{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:37:18Z","timestamp":1786981038834,"version":"build-2736575974"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700957"],"award-info":[{"award-number":["81700957"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800750"],"award-info":[{"award-number":["81800750"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A030310197"],"award-info":[{"award-number":["2016A030310197"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s10735-021-10004-2","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T09:02:56Z","timestamp":1627290176000},"page":"919-928","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["LPS-induced autophagy in human dental pulp cells is associated with p38"],"prefix":"10.1007","volume":"52","author":[{"given":"Yihua","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qimei","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"10004_CR1","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1080\/15548627.2017.1356550","volume":"13","author":"M Chen","year":"2017","unstructured":"Chen M, Liu J, Yang W, Ling W (2017) Lipopolysaccharide mediates hepatic stellate cell activation by regulating autophagy and retinoic acid signaling. Autophagy 13:1813\u20131827","journal-title":"Autophagy"},{"key":"10004_CR2","doi-asserted-by":"publisher","first-page":"935","DOI":"10.4161\/auto.7.9.15760","volume":"7","author":"EL Eskelinen","year":"2011","unstructured":"Eskelinen EL, Reggiori F, Baba M, Kovacs AL, Seglen PO (2011) Seeing is believing: the impact of electron microscopy on autophagy research. Autophagy 7:935\u2013956","journal-title":"Autophagy"},{"key":"10004_CR3","first-page":"2202","volume":"19","author":"Y Gao","year":"2020","unstructured":"Gao Y, You X, Liu Y, Gao F, Zhang Y, Yang J, Yang C (2020) Induction of autophagy protects human dental pulp cells from lipopolysaccharide-induced pyroptotic cell death. Exp Ther Med 19:2202\u20132210","journal-title":"Exp Ther Med"},{"key":"10004_CR4","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1016\/j.joen.2010.08.041","volume":"36","author":"QM Gong","year":"2010","unstructured":"Gong QM, Jiang HP, Wei XP, Ling JP, Wang JP (2010) Expression of erythropoietin and erythropoietin receptor in human dental pulp. J Endod 36:1972\u20131977","journal-title":"J Endod"},{"key":"10004_CR5","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.1159\/000445597","volume":"38","author":"C Han","year":"2016","unstructured":"Han C, Ding Z, Shi H, Qian W, Hou X, Lin R (2016) The role of probiotics in lipopolysaccharide-induced Autophagy in intestinal epithelial cells. Cell Physiol Biochem 38:2464\u20132478","journal-title":"Cell Physiol Biochem"},{"key":"10004_CR6","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1083\/jcb.201701049","volume":"217","author":"Y He","year":"2018","unstructured":"He Y, She H, Zhang T, Xu H, Cheng L, Yepes M, Zhao Y, Mao Z (2018) p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1. J Cell Biol 217:315\u2013328","journal-title":"J Cell Biol"},{"key":"10004_CR7","doi-asserted-by":"publisher","first-page":"3547","DOI":"10.3892\/mmr.2014.3120","volume":"11","author":"Y Huang","year":"2015","unstructured":"Huang Y, Jiang H, Gong Q, Li X, Ling J (2015a) Lipopolysaccharide stimulation improves the odontoblastic differentiation of human dental pulp cells. Mol Med Rep 11:3547\u20133552","journal-title":"Mol Med Rep"},{"key":"10004_CR8","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.febslet.2010.01.017","volume":"584","author":"CH Jung","year":"2010","unstructured":"Jung CH, Ro S, Cao J, Otto NM, Kim D (2010) mTOR regulation of autophagy. Febs Lett 584:1287\u20131295","journal-title":"Febs Lett"},{"key":"10004_CR9","doi-asserted-by":"publisher","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","volume":"19","author":"Y Kabeya","year":"2000","unstructured":"Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO JOURNAL 19:5720\u20135728","journal-title":"EMBO JOURNAL"},{"key":"10004_CR10","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","volume":"132","author":"B Levine","year":"2008","unstructured":"Levine B, Kroemer G (2008) Autophagy in the pathogenesis of disease. Cell 132:27\u201342","journal-title":"Cell"},{"key":"10004_CR11","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1111\/j.1365-2591.2012.02064.x","volume":"45","author":"L Li","year":"2012","unstructured":"Li L, Zhu YQ, Jiang L, Peng W (2012) Increased autophagic activity in senescent human dental pulp cells. Int Endod J 45:1074\u20131079","journal-title":"Int Endod J"},{"key":"10004_CR12","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/j.joen.2017.12.023","volume":"44","author":"Y Li","year":"2018","unstructured":"Li Y, Wang H, Pei F, Chen Z, Zhang L (2018) FoxO3a regulates inflammation-induced Autophagy in odontoblasts. J Endod 44:786\u2013791","journal-title":"J Endod"},{"key":"10004_CR13","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.lfs.2018.09.023","volume":"211","author":"J Liu","year":"2018","unstructured":"Liu J, Wang X, Zheng M, Luan Q (2018) Lipopolysaccharide from Porphyromonas gingivalis promotes autophagy of human gingival fibroblasts through the PI3K\/Akt\/mTOR signaling pathway. Life Sci 211:133\u2013139","journal-title":"Life Sci"},{"key":"10004_CR14","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1007\/s00018-004-4012-4","volume":"61","author":"G Marino","year":"2004","unstructured":"Marino G, Lopez-Otin C (2004) Autophagy: molecular mechanisms, physiological functions and relevance in human pathology. Cell Mol Life Sci 61:1439\u20131454","journal-title":"Cell Mol Life Sci"},{"key":"10004_CR15","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.biocel.2011.11.001","volume":"44","author":"N Meng","year":"2012","unstructured":"Meng N, Zhao J, Su L, Zhao B, Zhang Y, Zhang S, Miao J (2012a) A butyrolactone derivative suppressed lipopolysaccharide-induced autophagic injury through inhibiting the autoregulatory loop of p8 and p53 in vascular endothelial cells. Int J Biochem Cell Biol 44:311\u2013319","journal-title":"Int J Biochem Cell Biol"},{"key":"10004_CR16","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.biocel.2011.11.001","volume":"44","author":"N Meng","year":"2012","unstructured":"Meng N, Zhao J, Su L, Zhao B, Zhang Y, Zhang S, Miao J (2012b) A butyrolactone derivative suppressed lipopolysaccharide-induced autophagic injury through inhibiting the autoregulatory loop of p8 and p53 in vascular endothelial cells. Int J Biochem Cell Biol 44:311\u2013319","journal-title":"Int J Biochem Cell Biol"},{"issue":"Suppl 2","key":"10004_CR17","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1038\/sj.cdd.4401728","volume":"12","author":"N Mizushima","year":"2005","unstructured":"Mizushima N (2005) The pleiotropic role of autophagy: from protein metabolism to bactericide. Cell Death Differ 12(Suppl 2):1535\u20131541","journal-title":"Cell Death Differ"},{"key":"10004_CR18","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nature06639","volume":"451","author":"N Mizushima","year":"2008","unstructured":"Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008) Autophagy fights disease through cellular self-digestion. Nature 451:1069\u20131075","journal-title":"Nature"},{"key":"10004_CR19","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1002\/jcb.26360","volume":"119","author":"SY Park","year":"2018","unstructured":"Park SY, Sun EG, Lee Y, Kim MS, Kim JH, Kim WJ, Jung JY (2018) Autophagy induction plays a protective role against hypoxic stress in human dental pulp cells. J Cell Biochem 119:1992\u20132002","journal-title":"J Cell Biochem"},{"key":"10004_CR20","first-page":"880","volume":"40","author":"OJ Sul","year":"2017","unstructured":"Sul OJ, Park HJ, Son HJ, Choi HS (2017) Lipopolysaccharide (LPS)-induced Autophagy is responsible for enhanced osteoclastogenesis. Mol Cells 40:880\u2013887","journal-title":"Mol Cells"},{"key":"10004_CR21","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.archoralbio.2018.01.018","volume":"88","author":"JS Takanche","year":"2018","unstructured":"Takanche JS, Kim J, Kim J, Han S, Yi H (2018) Schisandrin C enhances odontoblastic differentiation through autophagy and mitochondrial biogenesis in human dental pulp cells. Arch Oral Biol 88:60\u201366","journal-title":"Arch Oral Biol"},{"key":"10004_CR22","first-page":"629","volume":"1","author":"A Trocoli","year":"2011","unstructured":"Trocoli A, Djavaheri-Mergny M (2011) The complex interplay between autophagy and NF-\u03baB signaling pathways in cancer cells. Am J Cancer Res 1:629","journal-title":"Am J Cancer Res"},{"key":"10004_CR23","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.joen.2009.11.018","volume":"36","author":"J Wang","year":"2010","unstructured":"Wang J, Wei X, Ling J, Huang Y, Gong Q (2010) Side population increase after simulated transient ischemia in human dental pulp cell. J Endod 36:453\u2013458","journal-title":"J Endod"},{"key":"10004_CR24","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1186\/1471-2180-13-255","volume":"13","author":"J Wang","year":"2013","unstructured":"Wang J, Feng X, Zeng Y, Fan J, Wu J, Li Z, Liu X, Huang R, Huang F, Yu X, Yang X (2013) Lipopolysaccharide (LPS)-induced autophagy is involved in the restriction of Escherichia coli in peritoneal mesothelial cells. BMC Microbiol 13:255","journal-title":"BMC Microbiol"},{"key":"10004_CR25","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1159\/000484506","volume":"43","author":"X Wang","year":"2017","unstructured":"Wang X, Wu TT, Jiang L, Rong D, Zhu YQ (2017) Deferoxamine-induced migration and odontoblast differentiation via ROS-dependent Autophagy in dental pulp stem cells. Cell Physiol Biochem 43:2535\u20132547","journal-title":"Cell Physiol Biochem"},{"key":"10004_CR26","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.biomaterials.2014.12.006","volume":"44","author":"JW Yang","year":"2015","unstructured":"Yang JW, Zhang YF, Wan CY, Sun ZY, Nie S, Jian SJ, Zhang L, Song GT, Chen Z (2015) Autophagy in SDF-1alpha-mediated DPSC migration and pulp regeneration. Biomaterials 44:11\u201323","journal-title":"Biomaterials"},{"key":"10004_CR27","first-page":"461","volume":"33","author":"A Yoshioka","year":"2008","unstructured":"Yoshioka A, Miyata H, Doki Y, Yamasaki M, Sohma I, Gotoh K, Takiguchi S, Fujiwara Y, Uchiyama Y, Monden M (2008) LC3, an autophagosome marker, is highly expressed in gastrointestinal cancers. Int J Oncol 33:461","journal-title":"Int J Oncol"},{"key":"10004_CR28","doi-asserted-by":"publisher","first-page":"15077","DOI":"10.1073\/pnas.2436255100","volume":"100","author":"Z Yue","year":"2003","unstructured":"Yue Z, Jin S, Yang C, Levine AJ, Heintz N (2003) Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A 100:15077\u201315082","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10004_CR29","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.joen.2013.02.001","volume":"39","author":"QD Zhou","year":"2013","unstructured":"Zhou QD, Liu HD, Sun QP, Zhang LP, Lin HP, Yuan GPD, Zhang LDP, Chen ZPD (2013) Adenosine monophosphate\u2013activated protein kinase\/mammalian target of rapamycin\u2013dependent Autophagy protects human dental pulp cells against hypoxia. J Endod 39:768\u2013773","journal-title":"J Endod"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-021-10004-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-021-10004-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-021-10004-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T18:03:35Z","timestamp":1633370615000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-021-10004-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,26]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10004"],"URL":"https:\/\/doi.org\/10.1007\/s10735-021-10004-2","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,26]]},"assertion":[{"value":"30 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}