{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:14:42Z","timestamp":1781777682966,"version":"3.54.5"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T00:00:00Z","timestamp":1502928000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Familial Cancer"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s10689-017-0032-8","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T08:47:53Z","timestamp":1502959673000},"page":"281-285","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sporadic endometrial adenocarcinoma with MMR deficiency due to biallelic MSH2 somatic mutations"],"prefix":"10.1007","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0703-9082","authenticated-orcid":false,"given":"Bruno","family":"Buecher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"De Pauw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Bazire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Houdayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Fievet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Moncoutier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh","family":"Farkhondeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Melaabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique Stoppa","family":"Lyonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Golmard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,17]]},"reference":[{"key":"32_CR1","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1038\/nm.4191","volume":"22","author":"RJ Hause","year":"2016","unstructured":"Hause RJ, Pritchard CC, Shendure J, Salipante SJ (2016) Classification and characterization of microsatellite instability across 18 cancer types. Nat Med 22:1342\u20131350","journal-title":"Nat Med"},{"key":"32_CR2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nature12113","volume":"497","author":"The Cancer Genome Atlas Research Network","year":"2013","unstructured":"The Cancer Genome Atlas Research Network (2013) Integrated genomic characterization of endometrial carcinoma. Nature 497: 67\u201373","journal-title":"Nature"},{"key":"32_CR3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/ajg.2014.435","volume":"110","author":"S Syngal","year":"2015","unstructured":"Syngal S, Brand RE, Church JM et al (2015) ACG clinical guideline: genetic testing and management of Hereditary Gastrointestinal Cancer Syndromes. Am J Gastroenterol 110:223\u2013262","journal-title":"Am J Gastroenterol"},{"key":"32_CR4","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1053\/j.gastro.2014.08.041","volume":"147","author":"S Haraldsdottir","year":"2014","unstructured":"Haraldsdottir S, Hampel H, Tomsic J et al (2014) Colon and endometrial cancers with mismatch repair deficiency can arise from somatic rather than germline, mutations. Gastroenterology 147:1308\u20131316","journal-title":"Gastroenterology"},{"key":"32_CR5","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1053\/j.gastro.2013.12.002","volume":"146","author":"AR Mensenkamp","year":"2014","unstructured":"Mensenkamp AR, Vogelaar IP, van Zelst-Stams WAG et al (2014) Somatic mutations in MLH1 and MSH2 are frequent cause of mismatch-repair deficiency in Lynch syndrome-like tumors. Gastroenterology 146:643\u2013646","journal-title":"Gastroenterology"},{"key":"32_CR6","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/annonc\/mdw542","volume":"28","author":"E Stelloo","year":"2016","unstructured":"Stelloo E, Jansen AML, Osse EM et al (2016) Practical guidance for mismatch repair-deficiency testing in endometrial cancer. Ann Oncol 28:96\u2013102","journal-title":"Ann Oncol"},{"key":"32_CR7","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1001\/jamaoncol.2016.5194","volume":"3","author":"R Pearlman","year":"2017","unstructured":"Pearlman R, Frankel WL, Swanson B et al (2017) Prevalence and spectrum of germline cancer susceptibility gene mutations among patients with early-onset colorectal cancer. JAMA Oncol 3:464\u2013471","journal-title":"JAMA Oncol"},{"key":"32_CR8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10689-012-9568-9","volume":"12","author":"I Sourrouille","year":"2013","unstructured":"Sourrouille I, Coulet F, Lefevre JH et al (2013) Somatic mosaicism and double somatic hits can lead to MSI colorectal tumors. Fam Cancer 12:27\u201333","journal-title":"Fam Cancer"},{"key":"32_CR9","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1038\/ejhg.2014.15","volume":"22","author":"M Morak","year":"2014","unstructured":"Morak M, Heidenreich B, Keller G et al (2014) Biallelic MUTYH mutations can mimic Lynch Syndrom. Eur J Hum Genet 22:1334\u20131337","journal-title":"Eur J Hum Genet"},{"key":"32_CR10","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ng.2503","volume":"45","author":"C Palles","year":"2013","unstructured":"Palles C, Cazier JB, Howarth KM et al (2013) Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. Nat Genet 45:136\u2013144","journal-title":"Nat Genet"}],"container-title":["Familial Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10689-017-0032-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-017-0032-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-017-0032-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T13:24:48Z","timestamp":1602768288000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10689-017-0032-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,17]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["32"],"URL":"https:\/\/doi.org\/10.1007\/s10689-017-0032-8","relation":{},"ISSN":["1389-9600","1573-7292"],"issn-type":[{"value":"1389-9600","type":"print"},{"value":"1573-7292","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,17]]}}}