":"2","author":"S Narayan","year":"2003","unstructured":"Narayan S, Roy D (2003) Role of APC and DNA mismatch repair genes in the development of colorectal cancers. Mol Cancer 2:41\u201355","journal-title":"Mol Cancer"},{"key":"9104_CR7","first-page":"1645","volume":"54","author":"LA Aaltonen","year":"1994","unstructured":"Aaltonen LA, Peltom\u00e4ki P, Mecklin J-P, J\u00e4rvinen H, Jass JR, Green JS et al (1994) Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients. Cancer Res 54:1645\u20131648","journal-title":"Cancer Res"},{"key":"9104_CR8","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/BF02053699","volume":"34","author":"HF Vasen","year":"1991","unstructured":"Vasen HF, Mecklin JP, Khan PM, Lynch HT (1991) The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Rectum 34:424\u2013425","journal-title":"Dis Colon Rectum"},{"key":"9104_CR9","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0016-5085(99)70510-X","volume":"116","author":"HF Vasen","year":"1999","unstructured":"Vasen HF, Watson P, Mecklin JP, Lynch HT (1999) New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology 116:1453\u20131456","journal-title":"Gastroenterology"},{"key":"9104_CR10","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1093\/jnci\/89.23.1758","volume":"89","author":"MA Rodriguez-Bigas","year":"1997","unstructured":"Rodriguez-Bigas MA, Boland CR, Hamilton SR, Henson DE, Jass JR, Khan PM et al (1997) A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: meeting highlights and Bethesda guidelines. J Natl Cancer Inst 89:1758\u20131762","journal-title":"J Natl Cancer Inst"},{"key":"9104_CR11","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/jnci\/djh034","volume":"96","author":"A Umar","year":"2004","unstructured":"Umar A, Boland CR, Terdiman JP, Syngal S, De La CA, Ruschoff J et al (2004) Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 96:261\u2013268","journal-title":"J Natl Cancer Inst"},{"key":"9104_CR12","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1023\/B:CACO.0000003840.94591.76","volume":"14","author":"ML Slattery","year":"2003","unstructured":"Slattery ML, Levin TR, Ma K, Goldgar D, Holubkov R, Edwards S (2003) Family history and colorectal cancer: predictors of risk. Cancer Causes Control 14:879\u2013887","journal-title":"Cancer Causes Control"},{"key":"9104_CR13","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1001\/jama.292.12.1480","volume":"292","author":"HJ Murff","year":"2004","unstructured":"Murff HJ, Spigel DR, Syngal S (2004) Does this patient have a family history of cancer? An evidence-based analysis of the accuracy of family cancer history. JAMA 292:1480\u20131489","journal-title":"JAMA"},{"key":"9104_CR14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.0009-9163.2004.00282.x","volume":"66","author":"PJ Ainsworth","year":"2004","unstructured":"Ainsworth PJ, Koscinski D, Fraser BP, Stuart JA (2004) Family cancer histories predictive of a high risk of hereditary non-polyposis colorectal cancer associate significantly with a genomic rearrangement in hMSH2 or hMLH1. Clin Genet 66:183\u2013188","journal-title":"Clin Genet"},{"key":"9104_CR15","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1136\/jmg.2003.017996","volume":"41","author":"DG Evans","year":"2004","unstructured":"Evans DG, Eccles DM, Rahman N, Young K, Bulman M, Amir E et al (2004) A new scoring system for the chances of identifying a BRCA1\/2 mutation outperforms existing models including BRCAPRO. J Med Genet 41:474\u2013480","journal-title":"J Med Genet"},{"key":"9104_CR16","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1001\/jama.293.16.1979","volume":"293","author":"NM Lindor","year":"2005","unstructured":"Lindor NM, Rabe K, Petersen GM, Haile R, Casey G, Baron J et al (2005) Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X. JAMA 293:1979\u20131985","journal-title":"JAMA"},{"key":"9104_CR17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s10689-004-4489-x","volume":"4","author":"CR Boland","year":"2005","unstructured":"Boland CR (2005) Evolution of the nomenclature for the hereditary colorectal cancer syndromes. Fam Cancer 4:211\u2013218","journal-title":"Fam Cancer"},{"key":"9104_CR18","doi-asserted-by":"crossref","first-page":"8698","DOI":"10.1073\/pnas.95.15.8698","volume":"95","author":"ML Veigl","year":"1998","unstructured":"Veigl ML, Kasturi L, Olechnowicz J, Ma AH, Lutterbaugh JD, Periyasamy S et al (1998) Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proc Natl Acad Sci USA 95:8698\u20138702","journal-title":"Proc Natl Acad Sci USA"},{"key":"9104_CR19","doi-asserted-by":"crossref","first-page":"6870","DOI":"10.1073\/pnas.95.12.6870","volume":"95","author":"JG Herman","year":"1998","unstructured":"Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JP et al (1998) Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci USA 95:6870\u20136875","journal-title":"Proc Natl Acad Sci USA"},{"key":"9104_CR20","first-page":"81","volume":"21","author":"M Cotterchio","year":"2000","unstructured":"Cotterchio M, Keown-Eyssen G, Sutherland H, Buchan G, Aronson M, Easson AM et al (2000) Ontario familial colon cancer registry: methods and first-year response rates. Chronic Dis Can 21:81\u201386","journal-title":"Chronic Dis Can"},{"key":"9104_CR21","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s10552-005-2370-3","volume":"16","author":"M Cotterchio","year":"2005","unstructured":"Cotterchio M, Manno M, Klar N, McLaughlin J, Gallinger S (2005) Colorectal screening is associated with reduced colorectal cancer risk: a case\u2013control study within the population-based Ontario Familial Colorectal Cancer Registry. Cancer Causes Control 16:865\u2013875","journal-title":"Cancer Causes Control"},{"key":"9104_CR22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10689-004-7251-5","volume":"4","author":"RC Green","year":"2005","unstructured":"Green RC, McLaughlin JR, Younghusband HB (2005) SISE matters: the Sum of Information on Seventy-yr-old Equivalents measures pedigree information content when assessing the risk of HNPCC in a family. Fam Cancer 4:169\u2013175","journal-title":"Fam Cancer"},{"key":"9104_CR23","doi-asserted-by":"crossref","first-page":"785","DOI":"10.7326\/0003-4819-118-10-199305150-00005","volume":"118","author":"DJ St John","year":"1993","unstructured":"St John DJ, McDermott FT, Hopper JL, Debney EA, Johnson WR, Hughes ES (1993) Cancer risk in relatives of patients with common colorectal cancer. Ann Intern Med 118:785\u2013790","journal-title":"Ann Intern Med"},{"key":"9104_CR24","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/BF02054116","volume":"38","author":"JP Mecklin","year":"1995","unstructured":"Mecklin JP, Jarvinen HJ, Hakkiluoto A, Hallikas H, Hiltunen KM, Harkonen N et al (1995) Frequency of hereditary nonpolyposis colorectal cancer. A prospective multicenter study in Finland. Dis Colon Rectum 38:588\u2013593","journal-title":"Dis Colon Rectum"},{"key":"9104_CR25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1023\/A:1025734200635","volume":"2","author":"L Olsson","year":"2003","unstructured":"Olsson L, Lindblom A (2003) Family history of colorectal cancer in a Sweden county. Fam Cancer 2:87\u201393","journal-title":"Fam Cancer"},{"key":"9104_CR26","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1002\/bjs.1800840924","volume":"84","author":"DG Evans","year":"1997","unstructured":"Evans DG, Walsh S, Jeacock J, Robinson C, Hadfield L, Davies DR et al (1997) Incidence of hereditary non-polyposis colorectal cancer in a population-based study of 1137 consecutive cases of colorectal cancer. Br J Surg 84:1281\u20131285","journal-title":"Br J Surg"},{"key":"9104_CR27","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/(SICI)1097-0142(19990215)85:4<779::AID-CNCR4>3.0.CO;2-C","volume":"85","author":"ML Cravo","year":"1999","unstructured":"Cravo ML, Fidalgo PO, Lage PA, Albuquerque CM, Chaves PP, Claro I et al (1999) Validation and simplification of Bethesda guidelines for identifying apparently sporadic forms of colorectal carcinoma with microsatellite instability. Cancer 85:779\u2013785","journal-title":"Cancer"},{"key":"9104_CR28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/gut.45.1.32","volume":"45","author":"MP Leon De","year":"1999","unstructured":"De Leon MP, Pedroni M, Benatti P, Percesepe A, Di Gregorio C, Foroni M et al (1999) Hereditary colorectal cancer in the general population: from cancer registration to molecular diagnosis. Gut 45:32\u201338","journal-title":"Gut"},{"key":"9104_CR29","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1086\/323658","volume":"69","author":"JM Cunningham","year":"2001","unstructured":"Cunningham JM, Kim CY, Christensen ER, Tester DJ, Parc Y, Burgart LJ et al (2001) The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinomas. Am J Hum Genet 69:780\u2013790","journal-title":"Am J Hum Genet"},{"key":"9104_CR30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gut.50.1.43","volume":"50","author":"N Katballe","year":"2002","unstructured":"Katballe N, Christensen M, Wikman FP, Orntoft TF, Laurberg S (2002) Frequency of hereditary non-polyposis colorectal cancer in Danish colorectal cancer patients. Gut 50:43\u201351","journal-title":"Gut"},{"key":"9104_CR31","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/cncr.10332","volume":"94","author":"T Furukawa","year":"2002","unstructured":"Furukawa T, Konishi F, Shitoh K, Kojima M, Nagai H, Tsukamoto T (2002) Evaluation of screening strategy for detecting hereditary nonpolyposis colorectal carcinoma. Cancer 94:911\u2013920","journal-title":"Cancer"},{"key":"9104_CR32","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S1542-3565(04)00352-0","volume":"2","author":"S Grover","year":"2004","unstructured":"Grover S, Stoffel EM, Bussone L, Tschoegl E, Syngal S (2004) Physician assessment of family cancer history and referral for genetic evaluation in colorectal cancer patients. Clin Gastroenterol Hepatol 2:813\u2013819","journal-title":"Clin Gastroenterol Hepatol"},{"key":"9104_CR33","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/00042737-200401000-00007","volume":"16","author":"V Pinol","year":"2004","unstructured":"Pinol V, Andreu M, Castells A, Paya A, Bessa X, Rodrigo J (2004) Frequency of hereditary non-polyposis colorectal cancer and other colorectal cancer familial forms in Spain: a multicentre, prospective, nationwide study. Eur J Gastroenterol Hepatol 16:39\u201345","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"9104_CR34","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1001\/jama.293.16.1986","volume":"293","author":"V Pinol","year":"2005","unstructured":"Pinol V, Castells A, Andreu M, Castellvi-Bel S, Alenda C, Llor X et al (2005) Accuracy of revised Bethesda guidelines, microsatellite instability, and immunohistochemistry for the identification of patients with hereditary nonpolyposis colorectal cancer1. JAMA 293:1986\u20131994","journal-title":"JAMA"},{"key":"9104_CR35","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s10689-005-0657-x","volume":"4","author":"RA Kerber","year":"2005","unstructured":"Kerber RA, Neklason DW, Samowitz WS, Burt RW (2005) Frequency of familial colon cancer and hereditary nonpolyposis colorectal cancer (Lynch syndrome) in a large population database. Fam Cancer 4:239\u2013244","journal-title":"Fam Cancer"},{"key":"9104_CR36","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1399-0004.2005.00458.x","volume":"68","author":"C Sarroca","year":"2005","unstructured":"Sarroca C, Valle AD, Fresco R, Renkonen E, Peltomaki P, Lynch H (2005) Frequency of hereditary non-polyposis colorectal cancer among Uruguayan patients with colorectal cancer. Clin Genet 68:80\u201387","journal-title":"Clin Genet"},{"key":"9104_CR37","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s004390051121","volume":"105","author":"L Spirio","year":"1999","unstructured":"Spirio L, Green J, Robertson J, Robertson M, Otterud B, Sheldon J et al (1999) The identical 5\u2032 splice-site acceptor mutation in five attenuated APC families from Newfoundland demonstrates a founder effect. Hum Genet 105:388\u2013398","journal-title":"Hum Genet"},{"key":"9104_CR38","first-page":"97","volume":"36","author":"NJ Froggatt","year":"1999","unstructured":"Froggatt NJ, Green J, Brassett C, Evans DG, Bishop DT, Kolodner R et al (1999) A common MSH2 mutation in English and North American HNPCC families: origin, phenotypic expression, and sex specific differences in colorectal cancer [In Process Citation]. J Med Genet 36:97\u2013102","journal-title":"J Med Genet"},{"key":"9104_CR39","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1158\/1078-0432.CCR-05-0726","volume":"11","author":"MO Woods","year":"2005","unstructured":"Woods MO, Hyde AJ, Curtis FK, Stuckless S, Green JS, Pollett AF et al (2005) High frequency of hereditary colorectal cancer in Newfoundland likely involves Novel Susceptibility Genes. Clin Cancer Res 11:6853\u20136861","journal-title":"Clin Cancer Res"},{"key":"9104_CR40","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1056\/NEJMoa043146","volume":"352","author":"H Hampel","year":"2005","unstructured":"Hampel H, Frankel WL, Martin E, Arnold M, Khanduja K, Kuebler P et al (2005) Screening for the Lynch syndrome (Hereditary Nonpolyposis Colorectal Cancer). N Engl J Med 352:1851\u20131860","journal-title":"N Engl J Med"},{"key":"9104_CR41","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1038\/bjc.1995.508","volume":"72","author":"A Percesepe","year":"1995","unstructured":"Percesepe A, Anti M, Roncucci L, Armelao F, Marra G, Pahor M et al (1995) The effect of family size on estimates of the frequency of hereditary non-polyposis colorectal cancer. Br J Cancer 72:1320\u20131323","journal-title":"Br J Cancer"},{"key":"9104_CR42","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.gastro.2005.05.011","volume":"129","author":"H Hampel","year":"2005","unstructured":"Hampel H, Stephens JA, Pukkala E, Sankila R, Aaltonen LA, Mecklin JP et al (2005) Cancer risk in hereditary nonpolyposis colorectal cancer syndrome: later age of onset. Gastroenterology 129:415\u2013421","journal-title":"Gastroenterology"},{"key":"9104_CR43","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/ajmg.a.30397","volume":"131","author":"KK Grewal","year":"2004","unstructured":"Grewal KK, Stefanelli MG, Meijer IA, Hand CK, Rouleau GA, Ives EJ (2004) A founder effect in three large Newfoundland families with a novel clinically variable spastic ataxia and supranuclear gaze palsy. Am J Med Genet A 131:249\u2013254","journal-title":"Am J Med Genet A"},{"key":"9104_CR44","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1086\/302686","volume":"65","author":"TL Young","year":"1999","unstructured":"Young TL, Woods MO, Parfrey PS, Green JS, Hefferton D, Davidson WS (1999) A founder effect in the Newfoundland population reduces the Bardet\u2013Biedl syndrome I (BBS1) interval to 1\u00a0cM. Am J Hum Genet 65:1680\u20131687","journal-title":"Am J Hum Genet"},{"key":"9104_CR45","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1046\/j.1523-1755.2002.00305.x","volume":"61","author":"PS Parfrey","year":"2002","unstructured":"Parfrey PS, Davidson WS, Green JS (2002) Clinical and genetic epidemiology of inherited renal disease in Newfoundland. Kidney Int 61:1925\u20131934","journal-title":"Kidney Int"},{"key":"9104_CR46","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/(SICI)1098-1004(1998)11:4<264::AID-HUMU2>3.0.CO;2-V","volume":"11","author":"SE Olufemi","year":"1998","unstructured":"Olufemi SE, Green JS, Manickam P, Guru SC, Agarwal SK, Kester MB et al (1998) Common ancestral mutation in the MEN1 gene is likely responsible for the prolactinoma variant of MEN1 (MEN1Burin) in four kindreds from Newfoundland. Hum Mutat 11:264\u2013269","journal-title":"Hum Mutat"},{"key":"9104_CR47","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1093\/jnci\/djh288","volume":"96","author":"Croitoru","year":"2004","unstructured":"Croitoru ME, Cleary SP, Di NN, Manno M, Selander T, Aronson M et al (2004) Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk. J Natl Cancer Inst 96:1631\u20131634","journal-title":"J Natl Cancer Inst"}],"container-title":["Familial Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-006-9104-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10689-006-9104-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-006-9104-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T17:45:55Z","timestamp":1559238355000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10689-006-9104-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,13]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,2,13]]}},"alternative-id":["9104"],"URL":"https:\/\/doi.org\/10.1007\/s10689-006-9104-x","relation":{},"ISSN":["1389-9600","1573-7292"],"issn-type":[{"value":"1389-9600","type":"print"},{"value":"1573-7292","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,13]]}}}