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E.E.K. has received speaker honoraria from Illumina and Regeneron Pharmaceuticals. The remaining authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The Icahn School of Medicine at Mount Sinai\u2019s Institutional Review Board approved this study (protocol number 18-1771), including a waiver of informed consent and a HIPAA waiver of authorization. The study population consisted of 30,223 participants aged 18\u00a0years or older from Mount Sinai\u2019s Bio<i>Me<\/i> Biobank (protocol number 07-0529). 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