{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T07:38:23Z","timestamp":1781336303594,"version":"3.54.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004772","name":"Natural Science Foundation of Ningxia Province","doi-asserted-by":"publisher","award":["2019AAC03081"],"award-info":[{"award-number":["2019AAC03081"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ningxia High School first-class Discipline","award":["NXYLXK2017B07"],"award-info":[{"award-number":["NXYLXK2017B07"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NO.81770459 and No.81970369"],"award-info":[{"award-number":["NO.81770459 and No.81970369"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Hist"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s10735-020-09909-1","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T06:32:44Z","timestamp":1599719564000},"page":"629-637","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Lycium barbarum polysaccharide protects against Homocysteine-induced Vascular smooth muscle cell proliferation and phenotypic transformation via PI3K\/Akt pathway"],"prefix":"10.1007","volume":"51","author":[{"given":"Minghao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smritee","family":"Pokharel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weirong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1419-0370","authenticated-orcid":false,"given":"Rong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,8]]},"reference":[{"key":"9909_CR1","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1002\/cncr.24280","volume":"115","author":"RJ Amato","year":"2009","unstructured":"Amato RJ, Jac J, Giessinger S et al (2009) A phase 2 study with a daily regimen of the oral mTOR inhibitor RAD001 (everolimus) in patients with metastatic clear cell renal cell cancer. Cancer 115:2438\u20132446","journal-title":"Cancer"},{"key":"9909_CR3","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.carbpol.2018.10.057","volume":"205","author":"R Bo","year":"2019","unstructured":"Bo R, Liu Z, Zhang J et al (2019) Mechanism of Lycium barbarum polysaccharides liposomes on activating murine dendritic cells. Carbohydr Polym 205:540\u2013549","journal-title":"Carbohydr Polym"},{"key":"9909_CR4","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1007\/s10495-014-0977-0","volume":"19","author":"K Chen","year":"2014","unstructured":"Chen K, Li G, Geng F et al (2014) Berberine reduces ischemia\/ reperfusion-induced myocardial apoptosis via activating AMPK and PI3K- Akt signaling in diabetic rats. Apoptosis 19:946\u2013957","journal-title":"Apoptosis"},{"key":"9909_CR6","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1161\/CIRCRESAHA.109.197517","volume":"105","author":"Y Cheng","year":"2009","unstructured":"Cheng Y, Liu X, Yang J et al (2009) MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation. Circ Res 105:158\u2013166","journal-title":"Circ Res"},{"key":"9909_CR7","doi-asserted-by":"crossref","unstructured":"Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D. miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature. 2009,6;460(7256):705\u201310.","DOI":"10.1038\/nature08195"},{"key":"9909_CR8","doi-asserted-by":"crossref","unstructured":"Fan Q-W, Cheng C, Hackett C et al. Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal, 2010, 3: ra81.","DOI":"10.1126\/scisignal.2001017"},{"key":"9909_CR9","doi-asserted-by":"publisher","first-page":"35302","DOI":"10.1038\/srep35302","volume":"6","author":"X Guo","year":"2016","unstructured":"Guo X, Li D, Chen M et al (2016) miRNA-145 inhibits VSMC proliferation by targeting CD40. Sci Rep 6:35302","journal-title":"Sci Rep"},{"key":"9909_CR10","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.cellsig.2019.01.014","volume":"57","author":"Y Higashi","year":"2019","unstructured":"Higashi Y, Mummidi S, Sukhanov S et al (2019) Minocycline inhibits PDGF-BB-induced human aortic smooth muscle cell proliferation and migration by reversing miR-221- and -222-mediated RECK suppression. Cell Signal 57:10\u201320","journal-title":"Cell Signal"},{"key":"9909_CR11","first-page":"6912","volume":"22","author":"Q-S Jin","year":"2018","unstructured":"Jin Q-S, Huang L-J, Zhao T-T et al (2018) HOXA11-AS regulates diabetic arteriosclerosis- related inflammation via PI3K\/AKT pathway. Eur Rev Med Pharmacol Sci 22:6912\u20136921","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"3","key":"9909_CR15","doi-asserted-by":"publisher","first-page":"E215","DOI":"10.1532\/hsf.2223","volume":"22","author":"S Li","year":"2019","unstructured":"Li S, Pan G, Chen H, Niu X (2019a) Determination of Serum Homocysteine and Hypersensitive C-reactive Protein and Their Correlation with Premature Coronary Heart Disease. Heart Surg Forum 22(3):E215\u2013E217","journal-title":"Heart Surg Forum"},{"issue":"5","key":"9909_CR16","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3389\/fcvm.2018.00151","volume":"23","author":"M Li","year":"2018","unstructured":"Li M, Qian M, Kyler K, Xu J (2018) Endothelial-Vascular Smooth Muscle Cells Interactions in Atherosclerosis. Front Cardiovasc Med 23(5):151","journal-title":"Front Cardiovasc Med"},{"issue":"22","key":"9909_CR17","doi-asserted-by":"publisher","first-page":"3751","DOI":"10.12998\/wjcc.v7.i22.3751","volume":"7","author":"J Li","year":"2019","unstructured":"Li J, Zhou F, Wu FX (2019b) Relationship between homocysteine level and prognosis of elderly patients with acute ischemic stroke treated by thrombolysis with recombinant tissue plasminogen activator. World J Clin Cases 7(22):3751\u20133756","journal-title":"World J Clin Cases"},{"key":"9909_CR18","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.ijcard.2018.07.043","volume":"269","author":"H Lin","year":"2018","unstructured":"Lin H, Ni T, Zhang J et al (2018) Knockdown of Herp alleviates hyperhomocysteinemia mediated atherosclerosis through the inhibition of vascular smooth muscle cell phenotype switching. Int J Cardiol 269:242\u2013249","journal-title":"Int J Cardiol"},{"issue":"2","key":"9909_CR19","first-page":"806","volume":"11","author":"LB Liu","year":"2019","unstructured":"Liu LB, Shen HF, Cha W, Jin ZJ, Xia HJ, Liu JJ, Hu JF (2019) SXBX pill suppresses homocysteine-induced vascular smooth muscle cells dedifferentiation by inhibiting NLRP3 inflammasomes activation via ERK\/p38 MAPK pathways. Am J Transl Res 11(2):806\u2013818","journal-title":"Am J Transl Res"},{"key":"9909_CR20","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/cvr\/cvn325","volume":"82","author":"F Morello","year":"2009","unstructured":"Morello F, Perino A, Hirsch E (2009) Phosphoinositide 3-kinase signalling in the vascular system. Cardiovasc Res 82:261\u2013271","journal-title":"Cardiovasc Res"},{"issue":"4","key":"9909_CR21","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.3892\/or.2014.3333","volume":"32","author":"Y Naito","year":"2014","unstructured":"Naito Y, Yasuno K, Tagawa H, Sakamoto N, Oue N, Yashiro M, Sentani K, Goto K, Shinmei S, Oo HZ, Yanagihara K, Hirakawa K, Yasui W (2014) MicroRNA-145 is a potential prognostic factor of scirrhous type gastric cancer. Oncol Rep 32(4):1720\u20131726","journal-title":"Oncol Rep"},{"key":"9909_CR23","doi-asserted-by":"publisher","first-page":"e110275","DOI":"10.1371\/journal.pone.0110275","volume":"9","author":"B Qi","year":"2014","unstructured":"Qi B, Ji Q, Wen Y et al (2014) Lycium barbarum polysaccharides protect human lens epithelial cells against oxidative stress-induced apoptosis and senescence. PLoS ONE 9:e110275","journal-title":"PLoS ONE"},{"issue":"3","key":"9909_CR24","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/BF03085963","volume":"15","author":"SS Rensen","year":"2007","unstructured":"Rensen SS, Doevendans PA, van Eys GJ (2007) Regulation and characteristics of vascular smooth muscle cell phenotypic diversity. Neth Heart J 15(3):100\u2013108","journal-title":"Neth Heart J"},{"issue":"14","key":"9909_CR25","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1096\/fj.99-0927com","volume":"14","author":"LA Schildmeyer","year":"2000","unstructured":"Schildmeyer LA, Braun R, Taffet G, Debiasi M, Burns AE, Bradley A, Schwartz RJ (2000) Impaired vascular contractility and blood pressure homeostasis in the smooth muscle alpha-actin null mouse. FASEB J 14(14):2213\u20132220","journal-title":"FASEB J"},{"issue":"1","key":"9909_CR26","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1080\/10717544.2019.1628116","volume":"26","author":"G Sun","year":"2019","unstructured":"Sun G, Li Y, Ji Z (2019) Up-regulation of MIAT aggravates the atherosclerotic damage in atherosclerosis mice through the activation of PI3K\/Akt signaling pathway. Drug Deliv 26(1):641\u2013649","journal-title":"Drug Deliv"},{"key":"9909_CR27","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.biopha.2018.04.104","volume":"103","author":"L Tang","year":"2018","unstructured":"Tang L, Bao S, Du Y et al (2018) Antioxidant effects of Lycium barbarum polysaccharides on photoreceptor degeneration in the light-exposed mouse retina. Biomed Pharmacother 103:829\u2013837","journal-title":"Biomed Pharmacother"},{"key":"9909_CR28","doi-asserted-by":"publisher","first-page":"H641","DOI":"10.1152\/ajpheart.00660.2016","volume":"313","author":"Y Tang","year":"2017","unstructured":"Tang Y, Yu S, Liu Y et al (2017) MicroRNA-124 controls human vascular smooth muscle cell phenotypic switch via Sp1. Am J Physiol Heart Circ Physiol 313:H641\u2013H649","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"9909_CR29","doi-asserted-by":"publisher","first-page":"2554","DOI":"10.2337\/db17-1434","volume":"67","author":"D Torella","year":"2018","unstructured":"Torella D, Iaconetti C, Tarallo R et al (2018) miRNA regulation of the hyperproliferative phenotype of vascular smooth muscle cells in diabetes. Diabetes 67:2554\u20132568","journal-title":"Diabetes"},{"key":"9909_CR30","doi-asserted-by":"publisher","first-page":"e90780","DOI":"10.1371\/journal.pone.0090780","volume":"9","author":"T Wang","year":"2014","unstructured":"Wang T, Li Y, Wang Y et al (2014) Lycium barbarum polysaccharide prevents focal cerebral ischemic injury by inhibiting neuronal apoptosis in mice. PLoS One 9:e90780","journal-title":"PLoS One"},{"key":"9909_CR31","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.yexcr.2016.08.004","volume":"347","author":"Y Wang","year":"2016","unstructured":"Wang Y, Wang X, Liang X et al (2016) Inhibition of hydrogen sulfide on the proliferation of vascular smooth muscle cells involved in the modulation of calcium sensing receptor in high homocysteine. Exp Cell Res 347:184\u2013191","journal-title":"Exp Cell Res"},{"issue":"47","key":"9909_CR32","doi-asserted-by":"publisher","first-page":"e18019","DOI":"10.1097\/MD.0000000000018019","volume":"8","author":"M Wei","year":"2019","unstructured":"Wei M, Wang L, Liu YS, Zheng MQ, Ma FF, Qi YC, Liu G (2019) Homocysteine as a potential predictive factor for high major adverse cardiovascular events risk in female patients with premature acute coronary syndrome. Medicine 8(47):e18019","journal-title":"Medicine"},{"key":"9909_CR34","doi-asserted-by":"crossref","unstructured":"Yang L, Lei L, Zhao Q et al. Lycium barbarum polysaccharide improves the development of mouse oocytes vitrified at the germinal vesicle stage.Cryobiology, 2018, 85: 7\u201311.","DOI":"10.1016\/j.cryobiol.2018.10.265"},{"key":"9909_CR35","doi-asserted-by":"publisher","first-page":"3801","DOI":"10.2147\/CMAR.S199291","volume":"11","author":"D Ye","year":"2019","unstructured":"Ye D, Zhou C, Deng H, Lin L, Zhou S (2019) MicroRNA-145 inhibits growth of laryngeal squamous cell carcinoma by targeting the PI3K\/Akt signaling pathway. Cancer Management and Research 11:3801\u20133812","journal-title":"Cancer Management and Research"},{"issue":"3","key":"9909_CR37","doi-asserted-by":"publisher","first-page":"e91","DOI":"10.1161\/ATVBAHA.118.312212","volume":"39","author":"Q Yu","year":"2019","unstructured":"Yu Q, Li W, Jin R, Yu S, Xie D, Zheng X, Zhong W, Cheng X, Hu S, Li M, Zheng Q, Li G, Song Z (2019) PI3K\u03b3 (Phosphoinositide 3-Kinase \u03b3) Regulates Vascular Smooth Muscle Cell Phenotypic Modulation and Neointimal Formation Through CREB (Cyclic AMP-Response Element Binding Protein)\/YAP (Yes-Associated Protein) Signaling. Arterioscler Thromb Vasc Biol 39(3):e91\u2013e105","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"9909_CR38","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.yjmcc.2012.07.010","volume":"53","author":"D Zhang","year":"2012","unstructured":"Zhang D, Chen Y, Xie X et al (2012) Homocysteine activates vascular smooth muscle cells by DNA demethylation of platelet-derived growth factor in endothelial cells. J Mol Cell Cardiol 53:487\u2013496","journal-title":"J Mol Cell Cardiol"},{"key":"9909_CR39","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.biopha.2018.12.073","volume":"111","author":"G Zheng","year":"2019","unstructured":"Zheng G, Ren H, Li H et al (2019a) Lycium barbarum polysaccharide reduces hyperoxic acute lung injury in mice through Nrf2 pathway. Biomed Pharmacother 111:733\u2013739","journal-title":"Biomed Pharmacother"},{"key":"9909_CR40","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.biopha.2018.12.073","volume":"111","author":"G Zheng","year":"2019","unstructured":"Zheng G, Ren H, Li H, Li X, Dong T, Xu S, Yan Y, Sun B, Bai J, Li Y (2019b) Lycium barbarum polysaccharide reduces hyperoxic acute lung injury in mice through Nrf2 pathway. Biomed Pharmacother 111:733\u2013739","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"9909_CR41","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1161\/ATVBAHA.118.311917","volume":"39","author":"L Zhong","year":"2019","unstructured":"Zhong L, He X, Si X, Wang H, Li B, Hu Y, Li M, Chen X, Liao W, Liao Y, Bin J (2019) SM22\u03b1 (smooth muscle 22\u03b1) prevents aortic aneurysm formation by inhibiting smooth muscle cell phenotypic switching through suppressing reactive oxygen species\/nF-\u03baB (nuclear factor-\u03baB). Arterioscler Thromb Vasc Biol 39(1):e10\u2013e25","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"9909_CR42","doi-asserted-by":"publisher","first-page":"3445","DOI":"10.3892\/mmr.2014.3128","volume":"11","author":"X Zhu","year":"2015","unstructured":"Zhu X, Hu S, Zhu L et al (2015) Effects of Lycium barbarum polysaccharides on oxidative stress in hyperlipidemic mice following chronic composite psychological stress intervention. Mol Med Rep 11:3445\u20133450","journal-title":"Mol Med Rep"},{"issue":"12","key":"9909_CR43","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1093\/abbs\/gmq102","volume":"42","author":"T Zou","year":"2010","unstructured":"Zou T, Yang W, Hou Z, Yang J (2010) Homocysteine enhances cell proliferation in vascular smooth muscle cells: role of p38 MAPK and p47phox. Acta Biochim Biophys Sin (Shanghai) 42(12):908\u2013915","journal-title":"Acta Biochim Biophys Sin (Shanghai)"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-020-09909-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-020-09909-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-020-09909-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T23:21:38Z","timestamp":1631056898000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-020-09909-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,8]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["9909"],"URL":"https:\/\/doi.org\/10.1007\/s10735-020-09909-1","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,8]]},"assertion":[{"value":"20 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All studies were completed with the approval of the ethics review committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}