{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:47:31Z","timestamp":1792698451748,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T00:00:00Z","timestamp":1661558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T00:00:00Z","timestamp":1661558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971240"],"award-info":[{"award-number":["31971240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Histol"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s10735-022-10094-6","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T05:03:31Z","timestamp":1661576611000},"page":"805-816","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The effect of matrix stiffness on the chondrogenic differentiation of mesenchymal stem cells"],"prefix":"10.1007","volume":"53","author":[{"given":"Yimei","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8320-2406","authenticated-orcid":false,"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,27]]},"reference":[{"issue":"1","key":"10094_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/0012-1606(77)90110-5","volume":"60","author":"PB Ahrens","year":"1977","unstructured":"Ahrens PB, Solursh M, Reiter RS (1977) Stage-related capacity for limb chondrogenesis in cell culture. Dev Biol 60(1):69\u201382","journal-title":"Dev Biol"},{"issue":"1","key":"10094_CR2","doi-asserted-by":"publisher","first-page":"4229","DOI":"10.1038\/s41467-021-24383-3","volume":"12","author":"I Andreu","year":"2021","unstructured":"Andreu I, Falcones B, Hurst S, Chahare N, Roca-Cusachs P (2021) The force loading rate drives cell mechanosensing through both reinforcement and fluidization. Nat Commun 12(1):4229","journal-title":"Nat Commun"},{"key":"10094_CR3","doi-asserted-by":"publisher","unstructured":"Bashirzadeh Y, Chatterji S, Palmer D, Dumbali S, Qian S, Maruthamuthu V (2018) Stiffness Measurement of Soft Silicone Substrates for Mechanobiology Studies Using a Widefield Fluorescence Microscope. J visualized experiments: JoVE 137. https:\/\/doi.org\/10.3791\/57797","DOI":"10.3791\/57797"},{"issue":"2","key":"10094_CR4","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.biomaterials.2012.09.052","volume":"34","author":"L Bian","year":"2013","unstructured":"Bian L, Hou C, Tous E, Rai R, Mauck RL, Burdick JA (2013a) The influence of hyaluronic acid hydrogel crosslinking density and macromolecular diffusivity on human MSC chondrogenesis and hypertrophy. Biomaterials 34(2):413\u2013421","journal-title":"Biomaterials"},{"issue":"2","key":"10094_CR5","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.biomaterials.2012.09.052","volume":"34","author":"L Bian","year":"2013","unstructured":"Bian L, Hou C, Tous E, Rai R, Mauck RL, Burdick JA (2013b) The influence of hyaluronic acid hydrogel crosslinking density and macromolecular diffusivity on human MSC chondrogenesis and hypertrophy. Biomaterials 34(2):413\u2013421. https:\/\/doi.org\/10.1016\/j.biomaterials.2012.09.052","journal-title":"Biomaterials"},{"issue":"1","key":"10094_CR6","doi-asserted-by":"publisher","first-page":"17947","DOI":"10.1038\/s41598-017-18044-z","volume":"7","author":"E Bonyadi Rad","year":"2017","unstructured":"Bonyadi Rad E, Musumeci G (2017) Runx2 mediated Induction of Novel Targets ST2 and Runx3 Leads to Cooperative Regulation of Hypertrophic Differentiation in ATDC5 Chondrocytes. Sci Rep 7(1):17947. https:\/\/doi.org\/10.1038\/s41598-017-18044-z","journal-title":"Sci Rep"},{"key":"10094_CR7","doi-asserted-by":"publisher","unstructured":"Brielle S, Bavli D, Motzik A, Kan-Tor Y, Sun X, Kozulin C (2021) Delineating the heterogeneity of matrix-directed differentiation toward soft and stiff tissue lineages via single-cell profiling. 118. https:\/\/doi.org\/10.1073\/pnas.2016322118. 19","DOI":"10.1073\/pnas.2016322118"},{"issue":"1","key":"10094_CR8","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s13287-020-01657-z","volume":"11","author":"K \u010camernik","year":"2020","unstructured":"\u010camernik K, Miheli\u010d A, Mihali\u010d R, Haring G, Herman S, Marolt Presen D, Jane\u017e A, Treb\u0161e R, Marc J, Zupan J (2020) Comprehensive analysis of skeletal muscle- and bone-derived mesenchymal stem\/stromal cells in patients with osteoarthritis and femoral neck fracture. Stem Cell Res Ther 11(1):146. https:\/\/doi.org\/10.1186\/s13287-020-01657-z","journal-title":"Stem Cell Res Ther"},{"key":"10094_CR9","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3389\/fcell.2019.00270","volume":"7","author":"S Diederichs","year":"2019","unstructured":"Diederichs S, Klampfleuthner FA, Moradi B, Richter W (2019a) Chondral differentiation of induced pluripotent stem cells without progression into the endochondral pathway. Front cell Dev biology 7:270","journal-title":"Front cell Dev biology"},{"issue":"19","key":"10094_CR10","doi-asserted-by":"publisher","first-page":"3875","DOI":"10.1007\/s00018-019-03099-0","volume":"76","author":"S Diederichs","year":"2019","unstructured":"Diederichs S, Tonnier V, M\u00e4rz M, Dreher SI, Geisb\u00fcsch A, Richter W (2019b) Regulation of WNT5A and WNT11 during MSC in vitro chondrogenesis: WNT inhibition lowers BMP and hedgehog activity, and reduces hypertrophy. Cell Mol Life Sci 76(19):3875\u20133889","journal-title":"Cell Mol Life Sci"},{"issue":"11","key":"10094_CR11","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1038\/nprot.2012.127","volume":"7","author":"RS Fischer","year":"2012","unstructured":"Fischer RS, Myers KA, Gardel ML, Waterman CM (2012) Stiffness-controlled three-dimensional extracellular matrices for high-resolution imaging of cell behavior. Nat Protoc 7(11):2056\u20132066. https:\/\/doi.org\/10.1038\/nprot.2012.127","journal-title":"Nat Protoc"},{"issue":"12","key":"10094_CR12","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1002\/term.2956","volume":"13","author":"HI Gungordu","year":"2019","unstructured":"Gungordu HI, Bao M, van Helvert S, Jansen JA, Leeuwenburgh SCG, Walboomers XF (2019) Effect of mechanical loading and substrate elasticity on the osteogenic and adipogenic differentiation of mesenchymal stem cells. J Tissue Eng Regen Med 13(12):2279\u20132290. https:\/\/doi.org\/10.1002\/term.2956","journal-title":"J Tissue Eng Regen Med"},{"key":"10094_CR13","doi-asserted-by":"crossref","unstructured":"Guo M, Pegoraro AF, Mao A, Zhou EH, Arany PR, Han Y, Burnette DT, Jensen MH, Kasza KE, Moore JR (2017a) Cell volume change through water efflux impacts cell stiffness and stem cell fate. Proceedings of the National Academy of Sciences 114(41):E8618-E8627","DOI":"10.1073\/pnas.1705179114"},{"issue":"41","key":"10094_CR14","doi-asserted-by":"publisher","first-page":"E8618","DOI":"10.1073\/pnas.1705179114","volume":"114","author":"M Guo","year":"2017","unstructured":"Guo M, Pegoraro AF, Mao A, Zhou EH, Arany PR, Han Y, Burnette DT, Jensen MH, Kasza KE, Moore JR, Mackintosh FC, Fredberg JJ, Mooney DJ, Lippincott-Schwartz J, Weitz DA (2017b) Cell volume change through water efflux impacts cell stiffness and stem cell fate. Proc Natl Acad Sci USA 114(41):E8618\u2013e8627. https:\/\/doi.org\/10.1073\/pnas.1705179114","journal-title":"Proc Natl Acad Sci USA"},{"issue":"10","key":"10094_CR15","doi-asserted-by":"publisher","first-page":"11129","DOI":"10.1021\/acsnano.9b03914","volume":"13","author":"P Han","year":"2019","unstructured":"Han P, Frith JE (2019) Five Piconewtons: The Difference between Osteogenic and Adipogenic Fate Choice in Human Mesenchymal Stem Cells. ACS Nano 13(10):11129\u201311143. https:\/\/doi.org\/10.1021\/acsnano.9b03914","journal-title":"ACS Nano"},{"issue":"6","key":"10094_CR16","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/nmat2732","volume":"9","author":"N Huebsch","year":"2010","unstructured":"Huebsch N, Arany PR, Mao AS, Shvartsman D, Ali OA, Bencherif SA, Rivera-Feliciano J, Mooney DJ (2010) Harnessing traction-mediated manipulation of the cell\/matrix interface to control stem-cell fate. Nat Mater 9(6):518\u2013526","journal-title":"Nat Mater"},{"issue":"1","key":"10094_CR17","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s40824-018-0120-3","volume":"22","author":"E-S Kang","year":"2018","unstructured":"Kang E-S, Kim D-S, Suhito IR, Lee W, Song I, Kim T-H (2018) Two-dimensional material-based bionano platforms to control mesenchymal stem cell differentiation. Biomaterials Res 22(1):10","journal-title":"Biomaterials Res"},{"issue":"1","key":"10094_CR18","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1166\/jbn.2019.2671","volume":"15","author":"SM Kim","year":"2019","unstructured":"Kim SM, Yi SW, Kim HJ, Park JS, Kim JH, Park KH (2019) Co-Delivery of RUNX2-Targeting miRNAs and shRNAs Using Nanoparticles Composed of Dexamethasone and PEI Induces Chondrogenesis of Human Mesenchymal Stem Cells. J Biomed Nanotechnol 15(1):113\u2013126. https:\/\/doi.org\/10.1166\/jbn.2019.2671","journal-title":"J Biomed Nanotechnol"},{"key":"10094_CR19","doi-asserted-by":"publisher","unstructured":"Lima AF, May G, D\u00edaz-Colunga J, Pedreiro S, Paiva A, Ferreira L, Enver T, Iborra FJ (2018) Osmotic modulation of chromatin impacts on efficiency and kinetics of cell fate modulation. 8:7210. https:\/\/doi.org\/10.1038\/s41598-018-25517-2. 1","DOI":"10.1038\/s41598-018-25517-2"},{"issue":"4","key":"10094_CR20","doi-asserted-by":"publisher","first-page":"e2100401","DOI":"10.1002\/biot.202100401","volume":"17","author":"L Luo","year":"2022","unstructured":"Luo L, Foster NC, Man KL, Brunet M, Hoey DA, Cox SC, Kimber SJ, El Haj AJ (2022) Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells. Biotechnol J 17(4):e2100401. https:\/\/doi.org\/10.1002\/biot.202100401","journal-title":"Biotechnol J"},{"issue":"3\u20134","key":"10094_CR21","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1089\/ten.TEA.2014.0133","volume":"21","author":"J Magalh\u00e3es","year":"2015","unstructured":"Magalh\u00e3es J, Lebourg M, Deplaine H, G\u00f3mez Ribelles JL, Blanco FJ (2015) Effect of the physicochemical properties of pure or chitosan-coated poly(L-lactic acid)scaffolds on the chondrogenic differentiation of mesenchymal stem cells from osteoarthritic patients. Tissue Eng Part A 21(3\u20134):716\u2013728. https:\/\/doi.org\/10.1089\/ten.TEA.2014.0133","journal-title":"Tissue Eng Part A"},{"issue":"1","key":"10094_CR22","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1186\/s13287-020-02026-6","volume":"11","author":"S Melnik","year":"2020","unstructured":"Melnik S, Gabler J, Dreher SI, Hecht N, Hofmann N, Gro\u00dfner T, Richter W (2020) MiR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2, MEF2C, and COL10A1. Stem Cell Res Ther 11(1):532. https:\/\/doi.org\/10.1186\/s13287-020-02026-6","journal-title":"Stem Cell Res Ther"},{"key":"10094_CR23","doi-asserted-by":"publisher","unstructured":"Nalluri SM, Krishnan GR, Cheah C, Arzumand A, Yuan Y, Richardson CA, Yang S, Sarkar D (2015) Hydrophilic polyurethane matrix promotes chondrogenesis of mesenchymal stem cells. Materials science & engineering C, Materials for biological applications 54:182\u2013195. https:\/\/doi.org\/10.1016\/j.msec.2015.05.043","DOI":"10.1016\/j.msec.2015.05.043"},{"issue":"8","key":"10094_CR24","doi-asserted-by":"publisher","first-page":"601","DOI":"10.2174\/1574888x12666170608124303","volume":"12","author":"R Nancarrow-Lei","year":"2017","unstructured":"Nancarrow-Lei R, Mafi P, Mafi R, Khan W (2017) A Systemic Review of Adult Mesenchymal Stem Cell Sources and their Multilineage Differentiation Potential Relevant to Musculoskeletal Tissue Repair and Regeneration. Curr Stem Cell Res Therapy 12(8):601\u2013610. https:\/\/doi.org\/10.2174\/1574888x12666170608124303","journal-title":"Curr Stem Cell Res Therapy"},{"issue":"3","key":"10094_CR25","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1093\/jb\/mvs004","volume":"151","author":"R Nishimura","year":"2012","unstructured":"Nishimura R, Hata K, Matsubara T, Wakabayashi M, Yoneda T (2012) Regulation of bone and cartilage development by network between BMP signalling and transcription factors. J BioChem 151(3):247\u2013254. https:\/\/doi.org\/10.1093\/jb\/mvs004","journal-title":"J BioChem"},{"issue":"1","key":"10094_CR26","doi-asserted-by":"publisher","first-page":"e0170312","DOI":"10.1371\/journal.pone.0170312","volume":"12","author":"R Olivares-Navarrete","year":"2017","unstructured":"Olivares-Navarrete R, Lee EM, Smith K, Hyzy SL, Doroudi M, Williams JK, Gall K, Boyan BD, Schwartz Z (2017) Substrate Stiffness Controls Osteoblastic and Chondrocytic Differentiation of Mesenchymal Stem Cells without Exogenous Stimuli. PLoS ONE 12(1):e0170312. https:\/\/doi.org\/10.1371\/journal.pone.0170312","journal-title":"PLoS ONE"},{"issue":"1","key":"10094_CR27","doi-asserted-by":"publisher","first-page":"20188","DOI":"10.1038\/s41598-021-99614-0","volume":"11","author":"N P\u00f6tter","year":"2021","unstructured":"P\u00f6tter N, Westbrock F, Grad S, Alini M, Stoddart MJ, Schmal H, Kubosch D, Salzmann G, Kubosch EJ (2021) Evaluation of the influence of platelet-rich plasma (PRP), platelet lysate (PL) and mechanical loading on chondrogenesis in vitro. Sci Rep 11(1):20188. https:\/\/doi.org\/10.1038\/s41598-021-99614-0","journal-title":"Sci Rep"},{"issue":"1","key":"10094_CR28","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.tice.2016.11.001","volume":"49","author":"A Pakfar","year":"2017","unstructured":"Pakfar A, Irani S, Hanaee-Ahvaz H (2017) Expressions of pathologic markers in PRP based chondrogenic differentiation of human adipose derived stem cells. Tissue Cell 49(1):122\u2013130","journal-title":"Tissue Cell"},{"issue":"6","key":"10094_CR29","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1007\/s10439-018-2008-8","volume":"46","author":"ME Piroli","year":"2018","unstructured":"Piroli ME, Jabbarzadeh E (2018) Matrix Stiffness Modulates Mesenchymal Stem Cell Sensitivity to Geometric Asymmetry Signals. Ann Biomed Eng 46(6):888\u2013898. https:\/\/doi.org\/10.1007\/s10439-018-2008-8","journal-title":"Ann Biomed Eng"},{"issue":"3","key":"10094_CR30","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1002\/jbm.a.36267","volume":"106","author":"Y Reinwald","year":"2018","unstructured":"Reinwald Y, El Haj AJ (2018) Hydrostatic pressure in combination with topographical cues affects the fate of bone marrow-derived human mesenchymal stem cells for bone tissue regeneration. J Biomedical Mater Res Part A 106(3):629\u2013640","journal-title":"J Biomedical Mater Res Part A"},{"issue":"1","key":"10094_CR31","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s00441-015-2195-7","volume":"362","author":"H Ro","year":"2015","unstructured":"Ro H, Park J, Yang K, Kim J, Yim H-G, Jung G, Lee H, Cho S-W, Hwang NS (2015) Osteogenic priming of mesenchymal stem cells by chondrocyte-conditioned factors and mineralized matrix. Cell Tissue Res 362(1):115\u2013126","journal-title":"Cell Tissue Res"},{"issue":"3","key":"10094_CR32","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.joca.2018.11.005","volume":"27","author":"M Ruiz","year":"2019","unstructured":"Ruiz M, Maumus M, Fonteneau G, Pers Y-M, Ferreira R, Dagneaux L, Delfour C, Houard X, Berenbaum F, Rannou F (2019) TGF\u03b2i is involved in the chondrogenic differentiation of mesenchymal stem cells and is dysregulated in osteoarthritis. Osteoarthr Cartil 27(3):493\u2013503","journal-title":"Osteoarthr Cartil"},{"key":"10094_CR33","doi-asserted-by":"crossref","unstructured":"Shafaie S, Hutter V, Brown MB, Cook MT, Chau DY (2017) Influence of surface geometry on the culture of human cell lines: A comparative study using flat, round-bottom and v-shaped 96 well plates.PloS one12(10)","DOI":"10.1371\/journal.pone.0186799"},{"key":"10094_CR34","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.biomaterials.2018.03.022","volume":"167","author":"A Srinivasan","year":"2018","unstructured":"Srinivasan A, Chang SY, Zhang S, Toh WS, Toh YC (2018) Substrate stiffness modulates the multipotency of human neural crest derived ectomesenchymal stem cells via CD44 mediated PDGFR signaling. Biomaterials 167:153\u2013167. https:\/\/doi.org\/10.1016\/j.biomaterials.2018.03.022","journal-title":"Biomaterials"},{"issue":"3","key":"10094_CR35","doi-asserted-by":"publisher","first-page":"257","DOI":"10.7150\/ijms.21620","volume":"15","author":"M Sun","year":"2018","unstructured":"Sun M, Chi G, Li P, Lv S, Xu J, Xu Z, Xia Y, Tan Y, Xu J, Li L (2018) Effects of matrix stiffness on the morphology, adhesion, proliferation and osteogenic differentiation of mesenchymal stem cells. Int J Med Sci 15(3):257","journal-title":"Int J Med Sci"},{"issue":"5","key":"10094_CR36","doi-asserted-by":"publisher","first-page":"L25","DOI":"10.1016\/j.bpj.2010.12.3744","volume":"100","author":"SY Tee","year":"2011","unstructured":"Tee SY, Fu J, Chen CS, Janmey PA (2011) Cell shape and substrate rigidity both regulate cell stiffness. Biophys J 100(5):L25\u201327. https:\/\/doi.org\/10.1016\/j.bpj.2010.12.3744","journal-title":"Biophys J"},{"issue":"7","key":"10094_CR37","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/nmat3339","volume":"11","author":"B Trappmann","year":"2012","unstructured":"Trappmann B, Gautrot JE, Connelly JT, Strange DG, Li Y, Oyen ML, Stuart MAC, Boehm H, Li B, Vogel V (2012) Extracellular-matrix tethering regulates stem-cell fate. Nat Mater 11(7):642\u2013649","journal-title":"Nat Mater"},{"issue":"10","key":"10094_CR38","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/nmat4051","volume":"13","author":"JH Wen","year":"2014","unstructured":"Wen JH, Vincent LG, Fuhrmann A, Choi YS, Hribar KC, Taylor-Weiner H, Chen S, Engler AJ (2014) Interplay of matrix stiffness and protein tethering in stem cell differentiation. Nat Mater 13(10):979\u2013987. https:\/\/doi.org\/10.1038\/nmat4051","journal-title":"Nat Mater"},{"issue":"1\u20132","key":"10094_CR39","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1089\/ten.TEA.2016.0123","volume":"23","author":"Y Wu","year":"2017","unstructured":"Wu Y, Yang Z, Law JB, He AY, Abbas AA, Denslin V, Kamarul T, Hui JH, Lee EH (2017) The Combined Effect of Substrate Stiffness and Surface Topography on Chondrogenic Differentiation of Mesenchymal Stem Cells. Tissue Eng Part A 23(1\u20132):43\u201354. https:\/\/doi.org\/10.1089\/ten.TEA.2016.0123","journal-title":"Tissue Eng Part A"},{"key":"10094_CR40","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.actbio.2018.08.018","volume":"79","author":"J Xie","year":"2018","unstructured":"Xie J, Zhang D, Zhou C, Yuan Q, Ye L, Zhou X (2018a) Substrate elasticity regulates adipose-derived stromal cell differentiation towards osteogenesis and adipogenesis through \u03b2-catenin transduction. Acta Biomater 79:83\u201395. https:\/\/doi.org\/10.1016\/j.actbio.2018.08.018","journal-title":"Acta Biomater"},{"key":"10094_CR41","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.actbio.2018.08.018","volume":"79","author":"J Xie","year":"2018","unstructured":"Xie J, Zhang D, Zhou C, Yuan Q, Ye L, Zhou X (2018b) Substrate elasticity regulates adipose-derived stromal cell differentiation towards osteogenesis and adipogenesis through \u03b2-catenin transduction. Acta Biomater 79:83\u201395","journal-title":"Acta Biomater"},{"issue":"2","key":"10094_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41368-019-0052-3","volume":"11","author":"C Zhou","year":"2019","unstructured":"Zhou C, Wang Q, Zhang D, Cai L, Du W, Xie J (2019a) Compliant substratum modulates vinculin expression in focal adhesion plaques in skeletal cells. Int J Oral Sci 11(2):1\u20139","journal-title":"Int J Oral Sci"},{"key":"10094_CR43","doi-asserted-by":"publisher","unstructured":"Zhou C, Zhang D, Zou J, Li X, Zou S, Xie J (2019b) Substrate Compliance Directs the Osteogenic Lineages of Stem Cells from the Human Apical Papilla via the Processes of Mechanosensing and Mechanotransduction. 11:26448\u201326459. https:\/\/doi.org\/10.1021\/acsami.9b07147. 29","DOI":"10.1021\/acsami.9b07147"},{"issue":"29","key":"10094_CR44","doi-asserted-by":"publisher","first-page":"26448","DOI":"10.1021\/acsami.9b07147","volume":"11","author":"C Zhou","year":"2019","unstructured":"Zhou C, Zhang D, Zou J, Li X, Zou S, Xie J (2019c) Substrate Compliance Directs the Osteogenic Lineages of Stem Cells from the Human Apical Papilla via the Processes of Mechanosensing and Mechanotransduction. ACS Appl Mater Interfaces 11(29):26448\u201326459","journal-title":"ACS Appl Mater Interfaces"}],"container-title":["Journal of Molecular Histology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-022-10094-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10735-022-10094-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10735-022-10094-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T12:53:18Z","timestamp":1662727998000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10735-022-10094-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,27]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10094"],"URL":"https:\/\/doi.org\/10.1007\/s10735-022-10094-6","relation":{},"ISSN":["1567-2379","1567-2387"],"issn-type":[{"value":"1567-2379","type":"print"},{"value":"1567-2387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,27]]},"assertion":[{"value":"6 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest to this work, financial or otherwise.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest\/Competing interests"}}]}}