{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:50:58Z","timestamp":1778932258312,"version":"3.51.4"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T00:00:00Z","timestamp":1587772800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T00:00:00Z","timestamp":1587772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004001","name":"Guizhou Science and Technology Department","doi-asserted-by":"publisher","award":["No. SY [2012]172"],"award-info":[{"award-number":["No. SY [2012]172"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004001","name":"Guizhou Science and Technology Department","doi-asserted-by":"publisher","award":["No. SY [2017]2882"],"award-info":[{"award-number":["No. SY [2017]2882"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004001","name":"Guizhou Science and Technology Department","doi-asserted-by":"publisher","award":["No. LH [2016]7477"],"award-info":[{"award-number":["No. LH [2016]7477"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Qian Wei Ji Ban Han","award":["NO.2017-24"],"award-info":[{"award-number":["NO.2017-24"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Hist"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s10735-020-09873-w","type":"journal-article","created":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T15:03:31Z","timestamp":1587827011000},"page":"209-220","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Enhanced tenogenic differentiation and tendon-like tissue formation by Scleraxis overexpression in human amniotic mesenchymal stem cells"],"prefix":"10.1007","volume":"51","author":[{"given":"Xizhong","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huazhang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jibin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8116-604X","authenticated-orcid":false,"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,4,25]]},"reference":[{"key":"9873_CR1","doi-asserted-by":"publisher","first-page":"232596711351993","DOI":"10.1177\/2325967113519935","volume":"2","author":"DA Ajibade","year":"2014","unstructured":"Ajibade DA, Vance DD, Hare JM, Kaplan LD, Lesniak BP (2014) Emerging applications of stem cell and regenerative medicine to sports injuries. Orthop J Sports Med 2:2325967113519935. https:\/\/doi.org\/10.1177\/2325967113519935","journal-title":"Orthop J Sports Med"},{"key":"9873_CR2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.bpobgyn.2015.08.014","volume":"31","author":"E Antoniadou","year":"2016","unstructured":"Antoniadou E, David AL (2016) Placental stem cells. Best Pract Res Clin Obstet Gynaecol 31:13\u201329. https:\/\/doi.org\/10.1016\/j.bpobgyn.2015.08.014","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"9873_CR3","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1089\/scd.2016.0279","volume":"26","author":"EP Bavin","year":"2017","unstructured":"Bavin EP, Atkinson F, Barsby T, Guest DJ (2017) Scleraxis is essential for tendon differentiation by equine embryonic stem cells and in equine fetal tenocytes. Stem Cells Dev 26:441\u2013450. https:\/\/doi.org\/10.1089\/scd.2016.0279","journal-title":"Stem Cells Dev"},{"key":"9873_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jor.20456","volume":"26","author":"DL Butler","year":"2008","unstructured":"Butler DL, Juncosa-Melvin N, Boivin GP, Galloway MT, Shearn JT, Gooch C, Awad H (2008) Functional tissue engineering for tendon repair: a multidisciplinary strategy using mesenchymal stem cells, bioscaffolds, and mechanical stimulation. J Orthop Res 26:1\u20139. https:\/\/doi.org\/10.1002\/jor.20456","journal-title":"J Orthop Res"},{"key":"9873_CR5","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1002\/adhm.201300646","volume":"3","author":"SR Caliari","year":"2014","unstructured":"Caliari SR, Harley BA (2014) Structural and biochemical modification of a collagen scaffold to selectively enhance MSC tenogenic, chondrogenic, and osteogenic differentiation. Adv Healthcare Mater 3:1086\u20131096. https:\/\/doi.org\/10.1002\/adhm.201300646","journal-title":"Adv Healthcare Mater"},{"key":"9873_CR7","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1089\/ten.TEA.2012.0656","volume":"20","author":"X Chen","year":"2014","unstructured":"Chen X, Yin Z, Chen JL, Liu HH, Shen WL, Fang Z, Zhu T, Ji J, Ouyang HW, Zou XH (2014) Scleraxis-overexpressed human embryonic stem cell-derived mesenchymal stem cells for tendon tissue engineering with knitted silk-collagen scaffold. Tissue Eng Part A 20:1583\u20131592. https:\/\/doi.org\/10.1089\/ten.TEA.2012.0656","journal-title":"Tissue Eng Part A"},{"key":"9873_CR6","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.1177\/0363546517721692","volume":"45","author":"T Chen","year":"2017","unstructured":"Chen T, Zhang P, Chen J, Hua Y, Chen S (2017) Long-term outcomes of anterior cruciate ligament reconstruction using either synthetics with remnant preservation or hamstring autografts: a 10-year longitudinal study. Am J Sports Med 45:2739\u20132750. https:\/\/doi.org\/10.1177\/0363546517721692","journal-title":"Am J Sports Med"},{"key":"9873_CR8","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1242\/dev.121.4.1099","volume":"121","author":"P Cserjesi","year":"1995","unstructured":"Cserjesi P, Brown D, Ligon KL, Lyons GE, Copeland NG, Gilbert DJ, Jenkins NA, Olson EN (1995) Scleraxis: a basic helix-loop-helix protein that prefigures skeletal formation during mouse embryogenesis. Development 121:1099\u20131110","journal-title":"Development"},{"key":"9873_CR9","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/j.biomaterials.2007.10.048","volume":"29","author":"H Fan","year":"2008","unstructured":"Fan H, Liu H, Toh SL, Goh JC (2008) Enhanced differentiation of mesenchymal stem cells co-cultured with ligament fibroblasts on gelatin\/silk fibroin hybrid scaffold. Biomaterials 29:1017\u20131027. https:\/\/doi.org\/10.1016\/j.biomaterials.2007.10.048","journal-title":"Biomaterials"},{"key":"9873_CR10","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.fcl.2017.07.002","volume":"22","author":"AE Federer","year":"2017","unstructured":"Federer AE, Steele JR, Dekker TJ, Liles JL, Adams SB (2017) Tendonitis and tendinopathy: what are they and how do they evolve? Foot Ankle Clin 22:665\u2013676. https:\/\/doi.org\/10.1016\/j.fcl.2017.07.002","journal-title":"Foot Ankle Clin"},{"key":"9873_CR11","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1097\/01.bco.0000176423.07865.d2","volume":"16","author":"BC Fleming","year":"2005","unstructured":"Fleming BC, Hulstyn MJ, Oksendahl HL, Fadale PD (2005) Ligament injury, reconstruction and osteoarthritis. Curr Opin Orthop 16:354\u2013362","journal-title":"Curr Opin Orthop"},{"key":"9873_CR12","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/wdev.201","volume":"5","author":"L Gaut","year":"2016","unstructured":"Gaut L, Duprez D (2016) Tendon development and diseases. Wiley Interdiscip Rev Dev Biol 5:5\u201323. https:\/\/doi.org\/10.1002\/wdev.201","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"key":"9873_CR13","doi-asserted-by":"publisher","DOI":"10.1002\/term.2495","author":"AI Goncalves","year":"2017","unstructured":"Goncalves AI, Gershovich PM, Rodrigues MT, Reis RL, Gomes ME (2017) Human adipose tissue-derived tenomodulin positive subpopulation of stem cells: a promising source of tendon progenitor cells. J Tissue Eng Regen Med. https:\/\/doi.org\/10.1002\/term.2495","journal-title":"J Tissue Eng Regen Med"},{"key":"9873_CR14","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1177\/0363546510395485","volume":"39","author":"LV Gulotta","year":"2011","unstructured":"Gulotta LV, Kovacevic D, Packer JD, Deng XH, Rodeo SA (2011) Bone marrow-derived mesenchymal stem cells transduced with scleraxis improve rotator cuff healing in a rat model. Am J Sports Med 39:1282\u20131289. https:\/\/doi.org\/10.1177\/0363546510395485","journal-title":"Am J Sports Med"},{"issue":"331\u2013340","key":"9873_CR15","doi-asserted-by":"publisher","first-page":"e332","DOI":"10.1016\/j.arthro.2017.07.010","volume":"34","author":"R Guo","year":"2018","unstructured":"Guo R, Gao L, Xu B (2018) Current evidence of adult stem cells to enhance anterior cruciate ligament treatment: a systematic review of animal trials. Arthroscopy 34(331\u2013340):e332. https:\/\/doi.org\/10.1016\/j.arthro.2017.07.010","journal-title":"Arthroscopy"},{"key":"9873_CR16","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/cpr.12242","volume":"49","author":"ZC Hao","year":"2016","unstructured":"Hao ZC, Wang SZ, Zhang XJ, Lu J (2016) Stem cell therapy: a promising biological strategy for tendon-bone healing after anterior cruciate ligament reconstruction. Cell Prolif 49:154\u2013162. https:\/\/doi.org\/10.1111\/cpr.12242","journal-title":"Cell Prolif"},{"key":"9873_CR17","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.orthres.2004.02.012","volume":"22","author":"MT Harris","year":"2004","unstructured":"Harris MT, Butler DL, Boivin GP, Florer JB, Schantz EJ, Wenstrup RJ (2004) Mesenchymal stem cells used for rabbit tendon repair can form ectopic bone and express alkaline phosphatase activity in constructs. J Orthop Res 22:998\u20131003. https:\/\/doi.org\/10.1016\/j.orthres.2004.02.012","journal-title":"J Orthop Res"},{"key":"9873_CR18","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1242\/jcs.114231","volume":"126","author":"N Hu","year":"2013","unstructured":"Hu N, Jiang D, Huang E, Liu X, Li R, Liang X, Kim SH, Chen X, Gao JL, Zhang H, Zhang W, Kong YH, Zhang J, Wang J, Shui W, Luo X, Liu B, Cui J, Rogers MR, Shen J, Zhao C, Wang N, Wu N, Luu HH, Haydon RC, He TC, Huang W (2013) BMP9-regulated angiogenic signaling plays an important role in the osteogenic differentiation of mesenchymal progenitor cells. J Cell Sci 126:532\u2013541. https:\/\/doi.org\/10.1242\/jcs.114231","journal-title":"J Cell Sci"},{"key":"9873_CR19","doi-asserted-by":"publisher","first-page":"550","DOI":"10.14348\/molcells.2017.0019","volume":"40","author":"SY Hyun","year":"2017","unstructured":"Hyun SY, Lee JH, Kang KJ, Jang YJ (2017) Effect of FGF-2, TGF-beta-1, and BMPs on teno\/ligamentogenesis and osteo\/cementogenesis of human periodontal ligament stem cells. Mol Cells 40:550\u2013557. https:\/\/doi.org\/10.14348\/molcells.2017.0019","journal-title":"Mol Cells"},{"key":"9873_CR20","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.1002\/jbm.a.36089","volume":"105","author":"GI Im","year":"2017","unstructured":"Im GI (2017) Bone marrow-derived stem\/stromal cells and adipose tissue-derived stem\/stromal cells: their comparative efficacies and synergistic effects. J Biomed Mater Res A 105:2640\u20132648. https:\/\/doi.org\/10.1002\/jbm.a.36089","journal-title":"J Biomed Mater Res A"},{"key":"9873_CR21","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1002\/term.2150","volume":"11","author":"Y Jiang","year":"2017","unstructured":"Jiang Y, Shi Y, He J, Zhang Z, Zhou G, Zhang W, Cao Y, Liu W (2017) Enhanced tenogenic differentiation and tendon-like tissue formation by tenomodulin overexpression in murine mesenchymal stem cells. J Tissue Eng Regen Med 11:2525\u20132536. https:\/\/doi.org\/10.1002\/term.2150","journal-title":"J Tissue Eng Regen Med"},{"key":"9873_CR22","first-page":"237","volume":"30","author":"Y Jin","year":"2016","unstructured":"Jin Y, Li Y, Zhang C, Wu S, Cheng D, Liu Y (2016) Experimental research of differentiation of human amniotic mesenchymal stem cells into ligament cells in vitro. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 30:237\u2013244","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"key":"9873_CR23","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.injury.2011.03.030","volume":"42","author":"E Jones","year":"2011","unstructured":"Jones E, Yang X (2011) Mesenchymal stem cells and bone regeneration: current status. Injury 42:562\u2013568. https:\/\/doi.org\/10.1016\/j.injury.2011.03.030","journal-title":"Injury"},{"key":"9873_CR24","doi-asserted-by":"publisher","first-page":"e17531","DOI":"10.1371\/journal.pone.0017531","volume":"6","author":"JY Lee","year":"2011","unstructured":"Lee JY, Zhou Z, Taub PJ, Ramcharan M, Li Y, Akinbiyi T, Maharam ER, Leong DJ, Laudier DM, Ruike T, Torina PJ, Zaidi M, Majeska RJ, Schaffler MB, Flatow EL, Sun HB (2011) BMP-12 treatment of adult mesenchymal stem cells in vitro augments tendon-like tissue formation and defect repair in vivo. PLoS ONE 6:e17531. https:\/\/doi.org\/10.1371\/journal.pone.0017531","journal-title":"PLoS ONE"},{"key":"9873_CR25","doi-asserted-by":"publisher","first-page":"17665","DOI":"10.1074\/jbc.M610113200","volume":"282","author":"V Lejard","year":"2007","unstructured":"Lejard V, Brideau G, Blais F, Salingcarnboriboon R, Wagner G, Roehrl MH, Noda M, Duprez D, Houillier P, Rossert J (2007) Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts. J Biol Chem 282:17665\u201317675. https:\/\/doi.org\/10.1074\/jbc.M610113200","journal-title":"J Biol Chem"},{"key":"9873_CR26","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1089\/scd.2012.0359","volume":"22","author":"M Leyva-Leyva","year":"2013","unstructured":"Leyva-Leyva M, Barrera L, Lopez-Camarillo C, Arriaga-Pizano L, Orozco-Hoyuela G, Carrillo-Casas EM, Calderon-Perez J, Lopez-Diaz A, Hernandez-Aguilar F, Gonzalez-Ramirez R, Kawa S, Chimal-Monroy J, Fuentes-Mera L (2013) Characterization of mesenchymal stem cell subpopulations from human amniotic membrane with dissimilar osteoblastic potential. Stem Cells Dev 22:1275\u20131287. https:\/\/doi.org\/10.1089\/scd.2012.0359","journal-title":"Stem Cells Dev"},{"key":"9873_CR28","doi-asserted-by":"publisher","first-page":"13149","DOI":"10.1038\/srep13149","volume":"5","author":"Y Li","year":"2015","unstructured":"Li Y, Ramcharan M, Zhou Z, Leong DJ, Akinbiyi T, Majeska RJ, Sun HB (2015) The role of scleraxis in fate determination of mesenchymal stem cells for tenocyte differentiation. Sci Rep 5:13149. https:\/\/doi.org\/10.1038\/srep13149","journal-title":"Sci Rep"},{"key":"9873_CR27","doi-asserted-by":"publisher","first-page":"7360354","DOI":"10.1155\/2017\/7360354","volume":"2017","author":"Y Li","year":"2017","unstructured":"Li Y, Liu Z, Jin Y, Zhu X, Wang S, Yang J, Ren Y, Fu Q, Xiong H, Zou G, Liu Y (2017) Differentiation of human amniotic mesenchymal stem cells into human anterior cruciate ligament fibroblast cells by in vitro coculture. Biomed Res Int 2017:7360354. https:\/\/doi.org\/10.1155\/2017\/7360354","journal-title":"Biomed Res Int"},{"key":"9873_CR29","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1089\/ten.TEB.2010.0662","volume":"17","author":"CF Liu","year":"2011","unstructured":"Liu CF, Aschbacher-Smith L, Barthelery NJ, Dyment N, Butler D, Wylie C (2011) What we should know before using tissue engineering techniques to repair injured tendons: a developmental biology perspective. Tissue Eng B Rev 17:165\u2013176. https:\/\/doi.org\/10.1089\/ten.TEB.2010.0662","journal-title":"Tissue Eng B Rev"},{"key":"9873_CR30","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s00441-014-1834-8","volume":"356","author":"H Liu","year":"2014","unstructured":"Liu H, Zhu S, Zhang C, Lu P, Hu J, Yin Z, Ma Y, Chen X, OuYang H (2014) Crucial transcription factors in tendon development and differentiation: their potential for tendon regeneration. Cell Tissue Res 356:287\u2013298. https:\/\/doi.org\/10.1007\/s00441-014-1834-8","journal-title":"Cell Tissue Res"},{"key":"9873_CR31","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/nprot.2007.135","volume":"2","author":"J Luo","year":"2007","unstructured":"Luo J, Deng ZL, Luo X, Tang N, Song WX, Chen J, Sharff KA, Luu HH, Haydon RC, Kinzler KW, Vogelstein B, He TC (2007) A protocol for rapid generation of recombinant adenoviruses using the AdEasy system. Nat Protoc 2:1236\u20131247. https:\/\/doi.org\/10.1038\/nprot.2007.135","journal-title":"Nat Protoc"},{"key":"9873_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081772","author":"L Mostaco-Guidolin","year":"2017","unstructured":"Mostaco-Guidolin L, Rosin NL, Hackett TL (2017) Imaging collagen in scar tissue: developments in second harmonic generation microscopy for biomedical applications. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms18081772","journal-title":"Int J Mol Sci"},{"key":"9873_CR33","doi-asserted-by":"publisher","first-page":"2697","DOI":"10.1242\/dev.001933","volume":"134","author":"ND Murchison","year":"2007","unstructured":"Murchison ND, Price BA, Conner DA, Keene DR, Olson EN, Tabin CJ, Schweitzer R (2007) Regulation of tendon differentiation by Scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons. Development 134:2697\u20132708. https:\/\/doi.org\/10.1242\/dev.001933","journal-title":"Development"},{"key":"9873_CR34","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1089\/scd.2009.0404","volume":"19","author":"O Parolini","year":"2010","unstructured":"Parolini O, Alviano F, Bergwerf I, Boraschi D, De Bari C, De Waele P, Dominici M, Evangelista M, Falk W, Hennerbichler S, Hess DC, Lanzoni G, Liu B, Marongiu F, McGuckin C, Mohr S, Nolli ML, Ofir R, Ponsaerts P, Romagnoli L, Solomon A, Soncini M, Strom S, Surbek D, Venkatachalam S, Wolbank S, Zeisberger S, Zeitlin A, Zisch A, Borlongan CV (2010) Toward cell therapy using placenta-derived cells: disease mechanisms, cell biology, preclinical studies, and regulatory aspects at the round table. Stem Cells Dev 19:143\u2013154. https:\/\/doi.org\/10.1089\/scd.2009.0404","journal-title":"Stem Cells Dev"},{"key":"9873_CR35","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1002\/jbm.a.35650","volume":"104","author":"MS Rehmann","year":"2016","unstructured":"Rehmann MS, Luna JI, Maverakis E, Kloxin AM (2016) Tuning microenvironment modulus and biochemical composition promotes human mesenchymal stem cell tenogenic differentiation. J Biomed Mater Res A 104:1162\u20131174. https:\/\/doi.org\/10.1002\/jbm.a.35650","journal-title":"J Biomed Mater Res A"},{"key":"9873_CR36","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/bjd.15079","volume":"177","author":"MR Roh","year":"2017","unstructured":"Roh MR, Kumar R, Rajadurai A, Njauw C, Ryoo UH, Chung KY, Tsao H (2017) Beta-catenin causes fibrotic changes in the extracellular matrix via upregulation of collagen I transcription. Br J Dermatol 177:312\u2013315. https:\/\/doi.org\/10.1111\/bjd.15079","journal-title":"Br J Dermatol"},{"key":"9873_CR37","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1242\/dev.128.19.3855","volume":"128","author":"R Schweitzer","year":"2001","unstructured":"Schweitzer R, Chyung JH, Murtaugh LC, Brent AE, Rosen V, Olson EN, Lassar A, Tabin CJ (2001) Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments. Development 128:3855\u20133866","journal-title":"Development"},{"key":"9873_CR38","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/jor.21220","volume":"29","author":"A Scott","year":"2011","unstructured":"Scott A, Sampaio A, Abraham T, Duronio C, Underhill TM (2011) Scleraxis expression is coordinately regulated in a murine model of patellar tendon injury. J Orthop Res 29:289\u2013296. https:\/\/doi.org\/10.1002\/jor.21220","journal-title":"J Orthop Res"},{"key":"9873_CR39","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.ydbio.2006.06.036","volume":"298","author":"C Shukunami","year":"2006","unstructured":"Shukunami C, Takimoto A, Oro M, Hiraki Y (2006) Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes. Dev Biol 298:234\u2013247. https:\/\/doi.org\/10.1016\/j.ydbio.2006.06.036","journal-title":"Dev Biol"},{"key":"9873_CR40","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jdsr.2016.04.003","volume":"52","author":"C Shukunami","year":"2016","unstructured":"Shukunami C, Yoshimoto Y, Takimoto A, Yamashita H, Hiraki Y (2016) Molecular characterization and function of tenomodulin, a marker of tendons and ligaments that integrate musculoskeletal components. Jpn Dent Sci Rev 52:84\u201392. https:\/\/doi.org\/10.1016\/j.jdsr.2016.04.003","journal-title":"Jpn Dent Sci Rev"},{"key":"9873_CR41","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1002\/dvg.22372","volume":"51","author":"Y Sugimoto","year":"2013","unstructured":"Sugimoto Y, Takimoto A, Hiraki Y, Shukunami C (2013) Generation and characterization of ScxCre transgenic mice. Genesis 51:275\u2013283. https:\/\/doi.org\/10.1002\/dvg.22372","journal-title":"Genesis"},{"key":"9873_CR42","doi-asserted-by":"publisher","first-page":"e97453","DOI":"10.1371\/journal.pone.0097453","volume":"9","author":"C Tan","year":"2014","unstructured":"Tan C, Lui PP, Lee YW, Wong YM (2014) Scx-transduced tendon-derived stem cells (tdscs) promoted better tendon repair compared to mock-transduced cells in a rat patellar tendon window injury model. PLoS ONE 9:e97453. https:\/\/doi.org\/10.1371\/journal.pone.0097453","journal-title":"PLoS ONE"},{"key":"9873_CR43","doi-asserted-by":"publisher","DOI":"10.1177\/0363546517727512","author":"T Thangarajah","year":"2017","unstructured":"Thangarajah T, Sanghani-Kerai A, Henshaw F, Lambert SM, Pendegrass CJ, Blunn GW (2017) Application of a demineralized cortical bone matrix and bone marrow-derived mesenchymal stem cells in a model of chronic rotator cuff degeneration. Am J Sports Med. https:\/\/doi.org\/10.1177\/0363546517727512","journal-title":"Am J Sports Med"},{"key":"9873_CR44","doi-asserted-by":"publisher","first-page":"2954","DOI":"10.1016\/j.biomaterials.2008.03.038","volume":"29","author":"B Wang","year":"2008","unstructured":"Wang B, Liu W, Zhang Y, Jiang Y, Zhang WJ, Zhou G, Cui L, Cao Y (2008) Engineering of extensor tendon complex by an ex vivo approach. Biomaterials 29:2954\u20132961. https:\/\/doi.org\/10.1016\/j.biomaterials.2008.03.038","journal-title":"Biomaterials"},{"key":"9873_CR45","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.jbiomech.2012.12.019","volume":"46","author":"J Xie","year":"2013","unstructured":"Xie J, Wang C, Huang DY, Zhang Y, Xu J, Kolesnikov SS, Sung KL, Zhao H (2013) TGF-beta1 induces the different expressions of lysyl oxidases and matrix metalloproteinases in anterior cruciate ligament and medial collateral ligament fibroblasts after mechanical injury. J Biomech 46:890\u2013898. https:\/\/doi.org\/10.1016\/j.jbiomech.2012.12.019","journal-title":"J Biomech"},{"key":"9873_CR46","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/bdrc.21041","volume":"99","author":"G Yang","year":"2013","unstructured":"Yang G, Rothrauff BB, Tuan RS (2013) Tendon and ligament regeneration and repair: clinical relevance and developmental paradigm. Birth Defects Res C Embryo Today 99:203\u2013222. https:\/\/doi.org\/10.1002\/bdrc.21041","journal-title":"Birth Defects Res C Embryo Today"},{"key":"9873_CR47","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1002\/jbm.a.36261","volume":"106","author":"JL Yang","year":"2018","unstructured":"Yang JL, Yao X, Qing Q, Zhang Y, Jiang YL, Ning LJ, Luo JC, Qin TW (2018) An engineered tendon\/ligament bioscaffold derived from decellularized and demineralized cortical bone matrix. J Biomed Mater Res A 106:468\u2013478. https:\/\/doi.org\/10.1002\/jbm.a.36261","journal-title":"J Biomed Mater Res A"},{"key":"9873_CR48","doi-asserted-by":"publisher","first-page":"45010","DOI":"10.1038\/srep45010","volume":"7","author":"Y Yoshimoto","year":"2017","unstructured":"Yoshimoto Y, Takimoto A, Watanabe H, Hiraki Y, Kondoh G, Shukunami C (2017) Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system. Sci Rep 7:45010. https:\/\/doi.org\/10.1038\/srep45010","journal-title":"Sci Rep"},{"key":"9873_CR49","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1159\/000374052","volume":"36","author":"N Zhou","year":"2015","unstructured":"Zhou N, Hu N, Liao JY, Lin LB, Zhao C, Si WK, Yang Z, Yi SX, Fan TX, Bao W, Liang X, Wei X, Chen H, Chen C, Chen Q, Lin X, Huang W (2015) HIF-1alpha as a regulator of BMP2-induced chondrogenic differentiation, osteogenic differentiation, and endochondral ossification in stem cells. Cell Physiol Biochem 36:44\u201360. https:\/\/doi.org\/10.1159\/000374052","journal-title":"Cell Physiol Biochem"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-020-09873-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-020-09873-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-020-09873-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T08:40:14Z","timestamp":1666428014000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-020-09873-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,25]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["9873"],"URL":"https:\/\/doi.org\/10.1007\/s10735-020-09873-w","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,25]]},"assertion":[{"value":"3 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study has been approved by the Research Ethics Committee of the Affiliated Hospital of Zunyi Medical College.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. All procedures performed in studies involving animals were in accordance with the ethical standards of the Zunyi Medical University.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}