{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:38:19Z","timestamp":1786981099895,"version":"build-2736575974"},"reference-count":119,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Fish Physiol Biochem"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10695-025-01627-3","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:11:22Z","timestamp":1766398282000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Remediation of hypoxia induced brain alteration with pyrimidine treatment in the freshwater catfish, Heteropneustes fossilis"],"prefix":"10.1007","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4227-4582","authenticated-orcid":false,"given":"Bulbul","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9980-8737","authenticated-orcid":false,"given":"Rohit Kumar","family":"Gautam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Arya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2411-8997","authenticated-orcid":false,"given":"Abha","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"1627_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2024\/5782274","volume":"2024","author":"D Agarwal","year":"2024","unstructured":"Agarwal D, Shanmugam SA, Kathirvelpandian A, Eswaran S, Rather MA, Rakkannan G (2024) Unraveling the impact of climate change on fish physiology: a focus on temperature and salinity dynamics. J Appl Ichthyol 2024:1\u201319. https:\/\/doi.org\/10.1155\/2024\/5782274","journal-title":"J Appl Ichthyol"},{"key":"1627_CR2","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.aquatox.2012.10.005","volume":"126","author":"GA Al-Bairuty","year":"2013","unstructured":"Al-Bairuty GA, Shaw BJ, Handy RD, Henry TB (2013) Histopathological effects of waterborne copper nanoparticles and copper sulphate on the organs of rainbow trout (Oncorhynchus mykiss). Aquat Toxicol 126:104\u2013115. https:\/\/doi.org\/10.1016\/j.aquatox.2012.10.005","journal-title":"Aquat Toxicol"},{"key":"1627_CR3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.22271\/fish.2022.v10.i4b.2693","volume":"10","author":"BA Ali","year":"2022","unstructured":"Ali BA, Mishra A (2022) Effects of dissolved oxygen concentration on freshwater fish: a review. Int J Fish Aquat Stud 10:113\u2013127. https:\/\/doi.org\/10.22271\/fish.2022.v10.i4b.2693","journal-title":"Int J Fish Aquat Stud"},{"key":"1627_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jahafs\/vsae003","volume":"37","author":"B Ali","year":"2025","unstructured":"Ali B, Pandey P, Pandey J, Mishra A (2025a) Pyrimidine analog effect on health and nutritional value of freshwater stinging catfish Heteropneustes fossilis. J Aquat Anim Health 37:1\u201310. https:\/\/doi.org\/10.1093\/jahafs\/vsae003","journal-title":"J Aquat Anim Health"},{"key":"1627_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10695-025-01481-3","volume":"51","author":"B Ali","year":"2025","unstructured":"Ali B, Sharma N, Gautam RK, Mishra A (2025b) Effects of pyrimidine on cellular and neuronal arrangement, oxidative stress and energy content in the brain of the freshwater catfish, Heteropneustes fossilis. Fish Physiol Biochem 51:1\u201314. https:\/\/doi.org\/10.1007\/s10695-025-01481-3","journal-title":"Fish Physiol Biochem"},{"key":"1627_CR6","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0165-0270(90)90016-9","volume":"33","author":"A Alvarez-Buylla","year":"1990","unstructured":"Alvarez-Buylla A, Ling CY, Kirn JR (1990) Cresyl violet: a red fluorescent Nissl stain. J Neurosci Methods 33:129\u2013133. https:\/\/doi.org\/10.1016\/0165-0270(90)90016-9","journal-title":"J Neurosci Methods"},{"key":"1627_CR7","doi-asserted-by":"publisher","first-page":"337","DOI":"10.4103\/0250-474x.34540","volume":"69","author":"M Amir","year":"2007","unstructured":"Amir M, Javed S, Kumar H (2007) Pyrimidine as anti-inflammatory agent: a review. Indian J Pharm Sci 69:337\u2013343. https:\/\/doi.org\/10.4103\/0250-474x.34540","journal-title":"Indian J Pharm Sci"},{"key":"1627_CR8","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s10072-012-0989-x","volume":"34","author":"TR Anju","year":"2013","unstructured":"Anju TR, Naijil G, Shilpa J, Roshni T, Paulose CS (2013) Neonatal hypoxic insult-mediated cholinergic disturbances in the brain stem: effect of glucose, oxygen and epinephrine resuscitation. Neurol Sci 34:287\u2013296. https:\/\/doi.org\/10.1007\/s10072-012-0989-x","journal-title":"Neurol Sci"},{"key":"1627_CR9","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1211\/0022357011775299","volume":"53","author":"S Anoopkumar-Dukie","year":"2001","unstructured":"Anoopkumar-Dukie S, Walker RB, Daya S (2001) A sensitive and reliable method for the detection of lipid peroxidation in biological tissues. J Pharm Pharmacol 53:263\u2013266. https:\/\/doi.org\/10.1211\/0022357011775299","journal-title":"J Pharm Pharmacol"},{"key":"1627_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0089643","volume":"9","author":"M Axelsson","year":"2014","unstructured":"Axelsson M, Gentili F (2014) A single-step method for rapid extraction of total lipids from green microalgae. PLoS ONE 9:1\u20136. https:\/\/doi.org\/10.1371\/journal.pone.0089643","journal-title":"PLoS ONE"},{"key":"1627_CR11","doi-asserted-by":"publisher","first-page":"8427","DOI":"10.1021\/acs.jmedchem.5b00575","volume":"58","author":"S Azran","year":"2015","unstructured":"Azran S, Danino O, F\u00f6rste D, Kenigsberg S, Reiser G, Dixit M, Singh V, Major DT, Fischer B (2015) Identification of highly promising antioxidants\/neuroprotectants based on nucleoside 5\u2032-phosphorothioate scaffold: synthesis, activity, and mechanisms of action. J Med Chem 58:8427\u20138443. https:\/\/doi.org\/10.1021\/acs.jmedchem.5b00575","journal-title":"J Med Chem"},{"key":"1627_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2191-2858-2-34","volume":"2","author":"T Bano","year":"2012","unstructured":"Bano T, Kumar N, Dudhe R (2012) Free radical scavenging properties of pyrimidine derivatives. Org Med Chem Lett 2:1\u20136. https:\/\/doi.org\/10.1186\/2191-2858-2-34","journal-title":"Org Med Chem Lett"},{"key":"1627_CR13","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1007\/s10695-021-01008-6","volume":"47","author":"M Bao","year":"2021","unstructured":"Bao M, Shang F, Liu F, Hu Z, Wang S, Yang X, Yu Y, Zhang H, Jiang C, Jiang J, Liu Y (2021) Comparative transcriptomic analysis of the brain in Takifugu rubripes shows its tolerance to acute hypoxia. Fish Physiol Biochem 47:1669\u20131685. https:\/\/doi.org\/10.1007\/s10695-021-01008-6","journal-title":"Fish Physiol Biochem"},{"key":"1627_CR14","doi-asserted-by":"publisher","first-page":"594","DOI":"10.3390\/cancers11050594","volume":"11","author":"N Bechmann","year":"2019","unstructured":"Bechmann N, Poser I, Seifert V, Greunke C, Ullrich M, Qin N, Walch A, Peitzsch M, Robledo M, Pacak K, Pietzsch J (2019) Impact of extrinsic and intrinsic hypoxia on catecholamine biosynthesis in absence or presence of Hif2\u03b1 in pheochromocytoma cells. Cancers (Basel) 11:594. https:\/\/doi.org\/10.3390\/cancers11050594","journal-title":"Cancers (Basel)"},{"key":"1627_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0169-328X(94)00217-3","volume":"29","author":"EJ Beilharz","year":"1995","unstructured":"Beilharz EJ, Williams CE, Dragunow M, Sirimanne ES, Gluckman PD (1995) Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss. Mol Brain Res 29:1\u201314. https:\/\/doi.org\/10.1016\/0169-328X(94)00217-3","journal-title":"Mol Brain Res"},{"key":"1627_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2021.126919","volume":"71","author":"B Ben-Azu","year":"2022","unstructured":"Ben-Azu B, Adebayo OG, Wopara I, Aduema W, Onyeleonu I, Umoren EB, Kolawole TA, Ebo OT, Akpotu AE, Ajibo DN, Onuoha OG (2022) Lead acetate induces hippocampal pyramidal neuron degeneration in mice via up-regulation of executioner caspase-3, oxido-inflammatory stress expression and decreased BDNF and cholinergic activity: reversal effects of Gingko biloba supplement. J Trace Elem Med Biol 71:126919. https:\/\/doi.org\/10.1016\/j.jtemb.2021.126919","journal-title":"J Trace Elem Med Biol"},{"key":"1627_CR17","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.jopr.2013.08.030","volume":"6","author":"VSM Bendi","year":"2013","unstructured":"Bendi VSM, Annapurna A, Avupati VR (2013) Studies on cerebroprotective potential of 2,4,6-trisubstituted-1,3,5-pyrimidines in global ischemia\/reperfusion induced cerebral infarction in rats. J Pharm Res 6:939\u2013944. https:\/\/doi.org\/10.1016\/j.jopr.2013.08.030","journal-title":"J Pharm Res"},{"key":"1627_CR18","doi-asserted-by":"publisher","first-page":"4090","DOI":"10.1021\/acschemneuro.1c00485","volume":"12","author":"M Bortolami","year":"2021","unstructured":"Bortolami M, Pandolfi F, Tudino V, Messore A, Madia VN, De Vita D, Di Santo R, Costi R, Romeo I, Alcaro S, Colone M (2021) New pyrimidine and pyridine derivatives as multitarget cholinesterase inhibitors: design, synthesis, and in vitro and in cellulo evaluation. ACS Chem Neurosci 12:4090\u20134112. https:\/\/doi.org\/10.1021\/acschemneuro.1c00485","journal-title":"ACS Chem Neurosci"},{"key":"1627_CR19","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.203901","volume":"222","author":"AA Cassidy","year":"2019","unstructured":"Cassidy AA, Lamarre SG (2019) Activation of oxygen-responsive pathways is associated with altered protein metabolism in Arctic char exposed to hypoxia. J Exp Biol 222:jeb203901. https:\/\/doi.org\/10.1242\/jeb.203901","journal-title":"J Exp Biol"},{"key":"1627_CR20","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.167601","volume":"221","author":"AA Cassidy","year":"2018","unstructured":"Cassidy AA, Driedzic WR, Campos D, Heinrichs-Caldas W, Almeida-Val VMF, Val AL, Lamarre SG (2018) Protein synthesis is lowered by 4EBP1 and eIF2-\u03b1 signaling while protein degradation may be maintained in fasting, hypoxic Amazonian cichlids (Astronotus ocellatus). J Exp Biol 221:jeb167601. https:\/\/doi.org\/10.1242\/jeb.167601","journal-title":"J Exp Biol"},{"key":"1627_CR21","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1002\/jez.10185","volume":"293","author":"R Chaube","year":"2002","unstructured":"Chaube R, Joy KP (2002) Effects of altered photoperiod and temperature, serotonin-affecting drugs, and melatonin on brain tyrosine hydroxylase activity in female catfish, Heteropneustes fossilis: a study correlating ovarian activity changes. J Exp Zool 293:585\u2013593. https:\/\/doi.org\/10.1002\/jez.10185","journal-title":"J Exp Zool"},{"key":"1627_CR22","doi-asserted-by":"publisher","DOI":"10.1590\/0001-3765201920180395","volume":"91","author":"CE Copatti","year":"2019","unstructured":"Copatti CE, Bolner KC, Londero EP, Rosso FLD, Pavanato MA, Baldisserotto B (2019) Low dissolved oxygen levels increase stress in piava (Megaleporinus obtusidens): iono-regulatory, metabolic and oxidative responses. An Acad Bras Cienc 91:e20180395. https:\/\/doi.org\/10.1590\/0001-3765201920180395","journal-title":"An Acad Bras Cienc"},{"key":"1627_CR23","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/s0021-9258(17)42415-x","volume":"269","author":"MF Czyzyk-Krzeska","year":"1994","unstructured":"Czyzyk-Krzeska MF, Furnari BA, Lawson EE, Millhorn DE (1994) Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) cells. J Biol Chem 269:760\u2013764. https:\/\/doi.org\/10.1016\/s0021-9258(17)42415-x","journal-title":"J Biol Chem"},{"key":"1627_CR24","doi-asserted-by":"publisher","first-page":"926","DOI":"10.2174\/1871527320666210804161400","volume":"21","author":"S Das","year":"2022","unstructured":"Das S, Akbar S, Ahmed B, Dewangan RP, Iqubal A, Pottoo FH, Joseph A (2022) Structural activity relationship based medicinal perspectives of pyrimidine derivatives as anti-Alzheimer\u2019s agents: a comprehensive review. CNS Neurol Disord Drug Targets 21:926\u2013939. https:\/\/doi.org\/10.2174\/1871527320666210804161400","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"1627_CR25","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1007\/BF02536177","volume":"27","author":"JP De la Cruz","year":"1992","unstructured":"De la Cruz JP, Carrasco T, Ortega G, De la Cuesta FS (1992) Inhibition of ferrous-induced lipid peroxidation by pyrimido-pyrimidine derivatives in human liver membranes. Lipids 27:192\u2013194. https:\/\/doi.org\/10.1007\/BF02536177","journal-title":"Lipids"},{"key":"1627_CR26","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.3389\/fphys.2018.01941","volume":"9","author":"JB Devaux","year":"2019","unstructured":"Devaux JB, Hedges CP, Birch N, Herbert N, Renshaw GM, Hickey AJ (2019) Acidosis maintains the function of brain mitochondria in hypoxia tolerant triplefin fish: a strategy to survive acute hypoxic exposure? Front Physiol 9:1941. https:\/\/doi.org\/10.3389\/fphys.2018.01941","journal-title":"Front Physiol"},{"key":"1627_CR27","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.neuroscience.2006.06.054","volume":"142","author":"VP Devoto","year":"2006","unstructured":"Devoto VP, Chavez JC, De Plazas SF (2006) Acute hypoxia and programmed cell death in developing CNS: Differential vulnerability of chick optic tectum layers. Neurosci 142:645\u2013653. https:\/\/doi.org\/10.1016\/j.neuroscience.2006.06.054","journal-title":"Neurosci"},{"key":"1627_CR28","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1126\/science.1156401","volume":"321","author":"RJ Diaz","year":"2008","unstructured":"Diaz RJ, Rosenber R (2008) Spreading dead zones and consequences for marine ecosystems. Sci 321:926\u2013929. https:\/\/doi.org\/10.1126\/science.1156401","journal-title":"Sci"},{"key":"1627_CR29","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jembe.2017.04.001","volume":"493","author":"RL Dixon","year":"2017","unstructured":"Dixon RL, Grecay PA, Targett TE (2017) Responses of juvenile Atlantic silverside, striped killifish, mummichog, and striped bass to acute hypoxia and acidification: aquatic surface respiration and survival. J Exp Mar Biol Ecol 493:20\u201330. https:\/\/doi.org\/10.1016\/j.jembe.2017.04.001","journal-title":"J Exp Mar Biol Ecol"},{"key":"1627_CR30","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1098\/rstb.2007.2103","volume":"362","author":"P Domenici","year":"2007","unstructured":"Domenici P, Lefran\u00e7ois C, Shingles A (2007) Hypoxia and the antipredator behaviours of fishes. Philos Trans R Soc Lond B Biol Sci 362:2105\u20132121. https:\/\/doi.org\/10.1098\/rstb.2007.2103","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"1627_CR31","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"GL Ellman","year":"1961","unstructured":"Ellman GL, Courtney KD, Andres JV, Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88\u201395. https:\/\/doi.org\/10.1016\/0006-2952(61)90145-9","journal-title":"Biochem Pharmacol"},{"key":"1627_CR32","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1134\/S1819712423030091","volume":"17","author":"A Essawy","year":"2023","unstructured":"Essawy A, Matta CA, Nabil B, Elkader HTA, Alhasani RH, Soffar AA (2023) Neuroprotective effect of curcumin on the rat model of Parkinson\u2019s disease induced by rotenone via modulating tyrosine hydroxylase and dopa decarboxylase expression levels. Neurochem J 17:457\u2013466. https:\/\/doi.org\/10.1134\/S1819712423030091","journal-title":"Neurochem J"},{"key":"1627_CR33","doi-asserted-by":"publisher","DOI":"10.1242\/bio.060069","volume":"12","author":"H Falfushynska","year":"2023","unstructured":"Falfushynska H, Sokolova IM (2023) Intermittent hypoxia differentially affects metabolic and oxidative stress responses in two species of cyprinid fish. Biol Open 12:bio060069. https:\/\/doi.org\/10.1242\/bio.060069","journal-title":"Biol Open"},{"key":"1627_CR34","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.ncl.2017.06.001","volume":"35","author":"JE Fugate","year":"2017","unstructured":"Fugate JE (2017) Anoxic-ischemic brain injury. Neurol Clin 35:601\u2013611. https:\/\/doi.org\/10.1016\/j.ncl.2017.06.001","journal-title":"Neurol Clin"},{"key":"1627_CR35","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s12185-012-1069-y","volume":"95","author":"N Goda","year":"2012","unstructured":"Goda N, Kanai M (2012) Hypoxia-inducible factors and their roles in energy metabolism. Int J Hematol 95:457\u2013463. https:\/\/doi.org\/10.1007\/s12185-012-1069-y","journal-title":"Int J Hematol"},{"key":"1627_CR36","doi-asserted-by":"publisher","first-page":"26","DOI":"10.31248\/GJFS2019.008","volume":"1","author":"EA Hagar","year":"2019","unstructured":"Hagar EA, Zaid AO, Abakar AEO, Ibrahim HS (2019) Tolerance of African catfish Clarias gariepinus fingerlings to chemotherapeutic doses of potassium permanganate. Glob J Fish Sci 1:26\u201331. https:\/\/doi.org\/10.31248\/GJFS2019.008","journal-title":"Glob J Fish Sci"},{"key":"1627_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.921709","volume":"13","author":"B Han","year":"2022","unstructured":"Han B, Meng Y, Tian H, Li C, Li Y, Gongbao C, Fan M, Ma R (2022) Effects of acute hypoxic stress on physiological and hepatic metabolic responses of triploid rainbow trout (Oncorhynchus mykiss). Front Physiol 13:921709. https:\/\/doi.org\/10.3389\/fphys.2022.921709","journal-title":"Front Physiol"},{"key":"1627_CR38","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1086\/591806","volume":"82","author":"CT Hasler","year":"2009","unstructured":"Hasler CT, Suski CD, Hanson KC, Cooke SJ, Tufts BL (2009) The influence of dissolved oxygen on winter habitat selection by largemouth bass: an integration of field biotelemetry studies and laboratory experiments. Physiol Biochem Zool 82:143\u2013152. https:\/\/doi.org\/10.1086\/591806","journal-title":"Physiol Biochem Zool"},{"key":"1627_CR39","doi-asserted-by":"publisher","first-page":"247","DOI":"10.21608\/ejchem.2019.18248.2136","volume":"63","author":"A Hassan","year":"2020","unstructured":"Hassan A, Ali MM, Diaa M, Germoush MO, Mohamed AM, El-Sayed W (2020) Oxidative stress of some triazolopyrimidine derivatives and their nucleoside analogues on Mcf-7 and A549 cell lines. Egypt J Chem 63:247\u2013253. https:\/\/doi.org\/10.21608\/ejchem.2019.18248.2136","journal-title":"Egypt J Chem"},{"key":"1627_CR40","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s00414-006-0122-x","volume":"121","author":"R Hausmann","year":"2007","unstructured":"Hausmann R, Seidl S, Betz P (2007) Hypoxic changes in Purkinje cells of the human cerebellum. Int J Legal Med 121:175\u2013183. https:\/\/doi.org\/10.1007\/s00414-006-0122-x","journal-title":"Int J Legal Med"},{"key":"1627_CR41","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/bab.1891","volume":"67","author":"S Heidari","year":"2020","unstructured":"Heidari S, Mahdiani S, Hashemi M, Kalalinia F (2020) Recent advances in neurogenic and neuroprotective effects of curcumin through the induction of neural stem cells. Biotechnol Appl Biochem 67:430\u2013441. https:\/\/doi.org\/10.1002\/bab.1891","journal-title":"Biotechnol Appl Biochem"},{"key":"1627_CR42","doi-asserted-by":"publisher","first-page":"2706","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.09.011","volume":"26","author":"HJ Hu","year":"2017","unstructured":"Hu HJ, Song M (2017) Disrupted ionic homeostasis in ischemic stroke and new therapeutic targets. J Stroke Cerebrovasc Dis 26:2706\u20132719. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2017.09.011","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"1627_CR43","doi-asserted-by":"publisher","first-page":"5763","DOI":"10.1007\/s12035-019-1489-2","volume":"56","author":"A Islam","year":"2019","unstructured":"Islam A, Kagawa Y, Miyazaki H, Shil SK, Umaru BA, Yasumoto Y, Yamamoto Y, Owada Y (2019) FABP7 protects astrocytes against ROS toxicity via lipid droplet formation. Mol Neurobiol 56:5763\u20135779. https:\/\/doi.org\/10.1007\/s12035-019-1489-2","journal-title":"Mol Neurobiol"},{"key":"1627_CR44","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3233\/RNN-1999-00097","volume":"14","author":"S Itoh","year":"1999","unstructured":"Itoh S, Samejima H, Shinomiya K, Awaya A (1999) The effect of neurotrophic pyrimidine heterocyclic compounds, MS-818 and MS-430, on the regeneration of injured peripheral nerves. Restor Neurol Neurosci 14:265\u2013273. https:\/\/doi.org\/10.3233\/RNN-1999-00097","journal-title":"Restor Neurol Neurosci"},{"key":"1627_CR45","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25126694","volume":"25","author":"L Jiang","year":"2024","unstructured":"Jiang L, Hao Y, Li Q, Dai Z (2024) Cinnamic acid, perillic acid, and tryptophan metabolites differentially regulate ion transport and serotonin metabolism and signaling in the mouse ileum in vitro. Int J Mol Sci 25:6694. https:\/\/doi.org\/10.3390\/ijms25126694","journal-title":"Int J Mol Sci"},{"key":"1627_CR46","doi-asserted-by":"publisher","first-page":"174","DOI":"10.5958\/0974-4517.2020.00021.X","volume":"22","author":"A Kalita","year":"2020","unstructured":"Kalita A, Das M (2020) Expression of stress response genes in mud-dwelling stinging catfish Heteropneustes fossilis during exposure to a drying mud-bed. Appl Biol Res 22:174\u2013183. https:\/\/doi.org\/10.5958\/0974-4517.2020.00021.X","journal-title":"Appl Biol Res"},{"key":"1627_CR47","first-page":"28","volume":"2","author":"R Kannadhasan","year":"2011","unstructured":"Kannadhasan R (2011) Quantitative and micro determination of urine sugar in experimental rats: modified anthrone method. Asian J Exp Biol Sci 2:28\u201333","journal-title":"Asian J Exp Biol Sci"},{"key":"1627_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2025.142334","volume":"1338","author":"H Khanam","year":"2025","unstructured":"Khanam H, Pandey J, Singh BD, Fatma S, Pathak A, Sharma A, Tiwari S, Pandey D, Bishnoi A (2025) Synthesis and photophysical properties of D-\u03c0-A-\u03c0-D 2-hydroxy-4, 6-bis-(arylvinyl)-pyrimidines based push-pull fluorophores: DFT studies and antibacterial activity. J Mol Struct 1338:142334. https:\/\/doi.org\/10.1016\/j.molstruc.2025.142334","journal-title":"J Mol Struct"},{"key":"1627_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2023.114216","volume":"334","author":"MJ Kim","year":"2023","unstructured":"Kim MJ, Kim JA, Song JA, Kho KH, Choi CY (2023) Synthetic microfiber exposure negatively affects reproductive parameters in male medaka (Oryzias latipes). Gen Comp Endocrinol 334:114216. https:\/\/doi.org\/10.1016\/j.ygcen.2023.114216","journal-title":"Gen Comp Endocrinol"},{"key":"1627_CR50","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1248\/bpb.20.138","volume":"20","author":"Y Koyama","year":"1997","unstructured":"Koyama Y, Awaya A, Ishikawa N, Fujita S, Tomino I, Yokoyama K, Araki S, Takesue M, Kato K, Ishiguro M, Kitahara T (1997) Neurotropic pyrimidine heterocyclic compounds. II. Effects of novel neurotropic pyrimidine derivatives on astrocytic morphological differentiation. Biol Pharm Bull 20:138\u2013141. https:\/\/doi.org\/10.1248\/bpb.20.138","journal-title":"Biol Pharm Bull"},{"key":"1627_CR51","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1113\/jphysiol.2006.112524","volume":"575","author":"GK Kumar","year":"2006","unstructured":"Kumar GK, Rai V, Sharma SD, Ramakrishnan DP, Peng YJ, Souvannakitti D, Prabhakar NR (2006) Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress. J Physiol 575:229\u2013239. https:\/\/doi.org\/10.1113\/jphysiol.2006.112524","journal-title":"J Physiol"},{"key":"1627_CR52","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1002\/slct.201702599","volume":"3","author":"J Kumar","year":"2018","unstructured":"Kumar J, Gill A, Shaikh M, Singh A, Shandilya A, Jameel E, Sharma N, Mrinal N, Hoda N, Jayaram B (2018) Pyrimidine-triazolopyrimidine and pyrimidine-pyridine hybrids as potential acetylcholinesterase inhibitors for Alzheimer\u2019s disease. ChemSelect 3:736\u2013747. https:\/\/doi.org\/10.1002\/slct.201702599","journal-title":"ChemSelect"},{"key":"1627_CR53","doi-asserted-by":"crossref","unstructured":"Kumar A, Mishra A (2023) Role of heterocyclic compounds in pharmaceuticals and medicines. J Exp Zool India 26:1\u20139. https:\/\/connectjournals.com\/03895.2023.26.1","DOI":"10.51470\/jez.2023.26.1.1"},{"key":"1627_CR54","unstructured":"Lacerte M, Shapshak AH, Mesfin FB (2023) Hypoxic brain injury. In\u00a0StatPearls [Internet]. StatPearls Publishing"},{"key":"1627_CR55","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1111\/j.1095-8649.2005.00884.x","volume":"67","author":"C Lefrancois","year":"2005","unstructured":"Lefrancois C, Shingles A, Domenici P (2005) The effect of hypoxia on locomotor performance and behaviour during escape in Liza aurata. J Fish Biol 67:1711\u20131729. https:\/\/doi.org\/10.1111\/j.1095-8649.2005.00884.x","journal-title":"J Fish Biol"},{"key":"1627_CR56","first-page":"185","volume":"18","author":"Y Li","year":"2007","unstructured":"Li Y, Schellhorn HE (2007) Rapid kinetic microassay for catalase activity. J Biomol Tech 18:185","journal-title":"J Biomol Tech"},{"key":"1627_CR57","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1152\/japplphysiol.00522.2005","volume":"99","author":"J Li","year":"2005","unstructured":"Li J, Grigoryev DN, Ye SQ, Thorne L, Schwartz AR, Smith PL, O\u2019Donnell CP, Polotsky VY (2005) Chronic intermittent hypoxia upregulates genes of lipid biosynthesis in obese mice. J Appl Physiol 99:1643\u20131648. https:\/\/doi.org\/10.1152\/japplphysiol.00522.2005","journal-title":"J Appl Physiol"},{"key":"1627_CR58","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.aquaculture.2018.05.031","volume":"495","author":"M Li","year":"2018","unstructured":"Li M, Wang X, Qi C, Li E, Du Z, Qin JG, Chen L (2018) Metabolic response of Nile tilapia (Oreochromis niloticus) to acute and chronic hypoxia stress. Aquac 495:187\u2013195. https:\/\/doi.org\/10.1016\/j.aquaculture.2018.05.031","journal-title":"Aquac"},{"key":"1627_CR59","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1152\/physrev.1999.79.4.1431","volume":"79","author":"P Lipton","year":"1999","unstructured":"Lipton P (1999) Ischemic cell death in brain neurons. Physiol Rev 79:1431\u20131568. https:\/\/doi.org\/10.1152\/physrev.1999.79.4.1431","journal-title":"Physiol Rev"},{"key":"1627_CR60","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.cmet.2017.08.024","volume":"26","author":"L Liu","year":"2017","unstructured":"Liu L, MacKenzie KR, Putluri N, Maleti\u0107-Savati\u0107 M, Bellen HJ (2017) The glia-neuron lactate shuttle and elevated ROS promote lipid synthesis in neurons and lipid droplet accumulation in glia via APOE\/D. Cell Metab 26:719\u2013737. https:\/\/doi.org\/10.1016\/j.cmet.2017.08.024","journal-title":"Cell Metab"},{"key":"1627_CR61","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1039\/C9FO02339A","volume":"11","author":"YH Liu","year":"2020","unstructured":"Liu YH, Lee CJ, Chen LC, Lee TL, Hsieh YY, Han CH, Yang CH, Huang WJ, Hou WC (2020) Acetylcholinesterase inhibitory activity and neuroprotection in vitro, molecular docking, and improved learning and memory functions of demethylcurcumin in scopolamine-induced amnesia ICR mice. Food Funct 11:2328\u20132338. https:\/\/doi.org\/10.1039\/C9FO02339A","journal-title":"Food Funct"},{"key":"1627_CR62","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.aquatox.2010.10.006","volume":"101","author":"VI Lushchak","year":"2011","unstructured":"Lushchak VI (2011) Environmentally induced oxidative stress in aquatic animals. Aqua Toxicol 101:13\u201330. https:\/\/doi.org\/10.1016\/j.aquatox.2010.10.006","journal-title":"Aqua Toxicol"},{"key":"1627_CR63","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1016\/j.biocel.2005.01.006","volume":"37","author":"VI Lushchak","year":"2005","unstructured":"Lushchak VI, Bagnyukova TV, Lushchak V, Storey JM, Storey KB (2005) Hypoxia and recovery perturb free radical processes and antioxidant potential in common carp (Cyprinus carpio) tissues. Int J Biochem Cell Biol 37:1319\u20131330. https:\/\/doi.org\/10.1016\/j.biocel.2005.01.006","journal-title":"Int J Biochem Cell Biol"},{"key":"1627_CR64","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s10695-022-01154-5","volume":"50","author":"Q Ma","year":"2024","unstructured":"Ma Q, Xu H, Wei Y, Liang M (2024) Effects of acute hypoxia on nutrient metabolism and physiological function in turbot, Scophthalmus maximus. Fish Physiol Biochem 50:367\u2013383. https:\/\/doi.org\/10.1007\/s10695-022-01154-5","journal-title":"Fish Physiol Biochem"},{"key":"1627_CR65","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3329\/bvet.v26i2.4953","volume":"26","author":"SMA Matin","year":"2009","unstructured":"Matin SMA, Hossain MA, Hashim MA (2009) Clove oil anaesthesia in singhi (Heteropneustes fossilis) and lata (Channa punctatus) fish. Bangladesh Vet 26:68\u201373. https:\/\/doi.org\/10.3329\/bvet.v26i2.4953","journal-title":"Bangladesh Vet"},{"key":"1627_CR66","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.acthis.2013.07.001","volume":"116","author":"A Mishra","year":"2014","unstructured":"Mishra A, Devi Y (2014) Histopathological alterations in the brain (optic tectum) of the fresh water teleost Channa punctatus in response to acute and subchronic exposure to the pesticide Chlorpyrifos. Acta Histochem 116:176\u2013181. https:\/\/doi.org\/10.1016\/j.acthis.2013.07.001","journal-title":"Acta Histochem"},{"key":"1627_CR67","first-page":"1043","volume":"23","author":"A Mishra","year":"2020","unstructured":"Mishra A, Singh A (2020) Effect of curcumin, ascorbic acid against chlorpyrifos toxicity on histotexture and bimolecular content of fresh water catfish Heteropneustes fossilis. J Exp Zool India 23:1043\u20131049","journal-title":"J Exp Zool India"},{"key":"1627_CR68","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.3171\/jns.2002.96.6.1072","volume":"96","author":"T Mitsuyama","year":"2002","unstructured":"Mitsuyama T, Kawamata T, Yamane F, Awaya A, Hori T (2002) Role of a synthetic pyrimidine compound, MS-818, in reduction of infarct size and amelioration of sensorimotor dysfunction following permanent focal cerebral ischemia in rats. J Neurosurg 96:1072\u20131076. https:\/\/doi.org\/10.3171\/jns.2002.96.6.1072","journal-title":"J Neurosurg"},{"key":"1627_CR69","first-page":"561","volume":"12","author":"BP Mohanty","year":"2018","unstructured":"Mohanty BP, Singh SD (2018) Fish and human nutrition. Food Agric Organ 12:561\u2013581","journal-title":"Food Agric Organ"},{"key":"1627_CR70","first-page":"257","volume":"5","author":"BP Mohanty","year":"2013","unstructured":"Mohanty BP, Pati MK, Bhattacharjee S, Hajra A, Sharma AP (2013) Small indigenous fishes and their importance in human health. Adv Fish Res 5:257\u2013278","journal-title":"Adv Fish Res"},{"key":"1627_CR71","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s11010-019-03670-0","volume":"465","author":"TK Motawi","year":"2020","unstructured":"Motawi TK, Sadik NA, Hamed MA, Ali SA, Khalil WK, Ahmed YR (2020) Potential therapeutic effects of antagonizing adenosine A2A receptor, curcumin and niacin in rotenone-induced Parkinson\u2019s disease mice model. Mol Cell Biochem 465:89\u2013102. https:\/\/doi.org\/10.1007\/s11010-019-03670-0","journal-title":"Mol Cell Biochem"},{"key":"1627_CR72","unstructured":"Nagata T, Suzuki T, Yoshimura A, Tadano N, Matsuno T, Satoh H, Saitoh K, Ohta S, Zenyaku Kogyo KK (2013) Pyrimidine derivative having cell protecting effect and uses thereof. U.S. Patent. 8,563,715"},{"key":"1627_CR73","doi-asserted-by":"publisher","first-page":"971","DOI":"10.2478\/aoas-2023-0007","volume":"23","author":"MA Naiel","year":"2023","unstructured":"Naiel MA, El-Kholy AI, Negm SS, Ghazanfar S, Shukry M, Zhang Z, Ahmadifar E, Abdel-Latif HM (2023) A mini-review on plant-derived phenolic compounds with particular emphasis on their possible applications and beneficial uses in aquaculture. Ann Anim Sci 23:971\u2013977. https:\/\/doi.org\/10.2478\/aoas-2023-0007","journal-title":"Ann Anim Sci"},{"key":"1627_CR74","doi-asserted-by":"publisher","first-page":"14","DOI":"10.36468\/pharmaceutical-sciences.890","volume":"84","author":"N Nair","year":"2022","unstructured":"Nair N, Majeed J, Pandey PK, Sweety R, Thakur R (2022) Antioxidant potential of pyrimidine derivatives against oxidative stress. Indian J Pharm Sci 84:14\u201326. https:\/\/doi.org\/10.36468\/pharmaceutical-sciences.890","journal-title":"Indian J Pharm Sci"},{"key":"1627_CR75","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2020.102682","volume":"92","author":"LF Nitz","year":"2020","unstructured":"Nitz LF, Pellegrin L, Maltez LC, Pinto D, Sampaio LA, Monserrat JM, Garcia L (2020) Temperature and hypoxia on oxidative stress responses in pacu Piaractus mesopotamicus. J Therm Biol 92:102682. https:\/\/doi.org\/10.1016\/j.jtherbio.2020.102682","journal-title":"J Therm Biol"},{"key":"1627_CR76","first-page":"105","volume":"36","author":"P Pandey","year":"2022","unstructured":"Pandey P, Mishra A (2022) Curcumin influence on antioxidative stress and energy macromolecules of stinging catfish, Heteropneustes fossilis (Bloch, 1794). J Environ Biosci 36:105\u2013113","journal-title":"J Environ Biosci"},{"key":"1627_CR77","doi-asserted-by":"publisher","first-page":"169","DOI":"10.21048\/IJND.2022.59.2.29282","volume":"59","author":"P Pandey","year":"2022","unstructured":"Pandey P, Mishra A, Pandey J (2022) Immunity and overall tissue health of stinging catfish, Heteropneustes fossilis (Bloch, 1974), in Curcumin Medium. Indian J Nutri Diet 59:169\u2013186. https:\/\/doi.org\/10.21048\/IJND.2022.59.2.29282","journal-title":"Indian J Nutri Diet"},{"key":"1627_CR78","doi-asserted-by":"publisher","first-page":"06","DOI":"10.33545\/27068919.2022.v4.i3a.810","volume":"4","author":"P Pandey","year":"2022","unstructured":"Pandey P, Ali B, Mishra A (2022a) Curcumin: a pharmacologically functional active ingredient from nature. Int J Adv Acad Stud 4:06\u201311. https:\/\/doi.org\/10.33545\/27068919.2022.v4.i3a.810","journal-title":"Int J Adv Acad Stud"},{"key":"1627_CR79","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmcr.2022.100095","volume":"6","author":"S Pant","year":"2022","unstructured":"Pant S, Kapri A, Nain S (2022) Pyrimidine analogues for the management of neurodegenerative diseases. Eur J Med Chem Rep 6:100095. https:\/\/doi.org\/10.1016\/j.ejmcr.2022.100095","journal-title":"Eur J Med Chem Rep"},{"key":"1627_CR80","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s12562-021-01511-y","volume":"87","author":"P Phrompanya","year":"2021","unstructured":"Phrompanya P, Panase P, Saenphet S, Saenphet K (2021) Histopathology and oxidative stress responses of Nile tilapia Oreochromis niloticus exposed to temperature shocks. Fish Sci 87:491\u2013502. https:\/\/doi.org\/10.1007\/s12562-021-01511-y","journal-title":"Fish Sci"},{"key":"1627_CR81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1139\/a06-006","volume":"15","author":"MS Pollock","year":"2007","unstructured":"Pollock MS, Clarke LMJ, Dub\u00e9 MG (2007) The effects of hypoxia on fishes: from ecological relevance to physiological effects. Environ Rev 15:1\u201314. https:\/\/doi.org\/10.1139\/a06-006","journal-title":"Environ Rev"},{"key":"1627_CR82","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1007\/s12668-018-0570-z","volume":"9","author":"TV Povysheva","year":"2019","unstructured":"Povysheva TV, Sabirova SR, Shashin MS, Galyametdinova IV, Semenov VE, Chelyshev YA (2019) Pyrimidine derivative ameliorates spinal cord injury via anti-apoptotic, anti-inflammatory, and antioxidant effects and by regulating Rho GTPases. BioNanoSci 9:224\u2013234. https:\/\/doi.org\/10.1007\/s12668-018-0570-z","journal-title":"BioNanoSci"},{"key":"1627_CR83","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.125476","volume":"414","author":"MD Proki\u0107","year":"2021","unstructured":"Proki\u0107 MD, Gavrilovi\u0107 BR, Radovanovi\u0107 TB, Gavri\u0107 JP, Petrovi\u0107 TG, Despotovi\u0107 SG, Faggio C (2021) Studying microplastics: lessons from evaluated literature on animal model organisms and experimental approaches. J Hazard Mater 414:125476. https:\/\/doi.org\/10.1016\/j.jhazmat.2021.125476","journal-title":"J Hazard Mater"},{"key":"1627_CR84","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s12595-020-00346-2","volume":"7","author":"T Purkayastha","year":"2020","unstructured":"Purkayastha T, Keot D, Das M (2020) Stress induced transcriptional activation of hif-1\u03b1 and hsp-70 genes in air-breathing Singhi catfish, Heteropneustes fossilis. J Biores 7:41\u201348. https:\/\/doi.org\/10.1007\/s12595-020-00346-2","journal-title":"J Biores"},{"key":"1627_CR85","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1007\/BF02433886","volume":"129","author":"IS Raginov","year":"2000","unstructured":"Raginov IS, Chelyshev YA, Khafiz\u2019yanova RK (2000) Effect of xymedone on posttraumatic survival of sensory neurons. Bull Exp Biol Med 129:216\u2013218. https:\/\/doi.org\/10.1007\/BF02433886","journal-title":"Bull Exp Biol Med"},{"key":"1627_CR86","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1177\/1925362118797728","volume":"8","author":"P Rahaman","year":"2018","unstructured":"Rahaman P, Del Bigio MR (2018) Histology of brain trauma and hypoxia ischemia. Acad Forensic Pathol 8:539\u2013554. https:\/\/doi.org\/10.1177\/1925362118797728","journal-title":"Acad Forensic Pathol"},{"key":"1627_CR87","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.neuroscience.2008.10.029","volume":"158","author":"MS Rahman","year":"2009","unstructured":"Rahman MS, Thomas P (2009) Molecular cloning, characterization and expression of two tryptophan hydroxylase (TPH-1 and TPH-2) genes in the hypothalamus of Atlantic croaker: down-regulation after chronic exposure to hypoxia. Neurosci 158:751\u2013765. https:\/\/doi.org\/10.1016\/j.neuroscience.2008.10.029","journal-title":"Neurosci"},{"key":"1627_CR88","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00130","volume":"8","author":"MS Rahman","year":"2014","unstructured":"Rahman MS, Thomas P (2014) Restoration of tryptophan hydroxylase functions and serotonin content in the Atlantic croaker hypothalamus by antioxidant treatment during hypoxic stress. Front Neurosci 8:130. https:\/\/doi.org\/10.3389\/fnins.2014.00130","journal-title":"Front Neurosci"},{"key":"1627_CR89","doi-asserted-by":"publisher","DOI":"10.5812\/thrita-143850","volume":"12","author":"M Rajabi","year":"2023","unstructured":"Rajabi M, Yari S, Fakhraei N, Fahanik-Babaei J, Amini A (2023) Curcumin affects the proliferation and neurogenesis of embryonic neural stem cells in rats. Thrita J Neu 12:e143850. https:\/\/doi.org\/10.5812\/thrita-143850","journal-title":"Thrita J Neu"},{"key":"1627_CR90","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1093\/toxsci\/63.2.208","volume":"63","author":"C Rosenfeld","year":"2001","unstructured":"Rosenfeld C, Kousba A, Sultatos LG (2001) Interactions of rat brain acetylcholinesterase with the detergent Triton X-100 and the organophosphate paraoxon. Toxicol Sci 63:208\u2013213. https:\/\/doi.org\/10.1093\/toxsci\/63.2.208","journal-title":"Toxicol Sci"},{"key":"1627_CR91","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112109","volume":"373","author":"TA Sapozhnikova","year":"2019","unstructured":"Sapozhnikova TA, Borisevich SS, Kireeva DR, Gabdrakhmanova SF, Khisamutdinova RY, Makara NS, Gibadullina NN, Khursa SL, Zarudii FS (2019) Effects of novel hexahydropyrimidine derivatives as potential ligands of M1 muscarinic acetylcholine receptor on cognitive function, hypoxia-induced lethality, and oxidative stress in rodents. Behav Brain Res 373:112109. https:\/\/doi.org\/10.1016\/j.bbr.2019.112109","journal-title":"Behav Brain Res"},{"key":"1627_CR92","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1046\/j.1471-4159.2003.01696.x","volume":"85","author":"PO Schnell","year":"2003","unstructured":"Schnell PO, Ignacak ML, Bauer AL, Striet JB, Paulding WR, Czyzyk Krzeska MF (2003) Regulation of tyrosine hydroxylase promoter activity by the von Hippel-Lindau tumor suppressor protein and hypoxia-inducible transcription factors. J Neurochem 85:483\u2013491. https:\/\/doi.org\/10.1046\/j.1471-4159.2003.01696.x","journal-title":"J Neurochem"},{"key":"1627_CR93","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2011.00068","volume":"2","author":"SE Seidl","year":"2011","unstructured":"Seidl SE, Potashkin JA (2011) The promise of neuroprotective agents in Parkinson\u2019s disease. Front Neurol 2:68. https:\/\/doi.org\/10.3389\/fneur.2011.00068","journal-title":"Front Neurol"},{"key":"1627_CR94","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2020.113439","volume":"291","author":"A Servili","year":"2020","unstructured":"Servili A, Canario AV, Mouchel O, Mu\u00f1oz-Cueto JA (2020) Climate change impacts on fish reproduction are mediated at multiple levels of the brain-pituitary-gonad axis. Gen Comp Endocrinol 291:113439. https:\/\/doi.org\/10.1016\/j.ygcen.2020.113439","journal-title":"Gen Comp Endocrinol"},{"key":"1627_CR95","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1016\/S0021-9258(19)76979-8","volume":"246","author":"R Shiman","year":"1971","unstructured":"Shiman R, Akino M, Kaufman S (1971) Solubilization and partial purification of tyrosine hydroxylase from bovine adrenal medulla. J Biol Chem 246:1330\u20131340. https:\/\/doi.org\/10.1016\/S0021-9258(19)76979-8","journal-title":"J Biol Chem"},{"key":"1627_CR96","doi-asserted-by":"publisher","DOI":"10.1002\/ajoc.202200479","volume":"11","author":"BD Singh","year":"2022","unstructured":"Singh BD, Pandey J, Khanam H, Singh S (2022) Lewis acid catalyzed [3+ 3] annulation\/aldol condensation in water: one pot synthesis of (E, E)-4, 6-Bis (styryl)-pyrimidines. Asian J Org Chem 11:e202200479. https:\/\/doi.org\/10.1002\/ajoc.202200479","journal-title":"Asian J Org Chem"},{"key":"1627_CR97","doi-asserted-by":"publisher","first-page":"R897","DOI":"10.1152\/ajpregu.1996.271.4.R897","volume":"271","author":"RW Smith","year":"1996","unstructured":"Smith RW, Houlihan DF, Nilsson G, Brechin JG (1996) Tissue-specific changes in protein synthesis rates in vivo during anoxia in crucian carp. Am J Physiol Regul Integr Comp Physiol 271:R897\u2013R904. https:\/\/doi.org\/10.1152\/ajpregu.1996.271.4.R897","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1627_CR98","doi-asserted-by":"publisher","first-page":"277","DOI":"10.4149\/gpb_2013027","volume":"32","author":"M Stankovic","year":"2013","unstructured":"Stankovic M, Mladenovic D, Ninkovic M, Vucevic D, Tomasevic T, Radosavljevic T (2013) Effects of caloric restriction on oxidative stress parameters. Gen Physiol Biophys 32:277\u2013283. https:\/\/doi.org\/10.4149\/gpb_2013027","journal-title":"Gen Physiol Biophys"},{"key":"1627_CR99","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s00360-010-0544-0","volume":"181","author":"SL Steele","year":"2011","unstructured":"Steele SL, Ekker M, Perry SF (2011) Interactive effects of development and hypoxia on catecholamine synthesis and cardiac function in zebrafish (Danio rerio). J Comp Physiol B 181:527\u2013538. https:\/\/doi.org\/10.1007\/s00360-010-0544-0","journal-title":"J Comp Physiol B"},{"key":"1627_CR100","first-page":"1488","volume":"40","author":"K Sugai","year":"1991","unstructured":"Sugai K, Sugai Y, Yamada E, Okuda C, Tanaka Y (1991) Effects of hypoxia on the brain cholinergic system in the rat. Masui Jpn J Anesthesiol 40:1488\u20131491","journal-title":"Masui Jpn J Anesthesiol"},{"key":"1627_CR101","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1002\/etc.5421","volume":"43","author":"JP Sumpter","year":"2024","unstructured":"Sumpter JP, Johnson AC, Runnalls TJ (2024) Pharmaceuticals in the aquatic environment: no answers yet to the major questions. Environ Toxicol Chem 43:589\u2013594. https:\/\/doi.org\/10.1002\/etc.5421","journal-title":"Environ Toxicol Chem"},{"key":"1627_CR102","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.135157","volume":"713","author":"JL Sun","year":"2020","unstructured":"Sun JL, Zhao LL, Wu H, Liu Q, Liao L, Luo J, Lian WQ, Cui C, Jin L, Ma JD, Li MZ (2020) Acute hypoxia changes the mode of glucose and lipid utilization in the liver of the largemouth bass (Micropterus salmoides). Sci Total Environ 713:135157. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.135157","journal-title":"Sci Total Environ"},{"key":"1627_CR103","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.3233\/JAD-170188","volume":"58","author":"M Tang","year":"2017","unstructured":"Tang M, Taghibiglou C (2017) The mechanisms of action of curcumin in Alzheimer\u2019s disease. J Alzheimers Dis 58:1003\u20131016. https:\/\/doi.org\/10.3233\/JAD-170188","journal-title":"J Alzheimers Dis"},{"key":"1627_CR104","doi-asserted-by":"publisher","first-page":"15452","DOI":"10.1073\/pnas.0803833105","volume":"105","author":"R Vaquer-Sunyer","year":"2008","unstructured":"Vaquer-Sunyer R, Duarte CM (2008) Thresholds of hypoxia for marine biodiversity. Proc Natl Acad Sci 105:15452\u201315457. https:\/\/doi.org\/10.1073\/pnas.0803833105","journal-title":"Proc Natl Acad Sci"},{"key":"1627_CR105","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/0300-9629(94)90399-9","volume":"107","author":"E Verheyen","year":"1994","unstructured":"Verheyen E, Blust R, Decleir W (1994) Metabolic rate, hypoxia tolerance and aquatic surface respiration of some lacustrine and riverine African cichlid fishes (Pisces: Cichlidae). Comp Biochem Physiol A 107:403\u2013411. https:\/\/doi.org\/10.1016\/0300-9629(94)90399-9","journal-title":"Comp Biochem Physiol A"},{"key":"1627_CR106","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1126\/science.aac6009","volume":"349","author":"CJ V\u00f6r\u00f6smarty","year":"2015","unstructured":"V\u00f6r\u00f6smarty CJ, Hoekstra AY, Bunn SE, Conway D, Gupta J (2015) Fresh water goes global. Science 349:478\u2013479. https:\/\/doi.org\/10.1126\/science.aac6009","journal-title":"Science"},{"key":"1627_CR107","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1177\/0394632016688025","volume":"30","author":"P Wang","year":"2017","unstructured":"Wang P, Su C, Feng H, Chen X, Dong Y, Rao Y, Jiang S (2017) Curcumin regulates insulin pathways and glucose metabolism in the brains of APPswe\/PS1dE9 mice. Int J Immunopathol Pharmacol 30:25\u201343. https:\/\/doi.org\/10.1177\/0394632016688025","journal-title":"Int J Immunopathol Pharmacol"},{"key":"1627_CR108","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2020.735903","volume":"531","author":"M Wang","year":"2021","unstructured":"Wang M, Wu F, Xie S, Zhang L (2021) Acute hypoxia and reoxygenation: effect on oxidative stress and hypoxia signal transduction in the juvenile yellow catfish (Pelteobagrus fulvidraco). Aquac 531:735903. https:\/\/doi.org\/10.1016\/j.aquaculture.2020.735903","journal-title":"Aquac"},{"key":"1627_CR109","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114597","volume":"241","author":"H Wang","year":"2022","unstructured":"Wang H, Cui E, Li J, Ma X, Jiang X, Du S, Qian S, Du L (2022) Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment. Eur J Med Chem 241:114597. https:\/\/doi.org\/10.1016\/j.ejmech.2022.114597","journal-title":"Eur J Med Chem"},{"key":"1627_CR110","doi-asserted-by":"publisher","unstructured":"Waterborg JH (2009) The lowry method for protein quantitation. In: Walker JM (eds) The protein protocols handbook. Springer Protocols Handbooks. Humana Press, Totowa, NJ. 1\u20137 https:\/\/doi.org\/10.1007\/978-1-59745-198-7_2","DOI":"10.1007\/978-1-59745-198-7_2"},{"key":"1627_CR111","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2113947119","volume":"119","author":"JL Wilkinson","year":"2022","unstructured":"Wilkinson JL, Boxall AB, Kolpin DW, Leung KM, Lai RW, Galb\u00e1n-Malag\u00f3n C, Adell AD, Mondon J, Metian M, Marchant RA, Bouzas-Monroy A (2022) Pharmaceutical pollution of the world\u2019s rivers. Proc Natl Acad Sci U S A 119:e2113947119. https:\/\/doi.org\/10.1073\/pnas.2113947119","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1627_CR112","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/are.12483","volume":"47","author":"Z Wu","year":"2016","unstructured":"Wu Z, You F, Wen A, Ma D, Zhang P (2016) Physiological and morphological effects of severe hypoxia, hypoxia and hyperoxia in juvenile turbot (Scophthalmus maximus L.). Aquac Res 47:219\u2013227. https:\/\/doi.org\/10.1111\/are.12483","journal-title":"Aquac Res"},{"key":"1627_CR113","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.neuroscience.2015.07.051","volume":"304","author":"F Yang","year":"2015","unstructured":"Yang F, Zhou L, Wang D, Wang Z, Huang QY (2015) Minocycline ameliorates hypoxia-induced blood\u2013brain barrier damage by inhibition of HIF-1\u03b1 through SIRT-3\/PHD-2 degradation pathway. Neurosci 304:250\u2013259. https:\/\/doi.org\/10.1016\/j.neuroscience.2015.07.051","journal-title":"Neurosci"},{"key":"1627_CR114","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.fsi.2017.06.035","volume":"67","author":"S Yang","year":"2017","unstructured":"Yang S, Yan T, Wu H, Xiao Q, Fu HM, Luo J, Zhou J, Zhao LL, Wang Y, Yang SY, Sun JL (2017) Acute hypoxic stress: effect on blood parameters, antioxidant enzymes, and expression of HIF-1\u03b1 and GLUT-1 genes in largemouth bass (Micropterus salmoides). Fish Shellfish Immunol 67:449\u2013458. https:\/\/doi.org\/10.1016\/j.fsi.2017.06.035","journal-title":"Fish Shellfish Immunol"},{"key":"1627_CR115","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.acthis.2018.08.009","volume":"120","author":"G Zaccone","year":"2018","unstructured":"Zaccone G, Lauriano ER, Capillo G, Kuciel M (2018) Air-breathing in fish: air-breathing organs and control of respiration: nerves and neurotransmitters in the air-breathing organs and the skin. Acta Histochem 120:630\u2013641. https:\/\/doi.org\/10.1016\/j.acthis.2018.08.009","journal-title":"Acta Histochem"},{"key":"1627_CR116","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9412767","volume":"2016","author":"A Zeb","year":"2016","unstructured":"Zeb A, Ullah F (2016) A simple spectrophotometric method for the determination of thiobarbituric acid reactive substances in fried fast foods. J Anal Methods Chem 2016:9412767. https:\/\/doi.org\/10.1155\/2016\/9412767","journal-title":"J Anal Methods Chem"},{"key":"1627_CR117","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1007\/s00360-017-1083-8","volume":"187","author":"G Zhang","year":"2017","unstructured":"Zhang G, Zhao C, Wang Q, Gu Y, Li Z, Tao P, Chen J, Yin S (2017) Identification of HIF-1 signaling pathway in Pelteobagrus vachelli using RNA-Seq: effects of acute hypoxia and reoxygenation on oxygen sensors, respiratory metabolism, and hematology indices. J Comp Physiol B 187:931\u2013943. https:\/\/doi.org\/10.1007\/s00360-017-1083-8","journal-title":"J Comp Physiol B"},{"key":"1627_CR118","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.neuint.2014.09.010","volume":"79","author":"Z Zhu","year":"2014","unstructured":"Zhu Z, Reiser G (2014) Signaling mechanism of protease activated receptor 1 induced proliferation of astrocytes: Stabilization of hypoxia inducible factor 1\u03b1 triggers glucose metabolism and accumulation of cyclin D1. Neurochem Int 79:20\u201332. https:\/\/doi.org\/10.1016\/j.neuint.2014.09.010","journal-title":"Neurochem Int"},{"key":"1627_CR119","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1007\/s00360-013-0762-3","volume":"183","author":"CD Zhu","year":"2013","unstructured":"Zhu CD, Wang ZH, Yan B (2013) Strategies for hypoxia adaptation in fish species: a review. J Comp Physiol B 183:1005\u20131013. https:\/\/doi.org\/10.1007\/s00360-013-0762-3","journal-title":"J Comp Physiol B"}],"container-title":["Fish Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10695-025-01627-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10695-025-01627-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10695-025-01627-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:39:04Z","timestamp":1772764744000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10695-025-01627-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,22]]},"references-count":119,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["1627"],"URL":"https:\/\/doi.org\/10.1007\/s10695-025-01627-3","relation":{},"ISSN":["0920-1742","1573-5168"],"issn-type":[{"value":"0920-1742","type":"print"},{"value":"1573-5168","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,22]]},"assertion":[{"value":"6 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"5"}}