{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:35:33Z","timestamp":1789788933388,"version":"4.0.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T00:00:00Z","timestamp":1356048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Familial Cancer"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1007\/s10689-012-9595-6","type":"journal-article","created":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T08:21:49Z","timestamp":1355991709000},"page":"503-507","source":"Crossref","is-referenced-by-count":30,"title":["Searching for E-cadherin gene mutations in early onset diffuse gastric cancer and hereditary diffuse gastric cancer in Korean patients"],"prefix":"10.1007","volume":"12","author":[{"given":"Sollip","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Won","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Dong","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Soo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Hoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yong","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee Don","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woochang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho June","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gin Hyug","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sail","family":"Chun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwoon-Yong","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Ki","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,12,21]]},"reference":[{"issue":"11","key":"9595_CR1","doi-asserted-by":"crossref","first-page":"e442","DOI":"10.1371\/journal.pmed.0030442","volume":"3","author":"CD Mathers","year":"2006","unstructured":"Mathers CD, Loncar D (2006) Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3(11):e442","journal-title":"PLoS Med"},{"issue":"3\u20134","key":"9595_CR2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000113015","volume":"72","author":"F Roviello","year":"2007","unstructured":"Roviello F, Corso G, Pedrazzani C et al (2007) High incidence of familial gastric cancer in Tuscany, a region in Italy. Oncology 72(3\u20134):243\u2013247","journal-title":"Oncology"},{"issue":"1","key":"9595_CR3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10120-005-0350-7","volume":"9","author":"M Bernini","year":"2006","unstructured":"Bernini M, Barbi S, Roviello F et al (2006) Family history of gastric cancer: a correlation between epidemiologic findings and clinical data. Gastric Cancer 9(1):9\u201313","journal-title":"Gastric Cancer"},{"issue":"1","key":"9595_CR4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/jcp.2006.043679","volume":"61","author":"F Carneiro","year":"2008","unstructured":"Carneiro F, Oliveira C, Suriano G, Seruca R (2008) Molecular pathology of familial gastric cancer, with an emphasis on hereditary diffuse gastric cancer. J Clin Pathol 61(1):25\u201330","journal-title":"J Clin Pathol"},{"issue":"7","key":"9595_CR5","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1136\/jmg.2009.074237","volume":"47","author":"RC Fitzgerald","year":"2010","unstructured":"Fitzgerald RC, Hardwick R, Huntsman D et al (2010) Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research. J Med Genet 47(7):436\u2013444","journal-title":"J Med Genet"},{"issue":"12","key":"9595_CR6","first-page":"873","volume":"36","author":"C Caldas","year":"1999","unstructured":"Caldas C, Carneiro F, Lynch HT et al (1999) Familial gastric cancer: overview and guidelines for management. J Med Genet 36(12):873\u2013880","journal-title":"J Med Genet"},{"issue":"5","key":"9595_CR7","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s10434-000-0346-9","volume":"7","author":"JB Koea","year":"2000","unstructured":"Koea JB, Karpeh MS, Brennan MF (2000) Gastric cancer in young patients: demographic, clinicopathological, and prognostic factors in 92 patients. Ann Surg Oncol 7(5):346\u2013351","journal-title":"Ann Surg Oncol"},{"key":"9595_CR8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2407-12-8","volume":"12","author":"G Corso","year":"2012","unstructured":"Corso G, Marrelli D, Pascale V, Vindigni C, Roviello F (2012) Frequency of CDH1 germline mutations in gastric carcinoma coming from high- and low-risk areas: metanalysis and systematic review of the literature. BMC Cancer 12:8","journal-title":"BMC Cancer"},{"issue":"5","key":"9595_CR9","first-page":"283","volume":"2","author":"K Umeyama","year":"1982","unstructured":"Umeyama K, Sowa M, Kamino K, Kato Y, Satake K (1982) Gastric carcinoma in young adults in Japan. Anticancer Res 2(5):283\u2013286","journal-title":"Anticancer Res"},{"issue":"3","key":"9595_CR10","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.gassur.2003.12.009","volume":"8","author":"A Ramos-De la Medina","year":"2004","unstructured":"Ramos-De la Medina A, Salgado-Nesme N, Torres-Villalobos G, Medina-Franco H (2004) Clinicopathologic characteristics of gastric cancer in a young patient population. J Gastrointest Surg 8(3):240\u2013244","journal-title":"J Gastrointest Surg"},{"issue":"2","key":"9595_CR11","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1046\/j.1365-2559.2003.01546.x","volume":"42","author":"S Lim","year":"2003","unstructured":"Lim S, Lee HS, Kim HS, Kim YI, Kim WH (2003) Alteration of E-cadherin-mediated adhesion protein is common, but microsatellite instability is uncommon in young age gastric cancers. Histopathology 42(2):128\u2013136","journal-title":"Histopathology"},{"issue":"4","key":"9595_CR12","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ejca.2010.10.011","volume":"47","author":"G Corso","year":"2011","unstructured":"Corso G, Pedrazzani C, Pinheiro H et al (2011) E-cadherin genetic screening and clinico-pathologic characteristics of early onset gastric cancer. Eur J Cancer 47(4):631\u2013639","journal-title":"Eur J Cancer"},{"issue":"5","key":"9595_CR13","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/hmg\/ddg048","volume":"12","author":"G Suriano","year":"2003","unstructured":"Suriano G, Oliveira C, Ferreira P et al (2003) Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands. Hum Mol Genet 12(5):575\u2013582","journal-title":"Hum Mol Genet"},{"key":"9595_CR14","unstructured":"Kaurah P, Huntsman DG. Hereditary Diffuse Gastric Cancer. GeneReviews\u2122 [Internet]. Seattle (WA): University of Washington, Seattle; 1993-. June 21, 2011 [cited 2012 Feb 23]; Available from http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1139"},{"issue":"6674","key":"9595_CR15","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/32918","volume":"392","author":"P Guilford","year":"1998","unstructured":"Guilford P, Hopkins J, Harraway J et al (1998) E-cadherin germline mutations in familial gastric cancer. Nature 392(6674):402\u2013405","journal-title":"Nature"},{"key":"9595_CR16","doi-asserted-by":"crossref","unstructured":"Yamada H, Shinmura K, Ito H, et al. (2011) Germline alterations in the CDH1 gene in familial gastric cancer in the Japanese population. Cancer Sci 102(10):1782\u20131788","DOI":"10.1111\/j.1349-7006.2011.02038.x"},{"issue":"9","key":"9595_CR17","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1093\/hmg\/ddp046","volume":"18","author":"C Oliveira","year":"2009","unstructured":"Oliveira C, Senz J, Kaurah P et al (2009) Germline CDH1 deletions in hereditary diffuse gastric cancer families. Hum Mol Genet 18(9):1545\u20131555","journal-title":"Hum Mol Genet"},{"issue":"3","key":"9595_CR18","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.mrrev.2005.01.002","volume":"589","author":"CV Moura Gallo de","year":"2005","unstructured":"de Moura Gallo CV, Azevedo ESMG, de Moraes E, Olivier M, Hainaut P (2005) TP53 mutations as biomarkers for cancer epidemiology in Latin America: current knowledge and perspectives. Mutat Res 589(3):192\u2013207","journal-title":"Mutat Res"},{"issue":"11","key":"9595_CR19","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s10038-004-0193-9","volume":"49","author":"IJ Kim","year":"2004","unstructured":"Kim IJ, Kang HC, Shin Y et al (2004) A TP53-truncating germline mutation (E287X) in a family with characteristics of both hereditary diffuse gastric cancer and Li-Fraumeni syndrome. J Hum Genet 49(11):591\u2013595","journal-title":"J Hum Genet"},{"issue":"12","key":"9595_CR20","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1016\/j.ejca.2004.04.027","volume":"40","author":"C Oliveira","year":"2004","unstructured":"Oliveira C, Ferreira P, Nabais S et al (2004) E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients. Eur J Cancer 40(12):1897\u20131903","journal-title":"Eur J Cancer"},{"key":"9595_CR21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","volume":"64","author":"P Lauren","year":"1965","unstructured":"Lauren P (1965) The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 64:31\u201349","journal-title":"Acta Pathol Microbiol Scand"},{"issue":"2","key":"9595_CR22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/humu.9473","volume":"28","author":"H More","year":"2007","unstructured":"More H, Humar B, Weber W et al (2007) Identification of seven novel germline mutations in the human E-cadherin (CDH1) gene. Hum Mutat 28(2):203","journal-title":"Hum Mutat"},{"issue":"21","key":"9595_CR23","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1001\/jama.297.21.2360","volume":"297","author":"P Kaurah","year":"2007","unstructured":"Kaurah P, MacMillan A, Boyd N et al (2007) Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer. JAMA 297(21):2360\u20132372","journal-title":"JAMA"},{"issue":"11","key":"9595_CR24","doi-asserted-by":"crossref","first-page":"725","DOI":"10.5483\/BMBRep.2011.44.11.725","volume":"44","author":"S Kim","year":"2011","unstructured":"Kim S, Ki CS, Kim KM, Lee MG, Bae JM, Kim JW (2011) Novel mechanism of a CDH1 splicing mutation in a Korean patient with signet ring cell carcinoma. BMB Rep 44(11):725\u2013729","journal-title":"BMB Rep"},{"issue":"7","key":"9595_CR25","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1136\/jmg.2004.018275","volume":"41","author":"AR Brooks-Wilson","year":"2004","unstructured":"Brooks-Wilson AR, Kaurah P, Suriano G et al (2004) Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria. J Med Genet 41(7):508\u2013517","journal-title":"J Med Genet"},{"issue":"3","key":"9595_CR26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s100380050137","volume":"44","author":"KA Yoon","year":"1999","unstructured":"Yoon KA, Ku JL, Yang HK, Kim WH, Park SY, Park JG (1999) Germline mutations of E-cadherin gene in Korean familial gastric cancer patients. J Hum Genet 44(3):177\u2013180","journal-title":"J Hum Genet"},{"issue":"2","key":"9595_CR27","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/gut.47.2.262","volume":"47","author":"HC Kim","year":"2000","unstructured":"Kim HC, Wheeler JM, Kim JC et al (2000) The E-cadherin gene (CDH1) variants T340A and L599\u00a0V in gastric and colorectal cancer patients in Korea. Gut 47(2):262\u2013267","journal-title":"Gut"},{"issue":"6","key":"9595_CR28","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1136\/jmg.2003.015594","volume":"41","author":"G Keller","year":"2004","unstructured":"Keller G, Vogelsang H, Becker I et al (2004) Germline mutations of the E-cadherin(CDH1) and TP53 genes, rather than of RUNX3 and HPP1, contribute to genetic predisposition in German gastric cancer patients. J Med Genet 41(6):e89","journal-title":"J Med Genet"},{"issue":"43","key":"9595_CR29","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1038\/sj.onc.1203874","volume":"19","author":"JH Lee","year":"2000","unstructured":"Lee JH, Han SU, Cho H et al (2000) A novel germ line juxtamembrane Met mutation in human gastric cancer. Oncogene 19(43):4947\u20134953","journal-title":"Oncogene"},{"issue":"8","key":"9595_CR30","doi-asserted-by":"crossref","first-page":"e97","DOI":"10.1136\/jmg.40.8.e97","volume":"40","author":"IJ Kim","year":"2003","unstructured":"Kim IJ, Park JH, Kang HC et al (2003) A novel germline mutation in the MET extracellular domain in a Korean patient with the diffuse type of familial gastric cancer. J Med Genet 40(8):e97","journal-title":"J Med Genet"},{"issue":"15","key":"9595_CR31","doi-asserted-by":"crossref","first-page":"5401","DOI":"10.1158\/1078-0432.CCR-05-0247","volume":"11","author":"G Suriano","year":"2005","unstructured":"Suriano G, Yew S, Ferreira P et al (2005) Characterization of a recurrent germ line mutation of the E-cadherin gene: implications for genetic testing and clinical management. Clin Cancer Res 11(15):5401\u20135409","journal-title":"Clin Cancer Res"},{"issue":"6","key":"9595_CR32","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/ijc.10258","volume":"98","author":"BA Jonsson","year":"2002","unstructured":"Jonsson BA, Bergh A, Stattin P, Emmanuelsson M, Gronberg H (2002) Germline mutations in E-cadherin do not explain association of hereditary prostate cancer, gastric cancer and breast cancer. Int J Cancer 98(6):838\u2013843","journal-title":"Int J Cancer"}],"container-title":["Familial Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-012-9595-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10689-012-9595-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-012-9595-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,7]],"date-time":"2019-07-07T06:08:30Z","timestamp":1562479710000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10689-012-9595-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,21]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["9595"],"URL":"https:\/\/doi.org\/10.1007\/s10689-012-9595-6","relation":{},"ISSN":["1389-9600","1573-7292"],"issn-type":[{"value":"1389-9600","type":"print"},{"value":"1573-7292","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,21]]}}}