{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:05:08Z","timestamp":1758125108068,"version":"3.37.3"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T00:00:00Z","timestamp":1460419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000106","name":"Saskatchewan Health Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000106","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Hist"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1007\/s10735-016-9673-4","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T06:45:30Z","timestamp":1460616330000},"page":"325-336","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Ghrelin, ghrelin-O-acyl transferase, nucleobindin-2\/nesfatin-1 and prohormone convertases in the pancreatic islets of Sprague Dawley rats during development"],"prefix":"10.1007","volume":"47","author":[{"given":"Haneesha","family":"Mohan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Gasner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naresh","family":"Ramesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suraj","family":"Unniappan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,4,12]]},"reference":[{"key":"9673_CR1","doi-asserted-by":"crossref","first-page":"E341","DOI":"10.1152\/ajpendo.00057.2010","volume":"299","author":"O Al-Massadi","year":"2010","unstructured":"Al-Massadi O, Crujeiras AB, Gonz\u00e1lez RC, Pardo M, Di\u00e9guez C, Casanueva FF, Seoane LM (2010) Age, sex, and lactating status regulate ghrelin secretion and GOAT mRNA levels from isolated rat stomach. Am J Physiol Endocrinol Metab 299:E341\u2013E350","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"9673_CR2","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1159\/000322338","volume":"26","author":"W An","year":"2010","unstructured":"An W, Li Y, Xu G, Zhao J, Xiang X, Ding L, Li J, Guan Y, Wang X, Tang C, Li X, Mulholland M, Zhang W (2010) Modulation of ghrelin O-acyltransferase expression in pancreatic islets. Cell Physiol Biochem 26:707\u2013716","journal-title":"Cell Physiol Biochem"},{"key":"9673_CR3","doi-asserted-by":"crossref","first-page":"e52026","DOI":"10.1371\/journal.pone.0052026","volume":"7","author":"L Arnes","year":"2012","unstructured":"Arnes L, Hill JT, Gross S, Magnuson MA, Sussel L (2012) Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population. PLoS ONE 7:e52026","journal-title":"PLoS ONE"},{"key":"9673_CR4","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1365-2362.1973.tb00360.x","volume":"3","author":"K Asplund","year":"1973","unstructured":"Asplund K (1973) Dynamics of insulin release from the foetal and neonatal rat pancreas. Eur J Clin Investig 3:338\u2013344","journal-title":"Eur J Clin Investig"},{"key":"9673_CR5","doi-asserted-by":"crossref","first-page":"124","DOI":"10.2337\/diabetes.51.1.124","volume":"51","author":"Y Date","year":"2002","unstructured":"Date Y, Nakazato M, Hashiguchi S, Dezaki K, Mondal MS, Hosoda H, Kojima M, Kangawa K, Arima T, Matsuo H, Yada T, Matsukura S (2002) Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes 51:124\u2013129","journal-title":"Diabetes"},{"key":"9673_CR6","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.2337\/db11-0368","volume":"60","author":"K Dezaki","year":"2011","unstructured":"Dezaki K, Damdindorj B, Sone H, Dyachok O, Tengholm A, Gylfe E, Kurashina T, Yoshida M, Kakei M, Yada T (2011) Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet \u03b2-cells. Diabetes 60:2315\u20132324","journal-title":"Diabetes"},{"key":"9673_CR7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1172\/JCI30076","volume":"117","author":"DJ Drucker","year":"2007","unstructured":"Drucker DJ (2007) The role of gut hormones in glucose homeostasis. J Clin Invest 117:24\u201332","journal-title":"J Clin Invest"},{"key":"9673_CR8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1677\/JOE-09-0254","volume":"204","author":"KS Foo","year":"2010","unstructured":"Foo KS, Brauner H, Ostenson CG, Broberger C (2010) Nucleobindin-2\/nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state. J Endocrinol 204:255\u2013263","journal-title":"J Endocrinol"},{"key":"9673_CR9","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.bbrc.2009.02.104","volume":"381","author":"R Gonzalez","year":"2009","unstructured":"Gonzalez R, Tiwari A, Unniappan S (2009) Pancreatic beta cells colocalize insulin and pronesfatin immunoreactivity in rodents. Biochem Biophys Res Commun 381:643\u2013648","journal-title":"Biochem Biophys Res Commun"},{"key":"9673_CR10","doi-asserted-by":"crossref","first-page":"e15201","DOI":"10.1371\/journal.pone.0015201","volume":"5","author":"R Gonzalez","year":"2010","unstructured":"Gonzalez R, Brent K, Chun A, Unniappan S (2010) Molecular, cellular and physiological evidences for the anorexigenic actions of nesfatin-1 in goldfish. PLoS ONE 5:e15201","journal-title":"PLoS ONE"},{"key":"9673_CR11","first-page":"R9","volume":"208","author":"R Gonzalez","year":"2011","unstructured":"Gonzalez R, Reingold BK, Gao X, Gaidhu MP, Tsushima RG, Unniappan S (2011) Nesfatin-1 exerts a direct, glucose-dependent insulinotropic action on mouse islet \u03b2- and MIN6 cells. J Endocrinol 208:R9\u2013R16","journal-title":"J Endocrinol"},{"key":"9673_CR12","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ygcen.2011.11.021","volume":"176","author":"R Gonzalez","year":"2012","unstructured":"Gonzalez R, Mohan H, Unniappan S (2012) Nucleobindins: bioactive precursor proteins encoding putative endocrine factors? Gen Comp Endocrinol 176:341\u2013346","journal-title":"Gen Comp Endocrinol"},{"key":"9673_CR13","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1073\/pnas.0800708105","volume":"105","author":"JA Gutierrez","year":"2008","unstructured":"Gutierrez JA, Solenberg PJ, Perkins DR, Willency JA, Knierman MD, Jin Z, Witcher DR, Luo S, Onyia JE, Hale JE (2008) Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci USA 105:6320\u20136325","journal-title":"Proc Natl Acad Sci USA"},{"key":"9673_CR80","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1089\/zeb.2014.1062","volume":"12","author":"A Hatef","year":"2015","unstructured":"Hatef A, Yufa Y, Unniappan S (2015) Ghrelin O-acyl transferase in zebrafish is an evolutionarily conserved peptide upregulated during calorie restriction. Zebrafish 12:327\u2013338","journal-title":"Zebrafish"},{"key":"9673_CR14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1677\/joe.0.1730239","volume":"173","author":"T Hayashida","year":"2002","unstructured":"Hayashida T, Nakahara K, Mondal MS, Date Y, Nakazato M, Kojima M, Kangawa K, Murakami N (2002) Ghrelin in neonatal rats: distribution in stomach and its possible role. J Endocrinol 173:239\u2013245","journal-title":"J Endocrinol"},{"key":"9673_CR15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.regpep.2009.02.013","volume":"157","author":"JT Hill","year":"2009","unstructured":"Hill JT, Mastracci TL, Vinton C, Doyle ML, Anderson KR, Loomis ZL, Schrunk JM, Minic AD, Prabakar KR, Pugliese A, Sun Y, Smith RG, Sussel L (2009) Ghrelin is dispensable for embryonic pancreatic islet development and differentiation. Regul Pept 157:51\u201356","journal-title":"Regul Pept"},{"key":"9673_CR16","first-page":"E167","volume":"254","author":"R Hole","year":"1988","unstructured":"Hole R, Smith MP, Sharp G (1988) Development of the biphasic response to glucose in fetal and neonatal rat pancreas. Am J Physiol 254:E167\u2013E174","journal-title":"Am J Physiol"},{"key":"9673_CR17","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1365-2826.2011.02246.x","volume":"24","author":"B Kerbel","year":"2011","unstructured":"Kerbel B, Unniappan S (2011) Nesfatin-1 suppresses energy intake, co-localises ghrelin in the brain and gut, and alters ghrelin, cholecystokinin and orexin MRNA expression in goldfish. J Neuroendocrinol 24:366\u2013377","journal-title":"J Neuroendocrinol"},{"key":"9673_CR18","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1152\/physrev.00012.2004","volume":"85","author":"M Kojima","year":"2005","unstructured":"Kojima M, Kangawa K (2005) Ghrelin: structure and function. Physiol Rev 85:495\u2013522","journal-title":"Physiol Rev"},{"key":"9673_CR19","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","volume":"402","author":"M Kojima","year":"1999","unstructured":"Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656\u2013660","journal-title":"Nature"},{"key":"9673_CR21","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.regpep.2009.11.003","volume":"159","author":"QC Li","year":"2010","unstructured":"Li QC, Wang H, Chen X, Guan HZ, Jiang ZY (2010) Fasting plasma levels of nesfatin-1 in patients with type 1 and type 2 diabetes mellitus and the nutrient-related fluctuation of nesfatin-1 level in normal humans. Regul Pept 159:72\u201377","journal-title":"Regul Pept"},{"key":"9673_CR22","doi-asserted-by":"crossref","first-page":"e71513","DOI":"10.1371\/journal.pone.0071513","volume":"8","author":"Z Li","year":"2013","unstructured":"Li Z, Gao L, Tang H, Yin Y, Xiang X, Li Y, Zhao J, Mulholland M, Zhang W (2013) Peripheral effects of nesfatin-1 on glucose homeostasis. PLoS ONE 8:e71513","journal-title":"PLoS ONE"},{"key":"9673_CR23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.regpep.2012.02.006","volume":"175","author":"H Mohan","year":"2012","unstructured":"Mohan H, Unniappan S (2012) Ontogenic pattern of nucleobindin-2\/nesfatin-1 expression in the gastroenteropancreatic tissues and serum of Sprague\u2013Dawley rats. Regul Pept 175:61\u201369","journal-title":"Regul Pept"},{"key":"9673_CR24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000346039","volume":"25","author":"H Mohan","year":"2013","unstructured":"Mohan H, Unniappan S (2013) Discovery of ghrelin O-acyltransferase. Endocr Dev 25:16\u201324","journal-title":"Endocr Dev"},{"key":"9673_CR25","first-page":"170","volume":"4","author":"JF O\u2019Dowd","year":"2013","unstructured":"O\u2019Dowd JF, Stocker CJ (2013) Endocrine pancreatic development: impact of obesity and diet. Front Physiol 4:170","journal-title":"Front Physiol"},{"key":"9673_CR26","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nature05162","volume":"443","author":"S Oh-I","year":"2006","unstructured":"Oh-I S, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K, Eguchi H, Yamamoto M, Imaki T, Hashimoto K, Tsuchiya T, Monden T, Horiguchi K, Yamada M, Mori M (2006) Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 443:709\u2013712","journal-title":"Nature"},{"key":"9673_CR27","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","volume":"29","author":"MW Pfaffl","year":"2001","unstructured":"Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45","journal-title":"Nucleic Acids Res"},{"key":"9673_CR28","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1073\/pnas.0308604100","volume":"101","author":"CL Prado","year":"2004","unstructured":"Prado CL, Pugh-Bernard AE, Elghazi L, Sosa-Pineda B, Sussel L (2004) Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci USA 101:2924\u20132929","journal-title":"Proc Natl Acad Sci USA"},{"key":"9673_CR29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01960221","volume":"44","author":"S Reddy","year":"1988","unstructured":"Reddy S, Elliott RB (1988) Ontogenic development of peptide hormones in the mammalian fetal pancreas. Experientia 44:1\u20139","journal-title":"Experientia"},{"key":"9673_CR30","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1073\/pnas.91.8.3242","volume":"91","author":"Y Rouill\u00e9","year":"1994","unstructured":"Rouill\u00e9 Y, Westermark G, Martin SK, Steiner DF (1994) Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells. Proc Natl Acad Sci USA 91:3242\u20133246","journal-title":"Proc Natl Acad Sci USA"},{"key":"9673_CR31","doi-asserted-by":"crossref","first-page":"26488","DOI":"10.1074\/jbc.270.44.26488","volume":"270","author":"Y Rouill\u00e9","year":"1995","unstructured":"Rouill\u00e9 Y, Martin S, Steiner DF (1995) Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide. J Biol Chem 270:26488\u201326496","journal-title":"J Biol Chem"},{"key":"9673_CR32","doi-asserted-by":"crossref","first-page":"217957","DOI":"10.1155\/2011\/217957","volume":"2011","author":"A Shlimun","year":"2011","unstructured":"Shlimun A, Unniappan S (2011) Ghrelin O-acyl transferase: bridging ghrelin and energy homeostasis. Int J Pept 2011:217957","journal-title":"Int J Pept"},{"key":"9673_CR33","first-page":"24","volume":"16","author":"A Stengel","year":"2012","unstructured":"Stengel A, Tache Y (2012) Ghrelin: a pleiotropic hormone secreted from endocrine x\/a-like cells of the stomach. Front Neurosci 16:24","journal-title":"Front Neurosci"},{"key":"9673_CR34","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1210\/en.2008-0747","volume":"150","author":"A Stengel","year":"2009","unstructured":"Stengel A, Goebel M, Yakubov I, Wang L, Witcher D, Coskun T, Tache Y, Sachs LN (2009) Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa. Endocrinology 150:232\u2013238","journal-title":"Endocrinology"},{"key":"9673_CR35","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.bbrc.2009.12.014","volume":"391","author":"Y Su","year":"2010","unstructured":"Su Y, Zhang J, Tang Y, Bi F, Liu JN (2010) The novel function of nesfatin-1: anti-hyperglycemia. Biochem Biophys Res Commun 391:1039\u20131042","journal-title":"Biochem Biophys Res Commun"},{"key":"9673_CR36","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1210\/en.2003-0088","volume":"144","author":"M Vincent","year":"2003","unstructured":"Vincent M, Guz Y, Rozenberg M, Webb G, Furuta M, Steiner D, Teitelman G (2003) Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased alpha-cell proliferation, and islet neogenesis. Endocrinology 144:4061\u20134069","journal-title":"Endocrinology"},{"key":"9673_CR37","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1210\/jcem.87.3.8279","volume":"87","author":"M Volante","year":"2002","unstructured":"Volante M, Allia E, Gugliotta P, Funaro A, Broglio F, Deghenghi R, Muccioli G, Ghigo E, Papotti M (2002) Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. J Clin Endocrinol Metab 87:1300\u20131308","journal-title":"J Clin Endocrinol Metab"},{"key":"9673_CR38","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1203\/PDR.0b013e31818bc134","volume":"65","author":"P Walia","year":"2009","unstructured":"Walia P, Asadi A, Kieffer TJ, Johnson JD, Chanoine JP (2009) Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach. Pediatr Res 65:39\u201344","journal-title":"Pediatr Res"},{"key":"9673_CR39","doi-asserted-by":"crossref","first-page":"118","DOI":"10.2337\/diab.44.1.118","volume":"44","author":"A Weinhaus","year":"1995","unstructured":"Weinhaus A, Poronnik P, Cook D, Tuch B (1995) Insulin secretagogues, but not glucose, stimulate an increase in [Ca++]i in the fetal rat beta-cell. Diabetes 44:118\u2013124","journal-title":"Diabetes"},{"key":"9673_CR40","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/002215540405200301","volume":"52","author":"N Wierup","year":"2004","unstructured":"Wierup N, Yang S, McEvilly RJ, Mulder H, Sundler F (2004) Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832\/13) cells. J Histochem Cytochem 52:301\u2013310","journal-title":"J Histochem Cytochem"},{"key":"9673_CR41","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2008.01.017","volume":"132","author":"J Yang","year":"2008","unstructured":"Yang J, Brown M, Liang G, Grishin NV, Goldstein JL (2008) Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132:387\u2013396","journal-title":"Cell"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-016-9673-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10735-016-9673-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-016-9673-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T19:03:12Z","timestamp":1559242992000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10735-016-9673-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,12]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["9673"],"URL":"https:\/\/doi.org\/10.1007\/s10735-016-9673-4","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"type":"print","value":"1567-2379"},{"type":"electronic","value":"1567-2387"}],"subject":[],"published":{"date-parts":[[2016,4,12]]}}}