{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:15:20Z","timestamp":1758935720103,"version":"3.37.3"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T00:00:00Z","timestamp":1532563200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2017YFD0502303"],"award-info":[{"award-number":["2017YFD0502303"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Fund, China","doi-asserted-by":"crossref","award":["NO. 31500747"],"award-info":[{"award-number":["NO. 31500747"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Glycoconj J"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s10719-018-9830-y","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T07:50:49Z","timestamp":1532591449000},"page":"451-459","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Conjugation of chitosan oligosaccharides via a carrier protein markedly improves immunogenicity of porcine circovirus vaccine"],"prefix":"10.1007","volume":"35","author":[{"given":"Guiqiang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiyuan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongtao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuguang","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,7,26]]},"reference":[{"issue":"3","key":"9830_CR1","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.tvjl.2004.01.012","volume":"169","author":"SL Chang","year":"2005","unstructured":"Chang, S.L., Chang, C.L., Chiang, Y.M., Hsieh, R.H., Tzeng, C.R., Wu, T.K., Sytwu, H.K., Shyur, L.F., Yang, W.C.: A review of porcine circovirus 2-associated syndromes and diseases. Vet. J. 169(3), 326\u2013336 (2005)","journal-title":"Vet. J."},{"issue":"2","key":"9830_CR2","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.prevetmed.2013.02.010","volume":"110","author":"A Pablo","year":"2013","unstructured":"Pablo, A., Jonathan, R., Barbara, W.: Cost of post-weaning multi-systemic wasting syndrome and porcine circovirus type-2 subclinical infection in England \u2013 an economic disease model. Prev. Vet. Med. 110(2), 88 (2013)","journal-title":"Prev. Vet. Med."},{"key":"9830_CR3","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.carbpol.2017.02.058","volume":"166","author":"G Zhang","year":"2017","unstructured":"Zhang, G., Jia, P., Cheng, G., Jiao, S., Ren, L., Ji, S., Hu, T., Liu, H., Du, Y.: Enhanced immune response to inactivated porcine circovirus type 2 (PCV2) vaccine by conjugation of chitosan oligosaccharides. Carbohydr. Polym. 166, 64 (2017)","journal-title":"Carbohydr. Polym."},{"issue":"8","key":"9830_CR4","doi-asserted-by":"publisher","first-page":"236","DOI":"10.3390\/md15080236","volume":"15","author":"G Zhang","year":"2017","unstructured":"Zhang, G., Cheng, G., Jia, P., Jiao, S., Feng, C., Hu, T., Liu, H., Du, Y.: The positive correlation of the enhanced immune response to PCV2 subunit vaccine by conjugation of chitosan oligosaccharide with the deacetylation degree. Marine Drugs. 15(8), 236 (2017)","journal-title":"Marine Drugs"},{"issue":"2","key":"9830_CR5","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.jconrel.2010.01.007","volume":"143","author":"B Sl\u00fctter","year":"2010","unstructured":"Sl\u00fctter, B., Soema, P.C., Ding, Z., Verheul, R., Hennink, W., Jiskoot, W.: Conjugation of ovalbumin to trimethyl chitosan improves immunogenicity of the antigen. J. Control. Release. 143(2), 207\u2013214 (2010)","journal-title":"J. Control. Release"},{"issue":"8","key":"9830_CR6","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.1002\/1521-4141(200208)32:8<2356::AID-IMMU2356>3.0.CO;2-Z","volume":"32","author":"T Maurer","year":"2015","unstructured":"Maurer, T., Heit, A., Hochrein, H., Ampenberger, F., O'Keeffe, M., Bauer, S., Lipford, G.B., Vabulas, R.M., Wagner, H.: CpG-DNA aided cross-presentation of soluble antigens by dendritic cells. Eur. J. Immunol. 32(8), 2356\u20132364 (2015)","journal-title":"Eur. J. Immunol."},{"issue":"3","key":"9830_CR7","first-page":"115","volume":"2","author":"I Mellman","year":"2011","unstructured":"Mellman, I., Coukos, G., Dranoff, G.: Cancer immunotherapy comes of age. Nat. Clin. Pract. Oncol. 2(3), 115 (2011)","journal-title":"Nat. Clin. Pract. Oncol."},{"issue":"1","key":"9830_CR8","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/anie.201306551","volume":"53","author":"RJ Mancini","year":"2014","unstructured":"Mancini, R.J., Tom, J.K., Esserkahn, A.P.: Covalently coupled immunostimulant heterodimers. Angew. Chem. Int. Ed. Eng. 53(1), 189\u2013192 (2014)","journal-title":"Angew. Chem. Int. Ed. Eng."},{"issue":"4","key":"9830_CR9","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1021\/acs.bioconjchem.6b00116","volume":"27","author":"Q Huang","year":"2016","unstructured":"Huang, Q., Yu, W., Hu, T.: Potent antigen-adjuvant delivery system by conjugation of Mycobacterium tuberculosis Ag85B-HspX fusion protein with arabinogalactan-poly(I:C) conjugate. Bioconjug. Chem. 27(4), 1165 (2016)","journal-title":"Bioconjug. Chem."},{"issue":"20","key":"9830_CR10","doi-asserted-by":"publisher","first-page":"10060","DOI":"10.1021\/acs.joc.5b01686","volume":"80","author":"L Wang","year":"2015","unstructured":"Wang, L., Feng, S., An, L., Gu, G., Guo, Z.: Synthetic and immunological studies of mycobacterial Lipoarabinomannan oligosaccharides and their protein conjugates. J. Organomet. Chem. 80(20), 10060\u201310075 (2015)","journal-title":"J. Organomet. Chem."},{"issue":"47","key":"9830_CR11","doi-asserted-by":"publisher","first-page":"19077","DOI":"10.1073\/pnas.1314476110","volume":"110","author":"F Micoli","year":"2013","unstructured":"Micoli, F., Romano, M.R., Tontini, M., Cappelletti, E., Gavini, M., Proietti, D., Rondini, S., Swennen, E., Santini, L., Filippini, S.: Development of a glycoconjugate vaccine to prevent meningitis in Africa caused by meningococcal serogroup X. Proc. Natl. Acad. Sci. U. S. A. 110(47), 19077 (2013)","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5683","key":"9830_CR12","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1126\/science.1095209","volume":"305","author":"V Verez-Bencomo","year":"2004","unstructured":"Verez-Bencomo, V., Fern\u00e1ndez-Santana, V., Hardy, E., Toledo, M.E., Rodr\u00edguez, M.C., Heynngnezz, L., Rodriguez, A., Baly, A., Herrera, L., Izquierdo, M.: A synthetic conjugate polysaccharide vaccine against Haemophilus influenzae type b. Science. 305(5683), 522 (2004)","journal-title":"Science"},{"issue":"4","key":"9830_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035106","volume":"7","author":"CA Munro","year":"2012","unstructured":"Munro, C.A., Xin, H., Cartmell, J., Bailey, J.J., Dziadek, S., Bundle, D.R., Cutler, J.E.: Self-Adjuvanting Glycopeptide conjugate vaccine against disseminated candidiasis. PLoS One. 7(4), e35106 (2012). \n                    https:\/\/doi.org\/10.1371\/journal.pone.0035106","journal-title":"PLoS One"},{"issue":"1","key":"9830_CR14","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1021\/acsnano.6b07343","volume":"11","author":"KT Gause","year":"2017","unstructured":"Gause, K.T., Wheatley, A.K., Cui, J., Yan, Y., Kent, S.J., Caruso, F.: Immunological principles guiding the rational Design of Particles for vaccine delivery. ACS Nano. 11(1), 54 (2017)","journal-title":"ACS Nano"},{"issue":"5","key":"9830_CR15","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.ejps.2010.09.006","volume":"41","author":"H Yue","year":"2010","unstructured":"Yue, H., Wei, W., Yue, Z., Lv, P., Wang, L., Maaa, G.: Particle size affects the cellular response in macrophages. Eur. J. Pharm. Sci. 41(5), 650 (2010)","journal-title":"Eur. J. Pharm. Sci."},{"issue":"42","key":"9830_CR16","doi-asserted-by":"publisher","first-page":"4827","DOI":"10.1016\/j.vaccine.2013.07.078","volume":"31","author":"M Tontini","year":"2013","unstructured":"Tontini, M., Berti, F., Romano, M.R., Proietti, D., Zambonelli, C., Bottomley, M.J., De, G.E., Del, G.G., Rappuoli, R., Costantino, P.: Comparison of CRM197, diphtheria toxoid and tetanus toxoid as protein carriers for meningococcal glycoconjugate vaccines. Vaccine. 31(42), 4827\u20134833 (2013)","journal-title":"Vaccine"},{"key":"9830_CR17","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.vetimm.2016.07.002","volume":"178","author":"M Mwirigi","year":"2016","unstructured":"Mwirigi, M., Nkando, I., Olum, M., Attahpoku, S., Ochanda, H., Berberov, E., Potter, A., Gerdts, V., Perezcasal, J., Wesonga, H.: Capsular polysaccharide from mycoplasma mycoides subsp. mycoides shows potential for protection against contagious bovine pleuropneumonia. Vet. Immunol. Immunopathol. 178, 64 (2016)","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"43","key":"9830_CR18","doi-asserted-by":"publisher","first-page":"5815","DOI":"10.1016\/j.vaccine.2015.09.021","volume":"33","author":"M Xu","year":"2015","unstructured":"Xu, M., Xing, X., Wu, Z., Du, Y., Hu, T.: Molecular shape and immunogenicity of meningococcal polysaccharide group a conjugate vaccine. Vaccine. 33(43), 5815\u20135821 (2015)","journal-title":"Vaccine"},{"issue":"46","key":"9830_CR19","doi-asserted-by":"publisher","first-page":"6122","DOI":"10.1016\/j.vaccine.2014.08.056","volume":"32","author":"G Stefanetti","year":"2014","unstructured":"Stefanetti, G., Rondini, S., Lanzilao, L., Saul, A., Maclennan, C.A., Micoli, F.: Impact of conjugation chemistry on the immunogenicity of S. Typhimurium conjugate vaccines. Vaccine. 32(46), 6122 (2014)","journal-title":"Vaccine"},{"issue":"17","key":"9830_CR20","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1016\/j.vaccine.2015.02.045","volume":"33","author":"W Qiao","year":"2015","unstructured":"Qiao, W., Ji, S., Zhao, Y., Hu, T.: Conjugation of \u03b2-glucan markedly increase the immunogencity of meningococcal group Y polysaccharide conjugate vaccine. Vaccine. 33(17), 2066 (2015)","journal-title":"Vaccine"},{"key":"9830_CR21","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.procbio.2016.09.029","volume":"52","author":"X Wan","year":"2017","unstructured":"Wan, X., Zhang, J., Yu, W., Shen, L., Ji, S., Hu, T.: Effect of protein immunogenicity and PEG size and branching on the anti-PEG immune response to PEGylated proteins. Process Biochem. 52, 183\u2013191 (2017)","journal-title":"Process Biochem."},{"issue":"12","key":"9830_CR22","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1016\/j.bbagen.2012.09.013","volume":"1820","author":"T Hu","year":"2012","unstructured":"Hu, T., Li, D., Wang, J., Wang, Q., Liang, Y., Su, Y., Ma, G., Su, Z., Wang, S.: Propylbenzmethylation at Val-1(\u03b1) markedly increases the tetramer stability of the PEGylated hemoglobin: a comparison with propylation at Val-1(\u03b1). Biochim. Biophys. Acta. 1820(12), 2044 (2012)","journal-title":"Biochim. Biophys. Acta"},{"key":"9830_CR23","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ejpb.2016.07.004","volume":"107","author":"A Donadei","year":"2016","unstructured":"Donadei, A., Balocchi, C., Mancini, F., Proietti, D., Gallorini, S., O'Hagan, D.T., D'Oro, U., Berti, F., Baudner, B.C., Adamo, R.: The adjuvant effect of TLR7 agonist conjugated to a meningococcal serogroup C glycoconjugate vaccine. Eur. J. Pharm. Biopharm. 107, 110 (2016)","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"10","key":"9830_CR24","doi-asserted-by":"publisher","first-page":"2705","DOI":"10.1021\/bm8002013","volume":"9","author":"ME Gindy","year":"2008","unstructured":"Gindy, M.E., Ji, S., Hoye, T.R., Panagiotopoulos, A.Z., Prud\u2019Homme, R.K.: Preparation of poly(ethylene glycol) protected nanoparticles with variable bioconjugate ligand density. Biomacromolecules. 9(10), 2705\u20132711 (2008)","journal-title":"Biomacromolecules"},{"issue":"6","key":"9830_CR25","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1016\/j.cimid.2009.11.003","volume":"33","author":"J G\u00f3mezlaguna","year":"2010","unstructured":"G\u00f3mezlaguna, J., Salguero, F.J., Pallar\u00e9s, F.J., Fern\u00e1ndez, D.M.M., Barranco, I., Cer\u00f3n, J.J., Mart\u00ednezsubiela, S., Van, R.K., Carrasco, L.: Acute phase response in porcine reproductive and respiratory syndrome virus infection. Comp. Immunol. Microbiol. Infect. Dis. 33(6), e51 (2010)","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"issue":"11","key":"9830_CR26","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1007\/s40264-015-0350-4","volume":"38","author":"N Petrovsky","year":"2015","unstructured":"Petrovsky, N.: Comparative safety of vaccine adjuvants: a summary of current evidence and future needs. Drug Saf. 38(11), 1059 (2015)","journal-title":"Drug Saf."},{"issue":"11","key":"9830_CR27","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1038\/15058","volume":"17","author":"M Singh","year":"1999","unstructured":"Singh, M., O'Hagan, D.: Advances in vaccine adjuvants. Nat. Biotechnol. 17(11), 1075 (1999)","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"9830_CR28","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.fsi.2015.10.012","volume":"47","author":"X Liu","year":"2015","unstructured":"Liu, X., Zhang, H., Gao, Y., Zhang, Y., Wu, H., Zhang, Y.: Efficacy of chitosan oligosaccharide as aquatic adjuvant administrated with a formalin-inactivated Vibrio anguillarum vaccine. Fish Shellfish Immunol. 47(2), 855\u2013860 (2015)","journal-title":"Fish Shellfish Immunol."},{"issue":"11","key":"9830_CR29","first-page":"4867","volume":"33","author":"MY Yeh","year":"2013","unstructured":"Yeh, M.Y., Wu, M.F., Shang, H.S., Chang, J.B., Shih, Y.L., Chen, Y.L., Hung, H.F., Lu, H.F., Yeh, C., Wood, W.G.: Effects of chitosan on xenograft models of melanoma in C57BL\/6 mice and hepatoma formation in SCID mice. Anticancer Res. 33(11), 4867 (2013)","journal-title":"Anticancer Res."},{"issue":"3","key":"9830_CR30","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.carbpol.2010.08.071","volume":"83","author":"Y Dang","year":"2011","unstructured":"Dang, Y., Li, S., Wang, W., Wang, S., Zou, M., Guo, Y., Fan, J., Du, Y., Zhang, J.: The effects of chitosan oligosaccharide on the activation of murine spleen CD11c + dendritic cells via toll-like receptor 4. Carbohydr. Polym. 83(3), 1075\u20131081 (2011)","journal-title":"Carbohydr. Polym."},{"issue":"9","key":"9830_CR31","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1007\/s12272-012-0913-1","volume":"35","author":"EJ Jeong","year":"2012","unstructured":"Jeong, E.J., Maeng, H.J., Lee, H.J., Kim, Y., Kim, C.K.: Effect of adjuvant on pharmacokinetics, organ distribution and humoral immunity of hepatitis b surface antigen after intramuscular injection to rats. Arch. Pharm. Res. 35(9), 1621\u20131628 (2012)","journal-title":"Arch. Pharm. Res."},{"issue":"11","key":"9830_CR32","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1089\/10799900260442494","volume":"22","author":"SM Santini","year":"2002","unstructured":"Santini, S.M., Di Pucchio, T., Lapenta, C., Parlato, S., Logozzi, M., Belardelli, F.: The natural alliance between type I interferon and dendritic cells and its role in linking innate and adaptive immunity. J. Interf. Cytokine Res. 22(11), 1071\u20131080 (2002)","journal-title":"J. Interf. Cytokine Res."},{"issue":"3","key":"9830_CR33","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.4049\/jimmunol.175.3.1373","volume":"175","author":"M Rossi","year":"2005","unstructured":"Rossi, M., Young, J.W.: Human dendritic cells: potent antigen-presenting cells at the crossroads of innate and adaptive immunity. J. Immunol. 175(3), 1373\u20131381 (2005)","journal-title":"J. Immunol."},{"issue":"1","key":"9830_CR34","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1146\/annurev.immunol.18.1.767","volume":"18","author":"J Banchereau","year":"1999","unstructured":"Banchereau, J., Briere, F., Caux, C., Davoust, J., Lebecque, S., Liu, Y.J., Pulendran, B., Palucka, K.: Immunobiology of dendritic cells. Annu. Rev. Immunol. 18(1), 767\u2013811 (1999)","journal-title":"Annu. Rev. Immunol."},{"issue":"2","key":"9830_CR35","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1128\/IAI.02857-14","volume":"83","author":"JO Jin","year":"2015","unstructured":"Jin, J.O., Zhang, W., Du, J.Y., Yu, Q.: Correction for Jin et al., BDCA1-positive dendritic cells (DCs) represent a unique human myeloid DC subset that induces innate and adaptive immune responses to Staphylococcus aureus infection. Infect. Immun. 83(2), 849 (2015)","journal-title":"Infect. Immun."},{"issue":"8","key":"9830_CR36","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1038\/ni1223","volume":"6","author":"G Napolitani","year":"2005","unstructured":"Napolitani, G., Rinaldi, A., Bertoni, F., Sallusto, F., Lanzavecchia, A.: Selected toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat. Immunol. 6(8), 769\u2013776 (2005)","journal-title":"Nat. Immunol."},{"issue":"4","key":"9830_CR37","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/nm.2306","volume":"17","author":"TL Flach","year":"2011","unstructured":"Flach, T.L., Ng, G., Hari, A., Desrosiers, M.D., Zhang, P., Ward, S.M., Seamone, M.E., Vilaysane, A., Mucsi, A.D., Yin, F.: Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity. Nat. Med. 17(4), 479 (2011)","journal-title":"Nat. Med."},{"issue":"2","key":"9830_CR38","doi-asserted-by":"publisher","first-page":"926","DOI":"10.4049\/jimmunol.168.2.926","volume":"168","author":"J Ismaili","year":"2002","unstructured":"Ismaili, J., Rennesson, J., Aksoy, E., Vekemans, J., Vincart, B., Amraoui, Z., Van, L.F., Goldman, M., Dubois, P.M.: Monophosphoryl lipid a activates both human dendritic cells and T cells. J. Immunol. 168(2), 926 (2002)","journal-title":"J. Immunol."},{"issue":"1","key":"9830_CR39","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1189\/jlb.0904541","volume":"78","author":"C Porporatto","year":"2005","unstructured":"Porporatto, C., Bianco, I.D., Correa, S.G.: Local and systemic activity of the polysaccharide chitosan at lymphoid tissues after oral administration. J. Leukoc. Biol. 78(1), 62 (2005)","journal-title":"J. Leukoc. Biol."},{"key":"9830_CR40","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.intimp.2015.12.015","volume":"31","author":"Y Fu","year":"2016","unstructured":"Fu, Y., Wang, T., Xiu, L., Shi, X., Bian, Z., Zhang, Y., Ruhan, A., Wang, X.: Levamisole promotes murine bone marrow derived dendritic cell activation and drives Th1 immune response in vitro and in vivo. Int. Immunopharmacol. 31, 57\u201365 (2016)","journal-title":"Int. Immunopharmacol."}],"container-title":["Glycoconjugate Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10719-018-9830-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10719-018-9830-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10719-018-9830-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T19:11:34Z","timestamp":1564081894000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10719-018-9830-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,26]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["9830"],"URL":"https:\/\/doi.org\/10.1007\/s10719-018-9830-y","relation":{},"ISSN":["0282-0080","1573-4986"],"issn-type":[{"type":"print","value":"0282-0080"},{"type":"electronic","value":"1573-4986"}],"subject":[],"published":{"date-parts":[[2018,7,26]]},"assertion":[{"value":"29 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This article contains animal studies, and all animal experiment procedures were approved by the Animal Ethical Experimentation Committee of Institute of Process Engineering, Chinese Academy of Sciences (Beijing, China).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}