{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:22:33Z","timestamp":1776842553413,"version":"3.51.2"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Familial Cancer"],"DOI":"10.1007\/s10689-026-00556-1","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T06:16:01Z","timestamp":1776838561000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual radiation-induced sarcomas after breast cancer in a TP53 variant carrier"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5148-5196","authenticated-orcid":false,"given":"Riccardo","family":"Ricci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Peyrat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armelle","family":"Dufrene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Papa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0904-7473","authenticated-orcid":false,"given":"Maria Adele","family":"Dammacco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"issue":"4","key":"556_CR1","doi-asserted-by":"publisher","first-page":"747","DOI":"10.7326\/0003-4819-71-4-747","volume":"71","author":"FP Li","year":"1969","unstructured":"Li FP, Fraumeni JF, Bethesda F (1969) Soft-tissue sarcomas, breast cancer, and other neoplasms a familial syndrome? Ann Intern Med 71(4):747\u2013752. https:\/\/doi.org\/10.7326\/0003-4819-71-4-747","journal-title":"Ann Intern Med"},{"key":"556_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-013-0020-0","author":"AD Sorrell","year":"2013","unstructured":"Sorrell AD, Espenschied CR, Culver JO, Weitzel JN (2013) Tumor protein p53 (TP53) testing and Li\u2013Fraumeni syndrome: current status of clinical applications and future directions. Mol Diagn Ther. https:\/\/doi.org\/10.1007\/s40291-013-0020-0","journal-title":"Mol Diagn Ther"},{"key":"556_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2021.188556","author":"LJ Hern\u00e1ndez Borrero","year":"2021","unstructured":"Hern\u00e1ndez Borrero LJ, El-Deiry WS (2021) Tumor suppressor p53: biology, signaling pathways, and therapeutic targeting. Biochimica et Biophysica Acta (BBA) Reviews on Cancer. https:\/\/doi.org\/10.1016\/j.bbcan.2021.188556","journal-title":"Biochimica et Biophysica Acta (BBA) Reviews on Cancer"},{"key":"556_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01347-1","author":"H Wang","year":"2023","unstructured":"Wang H, Guo M, Wei H, Chen Y (2023) Targeting p53 pathways: mechanisms, structures, and advances in therapy. Signal Transduct Target Ther. https:\/\/doi.org\/10.1038\/s41392-023-01347-1","journal-title":"Signal Transduct Target Ther"},{"issue":"23","key":"556_CR5","doi-asserted-by":"publisher","first-page":"3673","DOI":"10.1002\/cncr.30248","volume":"122","author":"PL Mai","year":"2016","unstructured":"Mai PL, Best AF, Peters JA, DeCastro RM, Khincha PP, Loud JT et al (2016) Risks of first and subsequent cancers among TP53 mutation carriers in the National Cancer Institute Li\u2013Fraumeni syndrome cohort. Cancer 122(23):3673\u20133681. https:\/\/doi.org\/10.1002\/cncr.30248","journal-title":"Cancer"},{"key":"556_CR6","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a026187","author":"T Guha","year":"2017","unstructured":"Guha T, Malkin D (2017) Inherited TP53 mutations and the Li\u2013Fraumeni syndrome. Cold Spring Harb Perspect Med. https:\/\/doi.org\/10.1101\/cshperspect.a026187","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"21","key":"556_CR7","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1200\/JCO.2014.59.5728","volume":"33","author":"G Bougeard","year":"2015","unstructured":"Bougeard G, Renaux-Petel M, Flaman JM, Charbonnier C, Fermey P, Belotti M et al (2015) Revisiting Li\u2013Fraumeni syndrome from TP53 mutation carriers. J Clin Oncol 33(21):2345\u20132352. https:\/\/doi.org\/10.1200\/JCO.2014.59.5728","journal-title":"J Clin Oncol"},{"issue":"1","key":"556_CR8","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1056\/NEJM198107023050102","volume":"305","author":"U Veronesi","year":"1981","unstructured":"Veronesi U (1981) Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast. N Engl J Med 305(1):6\u201311. https:\/\/doi.org\/10.1056\/NEJM198107023050102","journal-title":"N Engl J Med"},{"issue":"3","key":"556_CR9","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1097\/PRS.0b013e3181b179d2","volume":"124","author":"A Losken","year":"2009","unstructured":"Losken A, Hamdi M (2009) Partial breast reconstruction: current perspectives. Plast Reconstr Surg 124(3):722\u2013736. https:\/\/doi.org\/10.1097\/PRS.0b013e3181b179d2","journal-title":"Plast Reconstr Surg"},{"key":"556_CR10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2024-083975","author":"P McGale","year":"2025","unstructured":"McGale P, Dodwell D, Challenger A, Cutter D, Williams A, Broggio J et al (2025) Second cancers in 475 000 women with early invasive breast cancer diagnosed in England during 1993-2016: population based observational cohort study. BMJ. https:\/\/doi.org\/10.1136\/bmj-2024-083975","journal-title":"BMJ"},{"issue":"1","key":"556_CR11","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/sj.bjc.6605435","volume":"102","author":"BA De Gonzalez","year":"2010","unstructured":"De Gonzalez BA, Curtis RE, Gilbert E, Berg CD, Smith SA, Stovall M et al (2010) Second solid cancers after radiotherapy for breast cancer in SEER cancer registries. Br J Cancer 102(1):220\u2013226. https:\/\/doi.org\/10.1038\/sj.bjc.6605435","journal-title":"Br J Cancer"},{"issue":"7","key":"556_CR12","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.clon.2007.05.001","volume":"19","author":"A Salmon","year":"2007","unstructured":"Salmon A, Amikam D, Sodha N, Davidson S, Basel-Vanagaite L, Eeles RA et al (2007) Rapid development of post-radiotherapy sarcoma and breast cancer in a patient with a novel germline \u201cde-novo\u201d TP53 mutation. Clin Oncol 19(7):490\u2013493. https:\/\/doi.org\/10.1016\/j.clon.2007.05.001","journal-title":"Clin Oncol"},{"key":"556_CR13","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1038\/nrc2677","volume":"9","author":"L Mullenders","year":"2009","unstructured":"Mullenders L, Atkinson M, Paretzke H, Sabatier L, Bouffler S (2009) Assessing cancer risks of low-dose radiation. Nat Rev Cancer 9:596\u2013604. https:\/\/doi.org\/10.1038\/nrc2677","journal-title":"Nat Rev Cancer"},{"key":"556_CR14","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2018.00290","author":"CB Dracham","year":"2018","unstructured":"Dracham CB, Shankar A, Madan R (2018) Radiation induced secondary malignancies: a review article. Radiat Oncol J. https:\/\/doi.org\/10.3857\/roj.2018.00290","journal-title":"Radiat Oncol J"},{"issue":"12","key":"556_CR15","doi-asserted-by":"publisher","first-page":"e562","DOI":"10.1016\/S1470-2045(21)00425-3","volume":"22","author":"J Thariat","year":"2021","unstructured":"Thariat J (2021) Avoidance or adaptation of radiotherapy in patients with cancer with Li\u2013Fraumeni and heritable TP53-related cancer syndromes. Lancet Oncol 22(12):e562\u2013e574. https:\/\/doi.org\/10.1016\/S1470-2045(21)00425-3","journal-title":"Lancet Oncol"},{"key":"556_CR16","doi-asserted-by":"publisher","unstructured":"Evans DGR, Birch JM, Ramsden RT, Sharif S, Baser ME (2006) Malignant transformation and new primary tumours after therapeutic radiation for benign disease: substantial risks in certain tumour prone syndromes. Journal of Medical Genetics. BMJ Publishing Group, pp 289\u201394. https:\/\/doi.org\/10.1136\/jmg.2005.036319","DOI":"10.1136\/jmg.2005.036319"},{"key":"556_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17071206","author":"A Shrebati","year":"2025","unstructured":"Shrebati A, Loap P, Kirova Y (2025) Adjuvant radiotherapy and breast cancer in patients with Li\u2013Fraumeni syndrome: a critical review. Cancers. https:\/\/doi.org\/10.3390\/cancers17071206","journal-title":"Cancers"},{"key":"556_CR18","doi-asserted-by":"publisher","DOI":"10.5603\/ocp.98107","author":"J Huszno","year":"2024","unstructured":"Huszno J, Rutkowski T, Roch-Zniszczo\u0142 A, Stec R (2024) Radiotherapy in patients with breast cancer and Li\u2013Fraumeni syndrome\u2014a narrative review. Oncol Clin Pract. https:\/\/doi.org\/10.5603\/ocp.98107","journal-title":"Oncol Clin Pract"},{"issue":"4","key":"556_CR19","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1016\/j.ijrobp.2024.01.204","volume":"119","author":"V Petry","year":"2024","unstructured":"Petry V, Bonadio RC, Moutinho K, Leite LS, Testa L, Cohn DJBH et al (2024) Frequency of radiation therapy-induced malignancies in patients with Li\u2013Fraumeni syndrome and early-stage breast cancer and the influence of radiation therapy technique. Int J Radiat Oncol Biol Phys 119(4):1086\u20131091. https:\/\/doi.org\/10.1016\/j.ijrobp.2024.01.204","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"556_CR20","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/1097-0142(194805)1:1<3::AID-CNCR2820010103>3.0.CO;2-7","volume":"1","author":"WG Cahan","year":"1948","unstructured":"Cahan WG (1948) Sarcoma arising in irradiated bone: report of eleven cases. Cancer 1(1):3\u201329","journal-title":"Cancer"},{"issue":"1","key":"556_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.14740\/wjon996w","volume":"8","author":"GK Singh","year":"2017","unstructured":"Singh GK, Yadav V, Singh P, Bhowmik KT (2017) Radiation-induced malignancies making radiotherapy a \u201ctwo-edged sword\u201d: a review of literature. World J Oncol 8(1):1\u20136. https:\/\/doi.org\/10.14740\/wjon996w","journal-title":"World J Oncol"},{"issue":"3","key":"556_CR22","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/s41379-020-0610-4","volume":"34","author":"MG Kuba","year":"2021","unstructured":"Kuba MG, Lester SC, Bowman T, Stokes SM, Taneja KL, Garber JE et al (2021) Histopathologic features of breast cancer in Li\u2013Fraumeni syndrome. Mod Pathol 34(3):542\u2013548. https:\/\/doi.org\/10.1038\/s41379-020-0610-4","journal-title":"Mod Pathol"},{"key":"556_CR23","unstructured":"National Center for Biotechnology Information (NCBI). ClinVar record: NM_000546.6 (TP53): c.797G>A (p.Gly266Glu)\u2014VCV000161516. 2024"},{"issue":"5","key":"556_CR24","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/gim.2015.30","volume":"17","author":"S Richards","year":"2015","unstructured":"Richards S, Aziz N, Bale S, Bick D, Das S, Gastier-Foster J et al (2015) Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med 17(5):405\u2013424. https:\/\/doi.org\/10.1038\/gim.2015.30","journal-title":"Genet Med"},{"key":"556_CR25","unstructured":"Kato S, Han SY, Liu W, Otsuka K, Shibata H, Kanamaru R, et al Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis [Internet]. www.pnas.org"},{"key":"556_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-022-00976-3","author":"KC de Andrade","year":"2022","unstructured":"de Andrade KC, Lee EE, Tookmanian EM, Kesserwan CA, Manfredi JJ, Hatton JN et al (2022) The TP53 Database: transition from the International Agency for Research on Cancer to the US National Cancer Institute. Cell Death Differ. https:\/\/doi.org\/10.1038\/s41418-022-00976-3","journal-title":"Cell Death Differ"},{"key":"556_CR27","unstructured":"National Cancer Institute (2025) The TP53 Database (R21, Jan 2025)"},{"key":"556_CR28","doi-asserted-by":"crossref","unstructured":"Orta L, Suprun U, Goldfarb A, Bleiweiss I, Jaffer S (2006) Radiation-associated extraskeletal osteosarcoma of the chest wall. Arch Pathol Lab Med. https:\/\/aplm.kglmeridian.com","DOI":"10.5858\/2006-130-198-REOOTC"},{"key":"556_CR29","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-5-104","author":"S Heymann","year":"2010","unstructured":"Heymann S, Delaloge S, Rahal A, Caron O, Frebourg T, Barreau L et al (2010) Radio-induced malignancies after breast cancer postoperative radiotherapy in patients with Li\u2013Fraumeni syndrome. Radiat Oncol. https:\/\/doi.org\/10.1186\/1748-717X-5-104","journal-title":"Radiat Oncol"},{"key":"556_CR30","doi-asserted-by":"crossref","unstructured":"Henry E, Villalobos V, Lynn ;, Jensen KC, West R, Ganjoo K, et al (2012) Case report chest wall leiomyosarcoma after breast-conservative therapy for early-stage breast cancer in a young woman with Li\u2013Fraumeni Syndrome. J National Comprehensive Cancer Netw","DOI":"10.6004\/jnccn.2012.0097"},{"issue":"12","key":"556_CR31","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1016\/j.bjps.2018.07.028","volume":"71","author":"A Pennati","year":"2018","unstructured":"Pennati A, Riggio E, Marano G, Biganzoli E (2018) Autologous fat grafting after sarcoma surgery: evaluation of oncological safety. J Plast Reconstr Aesthet Surg 71(12):1723\u20131729. https:\/\/doi.org\/10.1016\/j.bjps.2018.07.028","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"5\u20136","key":"556_CR32","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.anplas.2020.05.009","volume":"65","author":"P Frobert","year":"2020","unstructured":"Frobert P, Vaucher R, Vaz G, Gouin F, Meeus P, Delay E (2020) The role of reconstructive surgery after soft tissue sarcoma resection. Ann Chir Plast Esthet 65(5\u20136):394\u2013422. https:\/\/doi.org\/10.1016\/j.anplas.2020.05.009","journal-title":"Ann Chir Plast Esthet"},{"key":"556_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-021-01464-0","author":"JX Ma","year":"2022","unstructured":"Ma JX, Li B, Xia YC, You WT, Zhang J, Sun YM et al (2022) Latissimus dorsi muscle flap transfer through endoscopic approach combined with the implant after tissue expansion for breast reconstruction of mastectomy patients. BMC Surg. https:\/\/doi.org\/10.1186\/s12893-021-01464-0","journal-title":"BMC Surg"},{"key":"556_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14051543","author":"MJ Cho","year":"2025","unstructured":"Cho MJ, Schroeder M, Flores Garcia J, Royfman A, Moreira A (2025) The current state of the art in autologous breast reconstruction: a review and modern\/future approaches. J Clin Med. https:\/\/doi.org\/10.3390\/jcm14051543","journal-title":"J Clin Med"},{"issue":"1","key":"556_CR35","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1245\/s10434-022-12567-0","volume":"30","author":"E Ostapenko","year":"2023","unstructured":"Ostapenko E, Nixdorf L, Devyatko Y, Exner R, Wimmer K, Fitzal F (2023) Prepectoral versus subpectoral implant-based breast reconstruction: a systemic review and meta-analysis. Ann Surg Oncol 30(1):126\u2013136. https:\/\/doi.org\/10.1245\/s10434-022-12567-0","journal-title":"Ann Surg Oncol"},{"key":"556_CR36","doi-asserted-by":"crossref","unstructured":"Morton LM, Onel K, Curtis RE, Hungate EA, Armstrong GT (2014) The rising incidence of second cancers: patterns of occurrence and identification of risk factors for children and adults","DOI":"10.14694\/EdBook_AM.2014.34.e57"},{"key":"556_CR37","unstructured":"Li FP, Fraumeni JF, Mulvihill JJ, Blattner WA, Dreyfus MG, Tucker MA, et al (1988) A cancer family syndrome in twenty-four Kindreds1. Cancer Res. http:\/\/aacrjournals.org\/cancerres\/article-pdf\/48\/18\/5358\/2432690\/cr0480185358.pdf"},{"key":"556_CR38","doi-asserted-by":"crossref","unstructured":"Limacher JM, Frebourg T, Natarajan-Ame S, Bergerat JP (2001) Two metachronous tumors in the radiotherapy fields of a patient with Li\u2013Fraumeni syndrome","DOI":"10.1002\/ijc.1021"},{"key":"556_CR39","doi-asserted-by":"crossref","unstructured":"Chadaz T, Hobbs SK, Son H (2013) Chest Wall Sarcoma 18 F-FDG PET\/CT in a Patient With Li\u2013Fraumeni Syndrome [Internet]. www.nuclearmed.com","DOI":"10.1097\/RLU.0b013e3182a20033"},{"issue":"2","key":"556_CR40","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1590\/1516-3180.2012.6740004","volume":"133","author":"OV Barbosa","year":"2015","unstructured":"Barbosa OV, Reiriz AB, Boff RA, Oliveira WP, Ossi RL (2015) Angiossarcoma em mama previamente irradiada em paciente portadora da s\u00edndrome de Li\u2013Fraumeni. Um relato de caso. Sao Paulo Med J 133(2):151\u2013153. https:\/\/doi.org\/10.1590\/1516-3180.2012.6740004","journal-title":"Sao Paulo Med J"},{"issue":"3","key":"556_CR41","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s10549-015-3424-1","volume":"151","author":"S Kappel","year":"2015","unstructured":"Kappel S, Janschek E, Wolf B, Rudas M, Teleky B, Jakesz R et al (2015) TP53 germline mutation may affect response to anticancer treatments: analysis of an intensively treated Li\u2013Fraumeni family. Breast Cancer Res Treat 151(3):671\u2013678. https:\/\/doi.org\/10.1007\/s10549-015-3424-1","journal-title":"Breast Cancer Res Treat"},{"issue":"2","key":"556_CR42","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.ciresp.2018.05.008","volume":"97","author":"A Garc\u00eda Novoa","year":"2019","unstructured":"Garc\u00eda Novoa A, Acea Nebril B, Bouz\u00f3n Alejandro A, Cereijo Garea C, Antol\u00edn Novoa S (2019) Radiation-induced angiosarcoma of the breast in a Li\u2013Fraumeni patient. Cir Esp 97(2):114\u2013116. https:\/\/doi.org\/10.1016\/j.ciresp.2018.05.008","journal-title":"Cir Esp"},{"issue":"1","key":"556_CR43","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s10689-019-00153-5","volume":"19","author":"V Petry","year":"2020","unstructured":"Petry V, Bonadio RC, Cagnacci AQC, Senna LAL, Campos RdoNG, Cotti GC et al (2020) Radiotherapy-induced malignancies in breast cancer patients with TP53 pathogenic germline variants (Li\u2013Fraumeni syndrome). Fam Cancer 19(1):47\u201353. https:\/\/doi.org\/10.1007\/s10689-019-00153-5","journal-title":"Fam Cancer"},{"issue":"21","key":"556_CR44","doi-asserted-by":"publisher","first-page":"7954","DOI":"10.1002\/cam4.3427","volume":"9","author":"PG Hendrickson","year":"2020","unstructured":"Hendrickson PG, Luo Y, Kohlmann W, Schiffman J, Maese L, Bishop AJ et al (2020) Radiation therapy and secondary malignancy in Li\u2013Fraumeni syndrome: a hereditary cancer registry study. Cancer Med 9(21):7954\u20137963. https:\/\/doi.org\/10.1002\/cam4.3427","journal-title":"Cancer Med"},{"issue":"1","key":"556_CR45","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s10549-020-05612-7","volume":"181","author":"AN Le","year":"2020","unstructured":"Le AN, Harton J, Desai H, Powers J, Zelley K, Bradbury AR et al (2020) Frequency of radiation-induced malignancies post-adjuvant radiotherapy for breast cancer in patients with Li\u2013Fraumeni syndrome. Breast Cancer Res Treat 181(1):181\u2013188. https:\/\/doi.org\/10.1007\/s10549-020-05612-7","journal-title":"Breast Cancer Res Treat"},{"issue":"2","key":"556_CR46","doi-asserted-by":"publisher","first-page":"175","DOI":"10.4048\/jbc.2021.24.e16","volume":"24","author":"H Alyami","year":"2021","unstructured":"Alyami H, Yoo TK, Cheun JH, Lee HB, Jung SM, Ryu JM et al (2021) Clinical features of breast cancer in South Korean patients with germline TP53 gene mutations. J Breast Cancer 24(2):175\u2013182. https:\/\/doi.org\/10.4048\/jbc.2021.24.e16","journal-title":"J Breast Cancer"},{"issue":"8","key":"556_CR47","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1093\/jnci\/djae074","volume":"116","author":"RL Sandoval","year":"2024","unstructured":"Sandoval RL, Bottosso M, Tianyu L, Polidorio N, Bychkovsky BL, Verret B et al (2024) TP53-associated early breast cancer: new observations from a large cohort. J Natl Cancer Inst 116(8):1246\u20131254. https:\/\/doi.org\/10.1093\/jnci\/djae074","journal-title":"J Natl Cancer Inst"},{"issue":"11","key":"556_CR48","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1001\/jamaoncol.2024.3683","volume":"10","author":"GV Cederquist","year":"2024","unstructured":"Cederquist GV, Boe LA (2024) Radiation-associated secondary cancer in patients with breast cancer harboring TP53 germline variants. JAMA Oncol 10(11):1588\u20131590. https:\/\/doi.org\/10.1001\/jamaoncol.2024.3683","journal-title":"JAMA Oncol"},{"key":"556_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2019.07.026","author":"C Bergom","year":"2019","unstructured":"Bergom C, West CM, Higginson DS, Abazeed ME, Arun B, Bentzen SM et al (2019) The implications of genetic testing on radiation therapy decisions: a guide for radiation oncologists. Int J Radiat Oncol Biol Phys. https:\/\/doi.org\/10.1016\/j.ijrobp.2019.07.026","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"556_CR50","doi-asserted-by":"publisher","unstructured":"Tung JCB (2020) Management of Hereditary Breast Cancer: American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology GUIDELINE. J Clin Oncol 38(38):1\u201329. https:\/\/doi.org\/10.1200\/JCO.20.00299","DOI":"10.1200\/JCO.20.00299"},{"issue":"10","key":"556_CR51","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1038\/s41431-020-0638-4","volume":"28","author":"T Frebourg","year":"2020","unstructured":"Frebourg T, Bajalica Lagercrantz S, Oliveira C, Magenheim R, Evans DG, Hoogerbrugge N (2020) Guidelines for the Li\u2013Fraumeni and heritable TP53-related cancer syndromes. Eur J Hum Genet 28(10):1379\u20131386. https:\/\/doi.org\/10.1038\/s41431-020-0638-4","journal-title":"Eur J Hum Genet"},{"issue":"1","key":"556_CR52","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.annonc.2022.10.004","volume":"34","author":"C Sessa","year":"2023","unstructured":"Sessa C, Balma\u00f1a J, Bober SL, Cardoso MJ, Colombo N, Curigliano G et al (2023) Risk reduction and screening of cancer in hereditary breast-ovarian cancer syndromes: ESMO clinical practice guideline \u2606. Ann Oncol 34(1):33\u201347. https:\/\/doi.org\/10.1016\/j.annonc.2022.10.004","journal-title":"Ann Oncol"},{"issue":"10","key":"556_CR53","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1158\/1078-0432.CCR-24-3301","volume":"31","author":"MI Achatz","year":"2025","unstructured":"Achatz MI, Villani A, Bertuch AA, Bougeard G, Chang VY, Doria AS et al (2025) Update on cancer screening recommendations for individuals with Li\u2013Fraumeni syndrome. Clin Cancer Res 31(10):1831\u20131840. https:\/\/doi.org\/10.1158\/1078-0432.CCR-24-3301","journal-title":"Clin Cancer Res"}],"container-title":["Familial Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-026-00556-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10689-026-00556-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-026-00556-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T06:16:13Z","timestamp":1776838573000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10689-026-00556-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,22]]},"references-count":53,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["556"],"URL":"https:\/\/doi.org\/10.1007\/s10689-026-00556-1","relation":{},"ISSN":["1573-7292"],"issn-type":[{"value":"1573-7292","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,22]]},"assertion":[{"value":"13 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Informed consent was obtained from the patient for publication of this case report and accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"42"}}