{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T18:48:21Z","timestamp":1782326901980,"version":"3.54.5"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,8,9]],"date-time":"2014-08-09T00:00:00Z","timestamp":1407542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Familial Cancer"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1007\/s10689-014-9742-3","type":"journal-article","created":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T04:53:14Z","timestamp":1407473594000},"page":"563-571","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["The secondary bile acid, deoxycholate accelerates intestinal adenoma\u2013adenocarcinoma sequence in Apc min\/+ mice through enhancing Wnt signaling"],"prefix":"10.1007","volume":"13","author":[{"given":"Hailong","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenhui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengque","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuli","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangmao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,9]]},"reference":[{"key":"9742_CR1","unstructured":"CDCUS (2009) United States Cancer Statistics: 1999\u20132005 incidence and mortality web-based report Atlanta [Online]. Cancer Statistics Working Group, Department of Health and Human Services, Centers for Disease Control and Prevention, and National Cancer Institute. http:\/\/apps.nccd.cdc.gov\/uscs\/[2009]"},{"key":"9742_CR2","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1053\/j.gastro.2009.06.015","volume":"137","author":"A Castells","year":"2009","unstructured":"Castells A, Castellv\u00ed-Bel S, Balaguer F (2009) Concepts in familial colorectal cancer: where do we stand and what is the future? Gastroenterology 137:404\u2013409","journal-title":"Gastroenterology"},{"key":"9742_CR3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.mrrev.2004.08.001","volume":"589","author":"H Bernstein","year":"2005","unstructured":"Bernstein H, Bernstein C, Payne CM, Dvorakova K, Garewal H (2005) Bile acids as carcinogens in human gastrointestinal cancers. Mutat Res 589:47\u201365","journal-title":"Mutat Res"},{"key":"9742_CR4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3109\/00365521003702734","volume":"45","author":"A Bajor","year":"2010","unstructured":"Bajor A, Gillberg PG, Abrahamsson H (2010) Bile acids: short and long term effects in the intestine. Scand J Gastroenterol 45:645\u2013664","journal-title":"Scand J Gastroenterol"},{"key":"9742_CR5","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1091\/mbc.E03-12-0894","volume":"15","author":"R Pai","year":"2004","unstructured":"Pai R, Tarnawski AS, Tran T (2004) Deoxycholic acid activates beta-catenin signaling pathway and increases colon cell cancer growth and invasiveness. Mol Biol Cell 15:2156\u20132163","journal-title":"Mol Biol Cell"},{"key":"9742_CR6","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1007\/s10495-011-0633-x","volume":"16","author":"J Ignacio Barrasa","year":"2011","unstructured":"Ignacio Barrasa J, Olmo N, P\u00e9rez-Ramos P et al (2011) Deoxycholic and chenodeoxycholic bile acids induce apoptosis via oxidative stress in human colon adenocarcinoma cells. Apoptosis 16:1054\u20131067","journal-title":"Apoptosis"},{"key":"9742_CR7","doi-asserted-by":"crossref","first-page":"785907","DOI":"10.1155\/2009\/785907","volume":"2009","author":"CM Payne","year":"2009","unstructured":"Payne CM, Crowley-Skillicorn C, Holubec H et al (2009) Deoxycholate, an endogenous cytotoxin\/genotoxin, induces the autophagic stress-survival pathway: implications for colon carcinogenesis. J Toxicol 2009:785907","journal-title":"J Toxicol"},{"key":"9742_CR8","doi-asserted-by":"crossref","first-page":"14948","DOI":"10.1074\/jbc.M506710200","volume":"281","author":"S Jean-Louis","year":"2006","unstructured":"Jean-Louis S, Akare S, Ali MA, Mash EA Jr, Meuillet E et al (2006) Deoxycholic acid induces intracellular signaling through membrane perturbations. J Biol Chem 281:14948\u201314960","journal-title":"J Biol Chem"},{"key":"9742_CR9","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00204-011-0648-7","volume":"85","author":"C Bernstein","year":"2011","unstructured":"Bernstein C, Holubec H, Bhattacharyya AK et al (2011) Carcinogenicity of deoxycholate, a secondary bile acid. Arch Toxicol 85:863\u2013871","journal-title":"Arch Toxicol"},{"key":"9742_CR10","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/ibd.21079","volume":"16","author":"CM Payne","year":"2010","unstructured":"Payne CM, Holubec H, Bhattacharyya AK, Bernstein C, Bernstein H (2010) Exposure of mouse colon to dietary bile acid supplement induces sessile adenomas. Inflamm Bowel Dis 16:729\u2013730","journal-title":"Inflamm Bowel Dis"},{"key":"9742_CR11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/359235a0","volume":"359","author":"SM Powell","year":"1992","unstructured":"Powell SM, Zilz N, Beazer-Barclay Y et al (1992) APC mutations occur early during colorectal tumorigenesis. Nature 359:235\u2013237","journal-title":"Nature"},{"key":"9742_CR12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/hmg\/1.4.229","volume":"1","author":"Y Miyoshi","year":"1992","unstructured":"Miyoshi Y, Nagase H, Ando H et al (1992) Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet 1:229\u2013233","journal-title":"Hum Mol Genet"},{"key":"9742_CR13","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nm.2143","volume":"16","author":"SH Lee","year":"2010","unstructured":"Lee SH, Hu LL, Gonzalez-Navajas J et al (2010) ERK activation drives intestinal tumorigenesis in Apc(min\/+) mice. Nat Med 16:665\u2013670","journal-title":"Nat Med"},{"key":"9742_CR14","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1073\/pnas.92.10.4482","volume":"92","author":"M Oshima","year":"1995","unstructured":"Oshima M, Oshima H, Kitagawa K, Kobayashi M, Itakura C et al (1995) Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc Natl Acad Sci U S A 92:4482\u20134486","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9742_CR15","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1126\/science.2296722","volume":"247","author":"AR Moser","year":"1990","unstructured":"Moser AR, Pitot HC, Dove WF (1990) A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247:322\u2013324","journal-title":"Science"},{"key":"9742_CR16","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3233\/CBM-2007-34-510","volume":"3","author":"MJ Pishvaian","year":"2007","unstructured":"Pishvaian MJ, Byers SW (2007) Biomarkers of WNT signaling. Cancer Biomarkers 3:263\u2013274","journal-title":"Cancer Biomarkers"},{"key":"9742_CR17","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1093\/carcin\/bgn001","volume":"29","author":"T Oyama","year":"2008","unstructured":"Oyama T, Yamada Y, Hata K et al (2008) Further upregulation of beta-catenin\/Tcf transcription is involved in the development of macroscopic tumors in the colon of ApcMin\/+ mice. Carcinogenesis 29:666\u2013672","journal-title":"Carcinogenesis"},{"key":"9742_CR18","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1073\/pnas.94.7.3308","volume":"94","author":"HS Wasan","year":"1997","unstructured":"Wasan HS, Novelli M, Bee J, Bodmer WF (1997) Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice. Proc Natl Acad Sci U S A 94:3308\u20133313","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9742_CR19","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1158\/0008-5472.CAN-09-3249","volume":"70","author":"S Rajamanickam","year":"2010","unstructured":"Rajamanickam S, Velmurugan B, Kaur M, Singh RP, Agarwal R (2010) Chemoprevention of intestinal tumorigenesis in APCmin\/+\u00a0mice by silibinin. Cancer Res 70:2368\u20132378","journal-title":"Cancer Res"},{"key":"9742_CR20","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/carcin\/20.2.299","volume":"20","author":"NN Mahmoud","year":"1999","unstructured":"Mahmoud NN, Dannenberg AJ, Bilinski RT et al (1999) Administration of an unconjugated bile acid increases duodenal tumors in a murine model of familial adenomatous polyposis. Carcinogenesis 20:299\u2013303","journal-title":"Carcinogenesis"},{"key":"9742_CR21","doi-asserted-by":"crossref","first-page":"9937","DOI":"10.1158\/0008-5472.CAN-07-1112","volume":"67","author":"G Shen","year":"2007","unstructured":"Shen G, Khor TO, Hu R et al (2007) Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin\/+\u00a0mouse. Cancer Res 67:9937\u20139944","journal-title":"Cancer Res"},{"key":"9742_CR22","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1093\/carcin\/bgq050","volume":"31","author":"DL Smith","year":"2010","unstructured":"Smith DL, Keshavan P, Avissar U, Ahmed K, Zucker SD (2010) Sodium taurocholate inhibits intestinal adenoma formation in APCMin\/+\u00a0mice, potentially through activation of the farnesoid X receptor. Carcinogenesis 31:1100\u20131109","journal-title":"Carcinogenesis"},{"key":"9742_CR23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1593\/neo.91718","volume":"12","author":"B Velmurugan","year":"2010","unstructured":"Velmurugan B, Singh RP, Kaul N, Agarwal R, Agarwal C (2010) Dietary feeding of grape seed extract prevents intestinal tumorigenesis in APCmin\/+\u00a0mice. Neoplasia 12:95\u2013102","journal-title":"Neoplasia"},{"key":"9742_CR24","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.3748\/wjg.15.3329","volume":"15","author":"H Bernstein","year":"2009","unstructured":"Bernstein H, Bernstein C, Payne CM, Dvorak K (2009) Bile acids as endogenous etiologic agents in gastrointestinal cancer. World J Gastroenterol 15:3329\u20133340","journal-title":"World J Gastroenterol"},{"key":"9742_CR25","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0016-5085(93)90846-5","volume":"104","author":"E Bayerd\u00f6rffer","year":"1993","unstructured":"Bayerd\u00f6rffer E, Mannes GA, Richter WO et al (1993) Increased serum deoxycholic acid levels in men with colorectal adenomas. Gastroenterology 104:145\u2013151","journal-title":"Gastroenterology"},{"key":"9742_CR26","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1002\/(SICI)1097-0142(19990415)85:8<1664::AID-CNCR4>3.0.CO;2-O","volume":"85","author":"T Ochsenk\u00fchn","year":"1999","unstructured":"Ochsenk\u00fchn T, Bayerd\u00f6rffer E, Meining A et al (1999) Colonic mucosal proliferation is related to serum deoxycholic acid levels. Cancer 85:1664\u20131669","journal-title":"Cancer"},{"key":"9742_CR27","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.dld.2005.01.015","volume":"37","author":"M Fracchia","year":"2005","unstructured":"Fracchia M, Galatola G, Sarotto I et al (2005) Serum bile acids, programmed cell death and cell proliferation in the mucosa of patients with colorectal adenomas. Dig Liver Dis 37:509\u2013514","journal-title":"Dig Liver Dis"},{"key":"9742_CR28","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0168-8278(00)80152-X","volume":"33","author":"P Sauer","year":"2000","unstructured":"Sauer P, Stiehl A, Fitscher BA et al (2000) Downregulation of ileal bile acid absorption in bile-duct-ligated rats. J Hepatol 33:2\u20138","journal-title":"J Hepatol"},{"key":"9742_CR29","doi-asserted-by":"crossref","first-page":"G60","DOI":"10.1152\/ajpgi.00170.2004","volume":"288","author":"H Li","year":"2005","unstructured":"Li H, Chen F, Shang Q et al (2005) FXR-activating ligands inhibit rabbit ASBT expression via FXR-SHP-FTF cascade. Am J Physiol Gastrointest Liver Physiol 288:G60\u2013G66","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"9742_CR30","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1242\/jcs.00653","volume":"116","author":"G Maga","year":"2003","unstructured":"Maga G, Hubscher U (2003) Proliferating cell nuclear antigen (PCNA): a dancer with many partners. J Cell Sci 116:3051\u20133060","journal-title":"J Cell Sci"},{"key":"9742_CR31","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1101\/gad.287404","volume":"18","author":"OJ Sansom","year":"2004","unstructured":"Sansom OJ, Reed KR, Hayes AJ et al (2004) Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev 18:1385\u20131390","journal-title":"Genes Dev"},{"key":"9742_CR32","first-page":"3781","volume":"25","author":"HK Knutsen","year":"2005","unstructured":"Knutsen HK, Olst\u00f8rn HB, Paulsen JE et al (2005) Increased levels of PPARbeta\/delta and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min\/+) mice. Anticancer Res 25:3781\u20133789","journal-title":"Anticancer Res"},{"key":"9742_CR33","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.1210\/en.2004-0959","volume":"145","author":"M Fu","year":"2004","unstructured":"Fu M, Wang C, Li Z, Sakamaki T, Pestell RG (2004) Minireview: cyclin D1: normal and abnormal functions. Endocrinology 145:5439\u20135447","journal-title":"Endocrinology"},{"key":"9742_CR34","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00384-005-0002-8","volume":"21","author":"TO Khor","year":"2006","unstructured":"Khor TO, Gul YA, Ithnin H, Seow HF (2006) A comparative study of the expression of Wnt-1, WISP-1, survivin and cyclin-D1 in colorectal carcinoma. Int J Colorectal Dis 21:291\u2013300","journal-title":"Int J Colorectal Dis"},{"key":"9742_CR35","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1038\/sj.onc.1208511","volume":"24","author":"B He","year":"2005","unstructured":"He B, Reguart N, You L et al (2005) Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations. Oncogene 24:3054\u20133058","journal-title":"Oncogene"}],"container-title":["Familial Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-014-9742-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10689-014-9742-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-014-9742-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T14:02:40Z","timestamp":1565704960000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10689-014-9742-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,9]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["9742"],"URL":"https:\/\/doi.org\/10.1007\/s10689-014-9742-3","relation":{},"ISSN":["1389-9600","1573-7292"],"issn-type":[{"value":"1389-9600","type":"print"},{"value":"1573-7292","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,9]]}}}