{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:36:34Z","timestamp":1786980994347,"version":"build-2736575974"},"reference-count":112,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Cukurova University","award":["TSA-2023-16079"],"award-info":[{"award-number":["TSA-2023-16079"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Fish Physiol Biochem"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10695-025-01621-9","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T09:00:56Z","timestamp":1765530056000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The effects of environmentally relevant concentrations of enrofloxacin on growth performance, oxidative stress, and mRNA expression of apoptotic enzymes (caspase-3, caspase-8)\/pro-inflammatory cytokines (IL-1\u03b2, TNF-\u03b2, and IL-6) in gills of Oreochromis niloticus"],"prefix":"10.1007","volume":"51","author":[{"given":"Petek","family":"Piner Benli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Ozdemir Kutahya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cagil","family":"Coskun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgur","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmut Ali","family":"Gokce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Celik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"1621_CR1","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.toxicon.2020.06.001","volume":"184","author":"MM Abdel-Daim","year":"2020","unstructured":"Abdel-Daim MM, Dawood MA, AlKahtane AA, Abdeen A, Abdel-Latif HM, Senousy HH, Aleya L, Alkahtani S (2020) Spirulina platensis mediated the biochemical indices and antioxidative function of Nile tilapia (Oreochromis niloticus) intoxicated with aflatoxin B. Toxicon 184:152\u2013157","journal-title":"Toxicon"},{"key":"1621_CR2","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jobaz.2015.04.001","volume":"72","author":"AA Abdel-Khalek","year":"2015","unstructured":"Abdel-Khalek AA, Kadry MA, Badran SR, Marie M-AS (2015) Comparative toxicity of copper oxide bulk and nano particles in Nile Tilapia; Oreochromis niloticus: biochemical and oxidative stress. J Basic Appl Zool 72:43\u201357","journal-title":"J Basic Appl Zool"},{"key":"1621_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.fsi.2022.06.001","volume":"127","author":"HMR Abdel-Latif","year":"2022","unstructured":"Abdel-Latif HMR, Shukry M, Abd-Elaziz RA (2022) Clinico-pathological findings and expression of inflammatory cytokines, apoptosis, and oxidative stress-related genes draw mechanistic insights in Nile tilapia reared under ammonia-N exposure and Aeromonas hydrophila challenge. Fish Shellfish Immunol 127:1\u201312","journal-title":"Fish Shellfish Immunol"},{"issue":"1-3","key":"1621_CR4","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.ejphar.2012.04.007","volume":"685","author":"AO Abdel-Zaher","year":"2012","unstructured":"Abdel-Zaher AO, Afify AH, Kamel SM, Farghaly HM, El-Osely GM, El-Awaad EA (2012) Involvement of glutamate, oxidative stress and inducible nitric oxide synthase in the convulsant activity of ciprofloxacin in mice. Eur J Pharmacol 685(1\u20133):30\u201337","journal-title":"Eur J Pharmacol"},{"key":"1621_CR5","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/S0076-6879(85)13073-9","volume":"113","author":"ME Anderson","year":"1985","unstructured":"Anderson ME (1985) Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol 113:548\u2013555","journal-title":"Methods Enzymol"},{"key":"1621_CR6","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.chemosphere.2014.06.062","volume":"119","author":"M Andrieu","year":"2015","unstructured":"Andrieu M, Rico A, Phu TM, Huong DTT, Phuong NT, Van den Brink PJ (2015) Ecological risk assessment of the antibiotic enrofloxacin applied to Pangasius catfish farms in the Mekong Delta. Vietnam Chemosphere 119:407\u2013414","journal-title":"Chemosphere"},{"key":"1621_CR7","unstructured":"APHA, AWWA, WEF (1998) Standard methods for the examination of water and wastewater. In: 20th edition, American Public Health Association, American Water Works  Association and Water Environmental Federation, Washington DC, p 1085"},{"issue":"9","key":"1621_CR8","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1080\/10408444.2021.2024496","volume":"51","author":"S Badawy","year":"2021","unstructured":"Badawy S, Yang Y, Liu Y, Marawan MA, Ares I, Martinez MA, Mart\u00ednez-Larra\u00f1aga MR, Wang X, Anad\u00f3n A, Mart\u00ednez M (2021) Toxicity induced by ciprofloxacin and enrofloxacin: oxidative stress and metabolism. Crit Rev Toxicol 51(9):754\u2013787","journal-title":"Crit Rev Toxicol"},{"issue":"8","key":"1621_CR9","first-page":"4046","volume":"56","author":"AE Barnhill","year":"2012","unstructured":"Barnhill AE, Brewer MT, Carlson SA (2012) Adverse effects of antimicrobials via predictable or idiosyncratic inhibition of host mitochondrial components antimicrobial agents and chemotherapy. 56(8 56(8):4046\u20134051","journal-title":"56(8"},{"key":"1621_CR10","first-page":"73","volume":"9","author":"E Baydan","year":"1998","unstructured":"Baydan E, Kurtdede A, Kaya S, B\u00f6rk\u00fc K, Yarsan E, Pekkaya S (1998) Sa\u011fl\u0131kl\u0131 ve piyelonefritisli k\u00f6peklerde enrofloksasinin farmakokineti\u011fi \u00fczerine \u00e7al\u0131\u015fmalar. Y\u00fcz\u00fcnc\u00fc Y\u0131l \u00dcniversitesi Veteriner Fak\u00fcltesi Dergisi 9:73\u201376","journal-title":"Y\u00fcz\u00fcnc\u00fc Y\u0131l \u00dcniversitesi Veteriner Fak\u00fcltesi Dergisi"},{"issue":"3","key":"1621_CR11","first-page":"566","volume":"8","author":"DB Bebo","year":"2020","unstructured":"Bebo DB, Zhu J, Sun SM, Song CY (2020) Effects of antibiotics on the growth, antioxidant capacity, activity of digestive enzymes and serum biochemical indices, liver and intestine morphology of Megalobrama amblycephala fry. Int J Fish Aquat Stud 8(3):566\u2013573","journal-title":"Int J Fish Aquat Stud"},{"key":"1621_CR12","unstructured":"Beutler E (1984) Red cell metabolism: a manual of biochemical methods. Grune and Starton, New York"},{"issue":"4","key":"1621_CR13","doi-asserted-by":"publisher","first-page":"994","DOI":"10.4049\/jimmunol.2000372","volume":"205","author":"F Bottiglione","year":"2020","unstructured":"Bottiglione F, Dee CT, Lea R, Zeef LAH, Badrock AP, Wane M, Bugeon L, Dallman MJ, Allen JE, Hurlstone AFL (2020) Zebrafish IL-4-like cytokines and IL-10 suppress inflammation but only IL-10 is essential for gill homeostasis. J Immunol 205(4):994\u20131008","journal-title":"J Immunol"},{"issue":"9","key":"1621_CR14","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1289\/ehp.1104477","volume":"120","author":"AB Boxall","year":"2012","unstructured":"Boxall AB, Rudd MA, Brooks BW, Caldwell DJ, Choi K, Hickmann S, Innes E, Ostapyk K, Staveley JP, Verslycke T, Ankley GT, Beazley KF, Belanger SE, Berninger JP, Carriquiriborde P, Coors A, Deleo PC, Dyer SD, Ericson JF, Gagn\u00e9 F, Van Der Kraak G (2012) Pharmaceuticals and personal care products in the environment: what are the big questions? Environ Health Perspect 120(9):1221\u20131229","journal-title":"Environ Health Perspect"},{"key":"1621_CR15","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantitites of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"1621_CR16","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/j.ecoenv.2017.12.001","volume":"148","author":"MA Burgos-Aceves","year":"2018","unstructured":"Burgos-Aceves MA, Cohen A, Smith Y, Faggio C (2018) MicroRNAs and their role on fish oxidative stress during xenobiotic environmental exposures. Ecotoxicol Environ Saf 148:995\u20131000","journal-title":"Ecotoxicol Environ Saf"},{"issue":"1-3","key":"1621_CR17","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0048-9697(02)00233-4","volume":"299","author":"ER Campagnolo","year":"2002","unstructured":"Campagnolo ER, Johnson KR, Karpati A, Rubin CS, Kolpin DW, Meyer MT, Esteban JE, Currier RW, Smith K, Thu KM, McGeehin M (2002) Antimicrobial residues in animal waste and water resources proximal to large-scale swine and poultry feding operations. Sci Total Environ 299(1\u20133):89\u201395","journal-title":"Sci Total Environ"},{"key":"1621_CR18","doi-asserted-by":"publisher","first-page":"5475","DOI":"10.1016\/S0021-9258(19)41206-4","volume":"250","author":"I Carlberg","year":"1975","unstructured":"Carlberg I, Mannervik B (1975) Purification and characterization of the flavoenzyme glutathione reductase from rat liver. J Biol Chem 250:5475\u20135480","journal-title":"J Biol Chem"},{"issue":"12","key":"1621_CR19","doi-asserted-by":"publisher","first-page":"2723","DOI":"10.3382\/ps.2011-01525","volume":"90","author":"K Chrzastek","year":"2011","unstructured":"Chrzastek K, Madej JP, Mytnik E, Wieliczko A (2011) The influence of antibiotics on B-cell number, percentage, and distribution in the bursa of Fabricius of newly hatched chicks. Poult Sci 90(12):2723\u20132729","journal-title":"Poult Sci"},{"key":"1621_CR20","doi-asserted-by":"crossref","unstructured":"Company R, Calduch-Giner JA, Kaushik S, ve P\u00e9rez-S\u00e1nchez J (1999) Growth performance and adiposity in gilthead sea bream (Sparus aurata): risks and benefits of high energy diets. Aquaculture 171(3\u20134):279\u2013292","DOI":"10.1016\/S0044-8486(98)00495-5"},{"issue":"5","key":"1621_CR21","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1099\/jmm.0.000475","volume":"66","author":"S Correia","year":"2017","unstructured":"Correia S, Poeta P, H\u00e9braud M, Capelo JL, Igrejas G (2017) Mechanisms of quinolone action and resistance: where do we stand? J Med Microbiol 66(5):551\u2013559","journal-title":"J Med Microbiol"},{"issue":"15-16","key":"1621_CR22","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1016\/j.molimm.2011.05.027","volume":"48","author":"MM Costa","year":"2011","unstructured":"Costa MM, Maehr T, Diaz-Rosales P, Secombes CJ, Wang T (2011) Bioactivity studies of rainbow trout (Oncorhynchus mykiss) interleukin-6: effects on macrophage growth and antimicrobial peptide gene expression. Mol Immunol 48(15\u201316):1903\u20131916","journal-title":"Mol Immunol"},{"issue":"3","key":"1621_CR23","doi-asserted-by":"publisher","first-page":"217","DOI":"10.2175\/106143016X14504669767616","volume":"88","author":"D Danabas","year":"2016","unstructured":"Danabas D, Yildirim NC, Yildirim N, Onal AO, Uslu G, Unlu E, Danabas S, Ergin C, Tayhan N (2016) Cytokine responses in gills of Capoeta umbla as biomarkers of environmental pollution. Water Environ Res 88(3):217\u2013222","journal-title":"Water Environ Res"},{"issue":"1-2","key":"1621_CR24","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/S0891-5849(98)00196-8","volume":"26","author":"LL De Zwart","year":"1999","unstructured":"De Zwart LL, Meerman JH, Commandeur JN, Vermeulen NP (1999) Biomarkers of free radical damage applications in experimental animals and in humans. Free Radic Biol Med 26(1\u20132):202\u2013226","journal-title":"Free Radic Biol Med"},{"key":"1621_CR25","doi-asserted-by":"publisher","first-page":"109398","DOI":"10.1016\/j.cbpc.2022.109398","volume":"259","author":"X Ding","year":"2022","unstructured":"Ding X, Jiang S, Li X, Wang Y, Zheng Z, Qin Y (2022) Cytotoxicity and apoptosis induced by enrofloxacin in loach fin cells in vitro\u201d. Comp Biochem Physiol Toxicol Pharmacol 259:109398","journal-title":"Comp Biochem Physiol Toxicol Pharmacol"},{"key":"1621_CR26","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.ecoenv.2013.07.015","volume":"97","author":"E Domenico","year":"2013","unstructured":"Domenico E, Mauceri A, Giordano D, Maisano M, Giannetto A, Parrino V, Natalotto A, D\u2019Agata A, Cappello T, Fasulo S (2013) Biological responses of juvenile European sea bass (Dicentrarchus labrax) exposed to contaminated sediments. Ecotoxicol Environ Saf 97:114\u2013123","journal-title":"Ecotoxicol Environ Saf"},{"key":"1621_CR27","unstructured":"El-Sayed A-FM (2020) Tilapia culture. 2nd edn. Academic Press (Elsevier), Cambridge, p 358"},{"key":"1621_CR28","doi-asserted-by":"crossref","unstructured":"Evans DH, Piermarini PM, Choe KP (2005) The multifunctional fish gill: dominant site of gas exchange, osmoregulation, acid-base regulation, and excretion of nitrogenous waste. Physiol Rev 85:97\u201317","DOI":"10.1152\/physrev.00050.2003"},{"key":"1621_CR29","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.scitotenv.2018.04.264","volume":"613","author":"C Faggio","year":"2018","unstructured":"Faggio C, Tsarpali V, Dailianis S (2018) Mussel digestive gland as a model for assessing xenobiotics: an overview. Science and Total Environment 613:220\u2013229","journal-title":"Science and Total Environment"},{"issue":"2","key":"1621_CR30","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.aquatox.2005.09.009","volume":"76","author":"K Fent","year":"2006","unstructured":"Fent K, Weston AA, Caminada D (2006) Ecotoxicology of human pharmaceuticals. Aquat Toxicol 76(2):122\u2013159","journal-title":"Aquat Toxicol"},{"issue":"2-3","key":"1621_CR31","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.scitotenv.2008.02.021","volume":"402","author":"MJ Focazio","year":"2008","unstructured":"Focazio MJ, Kolpin DW, Barnes KK, Furlong ET, Meyer MT, Zaugg SD, Barber LB, Thurman ME (2008) A national reconnaissance for pharmaceuticals and other organic wastewater contaminants in the United States--II) untreated drinking water sources. Sci Total Environ 402(2\u20133):201\u2013216","journal-title":"Sci Total Environ"},{"key":"1621_CR32","doi-asserted-by":"crossref","unstructured":"Frommeyer G, Eckardt L (2016) Drug-induced proarrhythmia: risk factors and electrophysiological mechanisms. Nat Rev Cardiol 13(1):36\u201347","DOI":"10.1038\/nrcardio.2015.110"},{"key":"1621_CR33","unstructured":"Fulton T (1902) Rate of growth of sea fish. In: 20th annual report of the fishery board for Scotland, London"},{"key":"1621_CR34","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1111\/are.12340","volume":"46","author":"MP Gaikowski","year":"2015","unstructured":"Gaikowski MP, Whitsel MK, Charles S, Schleis SM, Crouch LS, Endris RG (2015) Depletion of florfenicol amine in tilapia (Oreochromis sp.) maintained in a recirculating aquaculture system following Aquaflor-medicated feed therapy. Aquac Res 46:1842\u20131857","journal-title":"Aquac Res"},{"key":"1621_CR35","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1039\/c2em10916f","volume":"14","author":"L Gao","year":"2012","unstructured":"Gao L, Shi Y, Li W, Liu J, Cai Y (2012) Occurrence, distribution and bioaccumulation of antibiotics in the Haihe River in China. J Environ Monit 14:1248\u20131255","journal-title":"J Environ Monit"},{"issue":"5","key":"1621_CR36","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.dci.2003.09.008","volume":"28","author":"FW Goetz","year":"2004","unstructured":"Goetz FW, Planas JV, MacKenzie S (2004) Tumor necrosis factors. Dev Comp Immunol 28(5):487\u2013497","journal-title":"Dev Comp Immunol"},{"key":"1621_CR37","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.chemosphere.2014.03.132","volume":"111","author":"O Golovko","year":"2014","unstructured":"Golovko O, Kumar V, Fedorova\u00fc G, Randak T, Grabic R (2014) Seasonal changes in antibiotics, antidepressants\/psychiatric drugs, antihistamines and lipid regulators in a wastewater treatment plant. Chemosphere 111:418\u2013426","journal-title":"Chemosphere"},{"key":"1621_CR38","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","volume":"249","author":"WH Habig","year":"1974","unstructured":"Habig WH, Pabst MJ, Jakoby WB (1974) Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130\u20137139","journal-title":"J Biol Chem"},{"issue":"5","key":"1621_CR39","doi-asserted-by":"publisher","first-page":"374","DOI":"10.3109\/15376516.2015.1026008","volume":"25","author":"S Ilgin","year":"2015","unstructured":"Ilgin S, Can OD, Atli O, Ucel UI, Sener E, Guven I (2015) Ciprofloxacin induced neurotoxicity: evaluation of possible underlying mechanisms. Toxicol Mech Methods 25(5):374\u2013381","journal-title":"Toxicol Mech Methods"},{"key":"1621_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/00207459109150342","volume":"57","author":"JA Jesberger","year":"1991","unstructured":"Jesberger JA, Richardson JS (1991) Oxygen free radicals and brain dysfunction. Int J Neurosci 57:1\u201317","journal-title":"Int J Neurosci"},{"key":"1621_CR41","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/j.chemosphere.2010.11.028","volume":"82","author":"L Jiang","year":"2011","unstructured":"Jiang L, Hu X, Yin D, Zhang H, Yu Z (2011) Occurrence, distribution and seasonal variation of antibiotics in the Huangpu River, Shanghai, China. Chemosphere 82:822\u2013828","journal-title":"Chemosphere"},{"key":"1621_CR42","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.chemosphere.2014.04.075","volume":"112","author":"Y Jiang","year":"2014","unstructured":"Jiang Y, Li M, Guo C, An D, Xu J, Zhang Y, Xi B (2014) Distribution and ecological risk of antibiotics in a typical effluentreceiving river (Wangyang River) in north China. Chemosphere 112:267\u2013274","journal-title":"Chemosphere"},{"key":"1621_CR43","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.fsi.2018.08.060","volume":"86","author":"W Jiao","year":"2019","unstructured":"Jiao W, Han Q, Xu Y, Jiang H, Xing H, Teng X (2019) Impaired immune function and structural integrity in the gills of common carp (Cyprinus carpio L.) caused by chlorpyrifos exposure: through oxidative stress and apoptosis. Fish Shellfish Immunol 86:239\u2013245","journal-title":"Fish Shellfish Immunol"},{"issue":"7","key":"1621_CR44","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1046\/j.1365-2109.2003.00859.x","volume":"34","author":"M Jobling","year":"2003","unstructured":"Jobling M (2003) The thermal growth coefficient (TGC) model of fish growth: a cautionary note. Aquac Res 34(7):581\u2013584","journal-title":"Aquac Res"},{"key":"1621_CR45","doi-asserted-by":"publisher","first-page":"235e274","DOI":"10.1517\/14740338.2012.644272","volume":"11","author":"S Kar","year":"2012","unstructured":"Kar S, Roy K (2012) Risk assessment for ecotoxicity of pharmaceuticals \u2013 an emerging issue. Expert Opin Drug Saf 11:235e274","journal-title":"Expert Opin Drug Saf"},{"key":"1621_CR46","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.scitotenv.2004.01.015","volume":"328","author":"DW Kolpin","year":"2004","unstructured":"Kolpin DW, Skopec M, Meyer MT, Furlong ET, Zaugg SD (2004) Urban contribution of pharmaceuticals and other organic wastewater contaminants to streams during differing flow conditions. Sci Total Environ 328:119\u2013130","journal-title":"Sci Total Environ"},{"issue":"1","key":"1621_CR47","first-page":"201","volume":"24","author":"AY Korkut","year":"2007","unstructured":"Korkut AY, Aysun K, Demirta\u015f N, Cihaner A (2007) Bal\u0131k Beslemede Geli\u015fim Performans\u0131n\u0131n \u0130zlenme Y\u00f6ntemleri. Ege J Fish Aquat Sci 24(1):201\u2013205","journal-title":"Ege J Fish Aquat Sci"},{"key":"1621_CR48","doi-asserted-by":"publisher","first-page":"126351","DOI":"10.1016\/j.chemosphere.2020.126351","volume":"251","author":"P Kovalakova","year":"2020","unstructured":"Kovalakova P, Cizmas L, McDonald TJ, Marsalek B, Feng M, Sharma VK (2020) Occurrence and toxicity of antibiotics in the aquatic environment: a review. Chemosphere 251:126351","journal-title":"Chemosphere"},{"key":"1621_CR49","doi-asserted-by":"publisher","first-page":"448e461","DOI":"10.1016\/j.envint.2018.12.065","volume":"124","author":"M Kumar","year":"2019","unstructured":"Kumar M, Jaiswal S, Sodhi KK, Shree P, Singh DK, Agrawal PK, Shukla P (2019) Antibiotics bioremediation: perspectives on its ecotoxicity and resistance. Environ Int 124:448e461","journal-title":"Environ Int"},{"key":"1621_CR50","doi-asserted-by":"publisher","DOI":"10.3109\/03009734.2014.896438","volume":"119","author":"DGJ Larsson","year":"2014","unstructured":"Larsson DGJ (2014) Antibiotics in the environment. Ups J Med Sci 119:108e112","journal-title":"Ups J Med Sci"},{"key":"1621_CR51","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.jhazmat.2007.07.008","volume":"148","author":"DGJ Larsson","year":"2007","unstructured":"Larsson DGJ, de Pedro C, Paxeus N (2007) \u201cEffluent from drug manufactures contains extremely high levels of pharmaceuticals. J Hazard Mater 148:751\u2013755","journal-title":"J Hazard Mater"},{"key":"1621_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2020.103884","volume":"115","author":"K Li","year":"2021","unstructured":"Li K, Qiu H, Yan J, Shen X, Wei X, Duan M, Yang J (2021) The involvement of TNF-\u03b1 and TNF-\u03b2 as proinflammatory cytokines in lymphocyte-mediated adaptive immunity of Nile tilapia by initiating apoptosis. Dev Comp Immunol 115:103884","journal-title":"Dev Comp Immunol"},{"issue":"3","key":"1621_CR53","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s11259-007-9024-8","volume":"32","author":"S Lim","year":"2008","unstructured":"Lim S, Hossain MA, Park J, Choi SH, Kim G (2008) The effects of enrofloxacin on canine tendon cells and chondrocytes proliferation in vitro. Vet Res Commun 32(3):243\u2013253","journal-title":"Vet Res Commun"},{"key":"1621_CR54","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.envint.2018.03.034","volume":"115","author":"SM Limbu","year":"2018","unstructured":"Limbu SM, Zhou L, Sun S-X, Zhang M-L, Du Z-Y (2018) \u201cChronic exposure to low environmental concentrations and legal aquaculture doses of antibiotics cause systemic adverse effects in Nile tilapia and provoke differential human health risk. Environ Int 115:205\u2013219","journal-title":"Environ Int"},{"key":"1621_CR55","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.scitotenv.2019.05.067","volume":"680","author":"SM Limbu","year":"2019","unstructured":"Limbu SM, Ma Q, Zhang M-L, Du Z-Y (2019) High fat diet worsens the adverse effects of antibiotic on intestinal health in juvenile Nile tilapia (Oreochromis niloticus). Sci Total Environ 680:169\u2013180","journal-title":"Sci Total Environ"},{"key":"1621_CR56","doi-asserted-by":"publisher","first-page":"113508","DOI":"10.1016\/j.envpol.2019.113508","volume":"256","author":"SM Limbu","year":"2020","unstructured":"Limbu SM, Zhang H, Luo Y, Chen L-Q, Zhang M, Du Z-Y (2020) High carbohydrate diet partially protects Nile tilapia (Oreochromis niloticus) from oxytetracycline-induced side effects. Environ Pollut 256:113508","journal-title":"Environ Pollut"},{"issue":"2","key":"1621_CR57","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1111\/raq.12511","volume":"13","author":"SM Limbu","year":"2021","unstructured":"Limbu SM, Chen LQ, Zhang ML, Du ZY (2021) A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review. Rev Aquacult 13(2):1015\u20131059","journal-title":"Rev Aquacult"},{"issue":"2","key":"1621_CR58","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.fsi.2015.10.007","volume":"47","author":"B Liu","year":"2015","unstructured":"Liu B, Cui Y, Brown PB, Ge X, Xie J, Xu P (2015) Cytotoxic effects and apoptosis induction of enrofloxacin in hepatic cell line of grass carp (Ctenopharyngodon idellus). Fish Shellfish Immunol 47(2):639\u2013644","journal-title":"Fish Shellfish Immunol"},{"key":"1621_CR59","doi-asserted-by":"publisher","first-page":"140751","DOI":"10.1016\/j.chemosphere.2023.140751","volume":"348","author":"C Liu","year":"2024","unstructured":"Liu C, Pan K, Xu H, Song Y, Qi X, Lu Y, Jiang X, Liu H (2024) The effects of enrofloxacin exposure on responses to oxidative stress, intestinal structure and intestinal microbiome community of largemouth bass (Micropterus salmoides). Chemosphere 348:140751","journal-title":"Chemosphere"},{"issue":"4","key":"1621_CR60","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25(4):402\u2013408","journal-title":"Methods"},{"key":"1621_CR61","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.3390\/antibiotics11111461","volume":"11","author":"Z Maghsodian","year":"2022","unstructured":"Maghsodian Z, Sanati AM, Mashifana T, Sillanp\u00e4\u00e4 M, Feng S, Nhat T, Ramavandi B (2022) Occurrence and distribution of antibiotics in the water, sediment, and biota of freshwater and marine environments: a review. Antibiotics 11:1461","journal-title":"Antibiotics"},{"issue":"1","key":"1621_CR62","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.tvjl.2005.07.010","volume":"172","author":"M Martinez","year":"2006","unstructured":"Martinez M, McDermott P, Walker R (2006) Pharmacology of the fluoroquinolones: a perspective for the use in domestic animals. Vet J 172(1):10\u201328","journal-title":"Vet J"},{"key":"1621_CR63","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1007\/s10646-012-0871-x","volume":"21","author":"N Martins","year":"2012","unstructured":"Martins N, Pereira R, Abrantes N, Pereira J, Goncalves F, Marques CR (2012) Ecotoxicological effects of ciprofloxacin on freshwater species: data integration and derivation of toxicity thresholds for risk assessment. Ecotoxicol 21:1167\u20131176","journal-title":"Ecotoxicol"},{"key":"1621_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/8023935","volume":"2017","author":"K Michalak","year":"2017","unstructured":"Michalak K, Sobolewska-W\u0142odarczyk A, W\u0142odarczyk M, Sobolewska J, Wo\u017aniak P, Sobolewski B (2017) \u201cTreatment of the fluoroquinolone-associated disability: the pathobiochemical implications. Oxid Med Cell Longev 2017:1\u201315","journal-title":"Oxid Med Cell Longev"},{"key":"1621_CR65","first-page":"4992e5001","volume":"23","author":"L Minguez","year":"2016","unstructured":"Minguez L, Pedelucq J, Farcy E, Ballandonne C, Budzinski H, HalmLemeille MP (2016) Toxicities of 48 pharmaceuticals and their freshwater and marine environmental assessment in northwestern France. Environ Sci Pollut Control 23:4992e5001","journal-title":"Environ Sci Pollut Control"},{"issue":"3","key":"1621_CR66","doi-asserted-by":"publisher","first-page":"835","DOI":"10.2166\/wst.2018.255","volume":"2017","author":"B Nunes","year":"2018","unstructured":"Nunes B, Leal C, Rodrigues S, Antunes SC (2018) Assessment of ecotoxicological effects of ciprofloxacin in Daphnia magna: life-history traits, biochemical and genotoxic effects. Water Sci Technol 2017(3):835\u2013844","journal-title":"Water Sci Technol"},{"key":"1621_CR67","first-page":"5815","volume":"60","author":"K Ochs","year":"2000","unstructured":"Ochs K, Kaina B (2000) Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9\/3 regulated and Fas\/caspase-8 independent. Cancer Res 60:5815\u20135824","journal-title":"Cancer Res"},{"key":"1621_CR68","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1007\/s10646-008-0209-x","volume":"17","author":"S Park","year":"2008","unstructured":"Park S, Choi K (2008) Hazard assessment of commonly used agricultural antibiotics on aquatic ecosystem. Ecotoxicol 17:526\u2013538","journal-title":"Ecotoxicol"},{"key":"1621_CR69","doi-asserted-by":"publisher","first-page":"23371","DOI":"10.1007\/s11356-017-9849-9","volume":"24","author":"A Parpounas","year":"2017","unstructured":"Parpounas A, Litskas V, Hapeshi E, Michael C, FattaKassinos D (2017) Assessing the presence of enrofloxacin and ciprofloxacin in piggery wastewater and their adsorption behaviour onto solid materials, with a newly developed chromatographic method. Environ Sci Pollut Res 24:23371\u201323381","journal-title":"Environ Sci Pollut Res"},{"key":"1621_CR70","doi-asserted-by":"publisher","first-page":"2924","DOI":"10.1002\/jssc.200700363","volume":"30","author":"A Pena","year":"2007","unstructured":"Pena A, Chmielova D, Lino CM, Solich P (2007) Determination of fluoroquinolone antibiotics in surface waters from Mondego River by high performance liquid chromatography using a monolithic column. J Sep Sci 30:2924\u20132928","journal-title":"J Sep Sci"},{"issue":"3","key":"1621_CR71","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1080\/01480545.2016.1223093","volume":"40","author":"M Pomorska-M\u00f3l","year":"2017","unstructured":"Pomorska-M\u00f3l M, Czy\u017cewska-Dors E, Kwit K, Pejsak Z (2017) Enrofloxacin in therapeutic doses alters cytokine production by porcine PBMCs induced by lipopolysaccharide. Drug Chem Toxicol 40(3):295\u2013299","journal-title":"Drug Chem Toxicol"},{"key":"1621_CR72","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.jhazmat.2013.03.006","volume":"252\u2013253","author":"P Qin","year":"2013","unstructured":"Qin P, Liu R (2013) Oxidative stress response of two fluoroquinolones with catalase and erythrocytes: a combined molecular and cellular study. J Hazard Mater 252\u2013253:321\u2013329","journal-title":"J Hazard Mater"},{"key":"1621_CR73","doi-asserted-by":"crossref","unstructured":"Qiu W, Liu T, Liu X, Chen H, Luo S, Chen Q, Magnuson JT, Zheng C, Xu EG, Schlenk D (2022) Enrofloxacin induces intestinal microbiota-mediated immunosuppression in zebrafish. Environ Sci Technol 56(12):8428\u20138437","DOI":"10.1021\/acs.est.1c08712"},{"key":"1621_CR74","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.12659\/AJCR.911393","volume":"19","author":"M Radovanovic","year":"2018","unstructured":"Radovanovic M, Dushenkovska T, Cvorovic I, Radovanovic N, Ramasamy V, Milosavljevic K, Surla J, Jecmenica M, Radulovic M, Milovanovic T, Dumic I (2018) Idiosyncratic drug-\u0131nduced liver \u0131njury due to ciprofloxacin: a report of two cases and review of the literature. Am J Case Rep 19:1152\u20131161","journal-title":"Am J Case Rep"},{"issue":"1","key":"1621_CR75","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.imlet.2012.08.003","volume":"148","author":"PR Rauta","year":"2012","unstructured":"Rauta PR, Nayak B, Das S (2012) Immune system and immune responses in fish and their role in comparative immunity study: a model for higher organisms. Immunol Lett 148(1):23\u201333","journal-title":"Immunol Lett"},{"issue":"4","key":"1621_CR76","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1007\/s001289900896","volume":"62","author":"S Rebach","year":"1999","unstructured":"Rebach S (1999) Acute toxicity of permethrin\/piperonyl butoxide on hybrid striped bass. Bull Environ Contam Toxicol 62(4):448\u2013454","journal-title":"Bull Environ Contam Toxicol"},{"key":"1621_CR77","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.ejar.2013.12.001","volume":"39","author":"RM Reda","year":"2013","unstructured":"Reda RM, Ibrahim RE, Ahmed E-NG, El-Bouhy ZM (2013) \u201cEffect of oxytetracycline and florfenicol as growth promoters on the health status of cultured Oreochromis niloticus. Egypt J Aquat Res 39:241\u2013248","journal-title":"Egypt J Aquat Res"},{"key":"1621_CR78","unstructured":"Reed DJ (2000) Mechanisms of chemically induced cell injury and cellular protection. In: Hodgson E, Smart RC (eds), Introduction to Biochemical Toxicology. Wiley and Sons Inc., USA, pp 15\u201346."},{"key":"1621_CR79","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.envpol.2007.05.033","volume":"152","author":"F Reinstorf","year":"2008","unstructured":"Reinstorf F, Strauch G, Schirmer K, Gl\u00e4ser HR, M\u00f6der M, Wennrich R, Osenbr\u00fcck K, Schirmer M (2008) Mass fluxes and spatial trends of xenobiotics in the waters of the city of Halle, Germany. Environ Pollut 152:452\u2013460","journal-title":"Environ Pollut"},{"issue":"2","key":"1621_CR80","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.fsi.2011.11.018","volume":"32","author":"S Reyes-Cerpa","year":"2012","unstructured":"Reyes-Cerpa S, Reyes-L\u00f3pez FE, Toro-Ascuy D, Iba\u00f1ez J, Maisey K, Sandino AM, Imarai M (2012) IPNV modulation of pro and anti-inflammatory cytokine expression in Atlantic salmon might help the establishment of infection and persistence. Fish & Shellfish Immunology 32(2):291\u2013300","journal-title":"Fish & Shellfish Immunology"},{"key":"1621_CR81","doi-asserted-by":"crossref","unstructured":"Santinha PJM, Medale F, Corraze G, ve Gomes EFS (1999) Effects of the dietary protein: lipid ratio on growth and nutrient utilization in gilthead seabream (Sparus aurata L.).  Aquac Nutr 5(3):147\u2013156","DOI":"10.1046\/j.1365-2095.1999.00107.x"},{"key":"1621_CR82","first-page":"8","volume":"5","author":"BE Scully","year":"1990","unstructured":"Scully BE (1990) Pharmacology of the fluoroquinolones. Urology 5:8\u201310","journal-title":"Urology"},{"key":"1621_CR83","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.scitotenv.2018.03.076","volume":"631","author":"P Sehonova","year":"2018","unstructured":"Sehonova P, Svobodova Z, Dolezelova P, Vosmerova P, Faggio C (2018) Effects of waterborne antidepressants on non-target animals living in the aquatic environment: a review. Sci Total Environ 631:789\u2013794","journal-title":"Sci Total Environ"},{"key":"1621_CR84","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.etap.2019.02.002","volume":"67","author":"P Sehonova","year":"2019","unstructured":"Sehonova P, Tokanova N, Hodkovicova N, Kocour Kroupova H, Tumova J, Blahova J, Marsalek P, Plhalova L, Doubkova V, Dobsikova R, Chloupek P, Dolezalova P, Faldyna M, Svobodova Z, Faggio C (2019) Oxidative stress induced by fluoroquinolone enrofloxacin in zebrafish (Danio rerio) can be ameliorated after a prolonged exposure. Environ Toxicol Pharmacol 67:87\u201393","journal-title":"Environ Toxicol Pharmacol"},{"issue":"8","key":"1621_CR85","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1110\/ps.04789804","volume":"13","author":"Y Shi","year":"2004","unstructured":"Shi Y (2004) Caspase activation, inhibition, and reactivation: a mechanistic view. Protein Sci 13(8):1979\u20131987","journal-title":"Protein Sci"},{"issue":"3","key":"1621_CR86","doi-asserted-by":"publisher","DOI":"10.1016\/j.jece.2023.110168","volume":"11","author":"F Shi","year":"2023","unstructured":"Shi F, Yao M, Huang Y, Chen Z, Xiao J, Zhan F, Li Y, Lin Li, Qin Z (2023) Effects of antibiotics on immunity and apoptosis on grass carp liver and hepatocytes. J Environ Chem Eng 11(3):110168","journal-title":"J Environ Chem Eng"},{"key":"1621_CR87","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.chemosphere.2016.07.009","volume":"161","author":"C Song","year":"2016","unstructured":"Song C, Zhang C, Fan L, Qiu L, Wu W, Meng S, Hu G, Kamira B, Chen J (2016) Occurrence of antibiotics and their impacts to primary productivity in fishponds around Tai Lake, China. Chemosphere 161:127\u2013135","journal-title":"Chemosphere"},{"issue":"1","key":"1621_CR88","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jaci.2016.11.052","volume":"140","author":"A Strzepa","year":"2017","unstructured":"Strzepa A, Majewska-Szczepanik M, Lobo FM, Wen L, Szczepanik M (2017) Broad spectrum antibiotic enrofloxacin modulates contact sensitivity through gut microbiota in a murine model. J Allergy Clin Immunol 140(1):121-133.e3","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"1621_CR89","doi-asserted-by":"publisher","first-page":"337","DOI":"10.5455\/vetworld.2013.337-342","volume":"6","author":"V Sureshkumar","year":"2013","unstructured":"Sureshkumar V, Sarathchandra G, Ramesh J (2013) Effect of enrofloxacin on zootechnical performance, behaviour and immunohistopathological response in broiler chicken. Vet World 6(6):337\u2013342","journal-title":"Vet World"},{"key":"1621_CR90","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.scitotenv.2007.12.009","volume":"393","author":"F Tamtam","year":"2008","unstructured":"Tamtam F, Mercier F, Le Bot B, Eurin J, Tuc Dinh Q, Cl\u00e9ment M, Chevreuil M (2008) Occurrence and fate of antibiotics in the seine river in various hydrological conditions. Sci Total Environ 393:84\u201395","journal-title":"Sci Total Environ"},{"key":"1621_CR91","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1002\/etc.4532","volume":"38","author":"CM Teglia","year":"2019","unstructured":"Teglia CM, Perez FA, Michlig N, Repetti MR, Goicoechea HC, Culzoni MJ (2019) Occurrence, distribution, and ecological risk of fluoroquinolones in rivers and wastewaters. Environ Toxicol Chem 38:2305\u20132313","journal-title":"Environ Toxicol Chem"},{"issue":"3\u20134","key":"1621_CR92","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.aquaculture.2011.02.016","volume":"315","author":"GM Turchini","year":"2011","unstructured":"Turchini GM, Francis DS, Senadheera S, Thanuthong T, ve De Silva SS (2011) Fish oil replacement with different vegetable oils in Murray cod: 143 evidence of an \u2018omega-3 sparing effect\u2019 by other dietary fatty acids. Aquaculture 315(3\u20134):250\u2013259","journal-title":"Aquaculture"},{"key":"1621_CR93","doi-asserted-by":"crossref","unstructured":"Van Boeckel TP, Brower C, Gilbert M, Grenfell BT, Levin SA, Robinson TP, Teillant A, Laxminarayan R (2015) Global trends in antimicrobial use in food animals. Proc Natl Acad Sci USA 112:5649e5654","DOI":"10.1073\/pnas.1503141112"},{"key":"1621_CR94","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.ecoenv.2018.11.060","volume":"169","author":"M Varol","year":"2019","unstructured":"Varol M, S\u00fcnb\u00fcl MR (2019) Environmental contaminants in fish species from a large dam reservoir and their potential risks to human health. Ecotoxicol Environ Saf 169:507\u2013515","journal-title":"Ecotoxicol Environ Saf"},{"issue":"8","key":"1621_CR95","doi-asserted-by":"publisher","first-page":"888","DOI":"10.3390\/antibiotics10080888","volume":"10","author":"P Viana","year":"2021","unstructured":"Viana P, Meisel L, Lopes A, de Jesus R, Sarmento G, Duarte S, Sepodes B, Fernandes A, Dos Santos MMC, Almeida A, Oliveira MC (2021) Identification of antibiotics in surface-groundwater. A tool towards the ecopharmacovigilance approach: a Portuguese case-study. Antibiotics (Basel) 10(8):888","journal-title":"Antibiotics (Basel)"},{"key":"1621_CR96","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.scitotenv.2014.06.082","volume":"493","author":"M Wagil","year":"2014","unstructured":"Wagil M, Kumirska J, Stolte S, Puckowski A, Maszkowska J, Stepnowski P, Bia\u0142k-Bieli\u0144ska A (2014) Development of sensitive and reliable LC-MS\/MS methods for the determination of three fluoroquinolones in water and fish tissue samples and preliminary environmental risk assessment of their presence in two rivers in northern Poland. Sci Total Environ 493:1006\u20131013","journal-title":"Sci Total Environ"},{"issue":"11\u201312","key":"1621_CR97","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1016\/j.molimm.2009.04.003","volume":"46","author":"T Wang","year":"2009","unstructured":"Wang T, Secombes CJ (2009) Identification and expression analysis of two fish-specific IL-6 cytokine family members, the ciliary neurotrophic factor (CNTF)-like and M17 genes, in rainbow trout Oncorhynchus mykiss. Mol Immunol 46(11\u201312):2290\u20132298","journal-title":"Mol Immunol"},{"issue":"6","key":"1621_CR98","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1016\/j.fsi.2013.08.030","volume":"35","author":"T Wang","year":"2013","unstructured":"Wang T, Secombes CJ (2013) The cytokine networks of adaptive immunity in fish. Fish Shellfish Immunol 35(6):1703\u20131718","journal-title":"Fish Shellfish Immunol"},{"issue":"11","key":"1621_CR99","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/j.chemosphere.2009.09.038","volume":"77","author":"N Wang","year":"2009","unstructured":"Wang N, Nkejabega N, Hien NN, Huynh TT, Silvestre F, Phuong NT, Danyi S, Widart J, Douny C, Scippo ML, Kestemont P, Huong DT (2009) Adverse effects of enrofloxacin when associated with environmental stress in Tra catfish (Pangasianodon hypophthalmus). Chemosphere 77(11):1577\u20131584","journal-title":"Chemosphere"},{"issue":"7","key":"1621_CR100","doi-asserted-by":"publisher","first-page":"2350","DOI":"10.1016\/j.envpol.2010.03.019","volume":"158","author":"QJ Wang","year":"2010","unstructured":"Wang QJ, Mo CH, Li YW, Gao P, Tai YP, Zhang Y, Ruan ZL, Xu JW (2010) Determination of four fluoroquinolone antibiotics in tap water in Guangzhou and Macao. Environ Pollut 158(7):2350\u20132358","journal-title":"Environ Pollut"},{"issue":"10","key":"1621_CR101","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1002\/tox.21843","volume":"29","author":"H Wang","year":"2014","unstructured":"Wang H, Che B, Duan A, Mao J, Dahlgren RA, Zhang M, Zhang H, Zeng A, Wang X (2014) Toxicity evaluation of -diketone antibiotics on the development of embryo-larval zebrafish (Danio rerio). Environ Toxicol 29(10):1134\u20131146","journal-title":"Environ Toxicol"},{"key":"1621_CR102","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1016\/j.scitotenv.2008.11.059","volume":"407","author":"AJ Watkinson","year":"2009","unstructured":"Watkinson AJ, Murby EJ, Kolpin DW, Costanzo SD (2009) The occurrence of antibiotics in an urban watershed: from wastewater to drinking water. Sci Total Environ 407:2711\u20132723","journal-title":"Sci Total Environ"},{"issue":"5","key":"1621_CR103","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.2134\/jeq2012.0014","volume":"41","author":"R Wei","year":"2012","unstructured":"Wei R, Ge F, Chen M, Wang R (2012) Occurrence of ciprofloxacin, enrofloxacin, and florfenicol in animal wastewater and water resources. J Environ Qual 41(5):1481\u20131486","journal-title":"J Environ Qual"},{"key":"1621_CR104","doi-asserted-by":"publisher","DOI":"10.1042\/bj0990667","author":"ED Wills","year":"1966","unstructured":"Wills ED (1966) Mechanisms of lipid peroxide formation in animal tissues. Biochem J. https:\/\/doi.org\/10.1042\/bj0990667","journal-title":"Biochem J"},{"issue":"2","key":"1621_CR105","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s00248-015-0583-x","volume":"70","author":"W Xiong","year":"2015","unstructured":"Xiong W, Sun Y, Zhang T, Ding X, Li Y, Wang M, Zeng Z (2015) Antibiotics, antibiotic resistance genes, and bacterial community composition in fresh water aquaculture environment in China. Microb Ecol 70(2):425\u2013432","journal-title":"Microb Ecol"},{"key":"1621_CR106","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.scitotenv.2014.07.114","volume":"497\u2013498","author":"J Xu","year":"2014","unstructured":"Xu J, Zhang Y, Zhou C, Guo C, Wang D, Du P, Luo Y, Wan J, Meng W (2014) Distribution, sources and composition of antibiotics in sediment, overlying water and pore water from Taihu Lake China. Sci Total Environment 497\u2013498:267\u2013273","journal-title":"Sci Total Environment"},{"key":"1621_CR107","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2021.737541","volume":"547","author":"Y-H Xu","year":"2022","unstructured":"Xu Y-H, Wei X-L, Xu Y-C, Zhang D-G, Zhao T, Zheng H, Luo Z (2022) Waterborne enrofloxacin exposure activated oxidative stress and MAPK pathway, induced apoptosis and resulted in immune dysfunction in the gills of yellow catfish Pelteobagrus fulvidraco. Aquaculture 547:73754","journal-title":"Aquaculture"},{"key":"1621_CR108","unstructured":"Y\u0131lmaz O (2022) The effects of groundnut cake used partially instead of fish meal on development, nutritional profile and some physiological parameters in Nil Tilapias (Oreochromis niloticus, Linnaeus 1758) PhD Thesis. Cukurova University"},{"key":"1621_CR109","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.rvsc.2017.08.005","volume":"113","author":"A Zaccaroni","year":"2017","unstructured":"Zaccaroni A, Perez-Lopez M, de la Casa Resino I, Medri G, Ceneri F, Bertini S, Mordenti O, Cortinovis L, Sirri R, Mandrioli L (2017) Short communication: alteration in blood parameters by enrofloxacin in juvenile lesser spotted dogfish (Scyliorhinus canicula, Linnaeus, 1758) after intramuscular injection. Res Vet Sci 113:1\u20134","journal-title":"Res Vet Sci"},{"key":"1621_CR110","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.ecoenv.2018.11.042","volume":"169","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Wang L, Zhuang H, Li XX, Gao XJ, An ZH, Liu XD, Yang H, Wei WZ, Wei XJ (2019) Zhang excessive use of enrofloxacin leads to growth inhibition of juvenile giant freshwater prawn Macrobrachium rosenbergii. Ecotoxicolol Environ Safety 169:344\u2013352","journal-title":"Ecotoxicolol Environ Safety"},{"key":"1621_CR111","doi-asserted-by":"crossref","unstructured":"Zhao RX, Feng J, Liu J, Fu WJ, Li XY, Li B (2019) Deciphering of microbial community and antibiotic resistance genes in activated sludge reactors under high selective pressure of different antibiotics. Water Res 151:388e402","DOI":"10.1016\/j.watres.2018.12.034"},{"issue":"2","key":"1621_CR112","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3390\/biology5020023","volume":"5","author":"J Zou","year":"2016","unstructured":"Zou J, Secombes CJ (2016) The function of fish cytokines. Biology 5(2):23","journal-title":"Biology"}],"container-title":["Fish Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10695-025-01621-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10695-025-01621-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10695-025-01621-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:02:09Z","timestamp":1767175329000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10695-025-01621-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":112,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1621"],"URL":"https:\/\/doi.org\/10.1007\/s10695-025-01621-9","relation":{},"ISSN":["0920-1742","1573-5168"],"issn-type":[{"value":"0920-1742","type":"print"},{"value":"1573-5168","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"13 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments were carried out under the ethical guidelines and protocols approved by the Ethics Committee of the \u00c7ukurova University Faculty of Medicine Experimental Medicine Research and Application Center (approval code, 8; approval date, 27.03.2023).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors consented to the publication of this research article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"203"}}