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The MICRA was translated into Japanese using standardized translation procedures. The reliability and validity of the MICRA-J were evaluated in individuals who underwent <jats:italic>BRCA1<\/jats:italic>\/<jats:italic>2<\/jats:italic> testing for hereditary breast and ovarian cancer diagnosis. The 72 respondents included patients with <jats:italic>BRCA1<\/jats:italic>\/<jats:italic>2<\/jats:italic> pathogenic variants (n\u2009=\u200920), <jats:italic>BRCA1<\/jats:italic>\/<jats:italic>2<\/jats:italic> negative (n\u2009=\u200935), variants of uncertain significance (VUS, n\u2009=\u20096), participants with cascade testing positive (n\u2009=\u20097), and participants with cascade testing negative (n\u2009=\u20094). Total MICRA-J scores were positively correlated with Hospital Anxiety and Depression Scale (HADS) scores and negatively correlated with the 36-item short-form version 2 acute (SF-36v2 acute) scores (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The MICRA-J showed good internal consistency coefficients (\u03b1\u2009&gt;\u20090.70). Furthermore, high test\u2013retest correlations were obtained when the 64 participants responded to the MICRA-J twice within a short period (Pearson\u2019s correlation coefficient\u2009=\u20090.85). The MICRA-J Total score was higher in the groups with <jats:italic>BRCA1<\/jats:italic>\/<jats:italic>2<\/jats:italic> pathogenic variant carriers than in the <jats:italic>BRCA1<\/jats:italic>\/<jats:italic>2<\/jats:italic> negative group, whereas the HADS and SF36v2 acute did not differ significantly. These results suggest that the reliability and validity of the MICRA-J have been established. The MICRA-J, similar to the MICRA in other languages, is considered a useful tool to specifically measure the psychosocial impact of genetic testing.<\/jats:p>","DOI":"10.1007\/s10689-025-00496-2","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T09:00:37Z","timestamp":1756890037000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reliability and validity of the multidimensional impact of cancer risk assessment (MICRA) questionnaire: Japanese version"],"prefix":"10.1007","volume":"24","author":[{"given":"Tomoko","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minako","family":"Kakimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumie","family":"Hiraoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manami","family":"Matsukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Nagahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saki","family":"Horiguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miwa","family":"Toshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikako","family":"Tomozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Aitani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kuwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruhiko","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"issue":"1","key":"496_CR1","doi-asserted-by":"publisher","first-page":"77","DOI":"10.6004\/jnccn.2021.0001","volume":"19","author":"MB Daly","year":"2021","unstructured":"Daly MB, Pal T, Berry MP et al (2021) Genetic\/familial high-risk assessment: breast, ovarian, and pancreatic, version 2.2021, NCCN clinical practice guidelines in oncology. 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The research protocol was approved by the Research Ethics Review Committee of the National Cancer Center (2021-284). This protocol was in accordance with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and informed consent"}}],"article-number":"66"}}