{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:37:32Z","timestamp":1778891852377,"version":"3.51.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T00:00:00Z","timestamp":1336435200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Familial Cancer"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1007\/s10689-012-9529-3","type":"journal-article","created":{"date-parts":[[2012,5,7]],"date-time":"2012-05-07T14:53:25Z","timestamp":1336402405000},"page":"411-418","source":"Crossref","is-referenced-by-count":16,"title":["Ameloblastoma: a neglected criterion for nevoid basal cell carcinoma (Gorlin) syndrome"],"prefix":"10.1007","volume":"11","author":[{"given":"Giovanni","family":"Ponti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenza","family":"Pastorino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Pollio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Nasti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Pellacani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele D.","family":"Mignogna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Tomasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Del Forno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Longo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Bianchi-Scarr\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Ficarra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Seidenari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,5,8]]},"reference":[{"key":"9529_CR1","first-page":"71","volume-title":"Tumors and cysts of the jaw","author":"JJ Sciubba","year":"2001","unstructured":"Sciubba JJ, Fantasia JE, Kahn LB et al (2001) Tumors and cysts of the jaw. Armed Forces Institute of Pathology, Washinton, pp 71\u201379"},{"issue":"3","key":"9529_CR2","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0030-4220(94)90299-2","volume":"77","author":"TD Daley","year":"1994","unstructured":"Daley TD, Wysocki GP, Pringle GA (1994) Relative incidence of odontogenic tumors and oral and jaw cysts in a Canadian population. Oral Surg Oral Med Oral Pathol 77(3):276\u2013280","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"10","key":"9529_CR3","first-page":"771","volume":"36","author":"JA Regezi","year":"1978","unstructured":"Regezi JA, Kerr DA, Courtney RM (1978) Odontogenic tumors: analysis of 706 cases. J Oral Surg 36(10):771\u2013778","journal-title":"J Oral Surg"},{"key":"9529_CR4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0733-8635(18)30114-1","volume":"13","author":"RJ Gorlin","year":"1995","unstructured":"Gorlin RJ (1995) Nevoid basal cell carcinoma syndrome. Dermatol Clin 13:113\u2013125","journal-title":"Dermatol Clin"},{"key":"9529_CR5","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1136\/jmg.30.6.460","volume":"30","author":"DG Evans","year":"1993","unstructured":"Evans DG, Ladusans EJ, Rimmer S, Burnell LD, Thakker N, Farndon PA (1993) Complication of naevoid basal cell carcinoma syndrome: results of a population based study. J Med Genet 30:460\u2013464","journal-title":"J Med Genet"},{"key":"9529_CR6","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/humu.9317","volume":"25","author":"L Pastorino","year":"2005","unstructured":"Pastorino L, Cusano R, Nasti S et al (2005) Molecular characterization of Italian nevoid basal cell carcinoma syndrome patients. Hum Mutat 25:322\u2013323","journal-title":"Hum Mutat"},{"key":"9529_CR7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/384129a0","volume":"384","author":"DM Stone","year":"1996","unstructured":"Stone DM, Hynes M, Armanini M et al (1996) The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384:129\u2013134","journal-title":"Nature"},{"key":"9529_CR8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/(SICI)1096-8628(19970331)69:3<299::AID-AJMG16>3.0.CO;2-M","volume":"69","author":"VE Kimonis","year":"1997","unstructured":"Kimonis VE, Goldstein AM, Pastakia B et al (1997) Clinical manifestation in 105 person with nevoid basal cell carcinoma syndrome. Am J Med Genet 69:299\u2013308","journal-title":"Am J Med Genet"},{"key":"9529_CR9","unstructured":"Evans DG, Farndon PA (2002) Nevoid basal cell carcinoma syndrome. In: pagon RA, Bird TD, Dolan cr, Stephens k (eds) Gene Reviews (Internet). University of Washington, seattle; 1993\u20132002 Jun 20 (update 2020 Jul 22)"},{"key":"9529_CR10","doi-asserted-by":"crossref","unstructured":"Bree AF, Shah MR (2011) BCNS Colloquium Group. Consensus statement from the first international colloquium on basal cell nevus syndrome (BCNS). Am J Med Genet A 155A(9):2091\u20132097. doi: 10.1002\/ajmg.a.34128 . Epub 2011 Aug 10","DOI":"10.1002\/ajmg.a.34128"},{"key":"9529_CR11","first-page":"39","volume":"43","author":"RJ Gorlin","year":"1963","unstructured":"Gorlin RJ, Yunis JJ, Tuna N (1963) Multiple nevoid basal cell carcinoma, odontogenic keratocysts and skeletal anomalies. Syndrome. Acta Derm-Venerol (Stockh.) 43:39\u201355","journal-title":"Acta Derm-Venerol (Stockh.)"},{"key":"9529_CR12","doi-asserted-by":"crossref","unstructured":"Ponti G, Pollio A, Mignogna MD et al (2012) Unicystic ameloblastoma associated with the K729\u00a0M PTCH1 mutation in a patient with nevoid basal cell Carcinoma (Gorlin) syndrome. Cancer Genet (in press)","DOI":"10.1016\/j.cancergen.2012.01.012"},{"issue":"15","key":"9529_CR13","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1242\/dev.125.15.2803","volume":"125","author":"Z Hardcastle","year":"1998","unstructured":"Hardcastle Z, Mo R, Hui CC, Sharpe PT (1998) The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants. Development 125(15):2803\u20132811","journal-title":"Development"},{"key":"9529_CR14","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1242\/dev.127.22.4775","volume":"127","author":"HR Dassule","year":"2000","unstructured":"Dassule HR, Lewis P, Bei M, Maas R, McMahon AP (2000) Sonic hedgehog regulates growth and morphogenesis of the tooth. Development 127:4775\u20134785","journal-title":"Development"},{"key":"9529_CR15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0733-8635(18)30114-1","volume":"13","author":"L Lo Muzio","year":"1995","unstructured":"Lo Muzio L, Nocini P, Bucci P, Pannone G, Consolo U, Procaccini M (1995) Early diagnosis of nevoid basal cell carcinoma syndrome. Dermatol Clin 13:113\u2013125","journal-title":"Dermatol Clin"},{"key":"9529_CR16","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/sj.bdj.4800970","volume":"190","author":"R Leonardi","year":"2001","unstructured":"Leonardi R, Sorge G, Caltabino M (2001) Bilateral hyperplasia of the mandibular coronoid processes associated with the nevoid basal cell carcinoma syndrome in an Italian boy. Br Dent J 190:349\u2013350","journal-title":"Br Dent J"},{"key":"9529_CR17","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/ajmg.10432","volume":"110","author":"R Leonardi","year":"2002","unstructured":"Leonardi R, Caltabino M, Lo Muzio L et al (2002) Bilateral hyperplasia of the mandibular coronoid processes in patients with nevoid basal cell carcinoma syndrome: an undescribed sign. Am J Med Genet 110:400\u2013403","journal-title":"Am J Med Genet"},{"key":"9529_CR18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/1097-0142(196501)18:1<89::AID-CNCR2820180114>3.0.CO;2-9","volume":"18","author":"RJ Gorlin","year":"1965","unstructured":"Gorlin RJ, Vickers RA, Kelin E, Williamon J (1965) The multiple basal-cell nevi syndrome. Cancer 18:89\u2013104","journal-title":"Cancer"},{"key":"9529_CR19","unstructured":"Pincock LD (1970) Zit. Nach Vickers RA u. Gorlin RJ. Cancer (Philad.) 26:699"},{"key":"9529_CR20","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/0030-4220(59)90059-3","volume":"12","author":"KH Thoma","year":"1959","unstructured":"Thoma KH (1959) Polycystoma. Oral Surg 12:484\u2013488","journal-title":"Oral Surg"},{"key":"9529_CR21","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1365-2133.1962.tb13442.x","volume":"74","author":"F Davidson","year":"1962","unstructured":"Davidson F (1962) Multiple naevoid basal cell carcinomata and associated congenital abnormalities. Brit J Derm 74:439\u2013444","journal-title":"Brit J Derm"},{"key":"9529_CR22","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1001\/jama.1964.03060280008002","volume":"188","author":"WD Maddox","year":"1964","unstructured":"Maddox WD, Winkelmann RK, Harrison EG, Devine KD, Gibilisco JA (1964) Multiple nevoid basal cell epitheliomas, jaw cysts, and skeletal defects. JAMA 188:98\u2013103","journal-title":"JAMA"},{"key":"9529_CR23","first-page":"653","volume":"12","author":"W Rosental","year":"1962","unstructured":"Rosental W (1962) Die fakultativen Prakanzerosen. Dtsch Stomat 12:653\u2013663","journal-title":"Dtsch Stomat"},{"key":"9529_CR24","first-page":"229","volume":"69","author":"JB Block","year":"1997","unstructured":"Block JB, Clendenning WE (1997) Parathyroid hormone hyporesponsiveness in patients with basal-cell nevi and bone defects. N Engl J Med Genet 69:229\u2013308","journal-title":"N Engl J Med Genet"},{"key":"9529_CR25","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1148\/82.5.840","volume":"82","author":"JJ Pollard","year":"1964","unstructured":"Pollard JJ, New PFJ (1964) Hereditary Cutaneomandibular polyoncosis. Radiology 82:840","journal-title":"Radiology"},{"key":"9529_CR26","first-page":"324","volume":"15","author":"G Koedel","year":"1965","unstructured":"Koedel G (1965) Uber Entstehung, pathogenetische Wertigkeit und Differentialdiagnose: multiple Zysten \u2013 multilokulare Zystenbildung-Polyzystom der Kiefer. Dtsch Stomat 15:324\u2013336","journal-title":"Dtsch Stomat"},{"issue":"5","key":"9529_CR27","first-page":"131","volume":"42","author":"I Formas","year":"1967","unstructured":"Formas I (1967) Nevobasiloma. Z Haut Geschlechtskr 42(5):131\u2013140","journal-title":"Z Haut Geschlechtskr"},{"key":"9529_CR28","first-page":"290","volume":"24","author":"R Happle","year":"1973","unstructured":"Happle R (1973) Naevobasaliom und Ameloblastom. Hautarzt 24:290\u2013294","journal-title":"Hautarzt"},{"key":"9529_CR29","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0030-4220(78)90105-6","volume":"45","author":"MF Jensen","year":"1978","unstructured":"Jensen MF, Roser SM (1978) Gorlin\u2019s syndrome with ameloblastoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 45:325\u2013326","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"9529_CR30","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1097\/00004728-198709000-00033","volume":"11","author":"SM Schultz","year":"1987","unstructured":"Schultz SM, Twickler DM, Wheeler DE, Hogan TD (1987) Ameloblastoma associated with basal cell nevus (Gorlin) syndrome: CT findings. J Comput Assist Tomogr 11:901\u2013904","journal-title":"J Comput Assist Tomogr"},{"key":"9529_CR31","doi-asserted-by":"crossref","unstructured":"Eslami B, Lorente C, Kieff D et al (2008) Ameloblastoma associated with the nevoid basal cell carcinoma (Gorlin) syndrome. OralSurg Oral Med Oral Pathol Oral RadiolEndod 105:e10\u2013e13","DOI":"10.1016\/j.tripleo.2008.01.034"},{"key":"9529_CR32","first-page":"321","volume":"83","author":"B Domingo De","year":"2008","unstructured":"De Domingo B, Gonzalez F, Lorenzo P (2008) Gorlin syndrome (nevoid basal cell carcinoma syndrome). Arch Soc Esp Oftalmol 83:321\u2013324","journal-title":"Arch Soc Esp Oftalmol"},{"key":"9529_CR33","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1001\/archderm.1964.01600030005001","volume":"90","author":"WC Peterson Jr","year":"1964","unstructured":"Peterson WC Jr, Gorlin RJ (1964) Possible analogous cutaneous and odontogenic tumors. Arch Dermatol 90:255\u2013261","journal-title":"Arch Dermatol"},{"key":"9529_CR34","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/1097-0142(196101\/02)14:1<73::AID-CNCR2820140111>3.0.CO;2-T","volume":"14","author":"RJ Gorlin","year":"1961","unstructured":"Gorlin RJ, Chaudhry AP, Pindborg JJ (1961) Odontogenic tumors. Classification, histopathology, and clinical behavior in man and domesticated animals. Cancer 14:73\u2013101","journal-title":"Cancer"},{"key":"9529_CR35","first-page":"140","volume":"7","author":"RJ Gorlin","year":"1971","unstructured":"Gorlin RJ, Sedano HO (1971) Birth Defects. Original Article Series 7:140","journal-title":"Original Article Series"},{"key":"9529_CR36","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/1097-0142(197009)26:3<699::AID-CNCR2820260331>3.0.CO;2-K","volume":"26","author":"RA Vickers","year":"1970","unstructured":"Vickers RA, Gorlin RJ (1970) Ameloblastoma: delineation of early histopathologic features of neoplasia. Cancer 26:699\u2013710","journal-title":"Cancer"},{"key":"9529_CR37","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1699-0463.1963.tb01572.x","volume":"58","author":"JJ Pindborg","year":"1963","unstructured":"Pindborg JJ, Hansen J (1963) Studies on odontogenic cyst epithelium. Clinical and roentgenologic aspects of odontogenic keratocysts. Acta Path Microbiol Scand 58:283\u2013294","journal-title":"Acta Path Microbiol Scand"},{"key":"9529_CR38","first-page":"157","volume":"58","author":"E Machtens","year":"1972","unstructured":"Machtens E, Hjorting-Hansen E, Schmallenbach HJ, Werz L (1972) Keratocyst-ameloblastoma, a clinical diagnostic problem. Dtsch Zahn Mund u. Kieferheilk 58:157\u2013165","journal-title":"Kieferheilk"},{"issue":"1","key":"9529_CR39","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/ng0196-85","volume":"12","author":"S Levanat","year":"1996","unstructured":"Levanat S, Gorlin RJ, Fallet S, Johnson DR, Fantasia JE, Bale AE (1996) A two-hit model for developmental defects in Gorlin syndrome. Nat Genet 12(1):85\u201387","journal-title":"Nat Genet"},{"issue":"3","key":"9529_CR40","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0964-1955(95)00053-4","volume":"32B","author":"NJ Lench","year":"1996","unstructured":"Lench NJ, High AS, Markham AF, Hume WJ, Robinson PA (1996) Investigation of chromosome 9 q22.3-q31 DNA marker loss in odontogenic keratocysts. Eur J Cancer B Oral Oncol 32B(3):202\u2013206","journal-title":"Eur J Cancer B Oral Oncol"}],"container-title":["Familial Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-012-9529-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10689-012-9529-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-012-9529-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T02:49:58Z","timestamp":1642214998000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10689-012-9529-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,8]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["9529"],"URL":"https:\/\/doi.org\/10.1007\/s10689-012-9529-3","relation":{},"ISSN":["1389-9600","1573-7292"],"issn-type":[{"value":"1389-9600","type":"print"},{"value":"1573-7292","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,8]]}}}