{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T20:38:54Z","timestamp":1773693534017,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572106"],"award-info":[{"award-number":["81572106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s10735-021-09961-5","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T17:24:28Z","timestamp":1613755468000},"page":"397-406","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["cIAP2 expression and clinical significance in pigmented villonodular synovitis"],"prefix":"10.1007","volume":"52","author":[{"given":"Zhenyu","family":"Ding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenlong","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benben","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8260-7161","authenticated-orcid":false,"given":"Yaohua","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"9961_CR1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/1471-2407-9-125","volume":"9","author":"C Augello","year":"2009","unstructured":"Augello C et al (2009) Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma. BMC Cancer 9:125. https:\/\/doi.org\/10.1186\/1471-2407-9-125","journal-title":"BMC Cancer"},{"key":"9961_CR2","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1080\/03009740410009823","volume":"34","author":"I Berger","year":"2005","unstructured":"Berger I, Paessler HH, Weckauf H, Ehemann V, Helmchen B (2005) Strong expression of Bcl-2 in pigmented villonodular synovitis of the knee with aggressive clinical behaviour Scandinavian. J Rheumatol 34:68\u201370. https:\/\/doi.org\/10.1080\/03009740410009823","journal-title":"J Rheumatol"},{"key":"9961_CR3","doi-asserted-by":"publisher","first-page":"118688","DOI":"10.1016\/j.bbamcr.2020.118688","volume":"1867","author":"A Boice","year":"2020","unstructured":"Boice A, Bouchier-Hayes L (2020) Targeting apoptotic caspases in cancer. Biochim Biophys Acta Mol Cell Res 1867:118688. https:\/\/doi.org\/10.1016\/j.bbamcr.2020.118688","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"9961_CR4","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s00264-013-1789-5","volume":"37","author":"P Botez","year":"2013","unstructured":"Botez P, Sirbu PD, Grierosu C, Mihailescu D, Savin L, Scarlat MM (2013) Adult multifocal pigmented villonodular synovitis\u2014clinical review. Int Orthop 37:729\u2013733. https:\/\/doi.org\/10.1007\/s00264-013-1789-5","journal-title":"Int Orthop"},{"key":"9961_CR5","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s10735-009-9237-y","volume":"40","author":"H Chen","year":"2009","unstructured":"Chen H, Xue J, Zhang Y, Zhu X, Gao J, Yu B (2009) Comparison of quantum dots immunofluorescence histochemistry and conventional immunohistochemistry for the detection of caveolin-1 and PCNA in the lung cancer tissue microarray. J Mol Histol 40:261\u2013268. https:\/\/doi.org\/10.1007\/s10735-009-9237-y","journal-title":"J Mol Histol"},{"key":"9961_CR6","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3892\/or.2015.4350","volume":"35","author":"K Chen","year":"2016","unstructured":"Chen K, Ren Q, Han XR, Zhang XN, Wei B, Bai XZ (2016) Imatinib mesylate induces mitochondria-dependent apoptosis and inhibits invasion of human pigmented villonodular synovitis fibroblast-like synovial cells. Oncol Rep 35:197\u2013204. https:\/\/doi.org\/10.3892\/or.2015.4350","journal-title":"Oncol Rep"},{"key":"9961_CR7","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1038\/nm.4229","volume":"22","author":"M Chesi","year":"2016","unstructured":"Chesi M et al (2016) IAP antagonists induce anti-tumor immunity in multiple myeloma. Nat Med 22:1411\u20131420. https:\/\/doi.org\/10.1038\/nm.4229","journal-title":"Nat Med"},{"key":"9961_CR8","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12929-020-0627-5","volume":"27","author":"CHA Cheung","year":"2020","unstructured":"Cheung CHA, Chang YC, Lin TY, Cheng SM, Leung E (2020) Anti-apoptotic proteins in the autophagic world: an update on functions of XIAP, survivin, and BRUCE. J Biomed Sci 27:31. https:\/\/doi.org\/10.1186\/s12929-020-0627-5","journal-title":"J Biomed Sci"},{"key":"9961_CR9","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/mi.2015.46","volume":"9","author":"M Dagenais","year":"2016","unstructured":"Dagenais M, Dupaul-Chicoine J, Champagne C, Skeldon A, Morizot A, Saleh M (2016) A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways. Mucosal Immunol 9:146\u2013158. https:\/\/doi.org\/10.1038\/mi.2015.46","journal-title":"Mucosal Immunol"},{"key":"9961_CR10","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.7754\/Clin.Lab.2015.150312","volume":"61","author":"Y Dang","year":"2015","unstructured":"Dang Y, Wang Y, Ouyang X, Wang L, Huang Q (2015) High expression of IncRNA-PCNA-AS1 in human gastric cancer and its clinical significances. Clin Lab 61:1679\u20131685","journal-title":"Clin Lab"},{"key":"9961_CR14","doi-asserted-by":"publisher","first-page":"20621","DOI":"10.18632\/oncotarget.4139","volume":"6","author":"CF Duvefelt","year":"2015","unstructured":"Duvefelt CF et al (2015) Increased resistance to proteasome inhibitors in multiple myeloma mediated by cIAP2\u2014implications for a combinatorial treatment. Oncotarget 6:20621\u201320635. https:\/\/doi.org\/10.18632\/oncotarget.4139","journal-title":"Oncotarget"},{"key":"9961_CR11","first-page":"93","volume":"58","author":"A Falek","year":"2018","unstructured":"Falek A et al (2018) Pigmented villonodular synovitis. Folia Med Cracov 58:93\u2013104","journal-title":"Folia Med Cracov"},{"key":"9961_CR12","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1002\/art.21641","volume":"54","author":"K Finis","year":"2006","unstructured":"Finis K et al (2006) Analysis of pigmented villonodular synovitis with genome-wide complementary DNA microarray and tissue array technology reveals insight into potential novel therapeutic approaches. Arthritis Rheum 54:1009\u20131019. https:\/\/doi.org\/10.1002\/art.21641","journal-title":"Arthritis Rheum"},{"key":"9961_CR13","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.autrev.2010.07.001","volume":"9","author":"U Fiocco","year":"2010","unstructured":"Fiocco U et al (2010) Molecular pathways involved in synovial cell inflammation and tumoral proliferation in diffuse pigmented villonodular synovitis. Autoimmun Rev 9:780\u2013784. https:\/\/doi.org\/10.1016\/j.autrev.2010.07.001","journal-title":"Autoimmun Rev"},{"key":"9961_CR15","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s00264-016-3348-3","volume":"41","author":"D Georgiannos","year":"2016","unstructured":"Georgiannos D, Boutsiadis A, Agathangelidis F, Papastergiou S, Karataglis D, Bisbinas I (2016) Arthroscopically-assisted mini open partial synovectomy for the treatment of localized pigmented villonodular synovitis of the knee: a retrospective comparative study with long-term follow up. Int Orthop 41:925\u2013930. https:\/\/doi.org\/10.1007\/s00264-016-3348-3","journal-title":"Int Orthop"},{"key":"9961_CR16","doi-asserted-by":"publisher","first-page":"4901","DOI":"10.1002\/cncr.26529","volume":"118","author":"AM Griffin","year":"2012","unstructured":"Griffin AM et al (2012) Long-term outcome of the treatment of high-risk tenosynovial giant cell tumor\/pigmented villonodular synovitis with radiotherapy and surgery. Cancer 118:4901\u20134909. https:\/\/doi.org\/10.1002\/cncr.26529","journal-title":"Cancer"},{"key":"9961_CR17","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1097\/SCS.0000000000002792","volume":"27","author":"N Ibrahim","year":"2016","unstructured":"Ibrahim N, Nazimi AJ, Ajura AJ, Nordin R, Latiff ZA, Ramli R (2016) The Clinical features and expression of bcl-2, Cyclin D1, p53, and proliferating cell nuclear antigen in syndromic and nonsyndromic keratocystic odontogenic tumor. J Craniofac Surg 27:1361\u20131366. https:\/\/doi.org\/10.1097\/SCS.0000000000002792","journal-title":"J Craniofac Surg"},{"key":"9961_CR18","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1136\/ard.2004.025445","volume":"64","author":"K Ijiri","year":"2005","unstructured":"Ijiri K et al (2005) Increased expression of humanin peptide in diffuse-type pigmented villonodular synovitis: implication of its mitochondrial abnormality. Ann Rheum Dis 64:816\u2013823. https:\/\/doi.org\/10.1136\/ard.2004.025445","journal-title":"Ann Rheum Dis"},{"key":"9961_CR19","doi-asserted-by":"publisher","first-page":"13","DOI":"10.2174\/1874325001105010013","volume":"5","author":"N Imakiire","year":"2011","unstructured":"Imakiire N, Fujino T, Morii T, Honya K, Mochizuki K, Satomi K, Fujioka Y (2011) Malignant pigmented villonodular synovitis in the knee\u2014report of a case with rapid clinical progression. Open Orthop J 5:13\u201316. https:\/\/doi.org\/10.2174\/1874325001105010013","journal-title":"Open Orthop J"},{"key":"9961_CR20","first-page":"731","volume":"31","author":"HL Jaffe","year":"1941","unstructured":"Jaffe HL, Lichtenstein L, Sutro CJ (1941) Pigmented villonodular synovitis, bursitis and tenosynovitis. Arch Pathol 31:731\u2013765","journal-title":"Arch Pathol"},{"key":"9961_CR21","doi-asserted-by":"publisher","first-page":"297","DOI":"10.4155\/ppa.14.16","volume":"3","author":"JB Jaquith","year":"2014","unstructured":"Jaquith JB (2014) Targeting the inhibitor of apoptosis protein BIR3 binding domains. Pharm Pat Anal 3:297\u2013312. https:\/\/doi.org\/10.4155\/ppa.14.16","journal-title":"Pharm Pat Anal"},{"key":"9961_CR22","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s10735-011-9371-1","volume":"43","author":"Z Jia","year":"2012","unstructured":"Jia Z, Zhao W, Fan L, Sheng W (2012) The expression of PCNA, c-erbB-2, p53, ER and PR as well as atypical hyperplasia in tissues nearby the breast cancer. J Mol Histol 43:115\u2013120. https:\/\/doi.org\/10.1007\/s10735-011-9371-1","journal-title":"J Mol Histol"},{"key":"9961_CR23","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1002\/1521-1878(200011)22:11<1007::AID-BIES7>3.0.CO;2-4","volume":"22","author":"SH Kaufmann","year":"2000","unstructured":"Kaufmann SH, Gores GJ (2000) Apoptosis in cancer: cause and cure. Bioessays 22:1007\u20131017. https:\/\/doi.org\/10.1002\/1521-1878(200011)22:11%3c1007::AID-BIES7%3e3.0.CO;2-4","journal-title":"Bioessays"},{"key":"9961_CR24","doi-asserted-by":"publisher","first-page":"e0183122","DOI":"10.1371\/journal.pone.0183122","volume":"12","author":"S Khan","year":"2017","unstructured":"Khan S et al (2017) Racial differences in the expression of inhibitors of apoptosis (IAP) proteins in extracellular vesicles (EV) from prostate cancer patients. PLoS ONE 12:e0183122. https:\/\/doi.org\/10.1371\/journal.pone.0183122","journal-title":"PLoS ONE"},{"key":"9961_CR25","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12920-020-0661-x","volume":"13","author":"J Liang","year":"2020","unstructured":"Liang J, Zhao W, Tong P, Li P, Zhao Y, Li H, Liang J (2020) Comprehensive molecular characterization of inhibitors of apoptosis proteins (IAPs) for therapeutic targeting in cancer. BMC Med Genomics 13:7. https:\/\/doi.org\/10.1186\/s12920-020-0661-x","journal-title":"BMC Med Genomics"},{"key":"9961_CR26","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1302\/0301-620X.97B4.34907","volume":"97-B","author":"B Mollon","year":"2015","unstructured":"Mollon B, Lee A, Busse JW, Griffin AM, Ferguson PC, Wunder JS, Theodoropoulos J (2015) The effect of surgical synovectomy and radiotherapy on the rate of recurrence of pigmented villonodular synovitis of the knee: an individual patient meta-analysis. Bone Joint J 97-B:550\u2013557. https:\/\/doi.org\/10.1302\/0301-620X.97B4.34907","journal-title":"Bone Joint J"},{"key":"9961_CR27","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.semarthrit.2010.07.005","volume":"40","author":"S Ottaviani","year":"2011","unstructured":"Ottaviani S, Ayral X, Dougados M, Gossec L (2011) Pigmented villonodular synovitis: a retrospective single-center study of 122 cases and review of the literature. Semin Arthritis Rheum 40:539\u2013546. https:\/\/doi.org\/10.1016\/j.semarthrit.2010.07.005","journal-title":"Semin Arthritis Rheum"},{"key":"9961_CR28","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13569-015-0030-2","volume":"5","author":"A Righi","year":"2015","unstructured":"Righi A, Gambarotti M, Sbaraglia M, Frisoni T, Donati D, Vanel D, Dei Tos AP (2015) Metastasizing tenosynovial giant cell tumour, diffuse type\/pigmented villonodular synovitis. Clin Sarcoma Res 5:15. https:\/\/doi.org\/10.1186\/s13569-015-0030-2","journal-title":"Clin Sarcoma Res"},{"key":"9961_CR29","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1186\/s12885-015-1839-z","volume":"15","author":"G Rodriguez-Berriguete","year":"2015","unstructured":"Rodriguez-Berriguete G et al (2015) Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy. BMC Cancer 15:809. https:\/\/doi.org\/10.1186\/s12885-015-1839-z","journal-title":"BMC Cancer"},{"key":"9961_CR30","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s002640000147","volume":"24","author":"MA Rosa","year":"2000","unstructured":"Rosa MA, Galli M, Fadda G, Maggiano N, Gambino GF (2000) Proliferating cell nuclear antigen labelling index in localised pigmented villo-nodular synovitis and its relationship to the size of nodules. Int Orthop 24:197\u2013201","journal-title":"Int Orthop"},{"key":"9961_CR31","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.knee.2007.05.007","volume":"14","author":"H Sharma","year":"2007","unstructured":"Sharma H, Rana B, Mahendra A, Jane MJ, Reid R (2007) Outcome of 17 pigmented villonodular synovitis (PVNS) of the knee at 6 years mean follow-up. Knee 14:390\u2013394. https:\/\/doi.org\/10.1016\/j.knee.2007.05.007","journal-title":"Knee"},{"key":"9961_CR32","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/cdd.2016.147","volume":"24","author":"MC Tanzer","year":"2017","unstructured":"Tanzer MC et al (2017) Combination of IAP antagonist and IFNgamma activates novel caspase-10-and RIPK1-dependent cell death pathways. Cell Death Differ 24:481\u2013491. https:\/\/doi.org\/10.1038\/cdd.2016.147","journal-title":"Cell Death Differ"},{"key":"9961_CR33","doi-asserted-by":"publisher","first-page":"376","DOI":"10.5435\/00124635-200606000-00007","volume":"14","author":"WK Tyler","year":"2006","unstructured":"Tyler WK, Vidal AF, Williams RJ, Healey JH (2006) Pigmented villonodular synovitis. J Am Acad Orthop Surg 14:376\u2013385. https:\/\/doi.org\/10.5435\/00124635-200606000-00007","journal-title":"J Am Acad Orthop Surg"},{"key":"9961_CR34","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1007\/s00264-016-3208-1","volume":"40","author":"L van der Heijden","year":"2016","unstructured":"van der Heijden L, Piner SR, van de Sande MA (2016) Pigmented villonodular synovitis: a crowdsourcing study of two hundred and seventy two patients. Int Orthop 40:2459\u20132468. https:\/\/doi.org\/10.1007\/s00264-016-3208-1","journal-title":"Int Orthop"},{"key":"9961_CR35","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/icb.2016.118","volume":"95","author":"L Vasilikos","year":"2017","unstructured":"Vasilikos L, Spilgies LM, Knop J, Wong WW (2017) Regulating the balance between necroptosis, apoptosis and inflammation by inhibitors of apoptosis proteins. Immunol Cell Biol 95:160\u2013165. https:\/\/doi.org\/10.1038\/icb.2016.118","journal-title":"Immunol Cell Biol"},{"key":"9961_CR36","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1093\/rheumatology\/keu230","volume":"53","author":"FG Verspoor","year":"2014","unstructured":"Verspoor FG, Zee AA, Hannink G, van der Geest IC, Veth RP, Schreuder HW (2014) Long-term follow-up results of primary and recurrent pigmented villonodular synovitis. Rheumatology (Oxford, England) 53:2063\u20132070. https:\/\/doi.org\/10.1093\/rheumatology\/keu230","journal-title":"Rheumatology (Oxford, England)"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-021-09961-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10735-021-09961-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-021-09961-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T19:13:29Z","timestamp":1617218009000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10735-021-09961-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,18]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["9961"],"URL":"https:\/\/doi.org\/10.1007\/s10735-021-09961-5","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,18]]},"assertion":[{"value":"1 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the ethics committee of the Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}