{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T08:10:58Z","timestamp":1721203858432},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T00:00:00Z","timestamp":1715385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T00:00:00Z","timestamp":1715385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Familial Cancer"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1007\/s10689-024-00395-y","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T14:01:38Z","timestamp":1715436098000},"page":"365-372","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Familial and hereditary pancreatic cancer in Japan"],"prefix":"10.1007","volume":"23","author":[{"given":"Hiroyuki","family":"Matsubayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chigusa","family":"Morizane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,11]]},"reference":[{"key":"395_CR1","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s10147-023-02317-x","volume":"28","author":"T Okusaka","year":"2023","unstructured":"Okusaka T, Nakamura M, Yoshida M et al (2023) Clinical practice guidelines for pancreatic Cancer 2022 from the Japan Pancreas Society: a synopsis. Int J Clin Oncol 28:493\u2013511","journal-title":"Int J Clin Oncol"},{"key":"395_CR2","doi-asserted-by":"publisher","first-page":"322","DOI":"10.2958\/suizo.35.322","volume":"35","author":"M Kitano","year":"2020","unstructured":"Kitano M, Morizane C, Hijioka S et al (2020) Surveillance for the early diagnosis of familial pancreatic cancer (Expert consensus). Suizo 35:322\u2013330 (In Japanese with English abstract)","journal-title":"Suizo"},{"key":"395_CR3","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/s10038-022-01097-y","volume":"68","author":"H Matsubayashi","year":"2023","unstructured":"Matsubayashi H, Todaka A, Kawakami T et al (2023) Genetic medicine in companion diagnostics of germline BRCA testing of Japanese pancreatic cancer patients. J Hum Genet 68:81\u201386","journal-title":"J Hum Genet"},{"issue":"Suppl 4","key":"395_CR4","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1093\/annonc\/10.suppl_4.S69","volume":"10","author":"RH Hruban","year":"1999","unstructured":"Hruban RH, Petersen GM, Goggins M et al (1999) Familial pancreatic cancer. Ann Oncol 10(Suppl 4):69\u201373","journal-title":"Ann Oncol"},{"key":"395_CR5","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s00534-013-0611-5","volume":"20","author":"K Wada","year":"2013","unstructured":"Wada K, Takaori K, Traverso LW et al (2013) Clinical importance of familial pancreatic Cancer Registry in Japan: a report from kick-off meeting at International Symposium on Pancreas Cancer 2012. J Hepatobiliary Pancreat Sci 20:557\u2013566","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"395_CR6","doi-asserted-by":"publisher","first-page":"935","DOI":"10.3748\/wjg.v23.i6.935","volume":"23","author":"H Matsubayashi","year":"2017","unstructured":"Matsubayashi H, Takaori K, Morizane C et al (2017) Familial pancreatic cancer: Concept, management and issues. World J Gastroenterol 23:935\u2013948","journal-title":"World J Gastroenterol"},{"key":"395_CR7","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1097\/MPA.0b013e3182156e1b","volume":"40","author":"H Matsubayashi","year":"2011","unstructured":"Matsubayashi H, Maeda A, Kanemoto H et al (2011) Risk factors of familial pancreatic cancer in Japan: current smoking and recent onset of diabetes. Pancreas 40:974\u2013978","journal-title":"Pancreas"},{"key":"395_CR8","doi-asserted-by":"publisher","first-page":"74227","DOI":"10.18632\/oncotarget.12490","volume":"7","author":"E Takai","year":"2016","unstructured":"Takai E, Yachida S, Shimizu K et al (2016) Germline mutations in Japanese familial pancreatic cancer patients. Oncotarget 7:74227\u201374235","journal-title":"Oncotarget"},{"key":"395_CR9","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1093\/ije\/dyg062","volume":"32","author":"M Inoue","year":"2003","unstructured":"Inoue M, Tajima K, Takezaki T et al (2003) Epidemiology of pancreatic cancer in Japan: a nested case-control study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC). Int J Epidemiol 32:257\u2013262","journal-title":"Int J Epidemiol"},{"key":"395_CR10","doi-asserted-by":"publisher","first-page":"103033","DOI":"10.1016\/j.ebiom.2020.103033","volume":"60","author":"K Mizukami","year":"2020","unstructured":"Mizukami K, Iwasaki Y, Kawakami E et al (2020) Genetic characterization of pancreatic cancer patients and prediction of carrier status of germline pathogenic variants in cancer-predisposing genes. EBioMedicine 60:103033","journal-title":"EBioMedicine"},{"key":"395_CR11","doi-asserted-by":"publisher","first-page":"e652","DOI":"10.1097\/SLA.0000000000004213","volume":"275","author":"E Takai","year":"2022","unstructured":"Takai E, Nakamura H, Chiku S et al (2022) Whole-exome sequencing reveals new potential susceptibility genes for Japanese familial pancreatic Cancer. Ann Surg 275:e652\u2013e658","journal-title":"Ann Surg"},{"key":"395_CR12","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1158\/2159-8290.CD-15-0402","volume":"6","author":"NJ Roberts","year":"2016","unstructured":"Roberts NJ, Norris AL, Petersen GM et al (2016) Whole genome sequencing defines the genetic heterogeneity of familial pancreatic Cancer. Cancer Discov 6:166\u2013175","journal-title":"Cancer Discov"},{"key":"395_CR13","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1136\/gutjnl-2019-319352","volume":"69","author":"M Goggins","year":"2020","unstructured":"Goggins M, Overbeek KA, Brand R et al (2020) Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the pancreas Screening (CAPS) Consortium. Gut 69:7\u201317","journal-title":"Gut"},{"key":"395_CR14","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s10689-014-9755-y","volume":"14","author":"AL Norris","year":"2015","unstructured":"Norris AL, Roberts NJ, Jones S et al (2015) Familial and sporadic pancreatic cancer share the same molecular pathogenesis. Fam Cancer 14:95\u2013103","journal-title":"Fam Cancer"},{"key":"395_CR15","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/s41586-022-05448-9","volume":"612","author":"MD Kessler","year":"2022","unstructured":"Kessler MD, Damask A, O\u2019Keeffe S et al (2022) Common and rare variant associations with clonal haematopoiesis phenotypes. Nature 612:301\u2013309","journal-title":"Nature"},{"key":"395_CR16","doi-asserted-by":"publisher","first-page":"3995","DOI":"10.1111\/cas.15517","volume":"113","author":"K Sunami","year":"2022","unstructured":"Sunami K, Naito Y, Komine K et al (2022) Chronological improvement in precision oncology implementation in Japan. Cancer Sci 113:3995\u20134000","journal-title":"Cancer Sci"},{"key":"395_CR17","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1093\/jjco\/hyac046","volume":"52","author":"S Higashigawa","year":"2022","unstructured":"Higashigawa S, Matsubayashi H, Kiyozumi Y et al (2022) Present status of germline findings in precision medicine for Japanese cancer patients: issues in the current system. Jpn J Clin Oncol 52:599\u2013608","journal-title":"Jpn J Clin Oncol"},{"key":"395_CR18","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1007\/s10147-022-02176-y","volume":"27","author":"T Kondo","year":"2022","unstructured":"Kondo T, Yamamoto Y, Fukuyama K et al (2022) Germline sequencing for presumed germline pathogenic variants via tumor-only comprehensive genomic profiling. Int J Clin Oncol 27:1256\u20131263","journal-title":"Int J Clin Oncol"},{"key":"395_CR19","unstructured":"Japanese Organization of Hereditary Breast and Ovarian Cancer (JOHBOC) (2021) Guidelines for diagnosis and treatment of hereditary breast and ovarian cancer"},{"key":"395_CR20","unstructured":"Petrucelli N, Pal MBD T. BRCA1- and BRCA2-Associated Hereditary breast and ovarian Cancer. GeneReviews., 2022 (Revised)."},{"key":"395_CR21","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/s10038-023-01153-1","volume":"68","author":"A Ueki","year":"2023","unstructured":"Ueki A, Yoshida R, Kosaka T et al (2023) Clinical risk management of breast, ovarian, pancreatic, and prostatic cancers for BRCA1\/2 variant carriers in Japan. J Hum Genet 68:517\u2013526","journal-title":"J Hum Genet"},{"key":"395_CR22","doi-asserted-by":"publisher","first-page":"8829","DOI":"10.1038\/srep08829","volume":"5","author":"T Furukawa","year":"2015","unstructured":"Furukawa T, Sakamoto H, Takeuchi S et al (2015) Whole exome sequencing reveals recurrent mutations in BRCA2 and FAT genes in acinar cell carcinomas of the pancreas. Sci Rep 5:8829","journal-title":"Sci Rep"},{"key":"395_CR23","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1007\/s10147-021-01881-4","volume":"26","author":"N Tomita","year":"2021","unstructured":"Tomita N, Ishida H, Tanakaya K et al (2021) Japanese Society for Cancer of the Colon and rectum (JSCCR) guidelines 2020 for the clinical practice of Hereditary Colorectal Cancer. Int J Clin Oncol 26:1353\u20131419","journal-title":"Int J Clin Oncol"},{"key":"395_CR24","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12885-022-09172-5","volume":"22","author":"H Matsubayashi","year":"2022","unstructured":"Matsubayashi H, Higashigawa S, Kiyozumi Y et al (2022) Microsatellite instability is biased in Amsterdam II-defined Lynch-related cancer cases with family history but is rare in other cancers: a summary of 1000 analyses. BMC Cancer 22:73","journal-title":"BMC Cancer"},{"key":"395_CR25","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1111\/cas.14798","volume":"112","author":"K Akagi","year":"2021","unstructured":"Akagi K, Oki E, Taniguchi H et al (2021) Real-world data on microsatellite instability status in various unresectable or metastatic solid tumors. Cancer Sci 112:1105\u20131113","journal-title":"Cancer Sci"},{"key":"395_CR26","doi-asserted-by":"publisher","first-page":"12880","DOI":"10.1038\/s41598-021-91974-x","volume":"11","author":"F Dedeurwaerdere","year":"2021","unstructured":"Dedeurwaerdere F, Claes KB, Van Dorpe J et al (2021) Comparison of microsatellite instability detection by immunohistochemistry and molecular techniques in colorectal and endometrial cancer. Sci Rep 11:12880","journal-title":"Sci Rep"},{"key":"395_CR27","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1111\/his.14233","volume":"78","author":"MB Loughrey","year":"2021","unstructured":"Loughrey MB, McGrath J, Coleman HG et al (2021) Identifying mismatch repair-deficient colon cancer: near-perfect concordance between immunohistochemistry and microsatellite instability testing in a large, population-based series. Histopathology 78:401\u2013413","journal-title":"Histopathology"},{"key":"395_CR28","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.humpath.2022.12.016","volume":"135","author":"H Matsubayashi","year":"2023","unstructured":"Matsubayashi H, Oishi T, Sasaki K et al (2023) Discordance of microsatellite instability and mismatch repair immunochemistry occurs depending on the cancer type. Hum Pathol 135:54\u201364","journal-title":"Hum Pathol"},{"key":"395_CR29","doi-asserted-by":"publisher","first-page":"e000274","DOI":"10.1136\/bmjgast-2019-000274","volume":"6","author":"AE Hendifar","year":"2019","unstructured":"Hendifar AE, Larson BK, Rojansky R et al (2019) Pancreatic cancer \u2018mismatch\u2019 in Lynch syndrome. BMJ Open Gastroenterol 6:e000274","journal-title":"BMJ Open Gastroenterol"},{"key":"395_CR30","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1002\/jhbp.1063","volume":"29","author":"S Takamizawa","year":"2022","unstructured":"Takamizawa S, Morizane C, Tanabe N et al (2022) Clinical characteristics of pancreatic and biliary tract cancers associated with Lynch syndrome. J Hepatobiliary Pancreat Sci 29:377\u2013384","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"395_CR31","first-page":"1501","volume":"152","author":"M Goggins","year":"1998","unstructured":"Goggins M, Offerhaus GJ, Hilgers W et al (1998) Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+. Am J Pathol 152:1501\u20131507","journal-title":"Am J Pathol"},{"key":"395_CR32","unstructured":"Tempero MA, Malafa MP, Benson AB, et al (2024) NCCN clinical practical guidelines in oncology. Pancreatic Adenocarcinoma ver.1. 2024 https:\/\/www.nccn.org\/"},{"key":"395_CR33","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1001\/jamaoncol.2022.0476","volume":"8","author":"Y Momozawa","year":"2022","unstructured":"Momozawa Y, Sasai R, Usui Y et al (2022) Expansion of Cancer Risk Profile for BRCA1 and BRCA2 pathogenic variants. JAMA Oncol 8:871\u2013878","journal-title":"JAMA Oncol"},{"key":"395_CR34","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1200\/JCO.2015.64.0730","volume":"34","author":"H Vasen","year":"2016","unstructured":"Vasen H, Ibrahim I, Ponce CG et al (2016) Benefit of Surveillance for Pancreatic Cancer in High-Risk individuals: outcome of long-term prospective Follow-Up studies from three European Expert centers. J Clin Oncol 34:2010\u20132019","journal-title":"J Clin Oncol"},{"key":"395_CR35","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1158\/1940-6207.CAPR-20-0642","volume":"14","author":"CS Furniss","year":"2021","unstructured":"Furniss CS, Yurgelun MB, Ukaegbu C et al (2021) Novel Models of Genetic Education and Testing for Pancreatic Cancer interception: preliminary results from the GENERATE Study. Cancer Prev Res (Phila) 14:1021\u20131032","journal-title":"Cancer Prev Res (Phila)"},{"key":"395_CR36","doi-asserted-by":"publisher","first-page":"3257","DOI":"10.1200\/JCO.22.00298","volume":"40","author":"M Dbouk","year":"2022","unstructured":"Dbouk M, Katona BW, Brand RE et al (2022) The Multicenter Cancer of pancreas Screening Study: Impact on Stage and Survival. J Clin Oncol 40:3257\u20133266","journal-title":"J Clin Oncol"},{"key":"395_CR37","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1053\/j.gastro.2018.05.035","volume":"155","author":"MI Canto","year":"2018","unstructured":"Canto MI, Almario JA, Schulick RD et al (2018) Risk of neoplastic progression in individuals at high risk for pancreatic Cancer Undergoing Long-Term Surveillance. Gastroenterology 155:740\u2013751e2","journal-title":"Gastroenterology"},{"key":"395_CR38","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1053\/j.gastro.2023.02.032","volume":"164","author":"DCF Klatte","year":"2023","unstructured":"Klatte DCF, Boekestijn B, Onnekink AM et al (2023) Surveillance for pancreatic Cancer in high-risk individuals leads to Improved outcomes: a propensity score-matched analysis. Gastroenterology 164:1223\u20131231e4","journal-title":"Gastroenterology"},{"key":"395_CR39","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.pan.2017.11.007","volume":"18","author":"A Kanno","year":"2018","unstructured":"Kanno A, Masamune A, Hanada K et al (2018) Multicenter study of early pancreatic cancer in Japan. Pancreatology 18:61\u201367","journal-title":"Pancreatology"},{"key":"395_CR40","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1111\/den.14240","volume":"34","author":"K Hanada","year":"2022","unstructured":"Hanada K, Shimizu A, Kurihara K et al (2022) Endoscopic approach in the diagnosis of high-grade pancreatic intraepithelial neoplasia. Dig Endosc 34:927\u2013937","journal-title":"Dig Endosc"},{"key":"395_CR41","doi-asserted-by":"publisher","first-page":"e0280403","DOI":"10.1371\/journal.pone.0280403","volume":"18","author":"K Ikezawa","year":"2023","unstructured":"Ikezawa K, Tanaka S, Fukuda J et al (2023) Main pancreatic duct dilatation and pancreatic cysts in relatives and spouses of patients with pancreatic cancer. PLoS ONE 18:e0280403","journal-title":"PLoS ONE"},{"key":"395_CR42","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1148\/radiol.09090992","volume":"254","author":"S Tanaka","year":"2010","unstructured":"Tanaka S, Nakao M, Ioka T et al (2010) Slight dilatation of the main pancreatic duct and presence of pancreatic cysts as predictive signs of pancreatic cancer: a prospective study. Radiology 254:965\u2013972","journal-title":"Radiology"},{"key":"395_CR43","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ejrad.2017.03.010","volume":"91","author":"M Nakao","year":"2017","unstructured":"Nakao M, Katayama K, Fukuda J et al (2017) Evaluating the ability to detect pancreatic lesions using a special ultrasonography examination focusing on the pancreas. Eur J Radiol 91:10\u201314","journal-title":"Eur J Radiol"},{"key":"395_CR44","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.pan.2022.04.006","volume":"22","author":"S Hijioka","year":"2022","unstructured":"Hijioka S, Morizane C, Takaori K et al (2022) Study protocol for a multi-institutional prospective surveillance study among kindreds with familial pancreatic cancer and individuals with hereditary pancreatic cancer syndrome: the Diamond Study. Pancreatology 22:534\u2013538","journal-title":"Pancreatology"},{"key":"395_CR45","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1007\/s10147-020-01721-x","volume":"25","author":"N Okano","year":"2020","unstructured":"Okano N, Morizane C, Nomura S et al (2020) Phase II clinical trial of gemcitabine plus oxaliplatin in patients with metastatic pancreatic adenocarcinoma with a family history of pancreatic\/breast\/ovarian\/prostate cancer or personal history of breast\/ovarian\/prostate cancer (FABRIC study). Int J Clin Oncol 25:1835\u20131843","journal-title":"Int J Clin Oncol"},{"key":"395_CR46","doi-asserted-by":"publisher","first-page":"175883592210830","DOI":"10.1177\/17588359221083050","volume":"14","author":"M Emelyanova","year":"2022","unstructured":"Emelyanova M, Pudova E, Khomich D et al (2022) Platinum-based chemotherapy for pancreatic cancer: impact of mutations in the homologous recombination repair and fanconi anemia genes. Ther Adv Med Oncol 14:17588359221083050","journal-title":"Ther Adv Med Oncol"},{"key":"395_CR47","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/s41416-019-0582-7","volume":"122","author":"MM Wattenberg","year":"2020","unstructured":"Wattenberg MM, Asch D, Yu S et al (2020) Platinum response characteristics of patients with pancreatic ductal adenocarcinoma and a germline BRCA1, BRCA2 or PALB2 mutation. Br J Cancer 122:333\u2013339","journal-title":"Br J Cancer"},{"key":"395_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1200\/PO.17.00152","volume":"2","author":"KA Reiss","year":"2018","unstructured":"Reiss KA, Yu S, Judy R et al (2018) Retrospective survival analysis of patients with Advanced pancreatic ductal adenocarcinoma and germline BRCA or PALB2 mutations. JCO Precis Oncol 2:1\u20139","journal-title":"JCO Precis Oncol"},{"key":"395_CR49","doi-asserted-by":"crossref","unstructured":"Kitamura H, Morizane C, Tanabe N et al (2023) Clinical features of germline BRCA1\/2 or ATM pathogenic variant positive pancreatic cancer in Japan. Pancreatology","DOI":"10.1016\/j.pan.2023.10.017"},{"key":"395_CR50","doi-asserted-by":"publisher","first-page":"2497","DOI":"10.1200\/JCO.21.00003","volume":"39","author":"KA Reiss","year":"2021","unstructured":"Reiss KA, Mick R, O\u2019Hara MH et al (2021) Phase II study of maintenance rucaparib in patients with platinum-sensitive Advanced Pancreatic Cancer and a pathogenic germline or somatic variant in BRCA1, BRCA2, or PALB2. J Clin Oncol 39:2497\u20132505","journal-title":"J Clin Oncol"},{"key":"395_CR51","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/s43018-022-00439-1","volume":"3","author":"JJ Gruber","year":"2022","unstructured":"Gruber JJ, Afghahi A, Timms K et al (2022) A phase II study of talazoparib monotherapy in patients with wild-type BRCA1 and BRCA2 with a mutation in other homologous recombination genes. Nat Cancer 3:1181\u20131191","journal-title":"Nat Cancer"},{"key":"395_CR52","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1001\/jamaoncol.2022.5218","volume":"9","author":"AM Schram","year":"2023","unstructured":"Schram AM, Colombo N, Arrowsmith E et al (2023) Avelumab Plus Talazoparib in patients with BRCA1\/2- or ATM-Altered Advanced Solid Tumors: results from JAVELIN BRCA\/ATM, an Open-Label, Multicenter, phase 2b, tumor-agnostic trial. JAMA Oncol 9:29\u201339","journal-title":"JAMA Oncol"},{"key":"395_CR53","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1056\/NEJMoa1903387","volume":"381","author":"T Golan","year":"2019","unstructured":"Golan T, Hammel P, Reni M et al (2019) Maintenance olaparib for germline BRCA-Mutated metastatic pancreatic Cancer. N Engl J Med 381:317\u2013327","journal-title":"N Engl J Med"},{"key":"395_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1200\/JCO.19.02105","volume":"38","author":"A Marabelle","year":"2020","unstructured":"Marabelle A, Le DT, Ascierto PA et al (2020) Efficacy of Pembrolizumab in patients with Noncolorectal high microsatellite Instability\/Mismatch repair-deficient Cancer: results from the phase II KEYNOTE-158 study. J Clin Oncol 38:1\u201310","journal-title":"J Clin Oncol"},{"key":"395_CR55","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1200\/JCO.18.00283","volume":"37","author":"A Latham","year":"2019","unstructured":"Latham A, Srinivasan P, Kemel Y et al (2019) Microsatellite instability is Associated with the Presence of Lynch Syndrome Pan-cancer. J Clin Oncol 37:286\u2013295","journal-title":"J Clin Oncol"}],"container-title":["Familial Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-024-00395-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10689-024-00395-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-024-00395-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T07:38:55Z","timestamp":1721201935000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10689-024-00395-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,11]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["395"],"URL":"https:\/\/doi.org\/10.1007\/s10689-024-00395-y","relation":{},"ISSN":["1389-9600","1573-7292"],"issn-type":[{"value":"1389-9600","type":"print"},{"value":"1573-7292","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,11]]},"assertion":[{"value":"29 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}