{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:21:30Z","timestamp":1789147290270,"version":"build-2803163510"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Medizinische Hochschule Hannover (MHH)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>AP-2\u03b2 is a new mammary epithelial differentiation marker and its expression is preferentially retained and enhanced in lobular carcinoma in situ and invasive lobular breast cancer. In normal breast epithelium AP-2\u03b2 is expressed in a scattered subpopulation of luminal cells. So far, these cells have not been further characterized. Co-expression of AP-2\u03b2 protein and luminal epithelium markers (GATA3, CK8\/18), hormone receptors [estrogen receptor (ER), androgen receptor (AR)] and candidate stem cells markers (CK5\/14, CD44) were assessed by double-immunofluorescence staining in normal mammary gland epithelium. The subpopulation of AP-2\u03b2-positive mammary epithelial cells showed an almost complete, superimposable co-expression with GATA3 and a peculiar intense, ring-like appearing immunoreactivity for CK8\/18. Confocal immunofluorescence microscopy revealed an apicobasal staining for CK8\/18 in AP-2\u03b2-positive cells, which was not seen in in AP-2\u03b2-negative cells. Furthermore, AP-2\u03b2-positive displayed a partial co-expression with ER and AR, but lacked expression of candidate stem cell markers CK5\/14 and CD44. In summary, AP-2\u03b2 is a new luminal mammary epithelial differentiation marker, which is expressed in the GATA3-positive subpopulation of luminal epithelial cells. These AP-2\u03b2-positive\/GATA3-positive cells also show a peculiar CK8\/18-expression which may indicate a previously unknown functionally specialized mammary epithelial cell population.<\/jats:p>","DOI":"10.1007\/s10735-021-09980-2","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T17:02:57Z","timestamp":1623430977000},"page":"1257-1264","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Co-expression of transcription factor AP-2beta (TFAP2B) and GATA3 in human mammary epithelial cells with intense, apicobasal immunoreactivity for CK8\/18"],"prefix":"10.1007","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8338-6209","authenticated-orcid":false,"given":"M.","family":"Raap","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Gierendt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Werlein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Kuehnle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. H.","family":"Kreipe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Christgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,11]]},"reference":[{"key":"9980_CR1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s00292-008-1102-3","volume":"30","author":"W B\u00f6cker","year":"2009","unstructured":"B\u00f6cker W, Hungermann D, Decker T (2009) Anatomy of the breast. Pathologe 30:6\u201312. https:\/\/doi.org\/10.1007\/s00292-008-1102-3","journal-title":"Pathologe"},{"key":"9980_CR2","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1038\/s41374-018-0054-3","volume":"98","author":"W Boecker","year":"2018","unstructured":"Boecker W, van Horn L, Stenman G, Sturken C, Schumacher U, Loening T, Liesenfeld L, Korsching E, Glaser D, Tiemann K, Buchwalow I (2018) Spatially correlated phenotyping reveals K5-positive luminal progenitor cells and p63\u2013K5\/14-positive stem cell-like cells in human breast epithelium. Lab Investig 98:1065\u20131075","journal-title":"Lab Investig"},{"key":"9980_CR3","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/jcp.21943","volume":"222","author":"J Chou","year":"2010","unstructured":"Chou J, Provot S, Werb Z (2010) GATA3 in development and cancer differentiation: cells GATA have it! J Cell Physiol 222:42\u201349. https:\/\/doi.org\/10.1002\/jcp.21943","journal-title":"J Cell Physiol"},{"key":"9980_CR4","doi-asserted-by":"publisher","first-page":"7267","DOI":"10.1038\/sj.onc.1210525","volume":"26","author":"M Ebauer","year":"2007","unstructured":"Ebauer M, Wachtel M, Niggli FK, Schafer BW (2007) Comparative expression profiling identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3\/FKHR. Oncogene 26:7267\u20137281","journal-title":"Oncogene"},{"key":"9980_CR5","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/bcr1673","volume":"9","author":"C Fillmore","year":"2007","unstructured":"Fillmore C, Kuperwasser C (2007) Human breast cancer stem cell markers CD44 and CD24: enriching for cells with functional properties in mice or in man? Breast Cancer Res 9:303","journal-title":"Breast Cancer Res"},{"key":"9980_CR6","doi-asserted-by":"publisher","first-page":"8786","DOI":"10.1038\/ncomms9786","volume":"6","author":"AJ Fridriksdottir","year":"2015","unstructured":"Fridriksdottir AJ, Kim J, Villadsen R, Klitgaard MC, Hopkinson BM, Petersen OW, R\u00f8nnov-Jessen L (2015) Propagation of oestrogen receptor-positive and oestrogen-responsive normal human breast cells in culture. Nat Commun 6:8786. https:\/\/doi.org\/10.1038\/ncomms9786","journal-title":"Nat Commun"},{"key":"9980_CR7","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/modpathol.3800292","volume":"18","author":"N Friedrichs","year":"2005","unstructured":"Friedrichs N, Jager R, Paggen E, Rudlowski C, Merkelbach-Bruse S, Schorle H, Buettner R (2005) Distinct spatial expression patterns of AP-2alpha and AP-2gamma in non-neoplastic human breast and breast cancer. Mod Pathol 18:431\u2013438","journal-title":"Mod Pathol"},{"key":"9980_CR8","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/path.2430","volume":"217","author":"JM Gee","year":"2009","unstructured":"Gee JM, Eloranta JJ, Ibbitt JC, Robertson JF, Ellis IO, Williams T, Nicholson RI, Hurst HC (2009) Overexpression of TFAP2C in invasive breast cancer correlates with a poorer response to anti-hormone therapy and reduced patient survival. J Pathol 217:32\u201341","journal-title":"J Pathol"},{"key":"9980_CR9","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1111\/j.1365-2559.2009.03303.x","volume":"54","author":"B Grass","year":"2009","unstructured":"Grass B, Wachtel M, Behnke S, Leuschner I, Niggli FK, Schafer BW (2009) Immunohistochemical detection of EGFR, fibrillin-2, P-cadherin and AP2beta as biomarkers for rhabdomyosarcoma diagnostics. Histopathology 54:873\u2013879","journal-title":"Histopathology"},{"key":"9980_CR10","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1038\/onc.2011.301","volume":"31","author":"M Guedj","year":"2012","unstructured":"Guedj M, Marisa L, de Reynies A, Orsetti B, Schiappa R, Bibeau F, MacGrogan G, Lerebours F, Finetti P, Longy M, Bertheau P, Bertrand F, Bonnet F, Martin AL, Feugeas JP, Bieche I, Lehmann-Che J, Lidereau R, Birnbaum D, Bertucci F, de The H, Theillet C (2012) A refined molecular taxonomy of breast cancer. Oncogene 31:1196\u20131206","journal-title":"Oncogene"},{"key":"9980_CR11","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1080\/09513590802234204","volume":"24","author":"G Hallberg","year":"2008","unstructured":"Hallberg G, Persson I, Naess\u00e9n T, Magnusson C (2008) Effects of pre- and postmenopausal use of exogenous hormones on receptor content in normal human breast tissue: a randomized study. Gynecol Endocrinol 24:475\u2013480. https:\/\/doi.org\/10.1080\/09513590802234204","journal-title":"Gynecol Endocrinol"},{"key":"9980_CR12","doi-asserted-by":"publisher","first-page":"e23483","DOI":"10.1371\/journal.pone.0023483","volume":"6","author":"K Hesse","year":"2011","unstructured":"Hesse K, Vaupel K, Kurt S, Buettner R, Kirfel J, Moser M (2011) AP-2delta is a crucial transcriptional regulator of the posterior midbrain. PLoS ONE 6:e23483","journal-title":"PLoS ONE"},{"key":"9980_CR13","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/1471-2164-7-96","volume":"7","author":"Z Hu","year":"2006","unstructured":"Hu Z, Fan C, Oh DS, Marron JS, He X, Qaqish BF, Livasy C, Carey LA, Reynolds E, Dressler L, Nobel A, Parker J, Ewend MG, Sawyer LR, Wu J, Liu Y, Nanda R, Tretiakova M, Ruiz Orrico A, Dreher D, Palazzo JP, Perreard L, Nelson E, Mone M, Hansen H, Mullins M, Quackenbush JF, Ellis MJ, Olopade OI, Bernard PS, Perou CM (2006) The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics 7:96","journal-title":"BMC Genomics"},{"key":"9980_CR14","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.molonc.2015.10.020","volume":"10","author":"F Ikram","year":"2016","unstructured":"Ikram F, Ackermann S, Kahlert Y, Volland R, Roels F, Engesser A, Hertwig F, Kocak H, Hero B, Dreidax D, Henrich KO, Berthold F, Nurnberg P, Westermann F, Fischer M (2016) Transcription factor activating protein 2 beta (TFAP2B) mediates noradrenergic neuronal differentiation in neuroblastoma. Mol Oncol 10:344\u2013359","journal-title":"Mol Oncol"},{"key":"9980_CR15","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41523-018-0085-3","volume":"4","author":"KH Kensler","year":"2018","unstructured":"Kensler KH, Beca F, Baker GM, Heng YJ, Beck AH, Schnitt SJ, Hazra A, Rosner BA, Eliassen AH, Hankinson SE, Brown M, Tamimi RM (2018) Androgen receptor expression in normal breast tissue and subsequent breast cancer risk. NPJ Breast Cancer 4:33\u201343. https:\/\/doi.org\/10.1038\/s41523-018-0085-3","journal-title":"NPJ Breast Cancer"},{"key":"9980_CR16","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1002\/ijc.10737","volume":"102","author":"SA Khan","year":"2002","unstructured":"Khan SA, Yee KA, Kaplan C, Siddiqui JF (2002) Estrogen receptor alpha expression in normal human breast epithelium is consistent over time. Int J Cancer 102:334\u2013337. https:\/\/doi.org\/10.1002\/ijc.10737","journal-title":"Int J Cancer"},{"key":"9980_CR17","first-page":"7167","volume":"63","author":"JE Korkola","year":"2003","unstructured":"Korkola JE, DeVries S, Fridlyand J, Hwang ES, Estep AL, Chen YY, Chew KL, Dairkee SH, Jensen RM, Waldman FM (2003) Differentiation of lobular versus ductal breast carcinomas by expression microarray analysis. Cancer Res 63:7167\u20137175","journal-title":"Cancer Res"},{"key":"9980_CR18","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1309\/CPUX-KWEH-7B26-YE19","volume":"114","author":"HA Lehr","year":"2000","unstructured":"Lehr HA, Folpe A, Yaziji H, Kommoss F, Gown AM (2000) Cytokeratin 8 immunostaining pattern and E-cadherin expression distinguish lobular from ductal breast carcinoma. Am J Clin Pathol 114:190\u2013196. https:\/\/doi.org\/10.1309\/CPUX-KWEH-7B26-YE19","journal-title":"Am J Clin Pathol"},{"key":"9980_CR19","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1159\/000491463","volume":"47","author":"Z Li","year":"2018","unstructured":"Li Z, Xu X, Luo M, Hao J, Zhao S, Yu W, Xiao X, Wu J, Zheng F, Chen M, Li Y, Qin G, Liao Y, Zhao X, Yu X, Guo W, Zou L, Deng W (2018) Activator protein-2beta promotes tumor growth and predicts poor prognosis in breast cancer. Cell Physiol Biochem 47:1925\u20131935","journal-title":"Cell Physiol Biochem"},{"key":"9980_CR20","first-page":"849","volume":"9","author":"VB Martino","year":"2016","unstructured":"Martino VB, Sabljic T, Deschamps P, Green RM, Akula M, Peacock E, Ball A, Williams T, West-Mays JA (2016) Conditional deletion of AP-2beta in mouse cranial neural crest results in anterior segment dysgenesis and early-onset glaucoma. Dis Model Mech 9:849\u2013861","journal-title":"Dis Model Mech"},{"key":"9980_CR21","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/(SICI)1097-0177(199701)208:1<115::AID-AJA11>3.0.CO;2-5","volume":"208","author":"M Moser","year":"1997","unstructured":"Moser M, Ruschoff J, Buettner R (1997) Comparative analysis of AP-2 alpha and AP-2 beta gene expression during murine embryogenesis. Dev Dyn 208:115\u2013124","journal-title":"Dev Dyn"},{"key":"9980_CR22","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1042\/bj20031133","volume":"377","author":"F Orso","year":"2004","unstructured":"Orso F, Cottone E, Hasleton MD, Ibbitt JC, Sismondi P, Hurst HC, De Bortoli M (2004) Activator protein-2gamma (AP-2gamma) expression is specifically induced by oestrogens through binding of the oestrogen receptor to a canonical element within the 5\u2019-untranslated region. Biochem J 377:429\u2013438","journal-title":"Biochem J"},{"key":"9980_CR23","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.urology.2004.02.022","volume":"64","author":"M Oya","year":"2004","unstructured":"Oya M, Mikami S, Mizuno R, Miyajima A, Horiguchi Y, Nakashima J, Marumo K, Mukai M, Murai M (2004) Differential expression of activator protein-2 isoforms in renal cell carcinoma. Urology 64:162\u2013167","journal-title":"Urology"},{"key":"9980_CR24","first-page":"3487","volume":"8","author":"J Pellikainen","year":"2002","unstructured":"Pellikainen J, Kataja V, Ropponen K, Kellokoski J, Pietilainen T, Bohm J, Eskelinen M, Kosma VM (2002) Reduced nuclear expression of transcription factor AP-2 associates with aggressive breast cancer. Clin Cancer Res 8:3487\u20133495","journal-title":"Clin Cancer Res"},{"key":"9980_CR25","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1002\/ijc.22648","volume":"120","author":"JM Pellikainen","year":"2007","unstructured":"Pellikainen JM, Kosma VM (2007) Activator protein-2 in carcinogenesis with a special reference to breast cancer\u2013a mini review. Int J Cancer 120:2061\u20132067","journal-title":"Int J Cancer"},{"key":"9980_CR26","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/35021093","volume":"406","author":"CM Perou","year":"2000","unstructured":"Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lonning PE, Borresen-Dale AL, Brown PO, Botstein D (2000) Molecular portraits of human breast tumours. Nature 406:747\u2013752","journal-title":"Nature"},{"key":"9980_CR27","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/labinvest.2017.106","volume":"98","author":"M Raap","year":"2018","unstructured":"Raap M, Gronewold M, Christgen H, Glage S, Bentires-Alj M, Koren S, Derksen PW, Boelens M, Jonkers J, Lehmann U, Feuerhake F, Kuehnle E, Gluz O, Kates R, Nitz U, Harbeck N, Kreipe HH, Christgen M (2018) Lobular carcinoma in situ and invasive lobular breast cancer are characterized by enhanced expression of transcription factor AP-2beta. Lab Investig 98:117\u2013129","journal-title":"Lab Investig"},{"key":"9980_CR28","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/75578","volume":"25","author":"M Satoda","year":"2000","unstructured":"Satoda M, Zhao F, Diaz GA, Burn J, Goodship J, Davidson HR, Pierpont ME, Gelb BD (2000) Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus. Nat Genet 25:42\u201346","journal-title":"Nat Genet"},{"key":"9980_CR29","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, Preibisch S, Rueden C, Saalfeld S, Schmid B, Tinevez JY, White DJ, Hartenstein V, Eliceiri K, Tomancak P, Cardona A (2012) Fiji: an open-source platform for biological-image analysis. Nat Methods 9:676\u2013682. https:\/\/doi.org\/10.1038\/nmeth.2019","journal-title":"Nat Methods"},{"key":"9980_CR30","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ydbio.2015.08.006","volume":"407","author":"R Seki","year":"2015","unstructured":"Seki R, Kitajima K, Matsubara H, Suzuki T, Saito D, Yokoyama H, Tamura K (2015) AP-2beta is a transcriptional regulator for determination of digit length in tetrapods. Dev Biol 407:75\u201389","journal-title":"Dev Biol"},{"key":"9980_CR31","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/onc.2012.625","volume":"33","author":"KK Shiu","year":"2014","unstructured":"Shiu KK, Wetterskog D, Mackay A, Natrajan R, Lambros M, Sims D, Bajrami I, Brough R, Frankum J, Sharpe R, Marchio C, Horlings H, Reyal F, van der Vijver M, Turner N, Reis-Filho JS, Lord CJ, Ashworth A (2014) Integrative molecular and functional profiling of ERBB2-amplified breast cancers identifies new genetic dependencies. Oncogene 33:619\u2013631","journal-title":"Oncogene"},{"key":"9980_CR32","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/1755-8794-2-53","volume":"2","author":"K Thorell","year":"2009","unstructured":"Thorell K, Bergman A, Caren H, Nilsson S, Kogner P, Martinsson T, Abel F (2009) Verification of genes differentially expressed in neuroblastoma tumours: a study of potential tumour suppressor genes. BMC Med Genomics 2:53\u201353","journal-title":"BMC Med Genomics"},{"key":"9980_CR33","first-page":"5466","volume":"58","author":"BC Turner","year":"1998","unstructured":"Turner BC, Zhang J, Gumbs AA, Maher MG, Kaplan L, Carter D, Glazer PM, Hurst HC, Haffty BG, Williams T (1998) Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways. Cancer Res 58:5466\u20135472","journal-title":"Cancer Res"},{"key":"9980_CR34","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1200\/JCO.2005.03.4934","volume":"24","author":"M Wachtel","year":"2006","unstructured":"Wachtel M, Runge T, Leuschner I, Stegmaier S, Koscielniak E, Treuner J, Odermatt B, Behnke S, Niggli FK, Schafer BW (2006) Subtype and prognostic classification of rhabdomyosarcoma by immunohistochemistry. J Clin Oncol 24:816\u2013822","journal-title":"J Clin Oncol"},{"key":"9980_CR35","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1002\/mc.22646","volume":"56","author":"F Wang","year":"2017","unstructured":"Wang F, Huang W, Hu X, Chen C, Li X, Qiu J, Liang Z, Zhang J, Li L, Wang X, Ding X, Xiang S, Zhang J (2017) Transcription factor AP-2beta suppresses cervical cancer cell proliferation by promoting the degradation of its interaction partner beta-catenin. Mol Carcinog 56:1909\u20131923","journal-title":"Mol Carcinog"},{"key":"9980_CR36","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/path.2629","volume":"220","author":"B Weigelt","year":"2010","unstructured":"Weigelt B, Geyer FC, Natrajan R, Lopez-Garcia MA, Ahmad AS, Savage K, Kreike B, Reis-Filho JS (2010) The molecular underpinning of lobular histological growth pattern: a genome-wide transcriptomic analysis of invasive lobular carcinomas and grade- and molecular subtype-matched invasive ductal carcinomas of no special type. J Pathol 220:45\u201357","journal-title":"J Pathol"},{"key":"9980_CR37","doi-asserted-by":"publisher","first-page":"3591","DOI":"10.1038\/emboj.2009.290","volume":"28","author":"CM Williams","year":"2009","unstructured":"Williams CM, Scibetta AG, Friedrich JK, Canosa M, Berlato C, Moss CH, Hurst HC (2009) AP-2gamma promotes proliferation in breast tumour cells by direct repression of the CDKN1A gene. EMBO J 28:3591\u20133601","journal-title":"EMBO J"},{"key":"9980_CR38","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.ygyno.2018.03.057","volume":"149","author":"H Wu","year":"2018","unstructured":"Wu H, Zhang J (2018) Decreased expression of TFAP2B in endometrial cancer predicts poor prognosis: A study based on TCGA data. Gynecol Oncol 149:592","journal-title":"Gynecol Oncol"},{"key":"9980_CR39","doi-asserted-by":"publisher","first-page":"5857","DOI":"10.1158\/0008-5472.CAN-15-2745","volume":"76","author":"G Yoldi","year":"2016","unstructured":"Yoldi G, Pellegrini P, Trinidad EM, Cordero A, Gomez-Miragaya J, Serra-Musach J, Dougall WC, Munoz P, Pujana MA, Planelles L, Gonzalez-Suarez E (2016) RANK signaling blockade reduces breast cancer recurrence by inducing tumor cell differentiation. Cancer Res 76:5857\u20135869","journal-title":"Cancer Res"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-021-09980-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-021-09980-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-021-09980-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T09:19:16Z","timestamp":1637831956000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-021-09980-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,11]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["9980"],"URL":"https:\/\/doi.org\/10.1007\/s10735-021-09980-2","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,11]]},"assertion":[{"value":"10 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declared no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study has been performed according to the guidelines of the local ethics committee. The research did not involve human participants or animals.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}