{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T22:39:00Z","timestamp":1792535940129,"version":"4.5.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Familial Cancer"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Lynch syndrome, one of the most common hereditary cancer predisposition syndromes, is caused by pathogenic variants in the mismatch repair genes (\n                    <jats:italic>MLH1, MSH2, MSH6, PMS2<\/jats:italic>\n                    ) and the\n                    <jats:italic>EPCAM<\/jats:italic>\n                    gene. Individuals who inherit pathogenic variants in Lynch-associated genes experience increased lifetime risk of colorectal, endometrial, and several other cancer types. Risks of Lynch-associated cancers vary by the affected gene and within each gene, especially for lower penetrance genes. This poses challenges for clinicians to provide patients and families with accurate cancer risk estimates and determine individualized surveillance protocols. Compounding this challenge is that study designs and potential biases could yield different risk estimates. In this review, we present up-to-date Lynch syndrome cancer risk estimates and discuss how study design could impact these risk estimates.\n                  <\/jats:p>","DOI":"10.1007\/s10689-026-00598-5","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T09:45:57Z","timestamp":1792489557000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Updated cancer risks in lynch syndrome"],"prefix":"10.1007","volume":"25","author":[{"given":"Christine M.","family":"Drogan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia S.","family":"Kupfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"issue":"3","key":"598_CR1","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1158\/1055-9965.EPI-16-0693","volume":"26","author":"AK Win","year":"2017","unstructured":"Win AK et al (2017) Prevalence and penetrance of major genes and polygenes for colorectal cancer. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol 26(3):404\u2013412. https:\/\/doi.org\/10.1158\/1055-9965.EPI-16-0693","journal-title":"Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol"},{"issue":"9","key":"598_CR2","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1136\/jmg-2023-109791","volume":"61","author":"E Fummey","year":"2024","unstructured":"Fummey E, Navarro P, Plazzer J-P, Frayling IM, Knott S, Tenesa A (2024) Estimating cancer risk in carriers of Lynch syndrome variants in UK Biobank. J Med Genet 61(9):861\u2013869. https:\/\/doi.org\/10.1136\/jmg-2023-109791","journal-title":"J Med Genet"},{"key":"598_CR3","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.euros.2025.11.006","volume":"83","author":"L Rodgers-Fouch\u00e9","year":"2025","unstructured":"Rodgers-Fouch\u00e9 L et al (2025) Prostate cancer risk and DNA mismatch repair deficiency among Lynch syndrome patients. Eur Urol Open Sci 83:83\u201390. https:\/\/doi.org\/10.1016\/j.euros.2025.11.006","journal-title":"Eur Urol Open Sci"},{"issue":"1","key":"598_CR4","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.giec.2021.08.001","volume":"32","author":"C Drogan","year":"2022","unstructured":"Drogan C, Kupfer SS (2022) Colorectal cancer screening recommendations and outcomes in Lynch syndrome. Gastrointest Endosc Clin N Am 32(1):59\u201374. https:\/\/doi.org\/10.1016\/j.giec.2021.08.001","journal-title":"Gastrointest Endosc Clin N Am"},{"issue":"5","key":"598_CR5","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/BF02053699","volume":"34","author":"HFA Vasen","year":"1991","unstructured":"Vasen HFA, Mecklin J-P, Meera Khan P, Lynch HT (1991) The international collaborative group on hereditary non-polyposis colorectal cancer (ICG-HNPCC). Dis Colon Rectum 34(5):424. https:\/\/doi.org\/10.1007\/BF02053699","journal-title":"Dis Colon Rectum"},{"issue":"6","key":"598_CR6","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0016-5085(99)70510-X","volume":"116","author":"HFA Vasen","year":"1999","unstructured":"Vasen HFA, Watson P, Mecklin J-P, Lynch HT (1999) New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC. Gastroenterology 116(6):1453\u20131456. https:\/\/doi.org\/10.1016\/S0016-5085(99)70510-X","journal-title":"Gastroenterology"},{"key":"598_CR7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10689-025-00444-0","volume":"24","author":"CM Drogan","year":"2025","unstructured":"Drogan CM et al (2025) MSH6 c.3226C>T (p.Arg1076Cys): The first pathogenic germline low-penetrance lynch syndrome variant. Fam Cancer 24:65","journal-title":"Fam Cancer"},{"issue":"2","key":"598_CR8","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s10689-013-9614-2","volume":"12","author":"BA Talseth-Palmer","year":"2013","unstructured":"Talseth-Palmer BA, Wijnen JT, Grice DM, Scott RJ (2013) Genetic modifiers of cancer risk in Lynch syndrome: a review. Fam Cancer 12(2):207\u2013216. https:\/\/doi.org\/10.1007\/s10689-013-9614-2","journal-title":"Fam Cancer"},{"issue":"7","key":"598_CR9","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/S1470-2045(21)00189-3","volume":"22","author":"AK Win","year":"2021","unstructured":"Win AK et al (2021) Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study. Lancet Oncol 22(7):1014\u20131022. https:\/\/doi.org\/10.1016\/S1470-2045(21)00189-3","journal-title":"Lancet Oncol"},{"key":"598_CR10","doi-asserted-by":"publisher","DOI":"10.1200\/PO-25-00081","volume":"9","author":"TY Helfand","year":"2025","unstructured":"Helfand TY et al (2025) Polygenic score complements family history and lynch syndrome genes for predicting colorectal cancer risk. JCO Precis Oncol 9:e2500081. https:\/\/doi.org\/10.1200\/PO-25-00081","journal-title":"JCO Precis Oncol"},{"issue":"9","key":"598_CR11","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.1002\/ijc.31611","volume":"143","author":"SG Dashti","year":"2018","unstructured":"Dashti SG et al (2018) Physical activity and the risk of colorectal cancer in Lynch syndrome. Int J Cancer 143(9):2250\u20132260. https:\/\/doi.org\/10.1002\/ijc.31611","journal-title":"Int J Cancer"},{"issue":"10240","key":"598_CR12","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1016\/S0140-6736(20)30366-4","volume":"395","author":"J Burn","year":"1855","unstructured":"Burn J et al (1855) Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial. Lancet 395(10240):1855\u20131863. https:\/\/doi.org\/10.1016\/S0140-6736(20)30366-4","journal-title":"Lancet"},{"key":"598_CR13","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djag029","author":"WD Foulkes","year":"2026","unstructured":"Foulkes WD, Ahadova A (2026) Cancer risks in the Lynch syndromes. JNCI J Natl Cancer Inst. https:\/\/doi.org\/10.1093\/jnci\/djag029","journal-title":"JNCI J Natl Cancer Inst"},{"key":"598_CR14","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djaf349","author":"S Campoy","year":"2025","unstructured":"Campoy S, Drouet Y, Rochefort P, Bonadona V, Lasset C (2025) Cancer risks in Lynch syndrome carriers: a systematic review and meta-analysis. J Natl Cancer Inst. https:\/\/doi.org\/10.1093\/jnci\/djaf349","journal-title":"J Natl Cancer Inst"},{"issue":"6","key":"598_CR15","first-page":"1849","volume":"8","author":"J Ivanovich","year":"2002","unstructured":"Ivanovich J et al (2002) Evaluation of the family history collection process and the accuracy of cancer reporting among a series of women with endometrial cancer1. Clin Cancer Res 8(6):1849\u20131856","journal-title":"Clin Cancer Res"},{"issue":"1","key":"598_CR16","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/s41467-024-52562-5","volume":"16","author":"J Park","year":"2025","unstructured":"Park J, Karnati H, Rustgi SD, Hur C, Kong X-F, Kastrinos F (2025) Impact of population screening for Lynch syndrome insights from the All of Us data. Nat Commun 16(1):523. https:\/\/doi.org\/10.1038\/s41467-024-52562-5","journal-title":"Nat Commun"},{"key":"598_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.gimo.2025.102945","volume":"3","author":"A Bolze","year":"2025","unstructured":"Bolze A et al (2025) P101: Very low penetrance of loss-of-function variants in PMS2 for all Lynch syndrome relevant cancers in large US biobanks*. Genet Med Open 3:102945. https:\/\/doi.org\/10.1016\/j.gimo.2025.102945","journal-title":"Genet Med Open"},{"key":"598_CR18","doi-asserted-by":"publisher","first-page":"2PO.20.00290","DOI":"10.1200\/PO.20.00290","volume":"4","author":"RE Rosenblum","year":"2020","unstructured":"Rosenblum RE et al (2020) Lynch syndrome-associated variants and cancer rates in an ancestrally diverse biobank. JCO Precis Oncol 4:2PO.20.00290. https:\/\/doi.org\/10.1200\/PO.20.00290","journal-title":"JCO Precis Oncol"},{"issue":"1","key":"598_CR19","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41436-019-0596-9","volume":"22","author":"M Dominguez-Valentin","year":"2020","unstructured":"Dominguez-Valentin M et al (2020) Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database. Genet Med 22(1):15\u201325. https:\/\/doi.org\/10.1038\/s41436-019-0596-9","journal-title":"Genet Med"},{"key":"598_CR20","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/978-3-319-74259-5_28","volume-title":"Hereditary colorectal cancer: genetic basis and clinical implications","author":"P M\u00f8ller","year":"2018","unstructured":"M\u00f8ller P, Nakken S, Hovig E (2018) \u201cThe prospective Lynch syndrome database,.\u201d In: Valle L, Gruber SB, Capell\u00e1 G (eds) Hereditary colorectal cancer: genetic basis and clinical implications. Springer, Cham, pp 461\u2013468. https:\/\/doi.org\/10.1007\/978-3-319-74259-5_28"},{"issue":"5","key":"598_CR21","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1002\/path.5422","volume":"250","author":"G Cerretelli","year":"2020","unstructured":"Cerretelli G, Ager A, Arends MJ, Frayling IM (2020) Molecular pathology of Lynch syndrome. J Pathol 250(5):518\u2013531. https:\/\/doi.org\/10.1002\/path.5422","journal-title":"J Pathol"},{"issue":"3","key":"598_CR22","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.cgh.2025.06.040","volume":"24","author":"R H\u00fcneburg","year":"2026","unstructured":"H\u00fcneburg R et al (2026) Identifying risk factors for metachronous colorectal cancer in Lynch syndrome. Clin Gastroenterol Hepatol 24(3):824\u2013834. https:\/\/doi.org\/10.1016\/j.cgh.2025.06.040","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"9","key":"598_CR23","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1136\/gutjnl-2016-311403","volume":"66","author":"P M\u00f8ller","year":"2017","unstructured":"M\u00f8ller P et al (2017) Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database. Gut 66(9):1657\u20131664. https:\/\/doi.org\/10.1136\/gutjnl-2016-311403","journal-title":"Gut"},{"issue":"4","key":"598_CR24","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1200\/JCO.2014.55.8536","volume":"33","author":"MA Jenkins","year":"2015","unstructured":"Jenkins MA et al (2015) Short-term risk of colorectal cancer in individuals with Lynch syndrome: a meta-analysis. J Clin Oncol 33(4):326\u2013331. https:\/\/doi.org\/10.1200\/JCO.2014.55.8536","journal-title":"J Clin Oncol"},{"issue":"5","key":"598_CR25","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkaa027","volume":"4","author":"C Wang","year":"2020","unstructured":"Wang C, Wang Y, Hughes KS, Parmigiani G, Braun D (2020) Penetrance of colorectal cancer among mismatch repair gene mutation carriers: a meta-analysis. JNCI Cancer Spectr 4(5):pkaa027. https:\/\/doi.org\/10.1093\/jncics\/pkaa027","journal-title":"JNCI Cancer Spectr"},{"key":"598_CR26","unstructured":"Drogan CM et al. (2024) Cancer Risks Associated with Germline Pathogenic Variants in the MLH1, MSH2, MSH6, PMS2, and EPCAM Genes. [Conference presentation abstract]. InSiGHT biennial conference, Barcelona, Spain"},{"issue":"1","key":"598_CR27","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1002\/cncr.21560","volume":"106","author":"RR Broaddus","year":"2006","unstructured":"Broaddus RR et al (2006) Pathologic features of endometrial carcinoma associated with HNPCC. Cancer 106(1):87\u201394. https:\/\/doi.org\/10.1002\/cncr.21560","journal-title":"Cancer"},{"key":"598_CR28","doi-asserted-by":"publisher","first-page":"116098","DOI":"10.1016\/j.ejca.2025.116098","volume":"231","author":"AS van der Werf Lam","year":"2025","unstructured":"van der Werf Lam AS et al (2025) Cancer risks for MSH6 pathogenic variant carriers. Eur J Cancer 231:116098. https:\/\/doi.org\/10.1016\/j.ejca.2025.116098","journal-title":"Eur J Cancer"},{"key":"598_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2026.108829","author":"R Karimi","year":"2026","unstructured":"Karimi R, Kazemi I, Mansourian M, Marateb HR, Ma\u00f1anas MA (2026) Gene-specific cancer risks in female Lynch syndrome carriers: a copula-based meta-analysis. Maturitas. https:\/\/doi.org\/10.1016\/j.maturitas.2026.108829","journal-title":"Maturitas"},{"issue":"9","key":"598_CR30","doi-asserted-by":"publisher","first-page":"6877","DOI":"10.1245\/s10434-025-17664-4","volume":"32","author":"DC da Silva","year":"2025","unstructured":"da Silva DC, Sousa F, Silva A, Sousa-Pinto B (2025) Risk factors for gastric cancer in patients with Lynch syndrome: a systematic review and meta-analysis. Ann Surg Oncol 32(9):6877\u20136883. https:\/\/doi.org\/10.1245\/s10434-025-17664-4","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"598_CR31","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1245\/s10434-025-18189-6","volume":"33","author":"Y Cai","year":"2026","unstructured":"Cai Y, Liu L (2026) Letter to the editor of Annals of Surgical Oncology concerning \u2018Risk factors for gastric cancer in patients with Lynch syndrome: a systematic review and meta\u2010analysis. Ann Surg Oncol 33(1):342\u2013343. https:\/\/doi.org\/10.1245\/s10434-025-18189-6","journal-title":"Ann Surg Oncol"},{"issue":"35","key":"598_CR32","doi-asserted-by":"publisher","first-page":"4409","DOI":"10.1200\/JCO.2012.43.2278","volume":"30","author":"C Engel","year":"2012","unstructured":"Engel C et al (2012) Risks of less common cancers in proven mutation carriers with Lynch syndrome. J Clin Oncol 30(35):4409\u20134415. https:\/\/doi.org\/10.1200\/JCO.2012.43.2278","journal-title":"J Clin Oncol"},{"key":"598_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2025.103618","volume":"90","author":"S Negro","year":"2025","unstructured":"Negro S et al (2025) Incidence of non-colorectal\/endometrial malignancies in individuals with Lynch syndrome: a retrospective cohort study. eClinicalMedicine 90:103618. https:\/\/doi.org\/10.1016\/j.eclinm.2025.103618","journal-title":"eClinicalMedicine"},{"key":"598_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2026.103755","author":"AM Bogdanski","year":"2026","unstructured":"Bogdanski AM et al (2026) Pancreatic cancer risk and survival in patients with Lynch syndrome: a nationwide Dutch cohort study. eClinicalMedicine. https:\/\/doi.org\/10.1016\/j.eclinm.2026.103755","journal-title":"eClinicalMedicine"},{"issue":"16","key":"598_CR35","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1001\/jama.2009.1529","volume":"302","author":"F Kastrinos","year":"2009","unstructured":"Kastrinos F et al (2009) The risk of pancreatic cancer in families with lynch syndrome. JAMA J Am Med Assoc 302(16):1790\u20131795. https:\/\/doi.org\/10.1001\/jama.2009.1529","journal-title":"JAMA J Am Med Assoc"},{"key":"598_CR36","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ejca.2015.12.005","volume":"55","author":"JM Helder-Woolderink","year":"2016","unstructured":"Helder-Woolderink JM, Blok EA, Vasen HFA, Hollema H, Mourits MJ, Bock GHD (2016) Ovarian cancer in Lynch syndrome; a systematic review. Eur J Cancer 55:65\u201373. https:\/\/doi.org\/10.1016\/j.ejca.2015.12.005","journal-title":"Eur J Cancer"},{"issue":"2","key":"598_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15020506","volume":"15","author":"A-J Nassour","year":"2023","unstructured":"Nassour A-J, Jain A, Hui N, Siopis G, Symons J, Woo H (2023) Relative risk of bladder and kidney cancer in Lynch syndrome: systematic review and meta-analysis. Cancers (Basel) 15(2):506. https:\/\/doi.org\/10.3390\/cancers15020506","journal-title":"Cancers (Basel)"},{"issue":"4","key":"598_CR38","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1111\/ene.12647","volume":"22","author":"C Therkildsen","year":"2015","unstructured":"Therkildsen C, Ladelund S, Rambech E, Persson A, Petersen A, Nilbert M (2015) Glioblastomas, astrocytomas and oligodendrogliomas linked to Lynch syndrome. Eur J Neurol 22(4):717\u2013724. https:\/\/doi.org\/10.1111\/ene.12647","journal-title":"Eur J Neurol"},{"issue":"1","key":"598_CR39","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1111\/ajd.14628","volume":"67","author":"N Abu-Ghazaleh","year":"2026","unstructured":"Abu-Ghazaleh N, Abu-Ghazaleh D, Jerjen R, Gorelik A, Ross G, Macrae F (2026) A meta-analysis of the prevalence of mismatch repair germline mutations in patients with sebaceous neoplasms: are we missing an opportunity for Lynch syndrome detection? Australas J Dermatol 67(1):e1\u2013e10. https:\/\/doi.org\/10.1111\/ajd.14628","journal-title":"Australas J Dermatol"},{"key":"598_CR40","doi-asserted-by":"publisher","unstructured":"Adan F et al. (2026) Cumulative risk of skin tumours in patients with Lynch syndrome. Accessed 01 Mar 2026. https:\/\/doi.org\/10.1111\/bjd.16552","DOI":"10.1111\/bjd.16552"},{"key":"598_CR41","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1200\/PO.19.00271","volume":"4","author":"J Stoll","year":"2020","unstructured":"Stoll J, Rosenthal E, Cummings S, Willmott J, Bernhisel R, Kupfer SS (2020) No evidence of increased risk of breast cancer in women with Lynch syndrome identified by multigene panel testing. JCO Precis Oncol 4:51\u201360. https:\/\/doi.org\/10.1200\/PO.19.00271","journal-title":"JCO Precis Oncol"},{"issue":"3","key":"598_CR42","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1158\/1055-9965.EPI-13-1165","volume":"23","author":"S Ryan","year":"2014","unstructured":"Ryan S, Jenkins MA, Win AK (2014) Risk of prostate cancer in Lynch syndrome: a systematic review and meta-analysis. Cancer Epidemiol Biomark Prev 23(3):437\u2013449. https:\/\/doi.org\/10.1158\/1055-9965.EPI-13-1165","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"4","key":"598_CR43","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1200\/JCO.18.00283","volume":"37","author":"A Latham","year":"2019","unstructured":"Latham A et al (2019) Microsatellite instability is associated with the presence of Lynch syndrome pan-cancer. J Clin Oncol 37(4):286\u2013295. https:\/\/doi.org\/10.1200\/JCO.18.00283","journal-title":"J Clin Oncol"},{"issue":"2","key":"598_CR44","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1002\/ijc.33214","volume":"148","author":"M Dominguez-Valentin","year":"2021","unstructured":"Dominguez-Valentin M, Sampson JR, M\u00f8ller P, Sepp\u00e4l\u00e4 TT, PLSD Collaborators (2021) Analysis in the prospective Lynch syndrome database identifies sarcoma as part of the Lynch syndrome tumor spectrum. Int J Cancer 148(2):512\u2013513. https:\/\/doi.org\/10.1002\/ijc.33214","journal-title":"Int J Cancer"},{"issue":"2","key":"598_CR45","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-026-00552-5","volume":"25","author":"SG Patel","year":"2026","unstructured":"Patel SG et al (2026) Lynch syndrome integrative epidemiology and genetics (LINEAGE): rationale for cohort design. Fam Cancer 25(2):49. https:\/\/doi.org\/10.1007\/s10689-026-00552-5","journal-title":"Fam Cancer"}],"container-title":["Familial Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-026-00598-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10689-026-00598-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10689-026-00598-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T22:02:05Z","timestamp":1792533725000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10689-026-00598-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,20]]},"references-count":45,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["598"],"URL":"https:\/\/doi.org\/10.1007\/s10689-026-00598-5","relation":{},"ISSN":["1573-7292"],"issn-type":[{"value":"1573-7292","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,20]]},"assertion":[{"value":"18 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"97"}}