{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:12:42Z","timestamp":1791288762028,"version":"4.3.0"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Fish Physiol Biochem"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s10695-021-01008-6","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T14:02:50Z","timestamp":1630332170000},"page":"1669-1685","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparative transcriptomic analysis of the brain in Takifugu rubripes shows its tolerance to acute hypoxia"],"prefix":"10.1007","volume":"47","author":[{"given":"Mingxiu","family":"Bao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengqin","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengnan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yundeng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jielan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8195-7706","authenticated-orcid":false,"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"key":"1008_CR1","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1007\/s10695-019-00614-9","volume":"45","author":"M Abdel-Tawwab","year":"2019","unstructured":"Abdel-Tawwab M, Monier MN, Hoseinifar SH, Faggio C (2019) Fish response to hypoxia stress: growth, physiological, and immunological biomarkers. Fish Physiol Biochem 45:997\u20131013. https:\/\/doi.org\/10.1007\/s10695-019-00614-9","journal-title":"Fish Physiol Biochem"},{"key":"1008_CR2","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","volume":"31","author":"S Anders","year":"2015","unstructured":"Anders S, Pyl PT, Huber W (2015) HTSeq\u2013a Python framework to work with high-throughput sequencing data. Bioinformatics 31:166\u2013169. https:\/\/doi.org\/10.1093\/bioinformatics\/btu638","journal-title":"Bioinformatics"},{"key":"1008_CR3","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1111\/j.1365-2427.2010.02504.x","volume":"56","author":"KK Arend","year":"2011","unstructured":"Arend KK et al (2011) Seasonal and interannual effects of hypoxia on fish habitat quality in central Lake Erie. Freshw Biol 56:366\u2013383","journal-title":"Freshw Biol"},{"key":"1008_CR4","doi-asserted-by":"publisher","first-page":"368","DOI":"10.4161\/cc.4.3.1534","volume":"4","author":"A Avivi","year":"2005","unstructured":"Avivi A, Ashur-Fabian O, Amariglio N, Nevo E, Rechavi GJCC (2005) p53\u2013a key player in tumoral and evolutionary adaptation: a lesson from the Israeli blind subterranean mole rat. Cell Cycle 4:368\u2013372","journal-title":"Cell Cycle"},{"key":"1008_CR5","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/s0014-5793(99)00584-0","volume":"452","author":"A Avivi","year":"1999","unstructured":"Avivi A, Resnick MB, Nevo E, Joel A, Levy AP (1999) Adaptive hypoxic tolerance in the subterranean mole rat Spalax ehrenbergi: the role of vascular endothelial growth factor. FEBS Lett 452:133\u2013140. https:\/\/doi.org\/10.1016\/s0014-5793(99)00584-0","journal-title":"FEBS Lett"},{"key":"1008_CR6","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1177\/1535370213494558","volume":"238","author":"G Baumann","year":"2013","unstructured":"Baumann G, Travieso L, Liebl DJ, Theus MH (2013) Pronounced hypoxia in the subventricular zone following traumatic brain injury and the neural stem\/progenitor cell response. Exp Biol Med 238:830\u2013841. https:\/\/doi.org\/10.1177\/1535370213494558","journal-title":"Exp Biol Med"},{"key":"1008_CR7","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1146\/annurev.physiol.69.031905.162529","volume":"69","author":"PE Bickler","year":"2007","unstructured":"Bickler PE, Buck LT (2007) Hypoxia tolerance in reptiles, amphibians, and fishes: life with variable oxygen availability. Annu Rev Physiol 69:145\u2013170. https:\/\/doi.org\/10.1146\/annurev.physiol.69.031905.162529","journal-title":"Annu Rev Physiol"},{"key":"1008_CR8","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","volume":"30","author":"AM Bolger","year":"2014","unstructured":"Bolger AM, Lohse M, Usadel B (2014) Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics 30:2114\u20132120. https:\/\/doi.org\/10.1093\/bioinformatics\/btu170","journal-title":"Bioinformatics"},{"key":"1008_CR9","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/366265a0","volume":"366","author":"S Brenner","year":"1993","unstructured":"Brenner S, Elgar G, Sandford R, Macrae A, Venkatesh B, Aparicio S (1993) Characterization of the pufferfish (Fugu) genome as a compact model vertebrate genome. Nature 366:265\u2013268. https:\/\/doi.org\/10.1038\/366265a0","journal-title":"Nature"},{"key":"1008_CR10","first-page":"S29","volume":"62","author":"I Bruzzi","year":"1997","unstructured":"Bruzzi I, Benigni A, Remuzzi G (1997) Role of Increased Glomerular Protein Traffic in the Progression of Renal Failure. Kidney Int Suppl 62:S29-31","journal-title":"Kidney Int Suppl"},{"key":"1008_CR11","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.bbr.2017.09.004","volume":"339","author":"Y Cao","year":"2018","unstructured":"Cao Y et al (2018) Hypoxia-inducible factor-1alpha is involved in isoflurane-induced blood-brain barrier disruption in aged rats model of POCD. Behav Brain Res 339:39\u201346. https:\/\/doi.org\/10.1016\/j.bbr.2017.09.004","journal-title":"Behav Brain Res"},{"key":"1008_CR12","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1017\/S0007485318000512","volume":"109","author":"SF Cui","year":"2019","unstructured":"Cui SF, Wang L, Ma L, Wang YL, Qiu JP, Liu ZC, Geng XQ (2019) Comparative transcriptome analyses of adzuki bean weevil (Callosobruchus chinensis) response to hypoxia and hypoxia\/hypercapnia. Bull Entomol Res 109:266\u2013277. https:\/\/doi.org\/10.1017\/S0007485318000512","journal-title":"Bull Entomol Res"},{"key":"1008_CR13","doi-asserted-by":"publisher","first-page":"E42","DOI":"10.1152\/ajpendo.00034.2016","volume":"311","author":"I De Backer","year":"2016","unstructured":"De Backer I, Hussain SS, Bloom SR, Gardiner JV (2016) Insights into the Role of Neuronal Glucokinase. Am J Physiol Endocrinol Metab 311:E42-55. https:\/\/doi.org\/10.1152\/ajpendo.00034.2016","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"1008_CR14","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1096\/fj.14-250241","volume":"28","author":"EF Diekman","year":"2014","unstructured":"Diekman EF, van Weeghel M, Wanders RJ, Visser G, Houten SM (2014) Food withdrawal lowers energy expenditure and induces inactivity in long-chain fatty acid oxidation-deficient mouse models. FASEB J 28:2891\u20132900. https:\/\/doi.org\/10.1096\/fj.14-250241","journal-title":"FASEB J"},{"key":"1008_CR15","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.isci.2019.02.027","volume":"13","author":"EY Dimova","year":"2019","unstructured":"Dimova EY et al (2019) The circadian clock protein CRY1 is a negative regulator of HIF-1alpha. iScience 13:284\u2013304. https:\/\/doi.org\/10.1016\/j.isci.2019.02.027","journal-title":"iScience"},{"key":"1008_CR16","doi-asserted-by":"publisher","first-page":"109957","DOI":"10.1016\/j.ecoenv.2019.109957","volume":"189","author":"J Ding","year":"2020","unstructured":"Ding J et al (2020) Transcriptome and physiology analysis identify key metabolic changes in the liver of the large yellow croaker (Larimichthys crocea) in response to acute hypoxia. Ecotoxicol Environ Saf 189:109957. https:\/\/doi.org\/10.1016\/j.ecoenv.2019.109957","journal-title":"Ecotoxicol Environ Saf"},{"key":"1008_CR17","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1681\/ASN.2006040407","volume":"18","author":"E Erkan","year":"2007","unstructured":"Erkan E, Devarajan P, Schwartz GJ (2007) Mitochondria are the major targets in albumin-induced apoptosis in proximal tubule cells. J Am Soc Nephrol 18:1199\u20131208. https:\/\/doi.org\/10.1681\/ASN.2006040407","journal-title":"J Am Soc Nephrol"},{"key":"1008_CR18","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/nm0603-669","volume":"9","author":"N Ferrara","year":"2003","unstructured":"Ferrara N, Gerber HP, LeCouter J (2003) The biology of VEGF and its receptors. Nat Med 9:669\u2013676. https:\/\/doi.org\/10.1038\/nm0603-669","journal-title":"Nat Med"},{"key":"1008_CR19","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s10456-008-9107-3","volume":"11","author":"GH Fong","year":"2008","unstructured":"Fong GH (2008) Mechanisms of adaptive angiogenesis to tissue hypoxia. Angiogenesis 11:121\u2013140. https:\/\/doi.org\/10.1007\/s10456-008-9107-3","journal-title":"Angiogenesis"},{"key":"1008_CR20","doi-asserted-by":"publisher","first-page":"4064","DOI":"10.1093\/emboj\/19.15.4064","volume":"19","author":"H Gille","year":"2000","unstructured":"Gille H, Kowalski J, Yu L, Chen H, Pisabarro MT, Davis-Smyth T, Ferrara N (2000) A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3\u2019-kinase activation and endothelial cell migration. EMBO J 19:4064\u20134073. https:\/\/doi.org\/10.1093\/emboj\/19.15.4064","journal-title":"EMBO J"},{"key":"1008_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1101\/gad.1256405","volume":"19","author":"EE Govek","year":"2005","unstructured":"Govek EE, Newey SE, Van Aelst L (2005) The Role of the Rho GTPases in Neuronal Development. Genes Dev 19:1\u201349. https:\/\/doi.org\/10.1101\/gad.1256405","journal-title":"Genes Dev"},{"key":"1008_CR22","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s001090050187","volume":"76","author":"H Ishii","year":"1998","unstructured":"Ishii H, Koya D, King GL (1998) Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus. J Mol Med 76:21\u201331. https:\/\/doi.org\/10.1007\/s001090050187","journal-title":"J Mol Med"},{"key":"1008_CR23","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/jez.603","volume":"313","author":"DC Jackson","year":"2010","unstructured":"Jackson DC, Ultsch GR (2010) Physiology of hibernation under the ice by turtles and frogs. J Exp Zool A Ecol Genet Physiol 313:311\u2013327. https:\/\/doi.org\/10.1002\/jez.603","journal-title":"J Exp Zool A Ecol Genet Physiol"},{"key":"1008_CR24","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.archoralbio.2017.03.007","volume":"79","author":"K Janjic","year":"2017","unstructured":"Janjic K, Kurzmann C, Moritz A, Agis H (2017) Expression of circadian core clock genes in fibroblasts of human gingiva and periodontal ligament is modulated by L-Mimosine and hypoxia in monolayer and spheroid cultures. Arch Oral Biol 79:95\u201399. https:\/\/doi.org\/10.1016\/j.archoralbio.2017.03.007","journal-title":"Arch Oral Biol"},{"key":"1008_CR25","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.cbd.2017.05.003","volume":"24","author":"JL Jiang","year":"2017","unstructured":"Jiang JL, Mao MG, Lu HQ, Wen SH, Sun ML, Liu RT, Jiang ZQ (2017) Digital gene expression analysis of Takifugu rubripes brain after acute hypoxia exposure using next-generation sequencing. Comp Biochem Physiol Part D Genomics Proteomics 24:12\u201318. https:\/\/doi.org\/10.1016\/j.cbd.2017.05.003","journal-title":"Comp Biochem Physiol Part D Genomics Proteomics"},{"key":"1008_CR26","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1097\/00004647-200109000-00008","volume":"21","author":"NM Jones","year":"2001","unstructured":"Jones NM, Bergeron M (2001) Hypoxic preconditioning induces changes in HIF-1 target genes in neonatal rat brain. J Cereb Blood Flow Metab 21:1105\u20131114. https:\/\/doi.org\/10.1097\/00004647-200109000-00008","journal-title":"J Cereb Blood Flow Metab"},{"key":"1008_CR27","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1113\/jphysiol.2002.022236","volume":"543","author":"V Joseph","year":"2002","unstructured":"Joseph V, Mamet J, Lee F, Dalmaz Y, Van Reeth O (2002) Prenatal hypoxia impairs circadian synchronisation and response of the biological clock to light in adult rats. J Physiol 543:387\u2013395. https:\/\/doi.org\/10.1113\/jphysiol.2002.022236","journal-title":"J Physiol"},{"key":"1008_CR28","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1093\/gbe\/evr041","volume":"3","author":"W Kai","year":"2011","unstructured":"Kai W et al (2011) Integration of the genetic map and genome assembly of fugu facilitates insights into distinct features of genome evolution in teleosts and mammals. Genome Biol Evol 3:424\u2013442. https:\/\/doi.org\/10.1093\/gbe\/evr041","journal-title":"Genome Biol Evol"},{"key":"1008_CR29","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S (2000) KEGG: kyoto encyclopedia of genes and genomes. Nucleic acids research 28:27\u201330. https:\/\/doi.org\/10.1093\/nar\/28.1.27","journal-title":"Nucleic acids research"},{"key":"1008_CR30","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.3317","volume":"12","author":"D Kim","year":"2015","unstructured":"Kim D, Langmead B, Salzberg SL (2015) HISAT: a fast spliced aligner with low memory requirements. Nat Methods 12:357\u2013360. https:\/\/doi.org\/10.1038\/nmeth.3317","journal-title":"Nat Methods"},{"key":"1008_CR31","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1023\/a:1022544131826","volume":"24","author":"J Klepper","year":"1999","unstructured":"Klepper J, Wang D, Fischbarg J, Vera JC, Jarjour IT, O\u2019Driscoll KR, De Vivo DC (1999) Defective glucose transport across brain tissue barriers: a newly recognized neurological syndrome. Neurochem Res 24:587\u2013594. https:\/\/doi.org\/10.1023\/a:1022544131826","journal-title":"Neurochem Res"},{"key":"1008_CR32","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1186\/1471-2407-11-443","volume":"11","author":"M Labelle-Cote","year":"2011","unstructured":"Labelle-Cote M, Dusseault J, Ismail S, Picard-Cloutier A, Siegel PM, Larose L (2011) Nck2 promotes human melanoma cell proliferation, migration and invasion in vitro and primary melanoma-derived tumor growth in vivo. BMC cancer 11:443. https:\/\/doi.org\/10.1186\/1471-2407-11-443","journal-title":"BMC cancer"},{"key":"1008_CR33","doi-asserted-by":"publisher","unstructured":"Lafuente JV, Bermudez G, Camargo-Arce L, Bulnes S (2016) Blood-brain barrier changes in high altitude CNS & neurological disorders drug targets 15:1188-1197 https:\/\/doi.org\/10.2174\/1871527315666160920123911","DOI":"10.2174\/1871527315666160920123911"},{"key":"1008_CR34","doi-asserted-by":"publisher","first-page":"e62308","DOI":"10.1371\/journal.pone.0062308","volume":"8","author":"X Liao","year":"2013","unstructured":"Liao X, Cheng L, Xu P, Lu G, Wachholtz M, Sun X, Chen S (2013) Transcriptome analysis of crucian carp (Carassius auratus), an important aquaculture and hypoxia-tolerant species. PLoS One 8:e62308. https:\/\/doi.org\/10.1371\/journal.pone.0062308","journal-title":"PLoS One"},{"key":"1008_CR35","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1007\/s10695-018-0525-x","volume":"44","author":"W Liu","year":"2018","unstructured":"Liu W, Liu X, Wu C, Jiang L (2018) Transcriptome analysis demonstrates that long noncoding RNA is involved in the hypoxic response in Larimichthys crocea. Fish Physiol Biochem 44:1333\u20131347. https:\/\/doi.org\/10.1007\/s10695-018-0525-x","journal-title":"Fish Physiol Biochem"},{"key":"1008_CR36","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1107\/s0907444901004243","volume":"57","author":"XZ Liu","year":"2001","unstructured":"Liu XZ, Li SL, Jing H, Liang YH, Hua ZQ, Lu GY (2001) Avian haemoglobins and structural basis of high affinity for oxygen: structure of bar-headed goose aquomet haemoglobin. Acta Crystallogr D Biol Crystallogr 57:775\u2013783. https:\/\/doi.org\/10.1107\/s0907444901004243","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"1008_CR37","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"1008_CR38","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15:550. https:\/\/doi.org\/10.1186\/s13059-014-0550-8","journal-title":"Genome Biol"},{"key":"1008_CR39","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/ki.1997.73","volume":"51","author":"DE Millhorn","year":"1997","unstructured":"Millhorn DE et al (1997) Regulation of gene expression for tyrosine hydroxylase in oxygen sensitive cells by hypoxia. Kidney Int 51:527\u2013535. https:\/\/doi.org\/10.1038\/ki.1997.73","journal-title":"Kidney Int"},{"key":"1008_CR40","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1113\/EP086068","volume":"102","author":"G Mohaddes","year":"2017","unstructured":"Mohaddes G, Abdolalizadeh J, Babri S, Hossienzadeh F (2017) Ghrelin ameliorates blood-brain barrier disruption during systemic hypoxia. Exp Physiol 102:376\u2013382. https:\/\/doi.org\/10.1113\/EP086068","journal-title":"Exp Physiol"},{"key":"1008_CR41","doi-asserted-by":"publisher","first-page":"6540","DOI":"10.1523\/JNEUROSCI.20-17-06540.2000","volume":"20","author":"T Nakashiba","year":"2000","unstructured":"Nakashiba T, Ikeda T, Nishimura S, Tashiro K, Honjo T, Culotti JG, Itohara S (2000) Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins. J Neurosci 20:6540\u20136550","journal-title":"J Neurosci"},{"key":"1008_CR42","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.brainres.2010.09.064","volume":"1366","author":"OI Ndubuizu","year":"2010","unstructured":"Ndubuizu OI, Tsipis CP, Li A, LaManna JC (2010) Hypoxia-inducible factor-1 (HIF-1)-independent microvascular angiogenesis in the aged rat brain. Brain Res 1366:101\u2013109. https:\/\/doi.org\/10.1016\/j.brainres.2010.09.064","journal-title":"Brain Res"},{"key":"1008_CR43","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1007\/s00018-005-5018-2","volume":"62","author":"M Negishi","year":"2005","unstructured":"Negishi M, Oinuma I, Katoh H (2005) Plexins: axon guidance and signal transduction. Cell Mol Life Sci 62:1363\u20131371. https:\/\/doi.org\/10.1007\/s00018-005-5018-2","journal-title":"Cell Mol Life Sci"},{"key":"1008_CR44","doi-asserted-by":"publisher","first-page":"3131","DOI":"10.1242\/jeb.00979","volume":"207","author":"GE Nilsson","year":"2004","unstructured":"Nilsson GE, Renshaw GM (2004) Hypoxic survival strategies in two fishes: extreme anoxia tolerance in the North European crucian carp and natural hypoxic preconditioning in a coral-reef shark. J Exp Biol 207:3131\u20133139. https:\/\/doi.org\/10.1242\/jeb.00979","journal-title":"J Exp Biol"},{"key":"1008_CR45","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1083\/jcb.141.1.187","volume":"141","author":"CD Nobes","year":"1998","unstructured":"Nobes CD, Lauritzen I, Mattei M-G, Paris S, Hall A, Chardin P (1998) A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. J Cell Biol 141:187\u2013197","journal-title":"J Cell Biol"},{"key":"1008_CR46","doi-asserted-by":"publisher","first-page":"5874","DOI":"10.1038\/s41598-019-42390-9","volume":"9","author":"M Noda","year":"2019","unstructured":"Noda M, Iwamoto I, Tabata H, Yamagata T, Ito H, Nagata KI (2019) Role of Per3, a circadian clock gene, in embryonic development of mouse cerebral cortex. Sci Rep 9:5874. https:\/\/doi.org\/10.1038\/s41598-019-42390-9","journal-title":"Sci Rep"},{"key":"1008_CR47","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1749-8104-4-18","volume":"4","author":"TP O'Connor","year":"2009","unstructured":"O\u2019Connor TP, Cockburn K, Wang W, Tapia L, Currie E, Bamji SX (2009) Semaphorin 5B mediates synapse elimination in hippocampal neurons. Neural Dev 4:18. https:\/\/doi.org\/10.1186\/1749-8104-4-18","journal-title":"Neural Dev"},{"key":"1008_CR48","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1002\/embr.201438447","volume":"15","author":"JT Paridaen","year":"2014","unstructured":"Paridaen JT, Huttner WB (2014) Neurogenesis during development of the vertebrate central nervous system. EMBO Rep 15:351\u2013364","journal-title":"EMBO Rep"},{"key":"1008_CR49","doi-asserted-by":"publisher","unstructured":"Pelster B, Egg M (2018) Hypoxia-inducible transcription factors in fish: expression, function and interconnection with the circadian clock. J Exp Biol 221 https:\/\/doi.org\/10.1242\/jeb.163709","DOI":"10.1242\/jeb.163709"},{"key":"1008_CR50","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.expneurol.2008.08.014","volume":"214","author":"K Plaschke","year":"2008","unstructured":"Plaschke K, Staub J, Ernst E, Marti HH (2008) VEGF overexpression improves mice cognitive abilities after unilateral common carotid artery occlusion. Exp Neurol 214:285\u2013292. https:\/\/doi.org\/10.1016\/j.expneurol.2008.08.014","journal-title":"Exp Neurol"},{"key":"1008_CR51","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1038\/ng.2343","volume":"44","author":"Q Qiu","year":"2012","unstructured":"Qiu Q et al (2012) The yak genome and adaptation to life at high altitude. Nat Genet 44:946\u2013949. https:\/\/doi.org\/10.1038\/ng.2343","journal-title":"Nat Genet"},{"key":"1008_CR52","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.cbpa.2015.03.013","volume":"185","author":"MS Rahman","year":"2015","unstructured":"Rahman MS, Thomas P (2015) Molecular characterization and hypoxia-induced upregulation of neuronal nitric oxide synthase in Atlantic croaker: Reversal by antioxidant and estrogen treatments. Comp Biochem Physiol A Mol Integr Physiol 185:91\u2013106. https:\/\/doi.org\/10.1016\/j.cbpa.2015.03.013","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"1008_CR53","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.tcb.2006.08.006","volume":"16","author":"AJ Ridley","year":"2006","unstructured":"Ridley AJ (2006) Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking. Trends Cell Biol 16:522\u2013529. https:\/\/doi.org\/10.1016\/j.tcb.2006.08.006","journal-title":"Trends Cell Biol"},{"key":"1008_CR54","doi-asserted-by":"publisher","first-page":"4009","DOI":"10.1007\/s11033-011-1181-8","volume":"39","author":"S Rimoldi","year":"2012","unstructured":"Rimoldi S, Terova G, Ceccuzzi P, Marelli S, Antonini M, Saroglia M (2012) HIF-1alpha mRNA levels in Eurasian perch (Perca fluviatilis) exposed to acute and chronic hypoxia. Molecular Biol Rep 39:4009\u20134015. https:\/\/doi.org\/10.1007\/s11033-011-1181-8","journal-title":"Molecular Biol Rep"},{"key":"1008_CR55","doi-asserted-by":"publisher","first-page":"ii216","DOI":"10.1093\/neuonc\/noaa215.907","volume":"22","author":"A Sattiraju","year":"2020","unstructured":"Sattiraju A et al (2020) TAMI-18. Single-cell sequencing and genetic labeling to characterize hypoxic gbm cells in their microenvironment. Neuro-Oncology 22:ii216\u2013ii217. https:\/\/doi.org\/10.1093\/neuonc\/noaa215.907","journal-title":"Neuro-Oncology"},{"key":"1008_CR56","unstructured":"Schmidt R, Weits DA, Feulner CF, Dongen JVJPP (2018) Oxygen sensing and integrative stress signaling in plants:pp.01394.02017"},{"key":"1008_CR57","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1242\/jeb.052548","volume":"214","author":"GR Scott","year":"2011","unstructured":"Scott GR (2011) Elevated performance: the unique physiology of birds that fly at high altitudes. J Exp Biol 214:2455\u20132462. https:\/\/doi.org\/10.1242\/jeb.052548","journal-title":"J Exp Biol"},{"key":"1008_CR58","doi-asserted-by":"publisher","unstructured":"Semenza GL (2007) Hypoxia-inducible factor 1 (HIF-1) pathway Science's STKE : signal transduction knowledge environment 2007:cm8 https:\/\/doi.org\/10.1126\/stke.4072007cm8","DOI":"10.1126\/stke.4072007cm8"},{"key":"1008_CR59","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1530\/ERC-11-0211","volume":"19","author":"B Shan","year":"2012","unstructured":"Shan B et al (2012) RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells. Endocr Relat Cancer 19:13\u201327. https:\/\/doi.org\/10.1530\/ERC-11-0211","journal-title":"Endocr Relat Cancer"},{"key":"1008_CR60","doi-asserted-by":"publisher","first-page":"4763","DOI":"10.1021\/es0496423","volume":"38","author":"EH Shang","year":"2004","unstructured":"Shang EH, Wu RS (2004) Aquatic Hypoxia Is a Teratogen and Affects Fish Embryonic Development. Environ Sci Technol 38:4763\u20134767. https:\/\/doi.org\/10.1021\/es0496423","journal-title":"Environ Sci Technol"},{"key":"1008_CR61","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P et al (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13:2498\u20132504","journal-title":"Genome Res"},{"key":"1008_CR62","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nrm2354","volume":"9","author":"MC Simon","year":"2008","unstructured":"Simon MC, Keith B (2008) The role of oxygen availability in embryonic development and stem cell function. Nature reviews Molecular cell biology 9:285\u2013296. https:\/\/doi.org\/10.1038\/nrm2354","journal-title":"Nature reviews Molecular cell biology"},{"key":"1008_CR63","doi-asserted-by":"publisher","first-page":"e1002638","DOI":"10.1371\/journal.pgen.1002638","volume":"8","author":"TJ Stevenson","year":"2012","unstructured":"Stevenson TJ et al (2012) Hypoxia disruption of vertebrate CNS pathfinding through ephrinB2 Is rescued by magnesium. PLoS Genet 8:e1002638. https:\/\/doi.org\/10.1371\/journal.pgen.1002638","journal-title":"PLoS Genet"},{"key":"1008_CR64","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1152\/physiolgenomics.00128.2002","volume":"13","author":"C Ton","year":"2003","unstructured":"Ton C, Stamatiou D, Liew CC (2003) Gene expression profile of zebrafish exposed to hypoxia during development. Physiol Genomics 13:97\u2013106. https:\/\/doi.org\/10.1152\/physiolgenomics.00128.2002","journal-title":"Physiol Genomics"},{"key":"1008_CR65","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.2337\/db07-0339","volume":"57","author":"C Toth","year":"2008","unstructured":"Toth C et al (2008) Receptor for advanced glycation end products (RAGEs) and experimental diabetic neuropathy. Diabetes 57:1002\u20131017. https:\/\/doi.org\/10.2337\/db07-0339","journal-title":"Diabetes"},{"key":"1008_CR66","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1111\/j.1471-4159.2008.05233.x","volume":"105","author":"K Tureyen","year":"2008","unstructured":"Tureyen K, Brooks N, Bowen K, Svaren J, Vemuganti R (2008) Transcription factor early growth response-1 induction mediates inflammatory gene expression and brain damage following transient focal ischemia. J Neurochem 105:1313\u20131324. https:\/\/doi.org\/10.1111\/j.1471-4159.2008.05233.x","journal-title":"J Neurochem"},{"key":"1008_CR67","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.jalz.2016.09.004","volume":"13","author":"IF van der Velpen","year":"2017","unstructured":"van der Velpen IF, Feleus S, Bertens AS, Sabayan B (2017) Hemodynamic and serum cardiac markers and risk of cognitive impairment and dementia. Alzheimers Dement 13:441\u2013453. https:\/\/doi.org\/10.1016\/j.jalz.2016.09.004","journal-title":"Alzheimers Dement"},{"key":"1008_CR68","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.aquatox.2004.03.019","volume":"68","author":"KA Vuori","year":"2004","unstructured":"Vuori KA, Soitamo A, Vuorinen PJ, Nikinmaa M (2004) Baltic salmon (Salmo salar) yolk-sac fry mortality is associated with disturbances in the function of hypoxia-inducible transcription factor (HIF-1alpha) and consecutive gene expression. Aquat Toxicol 68:301\u2013313. https:\/\/doi.org\/10.1016\/j.aquatox.2004.03.019","journal-title":"Aquat Toxicol"},{"key":"1008_CR69","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1038\/cr.2013.104","volume":"23","author":"QH Wan","year":"2013","unstructured":"Wan QH et al (2013) Genome analysis and signature discovery for diving and sensory properties of the endangered Chinese alligator. Cell Res 23:1091\u20131105. https:\/\/doi.org\/10.1038\/cr.2013.104","journal-title":"Cell Res"},{"key":"1008_CR70","doi-asserted-by":"publisher","first-page":"29707","DOI":"10.1074\/jbc.M115.688671","volume":"290","author":"C Wang","year":"2015","unstructured":"Wang C, Liu W, Liu Z, Chen L, Liu X, Kuang S (2015) Hypoxia inhibits myogenic differentiation through p53 protein-dependent induction of Bhlhe40 protein. J Biol Chem 290:29707\u201329716. https:\/\/doi.org\/10.1074\/jbc.M115.688671","journal-title":"J Biol Chem"},{"key":"1008_CR71","doi-asserted-by":"crossref","unstructured":"Wang J, Wang Y, Duan Z, Hu WJIL (2020) Hypoxia\u2010induced alterations of transcriptome and chromatin accessibility in HL\u20101 cells","DOI":"10.1002\/iub.2297"},{"key":"1008_CR72","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1021\/es0258327","volume":"37","author":"RS Wu","year":"2003","unstructured":"Wu RS, Zhou BS, Randall DJ, Woo NY, Lam PK (2003) Aquatic hypoxia is an disrupter and impairs fish reproduction. Environ Sci Technol 37:1137\u20131141. https:\/\/doi.org\/10.1021\/es0258327","journal-title":"Environ Sci Technol"},{"key":"1008_CR73","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.gene.2017.10.002","volume":"639","author":"JH Xia","year":"2018","unstructured":"Xia JH, Li HL, Li BJ, Gu XH, Lin HR (2018) Acute hypoxia stress induced abundant differential expression genes and alternative splicing events in heart of tilapia. Gene 639:52\u201361. https:\/\/doi.org\/10.1016\/j.gene.2017.10.002","journal-title":"Gene"},{"key":"1008_CR74","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/s41419-018-0367-6","volume":"9","author":"J Xiang","year":"2018","unstructured":"Xiang J et al (2018) TCF7L2 positively regulates aerobic glycolysis via the EGLN2\/HIF-1alpha axis and indicates prognosis in pancreatic cancer. Cell Death Dis 9:321. https:\/\/doi.org\/10.1038\/s41419-018-0367-6","journal-title":"Cell Death Dis"},{"key":"1008_CR75","doi-asserted-by":"publisher","first-page":"W316","DOI":"10.1093\/nar\/gkr483","volume":"39","author":"C Xie","year":"2011","unstructured":"Xie C et al (2011) KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases. Nucleic Acids Res 39:W316-322. https:\/\/doi.org\/10.1093\/nar\/gkr483","journal-title":"Nucleic Acids Res"},{"key":"1008_CR76","doi-asserted-by":"publisher","first-page":"4002","DOI":"10.3892\/mmr.2015.3199","volume":"11","author":"C Yu","year":"2015","unstructured":"Yu C, Yang SL, Fang X, Jiang JX, Sun CY, Huang T (2015) Hypoxia disrupts the expression levels of circadian rhythm genes in hepatocellular carcinoma. Mol Med Rep 11:4002\u20134008. https:\/\/doi.org\/10.3892\/mmr.2015.3199","journal-title":"Mol Med Rep"},{"key":"1008_CR77","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang L-G, Han Y, He Q-Y (2012) clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16:284\u2013287. https:\/\/doi.org\/10.1089\/omi.2011.0118","journal-title":"OMICS"},{"key":"1008_CR78","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1080\/15592294.2019.1573066","volume":"14","author":"R Zhang","year":"2019","unstructured":"Zhang R et al (2019) EGLN2 DNA methylation and expression interact with HIF1A to affect survival of early-stage NSCLC. Epigenetics 14:118\u2013129. https:\/\/doi.org\/10.1080\/15592294.2019.1573066","journal-title":"Epigenetics"},{"key":"1008_CR79","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1101\/gad.242131.114","volume":"28","author":"X Zheng","year":"2014","unstructured":"Zheng X et al (2014) Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. Genes Dev 28:1429\u20131444. https:\/\/doi.org\/10.1101\/gad.242131.114","journal-title":"Genes Dev"},{"key":"1008_CR80","doi-asserted-by":"publisher","first-page":"549412","DOI":"10.1155\/2015\/549412","volume":"2015","author":"A Zimna","year":"2015","unstructured":"Zimna A, Kurpisz M (2015) Hypoxia-inducible factor-1 in physiological and pathophysiological angiogenesis: applications and therapies. Biomed Res Int 2015:549412. https:\/\/doi.org\/10.1155\/2015\/549412","journal-title":"Biomed Res Int"}],"container-title":["Fish Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10695-021-01008-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10695-021-01008-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10695-021-01008-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T13:20:33Z","timestamp":1632835233000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10695-021-01008-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,30]]},"references-count":80,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["1008"],"URL":"https:\/\/doi.org\/10.1007\/s10695-021-01008-6","relation":{},"ISSN":["0920-1742","1573-5168"],"issn-type":[{"value":"0920-1742","type":"print"},{"value":"1573-5168","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,30]]},"assertion":[{"value":"19 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Animal experiments were approved by the Animal Care and Use committee at Dalian Ocean University. All names in the author list have been involved in various stages of experimentation or writing.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors agreed to submit the paper for publication in the Journal of Fish Physiology and Biochemistry.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}