{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:34:35Z","timestamp":1791858875816,"version":"4.3.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T00:00:00Z","timestamp":1484524800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The Annabel Evans Memorial Fund"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Familial Cancer"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1007\/s10689-017-9965-1","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T05:00:12Z","timestamp":1484542812000},"page":"433-440","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Baseline results from the UK SIGNIFY study: a whole-body MRI screening study in TP53 mutation carriers and matched controls"],"prefix":"10.1007","volume":"16","author":[{"name":"The SIGNIFY Study Steering Committee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibel","family":"Saya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Killick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth K.","family":"Bancroft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"Rothwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Benafif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Mikropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Pope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Chamberlain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranga","family":"Gunapala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Izatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Side","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Tomkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Barwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki","family":"Wiles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Limb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Eccles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin O.","family":"Leach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Shanley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona J.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bala","family":"Rajashanker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Whitehouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dow-Mu","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Aslam","family":"Sohaib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Gareth","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalind A.","family":"Eeles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,16]]},"reference":[{"issue":"15","key":"9965_CR1","first-page":"3245","volume":"57","author":"JM Varley","year":"1997","unstructured":"Varley JM, McGown G, Thorncroft M et al (1997) Germ-line mutations of TP53 in Li-Fraumeni families: an extended study of 39 families. Cancer Res 57(15):3245\u20133252","journal-title":"Cancer Res"},{"issue":"3","key":"9965_CR2","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/humu.10185","volume":"21","author":"JM Varley","year":"2003","unstructured":"Varley JM (2003) Germline TP53 mutations and Li-Fraumeni syndrome. Hum Mutat 21(3):313\u2013320. doi: \n10.1002\/humu.10185","journal-title":"Hum Mutat"},{"issue":"4985","key":"9965_CR3","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1126\/science.1978757","volume":"250","author":"D Malkin","year":"1990","unstructured":"Malkin D, Li FP, Strong LC et al (1990) Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250(4985):1233\u20131238","journal-title":"Science"},{"issue":"4","key":"9965_CR4","doi-asserted-by":"crossref","first-page":"747","DOI":"10.7326\/0003-4819-71-4-747","volume":"71","author":"FP Li","year":"1969","unstructured":"Li FP, Fraumeni JF Jr (1969) Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? Ann Intern Med 71(4):747\u2013752","journal-title":"Ann Intern Med"},{"issue":"8","key":"9965_CR5","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1200\/JCO.2008.16.6959","volume":"27","author":"KD Gonzalez","year":"2009","unstructured":"Gonzalez KD, Noltner KA, Buzin CH et al (2009) Beyond li fraumeni syndrome: clinical characteristics of families with p53 germline mutations. J Clin Oncol 27(8):1250\u20131256","journal-title":"J Clin Oncol"},{"issue":"2","key":"9965_CR6","first-page":"83","volume":"10","author":"KE Nichols","year":"2001","unstructured":"Nichols KE, Malkin D, Garber JE, Fraumeni JF Jr, Li FP (2001) Germ-line p53 mutations predispose to a wide spectrum of early-onset cancers. Cancer Epidemiol Biomarkers Prev 10(2):83\u201387","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"8","key":"9965_CR7","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1093\/jnci\/90.8.606","volume":"90","author":"M Hisada","year":"1998","unstructured":"Hisada M, Garber JE, Fung CY, Fraumeni JF Jr, Li FP (1998) Multiple primary cancers in families with Li-Fraumeni syndrome. J Natl Cancer Inst 90(8):606\u2013611","journal-title":"J Natl Cancer Inst"},{"issue":"23","key":"9965_CR8","doi-asserted-by":"publisher","first-page":"36733681","DOI":"10.1002\/cncr.30248","volume":"122","author":"PL Mai","year":"2016","unstructured":"Mai PL, Best AF, Peters JA et al (2016) Risks of first and subsequent cancers among TP53 mutation carriers in the National Cancer Institute Li-Fraumeni syndrome cohort. Cancer. 122(23): 3673\u20133681. doi: \n10.1002\/cncr.30248","journal-title":"Cancer"},{"issue":"9363","key":"9965_CR9","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/s0140-6736(03)12856-5","volume":"361","author":"F Lalloo","year":"2003","unstructured":"Lalloo F, Varley J, Ellis D, et al. (2003) Prediction of pathogenic mutations in patients with early-onset breast cancer by family history. Lancet (London, England) 361(9363): 1101\u20131112 doi: \n10.1016\/s0140-6736(03)12856-5","journal-title":"Lancet"},{"key":"9965_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30249-2","author":"A Villani","year":"2016","unstructured":"Villani A, Shore A, Wasserman JD et al (2016) Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: 11\u00a0year follow-up of a prospective observational study. The Lancet Oncol. doi: \n10.1016\/S1470-2045(16)30249-2","journal-title":"The Lancet Oncol"},{"issue":"6","key":"9965_CR11","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/S1470-2045(11)70119-X","volume":"12","author":"A Villani","year":"2011","unstructured":"Villani A, Tabori U, Schiffman J et al (2011) Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: a prospective observational study. The Lancet Oncol 12(6):559\u2013567. doi: \n10.1016\/S1470-2045(11)70119-X","journal-title":"The Lancet Oncol"},{"issue":"4","key":"9965_CR12","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1097\/CCO.0000000000000200","volume":"27","author":"ML Ballinger","year":"2015","unstructured":"Ballinger ML, Mitchell G, Thomas DM (2015) Surveillance recommendations for patients with germline TP53 mutations. Curr Opin Oncol 27(4):332\u2013337. doi: \n10.1097\/CCO.0000000000000200","journal-title":"Curr Opin Oncol"},{"issue":"5","key":"9965_CR13","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/nrclinonc.2014.41","volume":"11","author":"KA McBride","year":"2014","unstructured":"McBride KA, Ballinger ML, Killick E et al (2014) Li-Fraumeni syndrome: cancer risk assessment and clinical management. Nat Rev Clin Oncol 11(5):260\u2013271. doi:\n10.1038\/nrclinonc.2014.41","journal-title":"Nat Rev Clin Oncol"},{"key":"9965_CR14","unstructured":"Caron O et al. (2011) Evaluation of whole body mri for early detection of cancers in subjects with P53 mutation (Li-Fraumeni Syndrome) (LIFSCREEN). In ASCO Annual Meeting Proceedings 31(15):TPS1607"},{"issue":"11","key":"9965_CR15","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1001\/jama.299.11.1315","volume":"299","author":"S Masciari","year":"2008","unstructured":"Masciari S, Van den Abbeele AD, Diller LR et al (2008) F18-fluorodeoxyglucose-positron emission tomography\/computed tomography screening in Li-Fraumeni syndrome. JAMA 299(11):1315\u20131319 p[doi]","journal-title":"JAMA"},{"key":"9965_CR16","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3389\/fonc.2015.00038","volume":"5","author":"STS Nogueira","year":"2015","unstructured":"Nogueira STS, Lima ENP, N\u00f3brega AF et al (2015) (18)F-FDG PET-CT for surveillance of Brazilian patients with Li-Fraumeni Syndrome. Front Oncol 5:38. doi:\n10.3389\/fonc.2015.00038","journal-title":"Front Oncol"},{"key":"9965_CR17","unstructured":"Brito JP., Morris JC, Montori VM (2013) Surveillance study investigating whole body magnetic resonance imaging and other diagnostic procedures in people at high risk of cancer"},{"key":"9965_CR18","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/1748-717X-5-104","volume":"5","author":"S Heymann","year":"2010","unstructured":"Heymann S, Delaloge S, Rahal A et al (2010) Radio-induced malignancies after breast cancer postoperative radiotherapy in patients with Li-Fraumeni syndrome. Radiat Oncol 5:104","journal-title":"Radiat Oncol"},{"issue":"4","key":"9965_CR19","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1136\/jmg.2005.036319","volume":"43","author":"DGR Evans","year":"2006","unstructured":"Evans DGR, Birch JM, Ramsden RT, Sharif S, Baser ME (2006) Malignant transformation and new primary tumours after therapeutic radiation for benign disease: substantial risks in certain tumour prone syndromes. J Med Genet 43(4):289\u2013294. doi: \n10.1136\/jmg.2005.036319","journal-title":"J Med Genet"},{"key":"9965_CR20","volume-title":"Stata Statistical Software: Release 14","author":"StataCorp","year":"2015","unstructured":"StataCorp (2015) Stata Statistical Software: Release 14. StataCorp LP, College Station"},{"issue":"21","key":"9965_CR21","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1200\/JCO.2014.59.5728","volume":"33","author":"G Bougeard","year":"2015","unstructured":"Bougeard G, Renaux-Petel M, Flaman JM et al (2015) Revisiting Li-Fraumeni Syndrome From TP53 Mutation Carriers. J Clin Oncol 33(21):2345\u20132352. doi: \n10.1200\/JCO.2014.59.5728","journal-title":"J Clin Oncol"},{"issue":"3","key":"9965_CR22","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s10549-014-2931-9","volume":"145","author":"DG Evans","year":"2014","unstructured":"Evans DG, Kesavan N, Lim Y et al (2014) MRI breast screening in high-risk women: cancer detection and survival analysis. Breast Cancer Res Treat 145(3):663\u2013672. doi: \n10.1007\/s10549-014-2931-9","journal-title":"Breast Cancer Res Treat"},{"issue":"7","key":"9965_CR23","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1158\/1055-9965.EPI-09-0138","volume":"18","author":"DG Evans","year":"2009","unstructured":"Evans DG, Lennard F, Pointon LJ et al (2009) Eligibility for magnetic resonance imaging screening in the United Kingdom: effect of strict selection criteria and anonymous DNA testing on breast cancer incidence in the MARIBS Study. Cancer Epidemiol Biomarkers Prev 18(7):2123\u20132131. doi: \n10.1158\/1055-9965.EPI-09-0138","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"9965_CR24","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1155\/2014\/919323","volume":"2014","author":"HLT Hoang","year":"2014","unstructured":"Hoang HLT, Ensor K, Rosen G, Leon Pachter H, Raccuia JS (2014) Prognostic factors and survival in patients treated surgically for recurrent metastatic uterine leiomyosarcoma. Intl J Surg Oncol 2014:8. doi: \n10.1155\/2014\/919323","journal-title":"Intl J Surg Oncol"},{"issue":"4","key":"9965_CR25","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1215\/15228517-2008-102","volume":"11","author":"DA Schomas","year":"2009","unstructured":"Schomas DA, Laack NNI, Rao RD, et al. (2009) Intracranial low-grade gliomas in adults: 30-year experience with long-term follow-up at Mayo Clinic. Neuro-Oncology 11(4): 437\u2013445 doi: \n10.1215\/15228517-2008-102","journal-title":"Neuro-Oncology"},{"issue":"1","key":"9965_CR26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4161\/cc.2.1.249","volume":"2","author":"C Pepper","year":"2003","unstructured":"Pepper C, Thomas A, Hoy T et al. (2003) Leukemic and non-leukemic lymphocytes from patients with Li Fraumeni syndrome demonstrate loss of p53 function, Bcl-2 family dysregulation and intrinsic resistance to conventional chemotherapeutic drugs but not flavopiridol. Cell cycle (Georgetown, Tex) 2(1): 53\u20138","journal-title":"Cell cycle"},{"issue":"2","key":"9965_CR27","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/humu.21151","volume":"31","author":"S Garritano","year":"2010","unstructured":"Garritano S, Gemignani F, Palmero EI, Olivier M, Martel-Planche G, Le Calvez-Kelm F, Brugi\u00e9res L, Vargas FR, Brentani RR, Ashton-Prolla P, Landi S, Tavtigian SV, Hainaut P, Achatz MI (2010) Detailed haplotype analysis at the TP53 locus in p.R337H mutation carriers in the population of Southern Brazil: evidence for a founder effect. Hum Mutat 31(2):143\u2013150. doi: \n10.1002\/humu.21151","journal-title":"Hum Mutat"},{"issue":"8","key":"9965_CR28","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1172\/JCI13972","volume":"109","author":"Z Saifudeen","year":"2002","unstructured":"Saifudeen Z, Dipp S, El-Dahr SS (2002) A role for p53 in terminal epithelial cell differentiation. J Clin Invest 109(8):1021\u20131030. doi: \n10.1172\/JCI13972","journal-title":"J Clin Invest"},{"issue":"11","key":"9965_CR29","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1681\/ASN.2008121224","volume":"20","author":"Z Saifudeen","year":"2009","unstructured":"Saifudeen Z, Dipp S, Stefkova J, Yao X, Lookabaugh S, El-Dahr SS (2009) p53 regulates metanephric development. J Am Soc Nephrol 20(11):2328\u20132337. doi:\n10.1681\/ASN.2008121224","journal-title":"J Am Soc Nephrol"}],"container-title":["Familial Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10689-017-9965-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-017-9965-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-017-9965-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T07:01:36Z","timestamp":1498114896000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10689-017-9965-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,16]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["9965"],"URL":"https:\/\/doi.org\/10.1007\/s10689-017-9965-1","relation":{},"ISSN":["1389-9600","1573-7292"],"issn-type":[{"value":"1389-9600","type":"print"},{"value":"1573-7292","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,16]]}}}