{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T21:08:11Z","timestamp":1777324091837,"version":"3.51.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,8,26]],"date-time":"2008-08-26T00:00:00Z","timestamp":1219708800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Familial Cancer"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1007\/s10689-008-9213-9","type":"journal-article","created":{"date-parts":[[2008,8,25]],"date-time":"2008-08-25T12:07:59Z","timestamp":1219666079000},"page":"103-108","source":"Crossref","is-referenced-by-count":29,"title":["Familial nasopharyngeal carcinoma in Hong Kong: epidemiology and implication in screening"],"prefix":"10.1007","volume":"8","author":[{"given":"Wai Tong","family":"Ng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheuk Wai","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C. H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siu Hong","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsz Kok","family":"Yau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne W. M.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,8,26]]},"reference":[{"key":"9213_CR1","unstructured":"Hong Kong Cancer Stat 2005 (2005) Hong Kong Cancer Registry, Hospital Authority. Hong Kong"},{"key":"9213_CR2","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1158\/1055-9965.EPI-06-0353","volume":"15","author":"ET Chang","year":"2006","unstructured":"Chang ET, Adami HO (2006) The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev 15:1765\u20131777. doi: 10.1158\/1055-9965.EPI-06-0353","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"9213_CR3","first-page":"1073","volume":"31","author":"SH Ng","year":"2004","unstructured":"Ng SH, Chang JT, Chan SC et al (2004) Nodal metastases of nasopharyngeal carcinoma: patterns of disease on MRI and FDG PET. Eur J Nucl Med Mol Imaging 31:1073\u20131080. doi: 10.1007\/s00259-004-1498-9","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"9213_CR4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0360-3016(02)02724-4","volume":"53","author":"N Lee","year":"2002","unstructured":"Lee N, Xia P, Quivey JM et al (2002) Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience. Int J Radiat Oncol Biol Phys 53:12\u201322. doi: 10.1016\/S0360-3016(02)02724-4","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"9213_CR5","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1200\/JCO.1998.16.4.1310","volume":"16","author":"M Al-Sarraf","year":"1998","unstructured":"Al-Sarraf M, LeBlanc M, Giri PG et al (1998) Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. J Clin Oncol 16:1310\u20131317","journal-title":"J Clin Oncol"},{"key":"9213_CR6","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.ijrobp.2004.07.702","volume":"61","author":"AW Lee","year":"2005","unstructured":"Lee AW, Sze WM, Au JS et al (2005) Treatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experience. Int J Radiat Oncol Biol Phys 61:1107\u20131116. doi: 10.1016\/j.ijrobp.2004.07.702","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"9213_CR7","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/ijc.10894","volume":"103","author":"AW Lee","year":"2003","unstructured":"Lee AW, Foo W, Mang O et al (2003) Changing epidemiology of nasopharyngeal carcinoma in Hong Kong over a 20-year period (1980\u201399): an encouraging reduction in both incidence and mortality. Int J Cancer 103:680\u2013685. doi: 10.1002\/ijc.10894","journal-title":"Int J Cancer"},{"key":"9213_CR8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0140-6736(74)91466-4","volume":"2","author":"EH Williams","year":"1974","unstructured":"Williams EH, de The G (1974) Letter: familial aggregation in nasopharyngeal carcinoma. Lancet 2:295\u2013296. doi: 10.1016\/S0140-6736(74)91466-4","journal-title":"Lancet"},{"key":"9213_CR9","first-page":"242","volume":"73","author":"PF Jung","year":"1965","unstructured":"Jung PF (1965) Familial tendency of nasopharyngeal carcinoma; a report of cases. Pac Med Surg 73:242\u2013243","journal-title":"Pac Med Surg"},{"key":"9213_CR10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0065-230X(08)60372-3","volume":"15","author":"JH Ho","year":"1972","unstructured":"Ho JH (1972) Nasopharyngeal carcinoma (NPC). Adv Cancer Res 15:57\u201392. doi: 10.1016\/S0065-230X(08)60372-3","journal-title":"Adv Cancer Res"},{"key":"9213_CR11","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/cncr.20372","volume":"101","author":"WH Jia","year":"2004","unstructured":"Jia WH, Feng BJ, Xu ZL et al (2004) Familial risk and clustering of nasopharyngeal carcinoma in Guangdong, China. Cancer 101:363\u2013369. doi: 10.1002\/cncr.20372","journal-title":"Cancer"},{"key":"9213_CR12","first-page":"661","volume":"19","author":"A Ung","year":"1999","unstructured":"Ung A, Chen CJ, Levine PH et al (1999) Familial and sporadic cases of nasopharyngeal carcinoma in Taiwan. Anticancer Res 19:661\u2013665","journal-title":"Anticancer Res"},{"key":"9213_CR13","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1001\/archotol.132.1.82","volume":"132","author":"KS Loh","year":"2006","unstructured":"Loh KS, Goh BC, Lu J, Hsieh WS, Tan L (2006) Familial nasopharyngeal carcinoma in a cohort of 200 patients. Arch Otolaryngol Head Neck Surg 132:82\u201385. doi: 10.1001\/archotol.132.1.82","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"9213_CR14","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0140-6736(01)06524-2","volume":"358","author":"Collaborative Group on Hormonal Factors in Breast Cancer","year":"2001","unstructured":"Collaborative Group on Hormonal Factors in Breast Cancer (2001) Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease. Lancet 358:1389\u20131399. doi: 10.1016\/S0140-6736(01)06524-2","journal-title":"Lancet"},{"key":"9213_CR15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10549-006-9433-3","volume":"105","author":"JC Figueiredo","year":"2007","unstructured":"Figueiredo JC, Ennis M, Knight JA et al (2007) Influence of young age at diagnosis and family history of breast or ovarian cancer on breast cancer outcomes in a population-based cohort study. Breast Cancer Res Treat 105:69\u201380. doi: 10.1007\/s10549-006-9433-3","journal-title":"Breast Cancer Res Treat"},{"key":"9213_CR16","first-page":"31","volume-title":"American Joint Committee on Cancer: AJCC cancer staging manual","author":"I Fleming","year":"1997","unstructured":"Fleming I, Cooper J, Henson D (1997) American Joint Committee on Cancer: AJCC cancer staging manual, 5th edn. Lippincott-Raven, Philadelphia, pp 31\u201339","edition":"5"},{"key":"9213_CR17","doi-asserted-by":"crossref","first-page":"abstr 1512","DOI":"10.1200\/jco.2008.26.15_suppl.1512","volume":"26","author":"AL Law","year":"2008","unstructured":"Law AL, Ng WT, Yau TK, Lee AW (2008) Screening for family members of patients with nasopharyngeal carcinoma\u2014does early detection improve outcome? J Clin Oncol 26:abstr 1512","journal-title":"J Clin Oncol"},{"key":"9213_CR18","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/1097-0142(19910915)68:6<1323::AID-CNCR2820680623>3.0.CO;2-S","volume":"68","author":"CM Coffin","year":"1991","unstructured":"Coffin CM, Rich SS, Dehner LP (1991) Familial aggregation of nasopharyngeal carcinoma and other malignancies. A clinicopathologic description. Cancer 68:1323\u20131328. doi 10.1002\/1097-0142(19910915)68:6<1323::AID-CNCR2820680623>3.0.CO;2-S","journal-title":"Cancer"},{"key":"9213_CR19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/00313028409067906","volume":"16","author":"A Fischer","year":"1984","unstructured":"Fischer A, Fischer GO, Cooper E (1984) Familial nasopharyngeal carcinoma. Pathology 16:23\u201324. doi: 10.3109\/00313028409067906","journal-title":"Pathology"},{"key":"9213_CR20","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1002\/1097-0142(19801115)46:10<2325::AID-CNCR2820461035>3.0.CO;2-3","volume":"46","author":"BW Gajwani","year":"1980","unstructured":"Gajwani BW, Devereaux JM, Beg JA (1980) Familial clustering of nasopharyngeal carcinoma. Cancer 46:2325\u20132327. doi 10.1002\/1097-0142(19801115)46:10<2325::AID-CNCR2820461035>3.0.CO;2-3","journal-title":"Cancer"},{"key":"9213_CR21","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1002\/1097-0142(19920901)70:5<1024::AID-CNCR2820700503>3.0.CO;2-4","volume":"70","author":"PH Levine","year":"1992","unstructured":"Levine PH, Pocinki AG, Madigan P, Bale S (1992) Familial nasopharyngeal carcinoma in patients who are not Chinese. Cancer 70:1024\u20131029. doi 10.1002\/1097-0142(19920901)70:5<1024::AID-CNCR2820700503>3.0.CO;2-4","journal-title":"Cancer"},{"key":"9213_CR22","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1080\/00016480510040155","volume":"125","author":"J Olajos","year":"2005","unstructured":"Olajos J, Fule E, Erfan J et al (2005) Familial clustering of nasopharyngeal carcinoma in a non-endemic geographical region. Report of two Hungarian cases and a review of the literature. Acta Otolaryngol 125:1008\u20131013. doi: 10.1080\/00016480510040155","journal-title":"Acta Otolaryngol"},{"key":"9213_CR23","doi-asserted-by":"crossref","first-page":"8567","DOI":"10.1158\/0008-5472.CAN-04-4208","volume":"65","author":"J Friborg","year":"2005","unstructured":"Friborg J, Wohlfahrt J, Koch A, Storm H, Olsen OR, Melbye M (2005) Cancer susceptibility in nasopharyngeal carcinoma families\u2013a population-based cohort study. Cancer Res 65:8567\u20138572. doi: 10.1158\/0008-5472.CAN-04-4208","journal-title":"Cancer Res"},{"key":"9213_CR24","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1044579X02000871","volume":"12","author":"YX Zeng","year":"2002","unstructured":"Zeng YX, Jia WH (2002) Familial nasopharyngeal carcinoma. Semin Cancer Biol 12:443\u2013450. doi: 10.1016\/S1044579X02000871","journal-title":"Semin Cancer Biol"},{"key":"9213_CR25","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/sj.ejhg.5201305","volume":"13","author":"WH Jia","year":"2005","unstructured":"Jia WH, Collins A, Zeng YX et al (2005) Complex segregation analysis of nasopharyngeal carcinoma in Guangdong, China: evidence for a multifactorial mode of inheritance (complex segregation analysis of NPC in China). Eur J Hum Genet 13:248\u2013252. doi: 10.1038\/sj.ejhg.5201305","journal-title":"Eur J Hum Genet"},{"key":"9213_CR26","first-page":"355","volume":"3","author":"AW Lee","year":"1997","unstructured":"Lee AW, Foo W, Law SC et al (1997) Nasopharyngeal carcinoma: presenting symptoms and duration before diagnosis. Hong Kong Med J 3:355\u2013361","journal-title":"Hong Kong Med J"},{"key":"9213_CR27","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1023\/A:1008301314812","volume":"10","author":"PO Chappuis","year":"1999","unstructured":"Chappuis PO, Rosenblatt J, Foulkes WD (1999) The influence of familial and hereditary factors on the prognosis of breast cancer. Ann Oncol 10:1163\u20131170. doi: 10.1023\/A:1008301314812","journal-title":"Ann Oncol"},{"key":"9213_CR28","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1002\/(SICI)1097-0142(19961001)78:7<1417::AID-CNCR7>3.0.CO;2-H","volume":"78","author":"KE Malone","year":"1996","unstructured":"Malone KE, Daling JR, Weiss NS, McKnight B, White E, Voigt LF (1996) Family history and survival of young women with invasive breast carcinoma. Cancer 78:1417\u20131425. doi 10.1002\/(SICI)1097-0142(19961001)78:7<1417::AID-CNCR7>3.0.CO;2-H","journal-title":"Cancer"},{"key":"9213_CR29","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/00001648-199311000-00011","volume":"4","author":"ML Slattery","year":"1993","unstructured":"Slattery ML, Berry TD, Kerber RA (1993) Is survival among women diagnosed with breast cancer influenced by family history of breast cancer? Epidemiology 4:543\u2013548. doi: 10.1097\/00001648-199311000-00011","journal-title":"Epidemiology"},{"key":"9213_CR30","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1075-122X.2004.21288.x","volume":"10","author":"T Kinoshita","year":"2004","unstructured":"Kinoshita T, Fukutomi T, Iwamoto E, Akashi-Tanaka S (2004) Prognosis of breast cancer patients with familial history classified according to their menopausal status. Breast J 10:218\u2013222. doi: 10.1111\/j.1075-122X.2004.21288.x","journal-title":"Breast J"},{"key":"9213_CR31","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1002\/ijc.20672","volume":"113","author":"WT Ng","year":"2005","unstructured":"Ng WT, Yau TK, Yung RW et al (2005) Screening for family members of patients with nasopharyngeal carcinoma. Int J Cancer 113:998\u20131001. doi: 10.1002\/ijc.20672","journal-title":"Int J Cancer"}],"container-title":["Familial Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-008-9213-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10689-008-9213-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-008-9213-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T17:45:58Z","timestamp":1559238358000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10689-008-9213-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,26]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["9213"],"URL":"https:\/\/doi.org\/10.1007\/s10689-008-9213-9","relation":{},"ISSN":["1389-9600","1573-7292"],"issn-type":[{"value":"1389-9600","type":"print"},{"value":"1573-7292","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,26]]}}}