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Microalgae such as\n                    <jats:italic>Microchloropsis gaditana<\/jats:italic>\n                    and\n                    <jats:italic>Arthrospira platensis<\/jats:italic>\n                    are rich in bioactive compounds with potential functional benefits. This study evaluated the effects of supplementing gilthead seabream (\n                    <jats:italic>Sparus aurata<\/jats:italic>\n                    ) diets with a 10% blend of raw or enzymatically hydrolyzed\n                    <jats:italic>M. gaditana<\/jats:italic>\n                    and\n                    <jats:italic>A. platensis<\/jats:italic>\n                    on intestinal microbiota composition and metabolomic profiles. Over a 41-day feeding trial, fish were fed either a control diet or diets supplemented with raw or hydrolyzed microalgae. Microbial communities were assessed via 16S rRNA gene sequencing, and intestinal metabolites were profiled using UPLC-QTOF and GC\u2013MS. The hydrolyzed microalgae diet induced a marked shift in microbial composition, characterized by a significant increase in Proteobacteria and reduced alpha diversity, particularly in the anterior intestine, whereas the raw diet preserved microbial diversity and promoted the presence of beneficial taxa such as\n                    <jats:italic>Fusobacteria<\/jats:italic>\n                    . Both supplemented diets led to a reduction in inflammation-related metabolites, including 12-keto-leukotriene B4 and 15-keto-prostaglandin E2, and facilitated the accumulation of beneficial long-chain fatty acids, such as oleic and stearic acids. Overall, these findings indicate that dietary inclusion of\n                    <jats:italic>M. gaditana<\/jats:italic>\n                    and\n                    <jats:italic>A. platensis<\/jats:italic>\n                    , particularly in hydrolyzed form, can modulate gut microbiota and intestinal metabolic responses in\n                    <jats:italic>S. aurata<\/jats:italic>\n                    , supporting their potential use as functional and sustainable aquafeed ingredients.\n                  <\/jats:p>","DOI":"10.1007\/s10695-026-01791-0","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:25:10Z","timestamp":1789381510000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The diet supplemented with raw and hydrolyzed Microchloropsis gaditana and Arthrospira platensis blend modulates intestinal microbiota and metabolomic profiles in Sparus aurata"],"prefix":"10.1007","volume":"52","author":[{"given":"Sonia","family":"Rohra-Ben\u00edtez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Garc\u00eda-M\u00e1rquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Bautista-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Vallejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"S\u00e1ez-Casado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"Martos-Sitcha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Mori\u00f1igo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3656-5009","authenticated-orcid":false,"given":"Silvana Teresa","family":"Tapia-Paniagua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"1791_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1098467","author":"MM Alba","year":"2023","unstructured":"Alba MM, Ebright B, Hua B, Slarve I, Zhou Y, Jia Y, Louie SG, Stiles BL (2023) Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer development. 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