{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:49:39Z","timestamp":1784771379271,"version":"3.55.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Fundation of China","doi-asserted-by":"crossref","award":["81970910"],"award-info":[{"award-number":["81970910"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Hist"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s10735-020-09857-w","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T14:03:02Z","timestamp":1580392982000},"page":"67-76","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Age-dependent role of SIRT6 in jawbone via regulating senescence and autophagy of bone marrow stromal cells"],"prefix":"10.1007","volume":"51","author":[{"given":"Xin","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiadong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongyao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,30]]},"reference":[{"key":"9857_CR1","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.stem.2008.03.002","volume":"2","author":"P Bianco","year":"2008","unstructured":"Bianco P, Robey PG, Simmons PJ (2008) Mesenchymal stem cells: revisiting history, concepts, and assays. Cell Stem Cell 2:313\u2013319. https:\/\/doi.org\/10.1016\/j.stem.2008.03.002","journal-title":"Cell Stem Cell"},{"key":"9857_CR2","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jbspin.2004.03.007","volume":"72","author":"F Bodic","year":"2005","unstructured":"Bodic F, Hamel L, Lerouxel E, Basl\u00e9 MF, Chappard D (2005) Bone loss and teeth. Joint Bone Spine 72:215\u2013221. https:\/\/doi.org\/10.1016\/j.jbspin.2004.03.007","journal-title":"Joint Bone Spine"},{"key":"9857_CR3","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1242\/dev.127.8.1671","volume":"127","author":"Y Chai","year":"2000","unstructured":"Chai Y et al (2000) Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development 127:1671\u20131679","journal-title":"Development"},{"key":"9857_CR4","doi-asserted-by":"publisher","first-page":"131","DOI":"10.4161\/auto.1.3.2017","volume":"1","author":"AM Cuervo","year":"2005","unstructured":"Cuervo AM, Bergamini E, Brunk UT, Droge W, Ffrench M, Terman A (2005) Autophagy and aging: the importance of maintaining \"clean\" cells. Autophagy 1:131\u2013140","journal-title":"Autophagy"},{"key":"9857_CR5","doi-asserted-by":"publisher","first-page":"701","DOI":"10.7150\/ijbs.29323","volume":"15","author":"Y Fan","year":"2019","unstructured":"Fan Y et al (2019) Sirt6 suppresses high glucose-induced mitochondrial dysfunction and apoptosis in podocytes through AMPK activation. Int J Biol Sci 15:701\u2013713. https:\/\/doi.org\/10.7150\/ijbs.29323","journal-title":"Int J Biol Sci"},{"key":"9857_CR6","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.biocel.2014.07.003","volume":"54","author":"Y Fu","year":"2014","unstructured":"Fu Y et al (2014) Histone deacetylase 8 suppresses osteogenic differentiation of bone marrow stromal cells by inhibiting histone H3K9 acetylation and RUNX2 activity. Int J Biochem Cell Biol 54:68\u201377. https:\/\/doi.org\/10.1016\/j.biocel.2014.07.003","journal-title":"Int J Biochem Cell Biol"},{"key":"9857_CR7","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/nature16187","volume":"529","author":"L Garc\u00eda-Prat","year":"2016","unstructured":"Garc\u00eda-Prat L et al (2016) Autophagy maintains stemness by preventing senescence. Nature 529:37\u201342. https:\/\/doi.org\/10.1038\/nature16187","journal-title":"Nature"},{"key":"9857_CR8","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/s10522-013-9478-8","volume":"14","author":"AA Gertler","year":"2013","unstructured":"Gertler AA, Cohen HY (2013) SIRT6, a protein with many faces. Biogerontology 14:629\u2013639. https:\/\/doi.org\/10.1007\/s10522-013-9478-8","journal-title":"Biogerontology"},{"key":"9857_CR9","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","volume":"43","author":"C He","year":"2009","unstructured":"He C, Klionsky DJ (2009) Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 43:67\u201393. https:\/\/doi.org\/10.1146\/annurev-genet-102808-114910","journal-title":"Annu Rev Genet"},{"key":"9857_CR10","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1111\/febs.14055","volume":"284","author":"J He","year":"2017","unstructured":"He J et al (2017) SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox-LDL condition. Febs J 284:1324\u20131337. https:\/\/doi.org\/10.1111\/febs.14055","journal-title":"Febs J"},{"key":"9857_CR11","doi-asserted-by":"publisher","first-page":"2694","DOI":"10.1016\/j.cellsig.2014.08.019","volume":"26","author":"D Heras-Sandoval","year":"2014","unstructured":"Heras-Sandoval D, Perez-Rojas JM, Hernandez-Damian J, Pedraza-Chaverri J (2014) The role of PI3K\/AKT\/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration. Cell Signal 26:2694\u20132701. https:\/\/doi.org\/10.1016\/j.cellsig.2014.08.019","journal-title":"Cell Signal"},{"key":"9857_CR12","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1002\/jbmr.1668","volume":"27","author":"LJ Hocking","year":"2012","unstructured":"Hocking LJ, Whitehouse C, Helfrich MH (2012) Autophagy: a new player in skeletal maintenance? J Bone Miner Res 27:1439\u20131447. https:\/\/doi.org\/10.1002\/jbmr.1668","journal-title":"J Bone Miner Res"},{"key":"9857_CR13","doi-asserted-by":"publisher","first-page":"101042831770853","DOI":"10.1177\/1010428317708532","volume":"39","author":"N Huang","year":"2017","unstructured":"Huang N et al (2017) Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells. Tumour Biol 39:1010428317708532. https:\/\/doi.org\/10.1177\/1010428317708532","journal-title":"Tumour Biol"},{"key":"9857_CR14","doi-asserted-by":"publisher","first-page":"101","DOI":"10.5624\/isd.2011.41.3.101","volume":"41","author":"K Koh","year":"2011","unstructured":"Koh K, Kim K (2011) Utility of the computed tomography indices on cone beam computed tomography images in the diagnosis of osteoporosis in women. Imaging Sci Dent 41:101. https:\/\/doi.org\/10.5624\/isd.2011.41.3.101","journal-title":"Imaging Sci Dent"},{"key":"9857_CR15","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.trsl.2016.03.002","volume":"172","author":"J Lu","year":"2016","unstructured":"Lu J et al (2016) SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy. Transl Res 172:96\u2013112.e6. https:\/\/doi.org\/10.1016\/j.trsl.2016.03.002","journal-title":"Transl Res"},{"key":"9857_CR16","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12709","author":"Y Ma","year":"2018","unstructured":"Ma Y et al (2018) Autophagy controls mesenchymal stem cell properties and senescence during bone aging. Aging Cell. https:\/\/doi.org\/10.1111\/acel.12709","journal-title":"Aging Cell"},{"key":"9857_CR17","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.bone.2017.02.013","volume":"98","author":"M McClung","year":"2017","unstructured":"McClung M, Baron R, Bouxsein M (2017) An update on osteoporosis pathogenesis, diagnosis, and treatment. Bone 98:37. https:\/\/doi.org\/10.1016\/j.bone.2017.02.013","journal-title":"Bone"},{"key":"9857_CR18","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/nature06736","volume":"452","author":"E Michishita","year":"2008","unstructured":"Michishita E et al (2008) SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 452:492\u2013496. https:\/\/doi.org\/10.1038\/nature06736","journal-title":"Nature"},{"key":"9857_CR19","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.cell.2005.11.044","volume":"124","author":"R Mostoslavsky","year":"2006","unstructured":"Mostoslavsky R et al (2006) Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124:315\u2013329. https:\/\/doi.org\/10.1016\/j.cell.2005.11.044","journal-title":"Cell"},{"key":"9857_CR20","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.phrs.2017.11.020","volume":"129","author":"W Mu","year":"2018","unstructured":"Mu W et al (2018) Metformin promotes the proliferation and differentiation of murine preosteoblast by regulating the expression of sirt6 and oct4. Pharmacol Res 129:462\u2013474. https:\/\/doi.org\/10.1016\/j.phrs.2017.11.020","journal-title":"Pharmacol Res"},{"key":"9857_CR21","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s11914-017-0381-0","volume":"15","author":"T Ono","year":"2017","unstructured":"Ono T, Takayanagi H (2017) Osteoimmunology in bone fracture healing. Curr Osteoporos Rep 15:367\u2013375. https:\/\/doi.org\/10.1007\/s11914-017-0381-0","journal-title":"Curr Osteoporos Rep"},{"key":"9857_CR22","doi-asserted-by":"publisher","first-page":"4498","DOI":"10.7150\/thno.17949","volume":"7","author":"M Qi","year":"2017","unstructured":"Qi M et al (2017) Autophagy maintains the function of bone marrow mesenchymal stem cells to prevent estrogen deficiency-induced osteoporosis. Theranostics 7:4498\u20134516. https:\/\/doi.org\/10.7150\/thno.17949","journal-title":"Theranostics"},{"key":"9857_CR23","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1111\/acel.12655","volume":"16","author":"M Revuelta","year":"2017","unstructured":"Revuelta M, Matheu A (2017) Autophagy in stem cell aging. Aging Cell 16:912\u2013915. https:\/\/doi.org\/10.1111\/acel.12655","journal-title":"Aging Cell"},{"key":"9857_CR24","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.bone.2015.10.019","volume":"106","author":"C Schlundt","year":"2018","unstructured":"Schlundt C et al (2018) Macrophages in bone fracture healing: their essential role in endochondral ossification. Bone 106:78\u201389. https:\/\/doi.org\/10.1016\/j.bone.2015.10.019","journal-title":"Bone"},{"key":"9857_CR25","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/8756-3282(93)90189-H","volume":"14","author":"MS Shih","year":"1993","unstructured":"Shih MS, Cook MA, Spence CA, Palnitkar S, McElroy H, Parfitt AM (1993) Relationship between bone formation rate and osteoblast surface on different subdivisions of the endosteal envelope in aging & osteoporosis. Bone 14:519\u2013521","journal-title":"Bone"},{"key":"9857_CR26","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1042\/EBC20170092","volume":"61","author":"M Smith","year":"2017","unstructured":"Smith M, Wilkinson S (2017) ER homeostasis and autophagy. Essays Biochem 61:625\u2013635. https:\/\/doi.org\/10.1042\/EBC20170092","journal-title":"Essays Biochem"},{"key":"9857_CR27","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1016\/j.jcyt.2014.04.006","volume":"16","author":"C Song","year":"2014","unstructured":"Song C, Song C, Tong F (2014) Autophagy induction is a survival response against oxidative stress in bone marrow-derived mesenchymal stromal cells. Cytotherapy 16:1361\u20131370. https:\/\/doi.org\/10.1016\/j.jcyt.2014.04.006","journal-title":"Cytotherapy"},{"key":"9857_CR28","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.bone.2015.07.018","volume":"81","author":"T Sugatani","year":"2015","unstructured":"Sugatani T, Agapova O, Malluche HH, Hruska KA (2015) SIRT6 deficiency culminates in low-turnover osteopenia. Bone 81:168\u2013177. https:\/\/doi.org\/10.1016\/j.bone.2015.07.018","journal-title":"Bone"},{"key":"9857_CR29","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1002\/stem.1671","volume":"32","author":"H Sun","year":"2014","unstructured":"Sun H, Wu Y, Fu D, Liu Y, Huang C (2014) SIRT6 regulates osteogenic differentiation of rat bone marrow mesenchymal stem cells partially via suppressing the nuclear factor-kappaB signaling pathway. Stem Cells 32:1943\u20131955. https:\/\/doi.org\/10.1002\/stem.1671","journal-title":"Stem Cells"},{"key":"9857_CR30","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1080\/15548627.2017.1384886","volume":"14","author":"L Wang","year":"2018","unstructured":"Wang L et al (2018) Aberrant SIRT6 expression contributes to melanoma growth: role of the autophagy paradox and IGF-AKT signaling. Autophagy 14:518\u2013533. https:\/\/doi.org\/10.1080\/15548627.2017.1384886","journal-title":"Autophagy"},{"key":"9857_CR31","doi-asserted-by":"publisher","first-page":"41903","DOI":"10.1074\/jbc.M112.415182","volume":"287","author":"C Xiao","year":"2012","unstructured":"Xiao C et al (2012) Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice. J Biol Chem 287:41903\u201341913. https:\/\/doi.org\/10.1074\/jbc.M112.415182","journal-title":"J Biol Chem"},{"key":"9857_CR32","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.exger.2016.09.001","volume":"84","author":"R Xu","year":"2016","unstructured":"Xu R et al (2016) Transplantation of osteoporotic bone marrow stromal cells rejuvenated by the overexpression of SATB2 prevents alveolar bone loss in ovariectomized rats. Exp Gerontol 84:71\u201379. https:\/\/doi.org\/10.1016\/j.exger.2016.09.001","journal-title":"Exp Gerontol"},{"key":"9857_CR33","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1002\/term.2652","volume":"12","author":"R Xu","year":"2018","unstructured":"Xu R et al (2018) Simvastatin improves oral implant osseointegration via enhanced autophagy and osteogenesis of BMSCs and inhibited osteoclast activity. J Tissue Eng Regen Med 12:1209\u20131219. https:\/\/doi.org\/10.1002\/term.2652","journal-title":"J Tissue Eng Regen Med"},{"key":"9857_CR34","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1016\/j.biopha.2017.01.130","volume":"89","author":"JF Xue","year":"2017","unstructured":"Xue JF, Shi ZM, Zou J, Li XL (2017) Inhibition of PI3K\/AKT\/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis. Biomed Pharmacother 89:1252\u20131261. https:\/\/doi.org\/10.1016\/j.biopha.2017.01.130","journal-title":"Biomed Pharmacother"},{"key":"9857_CR35","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.4161\/cc.8.16.9329","volume":"8","author":"B Yang","year":"2009","unstructured":"Yang B, Zwaans BM, Eckersdorff M, Lombard DB (2009) The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability. Cell Cycle 8:2662\u20132663. https:\/\/doi.org\/10.4161\/cc.8.16.9329","journal-title":"Cell Cycle"},{"key":"9857_CR36","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s00418-011-0908-x","volume":"137","author":"Y Yu","year":"2012","unstructured":"Yu Y et al (2012) Insulin-like growth factor 1 enhances the proliferation and osteogenic differentiation of human periodontal ligament stem cells via ERK and JNK MAPK pathways. Histochem Cell Biol 137:513\u2013525. https:\/\/doi.org\/10.1007\/s00418-011-0908-x","journal-title":"Histochem Cell Biol"},{"key":"9857_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10323-z","author":"P Zhang","year":"2017","unstructured":"Zhang P et al (2017) SIRT6 promotes osteogenic differentiation of mesenchymal stem cells through BMP signaling. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-017-10323-z","journal-title":"Sci Rep"},{"key":"9857_CR38","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/s41586-018-0437-z","volume":"560","author":"W Zhang","year":"2018","unstructured":"Zhang W et al (2018) SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature 560:661\u2013665. https:\/\/doi.org\/10.1038\/s41586-018-0437-z","journal-title":"Nature"},{"issue":"9","key":"9857_CR39","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.18632\/aging.101041","volume":"8","author":"Peipei Zhou","year":"2016","unstructured":"Zhou, P. et al. (2016) SATB2-Nanog axis links age-related intrinsic changes of mesenchymal stem cells from craniofacial bone. Aging 8:2006\u20132011. https:\/\/doi.org\/10.18632\/aging.101041","journal-title":"Aging"},{"key":"9857_CR40","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201801791RR","author":"W Zhu","year":"2019","unstructured":"Zhu W et al (2019) Zoledronic acid promotes TLR-4-mediated M1 macrophage polarization in bisphosphonate-related osteonecrosis of the jaw. Faseb J. https:\/\/doi.org\/10.1096\/fj.201801791RR","journal-title":"Faseb J"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-020-09857-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10735-020-09857-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-020-09857-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T14:20:30Z","timestamp":1665670830000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10735-020-09857-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,30]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["9857"],"URL":"https:\/\/doi.org\/10.1007\/s10735-020-09857-w","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,30]]},"assertion":[{"value":"5 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}