{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T19:48:07Z","timestamp":1782244087592,"version":"3.54.5"},"reference-count":88,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Fish Physiol Biochem"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s10695-026-01692-2","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:31:38Z","timestamp":1779197498000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A lansoprazole-like structure derived from Streptomyces metabolites: evaluation of its protective effects on hepatorenal function, antioxidant activity, and immune parameters in African catfish challenged with Staphylococcus aureus"],"prefix":"10.1007","volume":"52","author":[{"given":"Rewan","family":"Abdelaziz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeedah M.","family":"Almutairi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed R.","family":"AbdelGawwad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasim Sakran","family":"Abass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheeren","family":"Abdelaziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza SalahEldin","family":"El-Demerdash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riyadh","family":"Alotaibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Taha","family":"Yassin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"1692_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2025.108241","volume":"211","author":"R Abdelaziz","year":"2026","unstructured":"Abdelaziz R, Khalil AA, Ali R, Yassin MT, Al-Otibi FO, AbdelGawwad MR, Ahmed SA (2026) Telomycin nanoparticles from Streptomyces abietis: effects on hepatorenal function, antioxidant activity, immune responses, and histopathological and immunohistochemical alterations in African catfish (Clarias gariepinus) challenged with Staphylococcus aureus. Microb Pathog 211:108241. https:\/\/doi.org\/10.1016\/j.micpath.2025.108241","journal-title":"Microb Pathog"},{"key":"1692_CR2","doi-asserted-by":"crossref","unstructured":"Abdelaziz R, Elsheshtawy H, El-Houseiny W, Aloufi AS, Alwutayd K M.M, Abdallah T, Ghada H, Arisha AH, El-Murr A, Yassin A (2024) A novel metabolite of Streptomyces coeruleorubidus exhibits antibacterial activity against Streptococcus agalactiae through modulation of physiological performance, inflammatory cytokines, apoptosis, and oxidative stress-correlated gene expressions in Nile tilapia (Oreochromis niloticus). Fish Shellfish Immunol 148: 109496","DOI":"10.1016\/j.fsi.2024.109496"},{"key":"1692_CR3","first-page":"1110","volume":"44","author":"E Abdurabbah","year":"2021","unstructured":"Abdurabbah E, Mahmoud Y, Belgasem N, Fares N, Mousa H, Abo-Zeid F (2021) Outcomes of albino mice liver infected with contaminated camel milk. Histological and Ultrastructural Study 44:1110\u20135590","journal-title":"Histological and Ultrastructural Study"},{"key":"1692_CR4","first-page":"71","volume":"12","author":"I Adeshin","year":"2016","unstructured":"Adeshin I, Jenyo A, Emikpe B (2016) Use of Eugenia cayrophyllata oil as anaesthetic in farm raised African catfish Clarias gariepinus juveniles. Egypt. J. Exp. Biol.(Zool.) 12:71\u201376","journal-title":"Egypt. J. Exp. Biol.(Zool.)"},{"key":"1692_CR5","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121\u20136","journal-title":"Methods Enzymol"},{"issue":"2","key":"1692_CR6","first-page":"1","volume":"26","author":"T Akayli","year":"2011","unstructured":"Akayli T, Urku C, Basaran B (2011) Infection of Staphylococcus cohnii subsp. cohnii in cultured species. Turk J Aquat Sci 26(2):1\u201312","journal-title":"Turk J Aquat Sci"},{"key":"1692_CR7","first-page":"1","volume":"2","author":"N AL-Nakeeb","year":"2011","unstructured":"AL-Nakeeb N (2011) The pathogenesis of experimental infections by Staphylococcus aureus in rabbit. Kufa J Vet Med Sci 2:1\u201310","journal-title":"Kufa J Vet Med Sci"},{"key":"1692_CR8","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1373\/clinchem.2007.090811","volume":"53","author":"TM Annesley","year":"2007","unstructured":"Annesley TM (2007) Methanol-associated matrix effects in electrospray ionization tandem mass spectrometry. Clin Chem 53:1827\u201334","journal-title":"Clin Chem"},{"key":"1692_CR9","unstructured":"American Public Health Association (APHA), American Water Works Association (AWWA), & Water Environment Federation (WEF) (1998) Standard methods for the examination of water and wastewater, 20th ed. American Public Health Association"},{"key":"1692_CR10","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/srep34216","volume":"6","author":"N Arfatahery","year":"2016","unstructured":"Arfatahery N, Davoodabadi A, Abedimohtasab T (2016) Characterization of toxin genes and antimicrobial susceptibility of Staphylococcus aureus isolates in fishery products in Iran. Sci Rep 6:34\u2013216","journal-title":"Sci Rep"},{"key":"1692_CR11","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.vetmic.2010.02.004","volume":"144","author":"MA Atyah","year":"2010","unstructured":"Atyah MA, Zamri SM, Siti-Zahrah A (2010) First report of methicillin-resistant Staphylococcus aureus from cage-cultured tilapia (Oreochromis niloticus). Vet Microbiol 144:502\u20134","journal-title":"Vet Microbiol"},{"key":"1692_CR12","first-page":"26","volume":"7","author":"R Baskaran","year":"2011","unstructured":"Baskaran R, Vijayakumar R, Mohan PM (2011) Enrichment method for the isolation of bioactive actinomycetes from mangrove sediments of Andaman Islands. India. Malayas J Microbiol 7:26\u201332","journal-title":"Malayas J Microbiol"},{"key":"1692_CR13","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1111\/j.1365-2591.2005.00999.x","volume":"38","author":"L Bergmans","year":"2005","unstructured":"Bergmans L, Moisiadis P, Van M, Quirynen M, Lambrechts P (2005) Microscopic observation of bacteria: review highlighting the use of environmental SEM. Int Endod J 38:775\u2013788","journal-title":"Int Endod J"},{"key":"1692_CR14","first-page":"882","volume":"61","author":"E Beutler","year":"1963","unstructured":"Beutler E, Duron O, Kelly BM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882\u2013888","journal-title":"J Lab Clin Med"},{"key":"1692_CR15","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1111\/1462-2920.12134","volume":"5","author":"FC Cabello","year":"2013","unstructured":"Cabello FC, Godfrey HP, Tomova A (2013) Antimicrobial use in aquaculture re-examined: its relevance to antimicrobial resistance and to animal and human health. Environ Microbiol 5:1917\u20131942","journal-title":"Environ Microbiol"},{"key":"1692_CR16","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1111\/jai.14141","volume":"36","author":"\u00d6 \u00c7anak","year":"2020","unstructured":"\u00c7anak \u00d6, Timur G (2020) An initial survey on the occurrence of staphylococcal infections in Turkish marine aquaculture (2013\u20131014). J Appl Ichthyol 36:932\u2013941","journal-title":"J Appl Ichthyol"},{"key":"1692_CR17","unstructured":"Canadian Council on Animal Care (CCAC) (2005) CCAC guidelines on: the care and use of fish in research, teaching and testing. Canadian Council on Animal Care"},{"key":"1692_CR18","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jgar.2017.03.012","volume":"10","author":"EWL Chan","year":"2017","unstructured":"Chan EWL, Yee ZY, Raja I (2017) Synergistic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on antibacterial activity of cefuroxime and chloramphenicol against methicillin-resistant Staphylococcus aureus. J Glob Antimicrob Resist 10:70\u201374","journal-title":"J Glob Antimicrob Resist"},{"issue":"1","key":"1692_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-022-00448-x","volume":"28","author":"Z Cheng","year":"2022","unstructured":"Cheng Z, Liu Y, Ma M, Sun S, Ma Z, Wang Y, Yu L, Qian X, Sun L, Zhang X, Liu Y, Wang Y (2022) Lansoprazole-induced osteoporosis via the IP3R- and SOCE-mediated calcium signalling pathways. Mol Med 28(1):21","journal-title":"Mol Med"},{"key":"1692_CR20","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1093\/clinchem\/9.1.102","volume":"9","author":"J Coulombe","year":"1963","unstructured":"Coulombe J, Favreau L (1963) A new simple semimicro method for colorimetric determination of urea. Clin Chem 9:102\u2013108","journal-title":"Clin Chem"},{"key":"1692_CR21","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1345\/aph.19086","volume":"34","author":"J DiGiacinto","year":"2000","unstructured":"DiGiacinto J, Olsen K, Bergman K, Hoie E (2000) Stability of suspension formulations of Lansoprazole and Omeprazole stored in amber-colored plastic oral syringes. The Ann of pharmaco 34:600\u20135","journal-title":"The Ann of pharmaco"},{"key":"1692_CR22","first-page":"389","volume":"135","author":"N Duran","year":"2012","unstructured":"Duran N, Ozer B, Duran GG, Onlen Y, Demir C (2012) Antibiotic resistance genes and susceptibility patterns in staphylococci. Indian J Med Res 135:389\u2013960","journal-title":"Indian J Med Res"},{"key":"1692_CR23","doi-asserted-by":"publisher","first-page":"49","DOI":"10.2147\/IDR.S55778","volume":"8","author":"V Economou","year":"2015","unstructured":"Economou V, Gousia P (2015) Agriculture and food animals as a source of antimicrobial-resistant bacteria. Infect Drug Resist 8:49\u201361","journal-title":"Infect Drug Resist"},{"key":"1692_CR24","unstructured":"Ellis AE (1990) Lysozyme assays. In: Stolen JS, Fletcher TC, Anderson DP, Roberson BS, Van Muiswinkel WB (eds) Techniques in fish immunology. SOS Publications, Fair Haven, NJ, pp 101\u2013103"},{"key":"1692_CR25","unstructured":"Fogo AB, Cohen AH, Colvin RB (2014) Chapter 5. Postinfectious glomerulonephritis. Fundamentals of renal pathology. Springer, Berlin Heidelberg, pp 1\u201334"},{"key":"1692_CR26","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1038\/nrmicro1289","volume":"3","author":"TJ Foster","year":"2005","unstructured":"Foster TJ (2005) Immune evasion by staphylococci. Nat Rev Microbiol 3:948\u2013958","journal-title":"Nat Rev Microbiol"},{"key":"1692_CR27","doi-asserted-by":"publisher","DOI":"10.1111\/jfs.12411","author":"J Fri","year":"2018","unstructured":"Fri J, Ndip RN, Njom HA, Clarke AM (2018) First report of methicillin-resistant Staphylococcus aureus in tank cultured dusky kob (Argyrosomus japonicus), and evaluation of three phenotypic methods in the detection of MRSA. J Food Saf. https:\/\/doi.org\/10.1111\/jfs.12411","journal-title":"J Food Saf"},{"key":"1692_CR28","volume":"3","author":"AY Gaafar","year":"2015","unstructured":"Gaafar AY, Soliman MK, Ellakany HF, Affr NA, Elbialy AK, Mona S, Younes AM, Abozahra R (2015) Comparative pathogenecity of methicillin-resistant Staphylococcus aureus (MRSA) in Nile tilapia (Oreochromis niloticus) and Tilapia zilli. Life Sci J 3:12","journal-title":"Life Sci J"},{"issue":"3","key":"1692_CR29","first-page":"186","volume":"12","author":"A Gaafar","year":"2015","unstructured":"Gaafar A, Soliman M, Ellakany HF, Affr N, Elbialy AK, Mona SZ, Younes AM, Abozahra R (2015) Comparative pathogenicity of methicillin resistant Staphylococcus aureus (MRSA) in Nile tilapia (Oreochromis niloticus) and Tilapia zilli. Life Sci J 12(3):186\u2013194","journal-title":"Life Sci J"},{"key":"1692_CR30","volume":"12","author":"U Godswill","year":"2023","unstructured":"Godswill U, Chukwu T, Ulasi GF (2023) Review on status of African catfish aquaculture in Nigeria. Int J Latest Technol Eng Manag App Sci 12:811","journal-title":"Int J Latest Technol Eng Manag App Sci"},{"key":"1692_CR31","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.bjid.2014.03.005","volume":"5","author":"J Gong","year":"2014","unstructured":"Gong J, Dongzhi L, Yan J, Liu Y, Li D, Dong J, Gao Y, Sunb T, Yang G (2014) The accessory gene regulator (agr) controls Staphylococcus aureus virulence in a murine intracranial abscesses model. Braz J Infect Dis 5:501\u2013506","journal-title":"Braz J Infect Dis"},{"key":"1692_CR32","doi-asserted-by":"publisher","first-page":"124","DOI":"10.33974\/ijrpst.v1i4.201","volume":"1","author":"SK Haneesha","year":"2020","unstructured":"Haneesha SK, Venkataramana M, Ramarao N (2020) Formulation and evaluation of Lansoprazole loaded enteric coated microspheres. International Journal of Research in Pharma Sci and Techno 1:124\u2013130","journal-title":"International Journal of Research in Pharma Sci and Techno"},{"issue":"2","key":"1692_CR33","first-page":"93","volume":"1055","author":"ZMA Heikal","year":"2024","unstructured":"Heikal ZMA, Limam SA, Omer MB, Mostafa BMD, Khalifa AH (2024) Quality properties of African catfish (Clarias gariepinus) meat as affected by its color. Assiut J Agric Sci 1055(2):93\u2013110","journal-title":"Assiut J Agric Sci"},{"key":"1692_CR34","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1111\/j.1574-6976.2011.00311.x","volume":"36","author":"JA Hennekinne","year":"2012","unstructured":"Hennekinne JA, De Buyser ML, Dragacci S (2012) Staphylococcus aureus\u00a0and its food poisoning toxins: characterization and outbreak investigation. FEMS Microbiol Rev 36:815\u2013836","journal-title":"FEMS Microbiol Rev"},{"key":"1692_CR35","first-page":"739","volume":"566","author":"AA Hisham","year":"2023","unstructured":"Hisham AA, William GH, Luke AR, Terrill RH, Benjamin HB, Anita MK (2023) Epidemiology and economic impact of disease-related losses on commercial catfish farms: a seven-year case study from Alabama, USA,. Aquaculture 566:739\u2013206","journal-title":"Aquaculture"},{"issue":"4","key":"1692_CR36","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/0306-3623(95)02112-4","volume":"27","author":"JR Hoult","year":"1996","unstructured":"Hoult JR, Pay\u00e1 M (1996) Pharmacological and biochemical actions of simple coumarins: Natural products with therapeutic potential. Gen Pharmacol Vasc Sys 27(4):713\u2013722","journal-title":"General Pharmacology: The Vascular System"},{"issue":"2","key":"1692_CR37","first-page":"178","volume":"38","author":"SL Huang","year":"1999","unstructured":"Huang SL, Chen W, Shei MC, Liao IC, Chen SN (1999) Studies on epizootiology and pathogenecity of Staphylococcus epidermidis in tilapia (Oreochromis spp.) cultured in Taiwan. Zool Stud 38(2):178\u2013188","journal-title":"Zool Stud"},{"key":"1692_CR38","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1128\/AAC.35.3.490","volume":"3","author":"T Iwahi","year":"1991","unstructured":"Iwahi T, Satoh H, Nakao M, Iwasaki T, Yamazaki T, Kubo K, Tamura T, Imada A (1991) Lansoprazole, a novel benzimidazole proton pump inhibitor, and its related compounds have selective activity against Helicobacter pylori. Antimicrob Agents Chemother 3:490\u20136","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"1692_CR39","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-023-03465-7","volume":"13","author":"G James","year":"2023","unstructured":"James G, Geetha P, Puthiyedathu ST, Jayadradhan RK (2023) Applications of Actinobacteria in aquaculture: prospects and challenges. 3 Biotech 13(2):42","journal-title":"3 Biotech"},{"issue":"5","key":"1692_CR40","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1021\/ac60041a012","volume":"22","author":"RE Kitson","year":"1996","unstructured":"Kitson RE (1996) Spectrophotometric determination of phosphorus as molybdovanadophosphoric acid. Anal Chem 22(5):664\u2013667","journal-title":"Anal Chem"},{"issue":"3","key":"1692_CR41","first-page":"137","volume":"24","author":"A Kubilay","year":"2004","unstructured":"Kubilay A, Ulukoy G (2004) First isolation of Staphylococcus epidermidis from cultured gilthead seabream (Sparus aurata) in Turkey. Bulletin of European Association of Fish Pathologists 24(3):137\u2013143","journal-title":"Bulletin of European Association of Fish Pathologists"},{"issue":"4","key":"1692_CR42","first-page":"488","volume":"6","author":"S Kumaradevan","year":"2015","unstructured":"Kumaradevan S, Chow SC, Tshering D (2015) Antimicrobial activity of silver nanoparticles and microalgal extracts against selected human pathogens. Int J Pharma and Bio Sci 6(4):488\u2013495","journal-title":"Int J Pharma and Bio Sci"},{"key":"1692_CR43","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3389\/fmicb.2014.00446","volume":"5","author":"V Kumar","year":"2014","unstructured":"Kumar V, Naik B, Gusain O, Bisht GS (2014) An actinomycete isolate from solitary wasp mud nest having strong antibacterial activity and kills the Candida cells due to the shrinkage and the cytosolic loss. Front Microbiol 5:4\u201346","journal-title":"Front Microbiol"},{"key":"1692_CR44","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3147\/jsfp.16.15","volume":"16","author":"R Kusuda","year":"1981","unstructured":"Kusuda R, Sugiyama A (1981) Studies on the characters of Staphylococcus epidermidis isolated from diseased fishes \u2013 1. on the morphological, biological and biochemical properties. Fish Pathol 16:15\u201324","journal-title":"Fish Pathol"},{"key":"1692_CR45","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/0009-8981(72)90513-X","volume":"41","author":"K Larsen","year":"1972","unstructured":"Larsen K (1972) Creatinine assay by a reaction-kinetic principle. Clin Chim Acta 41:209\u2013217","journal-title":"Clin Chim Acta"},{"key":"1692_CR46","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.cbpb.2023.110876","volume":"269","author":"H Mahboub","year":"2024","unstructured":"Mahboub H, Eltanahy A, Omran A, Mansour AT, Safhi FA, Alwutayd KM, Khamis T, Husseiny W, Ismail SH, Yousefi M, Abdel Rahman AN (2024) Chitosan nanogel aqueous treatment improved blood biochemicals, antioxidant capacity, immune response, immune-related gene expression and infection resistance of Nile tilapia. Comp Biochem Physiol B Biochem Mol Biol 269:110\u2013876","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"issue":"23","key":"1692_CR47","first-page":"15","volume":"13","author":"RD Manzur","year":"2023","unstructured":"Manzur RD, L\u00f3pez HJ, Mart\u00ednez PM, Vargas AF, Garibay VE, Coronado MDE, Hern\u00e1ndez OM, V\u00e1zquez RF, Vel\u00e1zquez VLA, Santacruz A (2023) Staphylococcus haemolyticus\u00a0and\u00a0Providencia vermicola\u00a0infections occurring in farmed tilapia: two potentially emerging pathogens. Animals (Basel) 13(23):15\u201337","journal-title":"Animals (Basel)"},{"issue":"5","key":"1692_CR48","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1053\/jhep.2000.19621","volume":"32","author":"P Mathurin","year":"2000","unstructured":"Mathurin P, Deng QG, Keshavarzian A, Choudhary S, Holmes EW, Tsukamoto H (2000) Exacerbation of alcoholic liver injury by enteral endotoxin in rats. Hepatology 32(5):1008\u20131017","journal-title":"Hepatology"},{"key":"1692_CR49","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1016\/j.ejmech.2006.07.005","volume":"41","author":"A Mavrova","year":"2006","unstructured":"Mavrova A, Anichina K, Vuchev D, Tsenov J, Denkova P, Kondeva M, Micheva M (2006) Antihelminthic activity of some newly synthesized 5 (6)-(un) substituted-1H-benzimidazol-2-ylthioacetylpiperazine derivatives. Eur J Med Chem 41:1412\u20131420","journal-title":"Eur J Med Chem"},{"issue":"10","key":"1692_CR50","first-page":"094","volume":"7","author":"B Melekh","year":"2017","unstructured":"Melekh B, Ilkiv I, Lozynskyi A, Sklyarov A (2017) Antioxidant enzyme activity and lipid peroxidation in rat liver exposed to celecoxib and lansoprazole under epinephrine-induced stress. J Appl Pharm Sci 7(10):094\u2013099","journal-title":"J Appl Pharm Sci"},{"issue":"4","key":"1692_CR51","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7163\/10\/4\/046017","volume":"10","author":"AS Modak","year":"2016","unstructured":"Modak AS, Klyarytska I, Kriviy V, Tsapyak T, Rabotyagova Y (2016) The effect of proton pump inhibitors on the CYP2C19 enzyme activity evaluated by the Pantoprazole-13C breath test in GERD patients: clinical relevance for personalized medicine. J Breath Res 10(4):046017","journal-title":"J Breath Res"},{"key":"1692_CR52","first-page":"414","volume":"102","author":"H Montgomery","year":"1961","unstructured":"Montgomery H, Dymock JF (1961) The determination of nitrite in water. Analyst 102:414\u2013416","journal-title":"Analyst"},{"key":"1692_CR53","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/S0006-291X(72)80218-3","volume":"2","author":"M Nishikimi","year":"1972","unstructured":"Nishikimi M, Rao NA, Yagi K (1972) The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Commun 2:849\u2013854","journal-title":"Biochem Biophys Res Commun"},{"key":"1692_CR54","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1128\/JB.00006-08","volume":"190","author":"B Park","year":"2008","unstructured":"Park B, Nizet V, Liu GY (2008) Role of Staphylococcus aureus catalase in niche competition against Streptococcus pneumoniae. J Bacteriol 190:2275\u20132278","journal-title":"J Bacteriol"},{"key":"1692_CR55","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2015.1068907","author":"E Peatman","year":"2015","unstructured":"Peatman E, Lange M, Zhao H, Beck BH (2015) Physiology and immunology of mucosal barriers in catfish (Ictalurus spp.). Tissue Barriers. https:\/\/doi.org\/10.1080\/21688370.2015.1068907","journal-title":"Tissue Barriers"},{"key":"1692_CR56","first-page":"7","volume":"5","author":"G Pietrocola","year":"2017","unstructured":"Pietrocola G, Nobile G, Rindi S, Speziale P (2017) Staphylococcus aureus manipulates innate immunity through own and host-expressed proteases. Front Cell Infect Microbiol 5:7\u2013166","journal-title":"Front Cell Infect Microbiol"},{"key":"1692_CR57","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3389\/fmicb.2021.722661","volume":"12","author":"D Qi","year":"2021","unstructured":"Qi D, Zou L, Zhou D, Zhang M, Wei Y, Zhang L, Xie J, Wang W (2021) Identification and antifungal mechanism of a novel actinobacterium Streptomyces huiliensis sp. nov. against Fusarium oxysporum f. sp. cubense tropical race 4 of banana. Front Microbiol 12:72\u2013266","journal-title":"Front Microbiol"},{"key":"1692_CR58","first-page":"1","volume":"4","author":"G Rajivgandhi","year":"2018","unstructured":"Rajivgandhi G, Ramachandran G, Maruthupandy M, Saravanakumar S, Manoharan N, Viji R (2018) Antibacterial Effect of Endophytic Actinomycetes from Marine Algae against Multi Drug Resistant Gram-Negative Bacteria 4:1\u20138","journal-title":"Antibacterial Effect of Endophytic Actinomycetes from Marine Algae against Multi Drug Resistant Gram-Negative Bacteria"},{"key":"1692_CR59","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1007\/s11274-009-0113-4","volume":"25","author":"S Ramesh","year":"2009","unstructured":"Ramesh S, Mathivanan N (2009) Screening of marine actinomycetes isolated from the Bay of Bengal, India for antimicrobial activity and industrial enzymes. World J Microbiol Biotechnol 25:2103\u20132111","journal-title":"World J Microbiol Biotechnol"},{"key":"1692_CR60","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fmars.2020.00253","volume":"7","author":"E Ramirez","year":"2020","unstructured":"Ramirez E, Hilario A, Paulsen E, Costa CV, Bakken T, Johnsen G (2020) Benthic communities on the Mohn\u2019s treasure mound: implications for management of seabed mining in the Arctic Mid-Ocean Ridge. Front Mar Sci 7:18\u2013318","journal-title":"Front Mar Sci"},{"key":"1692_CR61","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1111\/j.1365-2958.2006.05290.x","volume":"61","author":"A Richardson","year":"2006","unstructured":"Richardson A, Dunman P, Fang F (2006) The nitrosative stress response of Staphylococcus aureus is required for resistance to innate immunity. Mol Microbiol 61:927\u2013939","journal-title":"Mol Microbiol"},{"key":"1692_CR62","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.tim.2005.10.002","volume":"13","author":"SH Rooijakkers","year":"2005","unstructured":"Rooijakkers SH, van Kessel KP, van Strijp JA (2005) Staphylococcal innate immune evasion. Trends Microbiol 13:596\u2013601","journal-title":"Trends Microbiol"},{"key":"1692_CR63","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/ncomms8659","volume":"6","author":"J Rybniker","year":"2015","unstructured":"Rybniker J, Vocat A, Sala C (2015) Lansoprazole is an antituberculous prodrug targetingcytochrome bc1. Nat Commun 6:7\u201359","journal-title":"Nat Commun"},{"key":"1692_CR64","first-page":"51","volume":"9","author":"DM Sahoo","year":"2014","unstructured":"Sahoo DM, Rukmini R (2014) Quantitative analysis of serum levels of alanine and aspartate aminotransferases, \u03b3-glutamyl transferase and alkaline phospatase as predictor of liver diseases. Am Int J Res Formal Appl Nat Sci 9:51\u201355","journal-title":"Am Int J Res Formal Appl Nat Sci"},{"key":"1692_CR65","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1371\/journal.pmed.1002521","volume":"15","author":"D Schar","year":"2018","unstructured":"Schar D, Sommanustweechai A, Laxminarayan R, Tangcharoensathien V (2018) Surveillance of antimicrobial consumption in animal production sectors of low- and middle-income countries: optimizing use and addressing antimicrobial resistance. PLoS Med 15:200\u2013521","journal-title":"PLoS Med"},{"key":"1692_CR66","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fmicb.2020.01325","volume":"11","author":"C Schwarz","year":"2020","unstructured":"Schwarz C, Hoerr V, T\u00f6re Y (2020) Isolating crucial steps in induction of infective endocarditis with preclinical modelling of host pathogen interaction. Front Microbiol 11:13\u201325","journal-title":"Front Microbiol"},{"key":"1692_CR67","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.semcdb.2017.04.003","volume":"72","author":"ES Seilie","year":"2017","unstructured":"Seilie ES, Bubeck Wardenburg J (2017) Staphylococcus aureus pore-forming toxins: the interface of pathogen and host complexity. Semin Cell Dev Biol 72:101\u2013116. https:\/\/doi.org\/10.1016\/j.semcdb.2017.04.003","journal-title":"Semin Cell Dev Biol"},{"key":"1692_CR68","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1002\/jms.3949","volume":"52","author":"G Shankar","year":"2017","unstructured":"Shankar G, Borkar RM, Suresh U, Guntuku L, Naidu VGM, Nagesh N, Srinivas R (2017) Forced degradation studies of lansoprazole using LC-ESI HRMS and 1 H-NMR experiments: in vitro toxicity evaluation of major degradation products. J Mass Spectrom 52:459\u2013471","journal-title":"J Mass Spectrom"},{"key":"1692_CR69","first-page":"909","volume-title":"Goodman & Gilman\u2019s the pharmacological basis of therapeutics","author":"KA Sharkey","year":"2018","unstructured":"Sharkey KA, McNaughton WK (2018) Pharmacotherapy of gastric acidity, peptic ulcers, and gastroesophageal reflux disease. In: Brunton LL, Hilal-Dandan R, Knollman BC (eds) Goodman & Gilman\u2019s the pharmacological basis of therapeutics, 13th edn. McGraw-Hill. Textbook of pharmacology and therapeutics, New York, pp 909\u20132000","edition":"13"},{"issue":"10","key":"1692_CR70","first-page":"12","volume":"11","author":"M Soliman","year":"2014","unstructured":"Soliman M, Ellakany H, Gaafar A, Elbialy A, Zaki M, Younes A (2014) Epidemiology and antimicrobial activity of methicillin-resistant Staphylococcus aureus (MRSA) isolated from Nile tilapia (Oreochromis niloticus) during an outbreak in Egypt. Life Sci J 11(10):12\u201345","journal-title":"Life Sci J"},{"key":"1692_CR71","doi-asserted-by":"crossref","unstructured":"Stevens A (2013) The hematoxylins and eosin. In: Suvarna SK, Layton C, Bancroft JD (eds.) Bancroft's theory and practice of histological techniques, 7th ed. Churchill Livingstone\/Elsevier, pp 173\u2013204","DOI":"10.1016\/B978-0-7020-4226-3.00010-X"},{"key":"1692_CR72","unstructured":"Suvarna SK, Layton C, Bancroft JD (2013) Bancroft's theory and practice of histological techniques, 7th ed. Churchill Livingstone\/Elsevier"},{"key":"1692_CR73","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.3109\/03639049209040850","volume":"18","author":"T Tabatar","year":"2008","unstructured":"Tabatar T, Makino T, Kashihara T, Hirai S, Kitamori N, Toguchi H (2008) Stabilization of a new antiulcer drug (Lansoprazole) in the solid dosage forms. Drug Dev Ind Pharm 18:1437\u20131447","journal-title":"Drug Dev Ind Pharm"},{"key":"1692_CR74","volume":"9","author":"CS Thirukanthan","year":"2023","unstructured":"Thirukanthan CS, Mohamad NA, Rumeaida MP, Fathurrahman L, Guillermo T, Huan G, Donald T, Zulhisyam AK, Noordiyana MN (2023) Catfishes: a global review of the literature. Heliyon 9:2405-8440","journal-title":"Heliyon"},{"key":"1692_CR75","first-page":"67","volume":"23","author":"G Timur","year":"2003","unstructured":"Timur G, Akayli T (2003) First study of staphylococcosis in farmed rainbow trout (Oncorhynchus mykiss) fry in Turkey. International Symposium on Fisheries & Zoology Istanbul, Turkey 23:67\u201379","journal-title":"International Symposium on Fisheries & Zoology Istanbul, Turkey"},{"key":"1692_CR76","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.1111\/1750-3841.14915","volume":"84","author":"M Vaiyapuri","year":"2019","unstructured":"Vaiyapuri M, Joseph TC, Rao BM, Lalitha KV, Prasad MM (2019) Methicillin-resistant Staphylococcus aureus in seafood: prevalence, laboratory detection, clonal nature, and control in seafood chain. J Food Sci 84:3341\u20133351","journal-title":"J Food Sci"},{"key":"1692_CR77","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1371\/journal.pone.0005234","volume":"4","author":"JM Van den Berg","year":"2009","unstructured":"Van den Berg JM, van Koppen E, Ahlin A, Belohradsky BH, Bernatowska E, Corbeel L, Espa\u00f1ol T, Fischer A, Kurenko-Deptuch M, Mouy R, Petropoulou T, Roesler J, Seger R, Stasia MJ, Valerius NH, Weening RS, Wolach B, Roos D, Kuijpers TW (2009) Chronicgranulomatous disease. The European experience. PLoS One 4:5\u2013234","journal-title":"PLoS One"},{"key":"1692_CR78","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1007\/s13213-011-0345-z","volume":"62","author":"R Vijayakumar","year":"2012","unstructured":"Vijayakumar R, Panneer Selvam K, Muthukumar C, Thajuddin N, Panneerselvam A, Saravanamuthu R (2012) Antimicrobial potentiality of a halophilic strain of Streptomyces sp. VPTSA18 isolated from the saltpan environment of Vedaranyam. India. Ann Microbiol 62:1039\u20131047","journal-title":"Ann Microbiol"},{"key":"1692_CR79","first-page":"57","volume":"17","author":"WS Wang","year":"1996","unstructured":"Wang WS, Chang YC, Shieh MT, Lin CC (1996) Staphylococcus epidermidis and cestode infection of cultured grass carp (Ctenopharyngodon idella) in Taiwan. Rep Fish Dis Res 17:57\u201363","journal-title":"Rep Fish Dis Res"},{"key":"1692_CR80","doi-asserted-by":"publisher","first-page":"13473","DOI":"10.1073\/pnas.1001815107","volume":"107","author":"G Wilke","year":"2010","unstructured":"Wilke G, Wardenburg J (2010) Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus \u03b1-hemolysin-mediated cellular injury. Proc Natl Acad Sci U S A 107:13473\u201313478","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1692_CR81","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1189\/jlb.1010550","volume":"89","author":"DA Wink","year":"2011","unstructured":"Wink DA, Hines HB, Cheng RY, Switzer CH, Flores-Santana W, Vitek MP, Ridnour LA, Colton CA (2011) Nitric oxide and redox mechanisms in the immune response. J Leukoc Biol 89:873\u2013891","journal-title":"J Leukoc Biol"},{"key":"1692_CR82","doi-asserted-by":"publisher","first-page":"51","DOI":"10.2147\/CCID.S130013","volume":"10","author":"U Wollina","year":"2017","unstructured":"Wollina U (2017) Microbiome in atopic dermatitis. Clin Cosmet Investig Dermatol 10:51\u201356","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"1692_CR83","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1111\/j.1469-0691.2008.01970.x","volume":"14","author":"M Wulf","year":"2008","unstructured":"Wulf M, Voss A (2008) MRSA in livestock animals-an epidemic waiting to happen? Clin Microbiol Infect 14:519\u2013521","journal-title":"Clin Microbiol Infect"},{"key":"1692_CR84","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0287788","author":"N Yamagishi","year":"2023","unstructured":"Yamagishi N, Yamamoto Y, Nishi T, Ito T, Kanai Y (2023) Lansoprazole protects hepatic cells against cisplatin-induced oxidative stress through the p38 MAPK\/ARE\/Nrf2 pathway. PLoS One. https:\/\/doi.org\/10.1371\/journal.pone.0287788","journal-title":"PLoS One"},{"key":"1692_CR85","first-page":"123","volume":"25","author":"M Y\u0131lmaz","year":"2019","unstructured":"Y\u0131lmaz M, Korun J, G\u00f6ko\u011flu M, \u00c7elik SY (2019) Isolation of Staphylococcus hominis from cultured gilthead sea bream (Sparus aurata L.) in Antalya Bay, Turkey. J Agric Sci 25:123\u2013128","journal-title":"J Agric Sci"},{"issue":"12","key":"1692_CR86","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.2169\/internalmedicine.2221-18","volume":"58","author":"M Yoshioka","year":"2019","unstructured":"Yoshioka M, Watanabe T, Iida M, Nakagawa Y, Uchinami H, Watanabe G, Abe Y, Yagi F, Yokoyama N, Yamamoto Y (2019) Effect of Lansoprazole on the control of the intragastric pH in a patient with short bowel syndrome. Intern Med 58(12):1723\u20131726","journal-title":"Intern Med"},{"key":"1692_CR87","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.aquaculture.2019.734319","volume":"512","author":"E Zahran","year":"2019","unstructured":"Zahran E, Mahgoub HA, Abdelhamid F, Sadeyen J, Risha E (2019) Experimental pathogenesis and host immune responses of Enterococcus faecalis infection in Nile tilapia (Oreochromis niloticus). Aquaculture 512:73-431.25","journal-title":"Aquaculture"},{"key":"1692_CR88","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1089\/10665270050081478","volume":"7","author":"Z Zhang","year":"2000","unstructured":"Zhang Z, Schwartz S, Wagner L, Miller W (2000) A greedy algorithm for aligning DNA sequences. J Comput Biol 7:203\u2013214","journal-title":"J Comput Biol"}],"container-title":["Fish Physiology and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10695-026-01692-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10695-026-01692-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10695-026-01692-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T19:02:40Z","timestamp":1782241360000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10695-026-01692-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":88,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["1692"],"URL":"https:\/\/doi.org\/10.1007\/s10695-026-01692-2","relation":{},"ISSN":["0920-1742","1573-5168"],"issn-type":[{"value":"0920-1742","type":"print"},{"value":"1573-5168","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]},"assertion":[{"value":"26 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Institutional Animal Care and Use Committee\u2019s Ethics Committee at Zagazig University in Egypt approved the experimental protocol. The NIH\u2019s general guidelines for the care and use of laboratory animals in scientific research (ZU\\IACUC\\1\\F\\205\\2024) were followed when the experiments were conducted. The fish were transported in plastic bags to the Wet Lab at Zagazig University\u2019s Department of Aquatic Animal Medicine in Egypt from Al-Abbassa Fish Hatchery in Sharkia Governorate, Egypt.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number in the manuscript"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"79"}}